• Amyotrophic lateral sclerosis: a team approach to primary care. (umassmed.edu)
  • Houde SC, Mangolds V. Amyotrophic lateral sclerosis: a team approach to primary care. (umassmed.edu)
  • Amyotrophic lateral sclerosis (ALS), commonly known as Lou Gehrig's disease, is a progressive and fatal neuromuscular disease for which no cure or viable treatment has been identified. (cdc.gov)
  • Amyotrophic Lateral Sclerosis (ALS) involves the progressive and often rapid death of motor neurons in the brain and spinal cord, as well as the loss of connections made by the spinal cord motor neurons to the muscle. (health.mil)
  • With support from a fiscal year 2013 Amyotrophic Lateral Sclerosis Research Program (ALSRP) Therapeutic Development Award (TDA), the Svendsen lab successfully delivered human neural progenitor cells secreting GDNF into the cortex of ALS models. (health.mil)
  • This paper presents a study of the lived experiences of people living with Amyotrophic Lateral Sclerosis, their caregivers, and members of the healthcare management team from a human-centered perspective in the pursuit of pain points, deeper understanding of the emotional needs, and revelation of opportunities for improving quality of life and human experience through more user-centered design. (illinois.edu)
  • Researchers at the University of Colorado Boulder have discovered a link between an ancient protein with virus-like characteristics, called PEG10, and the development of amyotrophic lateral sclerosis (ALS). (medicalnewstoday.com)
  • Until now, the relationship between C-reactive protein (CRP) levels and amyotrophic lateral sclerosis (ALS) risk has not been fully established. (frontiersin.org)
  • Amyotrophic lateral sclerosis and other motor neuron diseases are characterized by steady, relentless, progressive degeneration of corticospinal tracts, anterior horn cells, bulbar motor nuclei, or a combination. (msdmanuals.com)
  • Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease (MND). (msdmanuals.com)
  • Shared genetic links between amyotrophic lateral sclerosis and obesity-related traits: a genome-wide association study. (cdc.gov)
  • This study again elucidates that corticosteroid injections may have some benefit in the short term, but the long-term benefits are definitely lacking in the treatment of lateral epicondylitis. (medscape.com)
  • Distal femoral tumour resections are mostly performed through a medial or anteromedial approach. (scielo.org.za)
  • In this case series of three patients, we sought to describe a modified injection technique of the chin with hyaluronic acid-based filler using a tapered lateral to medial approach aimed at correcting mild to moderate chin retrusion and resorption. (jcadonline.com)
  • An advantage of using this approach is that starting from a lateral to medial approach with a needle allows the injector to rebuild the chin compartment using precise volumes of filler, requiring minimal total filler volume to achieve optimal corrective results. (jcadonline.com)
  • We sought to describe a modified injection technique of the chin with HA-based filler using a tapered lateral to medial approach. (jcadonline.com)
  • To partition the medial chin from the lateral chin, a straight line was drawn vertically from the nasal ala to the mandible. (jcadonline.com)
  • More precisely, the human FPl has access to both medial and lateral cortical circuits through its extensive connections with other frontal, parietal and temporal association areas. (nature.com)
  • These cords are defined by their spatial relationship to the axillary artery, and are designated as the lateral, posterior, and the medial cord. (asra.com)
  • Lateral and medial humeral epicondylitis. (medlineplus.gov)
  • Henderson CM, Hennessy RG, Shuey HM Jr, Shackelford EG (1983) Posterior-lateral foraminotomy as an exclusive operative technique for cervical radiculopathy: a review of 846 consecutively operated cases. (springer.com)
  • Numerous nuanced approaches have been used to access posterior inferior cerebellar artery (PICA) aneurysms for microsurgical clipping. (thejns.org)
  • When the volume of alveolar bone in the posterior maxillary region is less than 4 mm, maxillary sinus floor elevation (MSFE) with the lateral approach is an effective option. (biomedcentral.com)
  • Treatment of other lesions of the posterior facet of the subtalar joint and lateral wall of the os calcis. (orthofixar.com)
  • Make a second incision beginning approximately 6 to 8 cm above the skin of the heel, halfway between the posterior aspect of the fibula and the lateral aspect of the Achilles tendon. (orthofixar.com)
  • Brain imaging revealed that the rear (posterior) part of the lateral prefrontal cortex processes an individual's current situation, while the front (anterior) prepares for future situations. (elifesciences.org)
