Latter interaction setting the membrane potential. Medical search. Frequent questions

As you refer to in the paper you can certainly see that proteins appear to dimerize using fluorescent tags, and at Frederick we've used two or three different approaches to try to verify that kind of apparent dimerization in living cells or in cell membranes, using step photobleaching or FRET or BRET or visualizing fusion fluorescent proteins coming together in space. (cancer.gov)
In the present study it is shown that Popdc1 protein in the heart was predominantly localized to the intercalated disc, lateral membranes and T-tubularsystem, where it was co-localized with other cardiac membrane proteins such as Cav1.2, Caveolin 3 and NCX1. (uni-wuerzburg.de)
Functional proteomics is aimed to understand proteins' biological function and their regulation by studying protein-protein interactions within and among multiprotein complexes through affinity purification and mass spectrometric analysis. (mdanderson.org)
This may include lipids and membranes, proteins, and pharmaceuticals in the biomolecule category. (cecam.org)
After accounting for known malaria risky loci and other potential confounders such as parasite diversity, they narrowed in on a suspicious new chromosome 4 site falling between the FREM3 gene and the GYPE, GYPB, and GYPA genes, which code for glycophorin proteins expressed in the red blood cell membrane. (genomeweb.com)
At least two P. falciparum proteins bind host blood cells via interactions with the glycophorin proteins Glycophorin A and Glycophorin B, the team noted, consistent with a potential role for the glycophorin locus in helping to dodge severe malaria infection. (genomeweb.com)
Proteins, glycolipids, and phospholipids make up cellular membranes, which are crucial for protecting and limiting metabolic processes within cells while also preserving cellular integrity and homeostasis. (alliedacademies.org)
Most membrane proteins are less abundant and more hydrophobic than typical soluble proteins, which makes study of these proteins more challenging. (alliedacademies.org)
The sample preparation, which includes the enrichment and dissolution of the membrane proteins, is crucial for the successful identification of membrane proteins. (alliedacademies.org)
The enrichment of low-abundance membrane proteins at membrane and/or protein levels and the dissolution of hydrophobic membrane proteins have both been accomplished using a variety of established and recently developed techniques. (alliedacademies.org)
Transmembrane proteins are water insoluble, which makes them difficult to study using mass spectrometry and conventional biochemical methods, but not impossible (MS). In this review, we emphasise the importance of shotgun MS for hastening the discovery and investigation of membrane proteins. (alliedacademies.org)
Undoubtedly, the under-representation of membrane proteins in large-scale proteomic datasets is due to the relatively low abundance of these proteins in un-fractionated samples. (alliedacademies.org)
A significant rise in the representation of PM proteins in large-scale data sets has been attributed to a number of recent technological developments, including enhanced sample preparation, equipment, and liquid chromatographic (LC) performance [ 1 ]. (alliedacademies.org)
Even though the majority of membrane proteins cannot be accessed using conventional sample preparation methods, this is a subject that is very important to our discussion and has already been well reviewed. (alliedacademies.org)
This is necessary in order to completely characterise membrane proteins. (alliedacademies.org)
A significant advancement would be the identification of a comprehensive catalogue of membrane proteins, which might give a comprehensive overview of all the proteins at the PM [ 2 ]. (alliedacademies.org)
The hydrophobicity, intricate post-translational modifications (PTMs), and low quantity of membrane proteins make it difficult to analyse them. (alliedacademies.org)
The identification of membrane proteins is now more accurate than in earlier analyses due to improved instrument performance, making it possible to analyse complicated protein mixtures in greater detail. (alliedacademies.org)
With the commercial availability of column ovens, raising the temperature from degrees during micro LC has recently been demonstrated to increase the amount of membrane proteins detected in a typical analysis and should become standard practise. (alliedacademies.org)
Specifically, we are interested in post-translational modifications, changes to a protein after it's produced, which add an incredible level of diversity to the underlying proteins within a cell and can control a diverse array of processes, including protein stability, interactions, and activity. (upenn.edu)
Structural homology studies confirm similar membrane transport proteins in gut epithelial cells and the gut microbiome of the host that may compete for drug substrates with the host itself for its absorbance. (biomedcentral.com)
3] Most of the bacteria invade the mucous layer, but approximately 20% attach to the gastric epithelium via outer membrane proteins. (medscape.com)

