Nano-flow liquid chromatography tandem mass spectrometry (nano-flow LC-MS/MS) is the mainstay in proteome research because of its excellent sensitivity but often comes at the expense of robustness. (nature.com)
Trifluoroacetic acid is commonly used as a mobile phase additive in liquid chromatography-mass spectrometry (LC-MS). (sigmaaldrich.com)
Trifluoroacetic acid may be used as a mobile phase additive for the analysis of basic compounds in biological samples using hydrophilic interaction liquid chromatography-electrospray ionization coupled to tandem mass spectrometry (HILIC-ESI/MS/MS) and reversed-phase liquid chromatography coupled to tandem mass spectrometry (RP-LC-MS/MS). (sigmaaldrich.com)
The research aims to study the liquid chromatography with tandem mass spectrometry (LC-MS/MS) as an alternative to the current method for the detection of lipophilic toxins (LTs) in shellfish. (usda.gov)
LC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. (selectscience.net)
Thermo Fisher Scientific have introduced a new-generation triple quadrupole liquid chromatography-mass spectrometry (LC-MS) platform designed to transform quantitation experiments with extreme sensitivity, productivity, precision and usability. (labmate-online.com)
An oft-overlooked segment of the mass spectrometry market is time-of-flight LC-MS. Although LC-TOF does not possess the capabilities of more expensive mass spectrometry techniques, it fills an important price-to-performance segment of the market. (spectroscopyonline.com)
The common method used is gas chromatography (GC) coupled with electron capture detection (ECD) followed by identification using GC/mass spectrometry (MS). Since evidence indicates that heptachlor is metabolized to heptachlor epoxide in mammals, exposure to heptachlor is usually measured by determining levels of heptachlor epoxide in biological media. (cdc.gov)
Triple quadrupole5
The Agilent 6475 triple quadrupole LC/MS was developed to help labs solve these challenges. (agilent.com)
An innovative tuning algorithm using Particle Swarm Optimization (PSO) in the 6475 triple quadrupole LC/MS takes the guesswork out of achieving peak performance. (agilent.com)
Developing targeted triple quadrupole LC/MS (LC/TQ) methods from start to finish is a complex, time-consuming, and multi-step workflow. (agilent.com)
LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. (selectscience.net)
The TSQ Endura triple quadrupole mass spectrometer shares much of the advanced technology of the TSQ Quantiva MS, but was designed to deliver higher uptime than any competitive triple quadrupole instrument. (labmate-online.com)
Analyses4
Ultimately, LC-MS/MS analyses revealed that regarding the number of identifications, number of missed cleavages, proteome coverage, repeatability, reduction of handling time, and cost per assay, the SP3 on carboxylated magnetic particles proved to be the best alternative for SDS and other contaminants removal from plant sample lysate. (frontiersin.org)
The pharmaceutical industry accounts for the largest demand for LC-TOF instruments, which provide a more cost-effective method for routine analyses. (spectroscopyonline.com)
Waters Corporation today introduced the Oasis® PRiME HLB Family, a first-of-its-kind, next-generation solid phase extraction (SPE) product that provides cleaner samples in less time and with less effort for LC and LC-MS analyses. (technologynetworks.com)
Quick batch makes it easier to perform routine LC/MS/MS analyses and changes to the Control Panel help method development. (shimadzu.no)
HPLC1
Optimize Technologies is dedicated to providing the highest quality HPLC, UHPLC and LC/MS products available. (optimizetech.com)
Routine1
Routine work includes method development and optimization of LC-MS/MS methods. (lu.se)
Quantification1
We develop and optimize analytical methods for organic and organometallic compounds, using either liquid chromatography (UHPLC) or supercritical fluid chromatography (SFC) with MS and MS/MS characterization or quantification. (lu.se)
Therefore sample preparation has never more been more important than it is today for getting high-quality LC-MS results. (technologynetworks.com)
Metabolite1
Allen F, Greiner R, Wishart D: Competitive fragmentation modeling of ESI-MS/MS spectra for putative metabolite identification. (t3db.ca)
Digests1
28 reported the identification of about 2,800 human proteins in 60 min from 2 µg HeLa protein digests using an online LC-MS/MS method employing a 1 mm ID column. (nature.com)
Sensitivity2
Enter a new era of sensitivity and LC-MS/MS innovation with the SCIEX 7500 system. (selectscience.net)
The improvement of scan sensitivity in LCMS-8060 proposes you a new way for untargeted screening. (shimadzu.no)
Laboratories2
Laboratories can now process samples up to 40% faster and deliver samples that are up to 70% cleaner with fewer LC-MS matrix effects than samples prepared using other extraction techniques. (technologynetworks.com)
Brevetoxins can be detected in water and contaminated environmental samples by commercial laboratories using ELISA and LC-MS. (cdc.gov)
Sciex1
We strive to provide the best products and services, and live by the mantra, 'when customers talk, we listen,'" Dom Gostick, VP and general manager of LC-MS and chief technology officer at Sciex, said in a statement. (genomeweb.com)