  • In this extreme lateral approach, the sigmoid sinus is unroofed more superiorly and the bone flap includes not only a posterior fossa craniotomy but also a portion that extends just above the transverse sinus. (barrowneuro.org)
  • Our aim was to compare revision rate in general, as well as due to dislocation and infection, after DMC and conventional THA due to femoral neck fracture, for each of the two groups of lateral and posterior approach. (lu.se)
  • Kaplan-Meier survival analysis was used to investigate the 5-year revision rate after DMC and cTHA in the posterior and lateral approach groups. (lu.se)
  • The cumulative revision rate after posterior approach was 4.7% (95% CI 3.1-6.2) for DMC and 4.8% (3.8-5.7) for cTHA at 5 years. (lu.se)
  • The 5-year results for cumulative revision rate due to dislocation after posterior approach were 1.3% (0.4-2.2) for DMC and 2.2% (1.5-2.8) for cTHA. (lu.se)
  • The lateral parapatellar approach is an alternative method. (scielo.org.za)
  • All patients who underwent malignant distal femoral tumour resections through a lateral parapatellar approach between 2001 and 2019 were included in the study. (scielo.org.za)
  • Thirty-six patients were identified who underwent resection of their malignant distal femoral tumours via the lateral parapatellar approach. (scielo.org.za)
  • The findings suggest that a low risk of vascular complications can be expected when resecting malignant distal femoral tumours through a lateral parapatellar approach. (scielo.org.za)
  • This approach is also known as the Keblish approach or lateral parapatellar approach and is deemed to promote better soft tissue balance and patellar tracking for a total knee replacement on a valgus knee. (elyussif.com)
  • The role of the lateral geniculate nucleus (LGN) of the thalamus in visual encoding remains an open question. (jneurosci.org)
  • Although the core functions and structure of the lateral geniculate nucleus (LGN) are well understood, this core is surrounded by questions about the integration of feedforward and feedback connections, interactions between different channels of information, and how activity dependent development restructures synaptic networks. (wustl.edu)
  • Morgan, JL 2017, ' A connectomic approach to the lateral geniculate nucleus ', Visual Neuroscience , vol. 34, pp. (wustl.edu)
  • The pain is typically located just distal to the lateral epicondyle over the extensor tendon mass. (aafp.org)
  • Increasing adoption of kits & reagents and lateral flow assay readers for infectious diseases testing, veterinary diagnostics , and drug of abuse testing, cardiac marker testing . (marketsandmarkets.com)
  • This would impact health expenditure and thus negatively impact all healthcare product and service markets, including the lateral flow assay market. (marketsandmarkets.com)
  • The advantages of lateral flow assay tests in detecting COVID-19 antibodies include their affordability, ease of interpretation, and speedy diagnosis (within 15 minutes). (marketsandmarkets.com)
  • Since these tests can also be produced economically, all the major players in the lateral flow assay market launched COVID-19 tests in the past year. (marketsandmarkets.com)
  • Although easy to perform and more economical than laboratory tests, lateral flow assay tests have been observed to have lower accuracy. (marketsandmarkets.com)
  • Owing to its simplicity and low cost, the lateral flow assay (LFA) is the most extensively used point-of-care diagnostic test. (mdpi.com)
  • Various approaches, including specialized skull base approaches such as the lateral suboccipital, transcondylar, transcondylar fossa (supracondylar transjugular tubercle), extreme-lateral transcondylar, farlateral, and transpharyngeal-transclival have been described. (thejns.org)
  • De Bono cites the Judgement of Solomon as an example of lateral thinking, where King Solomon resolves a dispute over the parentage of a child by calling for the child to be cut in half, and making his judgment according to the reactions that this order receives. (wikipedia.org)
  • The Colonial Pipeline attack was an example of lateral movement. (scmagazine.com)
  • The wide-necked saccular/fusiform aneurysm arose from the lateral aspect of the right V 4 segment just proximal to the PICA origin, anterior to the jugular tubercle at the level of the hypoglossal canal. (thejns.org)
  • Given the proximal take off of the musculocutaneous nerve, the lateral proximal arm would often be spared. (asra.com)
  • Extreme Lateral Supracerebellar Infratentorial Approach to the Postero" by A. Giancarlo Vishteh, Carlos A. David et al. (barrowneuro.org)
  • An extreme lateral supracerebellar infratentorial approach with more radical resection of bone superiorly and laterally, and skeletonization of the sigmoid and transverse sinuses, was used to approach lesions at this location in eight patients. (barrowneuro.org)