In all other cells, DMT1 is found in intracellular membranes where it promotes the exit of endocytosed Fe 2+ from endosomes into the cytoplasm 9 . (nature.com)
The large-conductance, Ca 2+ and voltage-activated K + channel (BK, also termed as BK Ca , Maxi-K, K Ca1.1 or Slo1) is a unique member of the mammalian K + channel family, which has the largest single channel conductance and is dually activated by membrane voltage and intracellular Ca 2+ . (mdanderson.org)
The ligand-bound TM configuration promotes asymmetric dimerization of the intracellular juxta-membrane (JM) and kinase domains, which causes autophosphorylation of intracellular tyrosine residues ( 6 , 7 ). (biorxiv.org)
Thus, our discovery of the role of functional interaction between intracellular signaling pathways mediated by calcium ions (Ca 2+) and cyclic adenosine monophosphate (cAMP) (Ca 2+ /cAMP signaling interaction) in these cellular responses, opened a great avenue for the development of new antitumor therapeutic strategies. (researchgate.net)
Nakaoka et al (2009) - Spontaneous fluctuation of the resting membrane potential in Paramecium - amplification caused by intracellular Ca2+. (romainbrette.fr)

Ion channels have long been key therapeutic targets in disease intervention and pharmaceutical drug development because of their direct involvement in diverse diseases, vulnerability to small molecular modulation, and accessibility for direct activity measurement on cell membranes by patch-clamp recording from whole cell to single molecule levels. (mdanderson.org)
For example, CagA -positive strains of H pylori are believed to be quite virulent, causing increased cytokine production, leaky cell membranes, and other structural changes. (medscape.com)

Eight monophasic action potentials and ECG recordings showed a significant abbreviation of action potential duration (APD90 ), QT interval and effective refractory periods (ERP) after caffeine treatment. (researchgate.net)
An analysis focusing on the model's ability to fire spontaneously discloses the feedback mechanism and allows us to predict which combinations of ion concentrations that give rise to spontaneous firing of action potentials. (physiomeproject.org)
In addition, islet paracrine factors such as insulin, somatostatin, Zn 2+ , and GABA have the ability to cause islet α-cells to fire action potentials ( 2 - 8 ), in some cases by regulating ion channels such as K ATP ( 15 ). (diabetesjournals.org)

Broadly neutralizing antibodies (bNAbs) against the membrane-proximal external region (MPER) of the gp41 component of the human immunodeficiency virus type 1 (HIV-1) envelope (Env) are characterized by long, hydrophobic, heavy chain complementarity-determining region 3s (HCDR3s) that interact with the MPER and some viral membrane lipids to achieve increased local concentrations. (stanford.edu)
The interaction of paraffin chains at aqueous surfaces is a major factor in defining the stability of interfacial structures such as monolayers and membranes formed by lipids and surfactants. (princeton.edu)

Moreover, we identified two structural motifs in transmembrane segments 2 and 4 involved in mTRPA1-cholesterol interactions that are necessary for normal agonist sensitivity and plasma membrane localization. (elifesciences.org)
However, it is currently unknown whether TRPA1 is localized in specific domains of the plasma membrane, or whether cholesterol interacts with specific residues of TRPA1. (elifesciences.org)
The determination of the plasma membrane (PM) proteome, resolution of membrane protein topology, establishment of numerous receptor protein complexes, identification of ligand-receptor pairs, and elucidation of signalling networks originating at the PM have all benefited from recent developments in proteomic mass spectrometry. (alliedacademies.org)
HvPIP1;6, a Barley (Hordeum vulgare L.) Plasma Membrane Water Channel Particularly Expressed in Growing Compared with Non-Growing Leaf Tissues. (lu.se)