Peptides1
27 employed a standard 2.1 mm ID analytical column to identify about 800 proteins and 4,000 peptides from 40 µg E. coli protein digest using a 120 min LC gradient. (nature.com)
Instruments6
Through this collaboration, we are broadening the variety of LC instruments available to our growing customer base. (genomeweb.com)
The enhanced uptime of the 6475 LC/TQ increases your sample throughput and efficiency without having to add instruments and lab personnel or extend lab hours. (agilent.com)
LC-MS systems are complex and sensitive instruments, and even minor issues can lead to inaccurate results or instrument downtime, resulting in financial losses and delayed research. (sepscience.com)
Though they have been on the market for some time, LC-TOF instruments have offered somewhat limited performance. (spectroscopyonline.com)
However, technology has trickled down from high-end TOF-based instruments into more recently introduced LC-TOF models, which combined with a far lower price point, make the technique very attractive to some end-users. (spectroscopyonline.com)
LC-MS instruments are much more capable of detecting and identifying minute concentrations of sample constituents than ever before. (technologynetworks.com)
Analysis5
Quantitative protein extraction from biological samples, as well as contaminants removal before LC-MS/MS, is fundamental for the successful bottom-up proteomic analysis. (frontiersin.org)
SDS has to be depleted before digestion and MS analysis. (frontiersin.org)
Researchers attempting to overcome complex matrix interference in commercial food analysis have developed a targeted LC-MS/MS method and open source analysis software capable of identifying allergens in complex food matrices. (chromatographyonline.com)
LC-TOF has found significant demand in both environmental analysis and the agriculture & food industries because of its ability to identify contaminants in complex samples, as well as its price point. (spectroscopyonline.com)
Whether doing bioanalysis, food analysis or forensic toxicological screening by LC and LC-MS, few things are more important to getting quality analytical results than a clean sample. (technologynetworks.com)
System5
In a series of elegant experiments, that report demonstrated that discovery proteomics is feasible in principle using such a micro-flow LC-MS/MS system. (nature.com)
The TSQ Quantiva MS system is also extremely productive, with the ability to perform 500 SRM experiments per second, and positive/negative polarity switching in 20ms with no signal loss. (labmate-online.com)
The TSQ Quantiva MS system uses the same source housings as the company's new Orbitrap Fusion Tribrid LC-MS system, which was also introduced at ASMS. (labmate-online.com)
Samples are then back-extracted with diethyl ether, lyophilized, reconstituted, and injected into the LC system. (cas.cz)
It can be coupled to a highly modular supercritical fluid extraction (SFE) and LC/SFC system. (lu.se)
Proteomic1
This study demonstrates that micro-flow LC-MS/MS is suitable for a broad range of proteomic applications. (nature.com)
Reaction1
Current methods often use targeted LC-MS/MS in multiple reaction monitoring (MRM) mode. (chromatographyonline.com)
Systems2
LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. (selectscience.net)
The TSQ Quantiva MS has been shown using synthetic serum stress tests to operate approximately three times longer between maintenance intervals than the company's previous best systems, without loss of signal. (labmate-online.com)
Combine1
29 who introduced specialized new chromatographic hardware that aims to combine the advantages of micro-flow and nano-flow LC. (nature.com)
Methods1
Title : Various calibration procedures result in optimal standardization of routinely used 25(OH)D ID-LC-MS/MS methods Personal Author(s) : Dirks, Niek F.;Vesper, Hubert W.;van Herwaarden, Antonius E.;van den Ouweland, Jody M.W.;Kema, Ido P.;Krabbe, Johannes G.;Heijboer, Annemieke C. (cdc.gov)
Identification1
Wang F, Liigand J, Tian S, Arndt D, Greiner R, and Wishart D. CFM-ID 4.0: More Accurate ESI MS/MS Spectral Prediction and Compound Identification. (hmdb.ca)
Positive1
Following the positive ID of the five compounds of interest and their elution points, the drug mixture was then ready for a preparative LC-UV run on the puriFlash ® 5.250 iELSD. (advion.com)
High2
Although the lack of MS-MS capability limits the capabilities of LC-TOF, it does provide a high mass range, high speed, and very high resolution. (spectroscopyonline.com)
The biotechnology and forensics industries also contribute significant demand for LC-TOF due to the high mass range. (spectroscopyonline.com)
Products1
Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers. (selectscience.net)
Fast2
Manufactured specifically for accurate and fast LC-MS. (sigmaaldrich.com)
Fast Guards" er en nyutviklet forkolonne for UHPLC. (matriks.no)
Solution1
Commonly used as an auto-sampler cleaning solution in LC-MS. (fishersci.com)
Download1
Click the button below to download your free copy of Shimadzu's LC-MS troubleshooting guide. (sepscience.com)