  • CONCLUSION: The extreme lateral supracerebellar infratentorial approach differs from the midline and paramedian supracerebellar infratentorial variants in the area of exposure, patient positioning, and location of the craniotomy. (barrowneuro.org)
  • Higher-level cognition depends on the lateral prefrontal cortex (LPFC), but its functional organization has remained elusive. (elifesciences.org)
  • Part of the brain called the lateral prefrontal cortex has a critical role in many of the processes seen as hallmarks of human cognition, such as reasoning, planning and problem-solving. (elifesciences.org)
  • Individuals with damage to the lateral prefrontal cortex are disorganized and easily distracted, and may show behaviors that are inappropriate for their context. (elifesciences.org)
  • However, the involvement of the lateral prefrontal cortex in such a wide range of processes makes it difficult to study. (elifesciences.org)
  • Of particular interest is whether the lateral prefrontal cortex has a hierarchical organization wherein a region coordinates the roles of other regions, much like the chief executive of a company. (elifesciences.org)
  • Therefore, Nee and D'Esposito set out to map how the lateral prefrontal cortex is organized, and how its different regions communicate with each other to support complex cognition. (elifesciences.org)
  • With this strategic overview, the middle areas of the lateral prefrontal cortex are well positioned to play the part of the brain's chief executive. (elifesciences.org)
  • Future experiments should test whether the interactions observed between the different regions of the lateral prefrontal cortex are essential for complex planning and thinking. (elifesciences.org)
  • Finally, studying how these interactions are altered in disorders such as schizophrenia, where the lateral prefrontal cortex shows abnormal activity, might pave the way for more effective treatments. (elifesciences.org)
  • Measuring the distance between the greater trochanter and the lateral femoral condyle and dividing this distance by 2 determines the midpoint. (medscape.com)
  • The global lateral flow assays market in terms of revenue was estimated to be worth $20.5 billion in 2022 and is poised to reach $22.6 billion by 2027, growing at a CAGR of 2.0% from 2022 to 2027. (marketsandmarkets.com)
  • The lab of Dr. Clive Svendsen at Cedars-Sinai Medical Center utilizes a strategy to delay disease progression in ALS by delivering GDNF directly to motor neurons using a gene therapy approach. (health.mil)
  • Using this method, enhanced motor neuron function and extended survival was found, suggesting this approach confers protection of downstream motor neurons and may have positive effects on disease onset and patient lifespan. (health.mil)
  • Using a fluorescence-based Arc reporter, we were able to visually identify the distinct subset of lateral amygdala (LA) neurons activated during auditory fear conditioning. (nature.com)
  • Upper MNDs (eg, primary lateral sclerosis) affect neurons of the motor cortex, which extend to the brain stem (corticobulbar tracts) or spinal cord (corticospinal tracts). (msdmanuals.com)
  • A Feature Paper should be a substantial original Article that involves several techniques or approaches, provides an outlook for future research directions and describes possible research applications. (mdpi.com)
  • Although the origin of this failure is unclear, one candidate system involves control of emotional actions, coordinated through lateral frontopolar cortex (FPl) via amygdala and sensorimotor connections. (nature.com)
  • The procedure involves approaching the knee joint from the lateral side of the patella (kneecap) or on the outer aspect of the knee to remove and replace the worn-out or damaged surfaces of the knee joint with a prosthesis to treat valgus deformity of the knee. (elyussif.com)
  • 1 The neurobiological circuitry underlying auditory fear learning has been extensively investigated, wherein there is overwhelming evidence that the lateral amygdala (LA) is a critical site of plasticity. (nature.com)
  • The Lateral Approach to Calcaneus is mainly used for open reduction and internal fixation of the Calcaneal fracture. (orthofixar.com)
  • Users can choose to assign FRAX scores that reflect previous fracture defined only by self-reported fracture data, or they can assign FRAX scores that reflect both self-reported fracture data and morphometric vertebral fracture obtained from a lateral spine scan. (cdc.gov)
  • Information on vertebral fracture from a lateral dual-energy x-ray absorptiometry (DXA) scan is available in the vertebral fracture assessment examination file (DXXVFA_H) and can also be defined using vertebral dimensions provided in the vertebral morphometry files. (cdc.gov)