In 1982, Gurney moved to California to carry out postdoctoral research with Henry Lester at the California Institute of Technology, making use of novel light-sensitive compounds to study the interactions between drugs and receptors. (wikipedia.org)
Membrane Receptors, Channels and Transporters in Pulmonary Circulation. (wikipedia.org)
In addition we have recently started to explore the structure and molecular function of pain receptors from animals, i.e. transient receptor potential (TRP) ion channels, and their activation by temperature and various ligands. (lu.se)

As the frontline defense of the cell against exterior influences, the phospholipid membrane is key in structure, defense, and signaling, but current omics studies are only just now catching up to the potential hidden within cellular lipid profiles. (tennessee.edu)
To determine TRPA1 localization in cellular membranes we stained HEK293T cells transfected with the mTRPA1-mCherry construct with the Vybrant Alexa Fluor 488 Lipid Raft Labeling Kit. (elifesciences.org)
With the use of total internal reflection fluorescence (TIRF) microscopy we found a population of highly mobile vesicular structures near the cellular membrane containing both mTRPA1-mCherry and the lipid raft marker cholera toxin B ( Figure 1A and B , Video 1 ), as well as static areas where both fluorescent probes were colocalized at the membrane. (elifesciences.org)
The Sigma-1 Receptor (S1R) is a small, ligand-regulated integral membrane protein involved in cell homeostasis and the cellular stress response. (ox.ac.uk)
Kenji Hayashi After more than one shop The Mistress Diaries of interactions it gives lost a either cellular article, although new 1D phenomena need then poor. (taido-hannover.de)

Such results pronounce the idea of the existence of structural homology between membrane transporters of the gut microbiome and intestinal enterocytes of the host that may competitively absorb orally administered phenobarbital during transit in the small intestine. (biomedcentral.com)

Inhaled sulfur dioxide readily reacts with the moisture of mucous membranes to form sulfurous acid (H 2 SO 3 ), which is a severe irritant. (cdc.gov)
Exposures of 10 to 20 ppm cause irritation to mucous membranes. (cdc.gov)

For example, two 2018 papers are titled "K-Ras4B Remains Monomeric on Membranes over a Wide Range of Surface Densities and Lipid Compositions" 1 and "The Biological and Therapeutic Impact of KRAS Dimerization in KRAS-Mutant Cancer" 2 . (cancer.gov)
Using a flexible lipid extraction method using methyl tert -butyl ether (MTBE) combined with nanoscale hydrophilic interaction chromatography (HILIC) and nano-electrospray (nESI) tandem mass spectrometry (MS/MS), shifts in the lipidomes of several bacteria under consideration as industrial workhorses were investigated under variable growth conditions induced by introduction of toxic chemicals. (tennessee.edu)
We discuss the impact of such interactions on TRPA1 gating mechanisms, regulation by the lipid environment, and role of this channel in sensory membrane microdomains, all of which helps to understand the puzzling pharmacology and pathophysiology of this channel. (elifesciences.org)
Cardiovascular prevention is further complicated by increased rates of drug side effects in people with diabetes, including potential adverse glycaemic effects of lipid-modifying agents [ 6 , 7 ]. (springer.com)
Here, we show that increasing the local concentration of MPER-directed bNAbs at the cell surface via binding to the high-affinity Fc receptor FcγRI potentiates their ability to prevent viral entry in a manner analogous to the previously reported observation wherein the lipid-binding activity of MPER bNAbs increases their concentration at the viral surface membrane. (stanford.edu)
Therefore, lipid binding may not be a strict requirement for potent neutralization by MPER-targeting bNAbs, as alternative methods can achieve similar increases in local concentrations while avoiding potential liabilities associated with immunologic host tolerance. (stanford.edu)
Broadly neutralizing antibodies targeting the membrane proximal external region (MPER) of Env show lipid-binding characteristics, and modulating this interaction affects neutralization. (stanford.edu)
1981, 81, 41) for chain-chain interactions in insoluble lipid monolayers account rather well for the estimated second virial coefficients without recourse to corrections for "hydrophobic" effects in the two-dimensional alkane gases. (princeton.edu)
Solute transport on the sub 100 ms scale across the lipid bilayer membrane of individual proteoliposomes. (lu.se)
Structure and Stability of the Spinach Aquaporin SoPIP2;1 in Detergent Micelles and Lipid Membranes. (lu.se)

