There are three types of lathyrism: neurolathyrism, osteolathyrism, and angiolathyrism, all of which are incurable, differing in their symptoms and in the body tissues affected. (wikipedia.org)
Collagen3
Lathyrism produces poorly cross-linked Collagen in healing anastomosis, keeping a larger portion of the synthesized Collagen soluble. (istanbul.edu.tr)
Lathyrism is characterized by defective collagen synthesis due to inhibition of lysyl oxidase, an enzyme that is essential for interfibrillar collagen cross-linking. (omu.edu.tr)
Defective collagen metabolism such as lathyrism may negatively influence the interface between implant and surrounding soft tissue attachment. (omu.edu.tr)
Lower limbs1
The onset of lathyrism can be slow or sudden, and is often indicated by a feeling of heaviness and pain in the lower limbs. (theferns.info)
Connective tissue1
Therefore, the purpose of this study was to assess the effect of defective connective tissue metabolism on epithelial implant interface by using beta-APN created chronic lathyrism in the canine model. (omu.edu.tr)
Lathyrus4
Lathyrism is a condition caused by eating certain legumes of the genus Lathyrus. (wikipedia.org)
Some states in India have banned the sale of Lathyrus seed in order to prevent its consumption, which in turn lessens the possibility of lathyrism in the general population. (wikipedia.org)
in Lathyrus sativus and Human Lathyrism: Progress and Prospects. (wikipedia.org)
Chronic cyanide poisoning is thought to be a form of lathyrism, a neurotoxicity recognized in people in some eastern Asian countries where the seeds of certain peas (Lathyrus spp. (equinegutflush.com)
Neurological1
Historically the grass pea is known to produce adverse side effects with excessive human consumption which exacerbates the risk of a neurological disorder known as lathyrism which can cause permanent paralysis below the knees both in adults and children. (livingfield.co.uk)
Nervous system2
Medical problems caused by plants: Lathyrism" Archived 2012-02-04 at the Wayback Machine at Prince Leopold Institute of Tropical Medicine online database COHN, D.F. (1995) "Are other systems apart from the nervous system involved in human lathyrism? (wikipedia.org)
Although no records of toxicity have been found for this plant, the seed of some species in this genus contain a toxic amino acid that can cause a severe disease of the nervous system known as 'lathyrism' if they are eaten in large amounts (although small quantities are said to be nutritious)[65, 76]. (pfaf.org)
Paralysis1
Arhar dal is mixed with Khesari dal which causes lathyrism, a crippling disease characterised by paralysis of the leg. (thestatesman.com)
Disease1
Glutamate excitotoxicity is associated with diseases like amyotrophic lateral sclerosis, multiple sclerosis, lathyrism, and Alzheimer's disease (PMID: 20229265) and in epileptic seizures. (foodb.ca)
Genus1
A plant genus in the family FABACEAE known for LATHYRISM poisoning. (nih.gov)
Problems1
Congenital forms are believed to be due to mare factors including malpositioning of the foetus, influenza during pregnancy, thyroid problems, and lathyrism (poisoning by members of the pea family like Sweet Pea). (horsepower.com.au)
Review1
Barrow M.V., Simpson C.F., Miller E.J. Lathyrism: A Review .Quart. (kiev.ua)
Model1
This experimental model of lathyrism is appropriate for investigation of the lysyl oxi-dase inhibitors effect on extracellular matrix. (kiev.ua)
Consumption2
Lathyrism cases were identified using a case definition of symmetrical spastic leg weakness, and subacute or insidious onset, with no sensory deficit, and with a history of grass pea consumption before and at the onset of paralysis. (nih.gov)
Studies had linked lathyrism to consumption of certain species of legumes that contained the compound β- N -oxalylamino-ʟ-alanine (BOAA). (nih.gov)
Connective2
Osteolathyrism, a different type of lathyrism, affects the connective tissues, not the motor neurons. (wikipedia.org)
Because collagens and elastin are important components of the extracellular matrix, abnormalities in their modification can be expected to affect many tissues, as seen in lathyrism, a connective tissue disorder caused by the administration of ß-aminopropionitrile, an irreversible inhibitor of lysyl oxidases. (adhd-npf.com)
Cramps1
Lathyrism, leg cramps, and thrombocytopenia: cascade of events starting in a concentration camp. (nih.gov)
Legumes1
citation needed] Eating the grasspea with legumes having high concentrations of sulphur-based amino acids reduces the risk of lathyrism if such grain is available. (wikipedia.org)
India1
The discovery was serendipitous, an offshoot of research on lathyrism, a progressive paralysis of the legs found in people in China, India, and the Middle East. (nih.gov)
Disease2
Lathyrism is a disease of the Muscles of the Legs. (herbpathy.com)
Enzymatic crosslinking can be limited by compounds such as β-aminopropionitrile (BAPN) and result in a crosslink deficiency characterizing a disease known as lathyrism. (purdue.edu)
Current1
The Lathyrism problem : current status and new dimensions. (who.int)
Similar1
A third type of lathyrism is angiolathyrism, which is similar to osteolathyrism in its mechanism, employing the toxin beta-aminopropionitrile. (wikipedia.org)
Administration1
In the experimental group, lathyrism was induced by a once daily subcutaneous administration of beta-APN at a dose of 5mg in 0.4ml distilled water per 100g of body weight for 40 days. (bvsalud.org)