  • The following interventions are probably helpful for lateral epicondylitis: watchful waiting, short-term topical NSAIDs, corticosteroid injection (short-term relief), exercise regimens, NSAID iontophoresis, ultrasonography. (aafp.org)
  • One RCT found that at one year a watchful-waiting approach was comparable with physical therapy and superior to corticosteroid injection in alleviating a patient's main complaint. (aafp.org)
  • In 2006, Bisset et al investigated treating lateral epicondylitis with physiotherapy, corticosteroid injection, or watchful waiting in 198 individuals with symptoms for greater than 6 weeks. (medscape.com)
  • [ 10 ] Smidt et al found that administering a corticosteroid injection decreased pain in lateral epicondylitis at 6 weeks but not beyond that period. (medscape.com)
  • After the cerebrospinal fluid has been drained, the lateral aspect of the brainstem is approached via the cerebellar surface. (barrowneuro.org)
  • Use of both administrative national databases and self-report from patients enables a comprehensive approach to estimate ALS prevalence. (cdc.gov)
  • Extend this second incision distally to meet the first incision overlying the lateral aspect of the os calcis. (orthofixar.com)
  • Your surgeon will make a longitudinal incision lateral to the patella to expose the knee joint. (elyussif.com)
  • 1, 2] Traditionally, surgical removal of the spleen was done by an open approach using either an upper midline or left subcostal incision. (medscape.com)
  • This approach eliminates the need for skin incisions in the lower eyelid, as well as its complications. (bvsalud.org)
  • Lateral epicondylitis presents as a history of occupation- or activity-related pain at the lateral elbow. (aafp.org)
  • A Cochrane review looked at 17 comparisons of 759 participants and noted: "There remains limited evidence from which to draw firm conclusions about the benefits or harms of topical or oral NSAIDs in treating lateral elbow pain. (medscape.com)
  • A study looked at 297 patients with lateral epicondylitis and found that individuals treated with structured physical therapy had less pain than patients treated with corticosteroid injections or NSAIDs and experienced better function than those treated with corticosteroid injections. (medscape.com)
  • Maxillary sinus elevation by lateral window approach: evolution of technology and technique. (mectron.com)
  • Graftless Maxillary Sinus Lift Using Lateral Window Approach: A Systematic Review. (bvsalud.org)
  • Cornelius JF, Bruneau M, George B (2007) Microsurgical cervical nerve root decompression via an anterolateral approach: clinical outcome of patients treated for spondylotic radiculopathy. (springer.com)
  • 1 Patients with lateral epicondylitis are typically 40 years or older and have a history of repetitive activity during work or recreation. (aafp.org)
  • Given encouraging outcomes from this initial trial, a combined cell and gene therapy approach holds great promise for patients with this relentless disease that has no effective treatment. (health.mil)
  • METHODS: Five cavernous malformations, two juvenile pilocytic astrocytomas, and one peripheral superior cerebellar artery aneurysm located in this region were approached in eight patients. (barrowneuro.org)
  • A procedure of lateral thoracic expansion has been described in JS. (medscape.com)
  • Lateral approach total knee replacement is a surgical procedure employed for the treatment of valgus deformity of the osteoarthritic knee. (elyussif.com)
  • A contralateral far-lateral approach to VA-PICA aneurysms should be considered when aneurysms cross the midline. (thejns.org)
  • 1 , 9 , 12 , 18 We report a case of a VA-PICA aneurysm located at the midline skull base, which was successfully clipped via a contralateral farlateral approach. (thejns.org)
  • The midline and paramedian variations of the supracerebellar infratentorial approaches do not adequately expose this region. (barrowneuro.org)
  • As compared to the transalveolar approach, MSFE with the lateral approach provides a direct view of the surgical field, minimizes the risk of perforation, and ensures an adequate volume of grafted bone material [ 2 , 3 , 4 ]. (biomedcentral.com)
  • The target registration error (TRE) was measured at 28 surgical landmarks during and after performing the standard translabyrinthine and middle cranial fossa surgical approaches to the internal acoustic canal. (laryngoscopewiley.tw)
  • The similar outcome is regardless of surgical approach. (lu.se)
  • Smidt et al noted a greater improvement in pain symptoms from lateral epicondylitis at 52 weeks when employing watchful waiting relative to the administration of corticosteroid injections. (medscape.com)