β-Cells depend on the islet basement membrane (BM). (nature.com)

In the paper we go into detail also to show that the mutation doesn't affect some of the other known properties of RAS, membrane localization or nucleotide exchange or GTP hydrolysis, etc., those were not impacted, meaning that we believe that the finding here is truly due to dimerization, and opens some hopefully new therapeutic avenues for RAS mutant cancers. (cancer.gov)

The structure also raises many interesting questions and provides an excellent starting point for understanding the molecular tricks employed by this small membrane receptor to modulate a large number of signaling events. (ox.ac.uk)
Our group has previously studied the nature of chemical interactions within a mixture that could modulate absorption across the skin. (cdc.gov)

The researchers have already demonstrated that the dendricolloids can be used to make membranes for growing live cells, or to create hydrophobic and hydrophilic coatings. (materialstoday.com)

Ion channels are membrane protein complexes that translocate ions across cell or organelle membranes, underlying a broad range of the most basic physiological processes from nerve and muscle excitability, to membrane potential setting, pH/cell volume regulation, secretion and absorption. (mdanderson.org)
Here we combine a relatively detailed model of glial membrane transport of water and ions and a Hodgkin-Huxley type neuron model to examine the effectof perturbing the magnitudes of transport rates in the glial membrane that may influence this feedback. (physiomeproject.org)

To better understand membrane protein structure, protein-protein interactions, and signalling networks that emerge from the membrane surface, we briefly discuss recent MS developments to determine the entire membrane proteome. (alliedacademies.org)

We observed that PET1 behaves as a pH-responsive peptide that modulates the configuration of the EGFR TM through a direct interaction. (biorxiv.org)
This study is a proof-of-concept that acidity-responsive membrane peptide ligands can be generally applied to RTKs. (biorxiv.org)

Interactions of Surfactants with Biomimetic Membranes-2. (mdpi.com)
It is discovered that noncharged surfactants lead to electric effects that interact with biomimetic membranes made of nitrocellulose filters, which are impregnated with fatty acid esters. (mdpi.com)

To mediate these processes, the extracellular ligand binding region of EGFR senses environmental cues via interactions with one of its 7 known ligands, of which epidermal growth factor (EGF) is the most well characterized ( 2 , 3 ). (biorxiv.org)
Here, we review insights from the structures of ligand-bound S1R in the context of previous biochemical studies and propose, from a structural viewpoint, a set of important future directions. (ox.ac.uk)

While there she identified a positive feedback effect of cytoplasmic Ca2+ on cardiac calcium channels, a role for ATP-sensitive potassium channels in regulating the membrane potential of artery smooth muscle cells and the main features of the ion channels that set the resting potential of pulmonary artery smooth muscle cells. (wikipedia.org)
The effects of different fluorescent pseudomonads, including some known biocontrol agents of other plant pathogens, on fungal growth of the haploid Verticillium dahliae and/or the amphidiploid Verticillium longisporum were compared on pectin-rich medium, in microfluidic interaction channels, allowing visualization of single hyphae, or on Arabidopsis thaliana roots. (frontiersin.org)
A more detailed analyses on bacterial-fungal co-cultivation in narrow interaction channels of microfluidic devices revealed that the strongest inhibitory potential was found for Pseudomonas protegens CHA0, with its inhibitory potential depending on the presence of the GacS/GacA system controlling several bacterial metabolites. (frontiersin.org)
Hyphal tip polarity was altered when V. longisporum was confronted with pseudomonads in narrow interaction channels, resulting in a curly morphology instead of straight hyphal tip growth. (frontiersin.org)
The depolarization first activates the low voltage-activated T-type Ca 2+ channels, which have been implicated in action potential initiation ( 10 ). (diabetesjournals.org)
Activation of K + channels then shapes the α-cell action potential upstroke. (diabetesjournals.org)
Action potential repolarization then follows with the activation of voltage-gated potassium (N) channels ( 12 ). (diabetesjournals.org)
In islet β-cells, elevations in glucose increase the ATP-to-ADP ratio, resulting in the closure of ATP-sensitive K + (K ATP ) channels and causing action potential firing. (diabetesjournals.org)

By solving the model equations repeatedly for a large number of empirically valid parameter sets, we find that both the high [K+]o-induced duration of neuronal firing and the prevalence of depolarization block show high sensitivities to variation in the time scale of the glial membrane dynamics and to the magnitudes of the sodium-potassium pump rate and the potassium ion channel conductance. (physiomeproject.org)
Simultaneously we are able to monitor changes in molecular dynamics of the added molecules inside SC, enabling us to draw conclusions on interactions and partitioning of these molecules in SC. (lu.se)

The peri-islet membrane, which encapsulates the islets, separates the endocrine cells from the exocrine pancreas and serves as a barrier from immune cell infiltration to the islets. (nature.com)
Thus, human endocrine cells are not in direct contact with the vascular BM components but with the invaginated peri-islet membrane. (nature.com)

Signaling is then transduced across the membrane by altering the configuration of the transmembrane (TM) domain, by dimerization of the TM helical region or a change in the arrangement of the TM helices within such a dimer. (biorxiv.org)

At a surfactant concentration as low as 64 microM in one of the solutions, they lead to the transient formation of transmembrane electric potential. (mdpi.com)

The firm has its targets set far as it delivers a very solid experience to the market. (forextrading-madeeasy.com)

Our hope is that through our work, we will not only provide insight into the processes underlying disease, but also provide new therapeutic strategies which can be used in a clinical setting to ultimately improve patient outcomes. (upenn.edu)

Fatemeh M. Membrane proteome for analysis by later mass spectrometry. (alliedacademies.org)

Basic to understanding these structures are the intermolecular pair potentials as expressed in the two-dimensional virial coefficients. (princeton.edu)

Connolly and Kerkut (1983) - Ion regulation and membrane potential in tetrahymena and paramecium . (romainbrette.fr)

This study aims to determine if pathologic mitochondrial fission mediated by Drp1/Fis1 interaction impacts extracellular mitochondrial content and macrophage function in sepsis-induced immunoparalysis.DESIGN: Laboratory investigation.SETTING: University laboratory.SUBJECTS: C57BL/6 and BALB/C mice.INTERVENTIONS: Using in vitro and murine models of endotoxin tolerance (ET), we evaluated changes in Drp1/Fis1-dependent pathologic fission and simultaneously measured the quantity and quality of extracellular mitochondria. (stanford.edu)

In agreement with this conclusion, the European Union's Scientific Committee on Food published a report in March 2003 summarizing its investigation into potential interactions of the ingredients in energy drinks. (researchgate.net)

We found that the potential for formation of bacterial lipopeptide syringomycin resulted in stronger growth reduction effects on saprophytic Aspergillus nidulans compared to Verticillium spp. (frontiersin.org)

Although these interactions remain to be further examined in humans, the physiological functions of taurine appear to be inconsistent with the adverse cardiovascular symptoms associated with excessive consumption of caffeine-taurine containing beverages. (researchgate.net)

In all likelihood, an interaction of several signals regulates glucagon secretion in vivo. (diabetesjournals.org)

Figure 1 shows how the Ca 2+ /cAMP signaling interaction could be pharmacologically modulated by the combined use of the Ca 2+ channel blockers (CCB) and drugs that promote the increase of [cAMP] c (cAMP-enhancer compounds). (researchgate.net)
However, absorption of orally administered non-antibiotic drugs by the gut microbiome, during drug-microbiome interaction, is barely addressed. (biomedcentral.com)
This phenomenon suggests the microbiome as a potential candidate that can significantly alter the pharmacokinetics of drugs. (biomedcentral.com)

Omics technologies have rapidly evolved over the last half century through vast improvements in efficient extraction methodologies, advances in instrumentation for data collection, and a wide assortment of informatics tools to help deconvolute sample data sets. (tennessee.edu)
Recent experimental advances in aptamer selection techniques both in-vivo (phage-display, cell-surface display) and in-vitro (messengerRNA display) have opened up new vistas for combining biological and traditional materials via controlled interactions at the biointerface. (cecam.org)
Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants. (genomeweb.com)

The protein may contain charges and their interaction with the solute will contribute to "solvation energy. (lu.se)
The calculation works like this: First the potential due to the solute charges (call them rho_solute) in the above described dielectric environment is calculated. (lu.se)
Next the potential due to rho_solute is calculated in the vacuum dielectric environment described above. (lu.se)
The reaction field component of the solvation energy is then, (rho_solute*phi_sol - rho_solute*phi_vac)/2, where "*" indicates a suitable sum or integral of charge times potential. (lu.se)

However, while many studies demonstrated the importance of the ECM, its interactions with β-cells are still not fully understood. (nature.com)
The interactions with the various BM components differentially affect β-cells, although the underlying mechanism is largely unknown. (nature.com)
Moreover, these cells exhibited enhanced mitochondrial membrane potential and generation of mitochondrial reactive oxygen species (mtROS) along with lower levels of mitophagy. (stanford.edu)
Also, they can clump together or agglomerate, which can affect their potential for settling in the lungs if inhaled, their ability to penetrate the body's membranes and consequently move from the lungs to other organs, and their interaction with cells and tissue. (cdc.gov)
Collectively, this host-microbiome interaction can harbor trillions of cells, more than 100 folds of genes present in the human genome. (biomedcentral.com)
thus, glucose responsiveness has been linked to the activity of K ATP , which sets the resting membrane potential of pancreatic β-cells. (diabetesjournals.org)
In contrast to β-cells, K ATP channel closure in α-cells has been linked to the termination of action potential firing ( 10 ). (diabetesjournals.org)

Maximum changes of this potential are proportional to the log of noncharged surfactant concentrations when it changes by three orders of magnitude. (mdpi.com)

Molecular Membrane Biology 2013, 30 (3):246-260. (lu.se)

Therefore, this study aimed to identify a set of point mutations distributed throughout the T. solium mitochondrial genome that differentiate the African-American from the Asian genotype. (cdc.gov)

The perturbations reflect pathological conditions and/or heterogeneity in glial membrane transporter density. (physiomeproject.org)
There are specific cutoff values of certain optical density, read by spectrophotometry, that are set by manufacturers for positive, negative, and equivocal results. (medscape.com)

Les interactions sucres/protéines (enzymes, lectines) sont au cœur de la communication cellulaire tant extracellulaire (interactions cellule-cellule, cellule-matrice, hôte-pathogène) qu'intracellulaire (GlcNAcylation en tant que modification post-traductionnelle). (univ-nantes.fr)

So that was the first observation that this inhibitory effect was somehow mediated by interaction of wild type with mutant KRAS. (cancer.gov)

The receptor has a multitude of protein and small molecule interaction partners with therapeutic potential. (ox.ac.uk)

Purification and Proteomic Analysis of Plant Plasma Membranes. (lu.se)

GII.17 noroviruses are composed of distinct genetic clusters (I, II, IIIa, and IIIb) and have shown potential for replacing historically more prevalent GII.4 strains, but the serological basis for GII.17 antigenic diversity has not been studied in children. (cdc.gov)

The pharmacological modulation of Ca2+/cAMP signalling interaction is also cited. (researchgate.net)

Although the mechanism of absorption of a single chemical has been well studied, effects of co-administered chemicals on absorption of a systemic toxicant may ultimately determine whether this potential toxicity is ever realized. (cdc.gov)
The objective of this present grant was to extend the analysis of chemical mixture interactions that affect percutaneous absorption to define the physical chemical characteristics of the mixture that allow significant mixture interactions to be detected. (cdc.gov)

Affinity tags can reduce merohedral twinning of membrane protein crystals. (lu.se)

Despite the enormous potential for pharmaceutical applications, the molecular details of the changes in the stratum corneum (SC) associated with high permeability in the presence of different added chemicals are still not fully understood. (lu.se)

1,2 The effective management and prevention of VRE requires appropriate antimicrobial selection and aggressive infection-control measures, and pharmacists across healthcare settings play a significant role in optimal patient care. (uspharmacist.com)
How is it used: To assist healthcare facilities in preventing transmission of COVID-19 in healthcare settings. (cdc.gov)

Feature papers represent the most advanced research with significant potential for high impact in the field. (mdpi.com)
Statistical techniques were used to define significant mixture interactions. (cdc.gov)
A number of significant interactions were detected across all model systems that altered the normally linear relationship between a compound's octanol/water partition coefficient arid dermal permeability. (cdc.gov)

The second set of parameters is the concentration of the polymer in the polymer solution. (materialstoday.com)
Enhancing HIV-1 Neutralization by Increasing the Local Concentration of Membrane-Proximal External Region-Directed Broadly Neutralizing Antibodies. (stanford.edu)

Because multiple other factors can contribute to AKI development in the complex clinical setting of LuTx, we next investigated the role of exogenous CFH administration in a mouse model of mild bilateral renal ischemia reperfusion injury (IRI). (stanford.edu)

These data indicate that multiple antigenically distinct GII.17 variants co-circulate in young children, suggesting retention of cluster diversity alongside potential for immune escape given the existence of antibody-defined cluster-specific epitopes elicited during infection. (cdc.gov)

Despite emergent evidence that TRPA1 is regulated by the membrane environment, it remains unknown whether this channel localizes in membrane microdomains or whether it interacts with cholesterol. (elifesciences.org)

RESULTS: A set of 31 novel non-synonymous point mutations present in all genomes of the African-American genotype were identified. (cdc.gov)
In the pretreatment setting, positive results indicate infection with H pylori, and negative results indicate lack of infection. (medscape.com)
In the posttreatment setting, negative results indicate eradication if testing is performed at least 4 weeks after therapy is stopped. (medscape.com)

For the current study, the team set out to expand on those findings, first assessing genetic patterns in 5,633 children with severe malaria from The Gambia, Kenya, and Malawi and more than 5,900 unaffected children from the same populations. (genomeweb.com)
In this study, we tested the neutralization potencies of variants of the MPER-targeting antibody 10E8 with different viral-membrane-binding and host FcγRI-binding capabilities. (stanford.edu)

Information Management Systems), which allow for collection and processing of large data sets. (lu.se)

A membrane receptor reagent and assay is disclosed in which liposomes are bound to an evanescent wave emitting surface. (google.com)

Anatomy50

Organisms20

Chemicals and Drugs100

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes55

Disciplines and Occupations4

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Proteins22

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Cell membranes2

Action potentials3

Lipids2

Plasma membrane4

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Mucous2

Lipid10

Basement membrane1

Localization1

Modulate2

Hydrophobic1

Ions2

Protein-protein inte1

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Channels8

Dynamics2

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Dimerization1

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Processes1

MASS SPECTROMETRY1

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