  • Eleven of 17 (65%) of the targets in the translabyrinthine approach and five of 11 (45%) of the targets in the middle fossa approach could be identified in the navigation system with TRE of less than 0.5 mm. (laryngoscopewiley.tw)
  • The authors report the case of a patient with a right vertebral artery (VA)-PICA aneurysm that was reached via a contralateral far-lateral approach. (thejns.org)
  • The Cascadia Lateral 3D Interbody System includes a full range of implant sizes designed to accommodate the vertebral anatomy. (stryker.com)
  • The present research examined the joint and independent contributions of two fundamental motivational systems - behavioural approach and inhibition systems (BAS and BIS) - to lateral spatial bias in a locomotion task. (boyao.science)
  • These results demonstrate for the first time an association between BIS and lateral spatial bias independently of variations in BAS. (boyao.science)
  • If untreated, lateral epicondylitis persists for an average of six to 24 months. (aafp.org)
  • Transconjunctival approach with lateral canthotomy enables the surgeon adequate exposure of the infraorbital rim, the lateral margin of the orbit and orbital floor, with a low complication rate and excellent cosmetic results. (bvsalud.org)
  • However, the clinical accuracy of the electromagnetic tracking system has not been examined in lateral skull base surgery. (laryngoscopewiley.tw)
  • This study evaluates the accuracy of electromagnetic navigation in lateral skull base surgery. (laryngoscopewiley.tw)
  • While law firms have developed processes and protocols to better integrate new lateral hires, one crucial aspect has been often overlooked: integrating the client. (legalsales.org)
  • This report describes an observational approach for assessing postural stress of the trunk and upper limbs that is intended to improve risk analysis for prevention of musculoskeletal disorders. (cdc.gov)
  • Computed tomography angiography with volume rendering and interactive software capabilities can help identify the relationship of such an aneurysm to an individual's particular skull base osseous anatomy and is paramount in selecting the optimal microsurgical approach. (thejns.org)
  • Analyzing piles subjected to lateral loads significantly depends on soil resistance at any point along the pile as a function of pile deflection, known as the p-y curve. (shilav.ir)
  • We tested the ability of five linear models to predict a small lateral adjustment made by a hydrofoil undergoing biased pitch oscillations. (mdpi.com)
  • This ultra-small fabrication capability will then be used to study fundamental transport properties in low dimensionality structures at low temperatures, including new approaches such as an independent size and carrier concentration control, and the integration of ballistic injection and quantum interference effects. (europa.eu)
  • [2] ICB has less impact on pulmonary function but is more likely to spare the radial nerve distribution if a single injection is used compared with the supraclavicular approach. (asra.com)
  • Traditionally, this standard approach is usually conducted at 4-6 months after tooth extraction (standard MSFE). (biomedcentral.com)
  • Cervical nerve root compression caused by disco-osteophytic changes is classically operated by anterior transdiscal approach with disc replacement. (springer.com)
  • We recommend the lateral cervical approach (retrojugular) as salvage operation in such cases. (springer.com)
  • We report a patient with cervical nerve root compression operated by anterior transdiscal approach with plate and bone graft. (springer.com)
  • The lateral cervical approach (retrojugular) as reported here, is an excellent alternative pathway if reoperation after anterior transdiscal surgery with disc replacement becomes necessary. (springer.com)
  • Bruneau M, Cornelius JF, George B (2006) Microsurgical cervical nerve root decompression by anterolateral approach. (springer.com)
  • Treating multiple sites, using this approach, may further enhance clinically meaningful effects, and this therapeutic approach is now being considered for the cervical spinal cord and motor cortex, two regions showing benefit from these cells in ALS models. (health.mil)
  • Edward de Bono also links lateral thinking with humour, arguing it entails a switch-over from a familiar pattern to a new, unexpected one. (wikipedia.org)
  • [1] The aim of his approach was to avoid the positioning limitations and sparing of the musculocutaneous nerve associated with the axillary block, while decreasing the chance of pneumothorax inherent with the Labat approach, by aiming the needle laterally. (asra.com)
  • Furthermore, the results of a numerical study on the lateral pile-soil systems are used in order to show the efficiency of the proposed model in predicting lateral pile response. (shilav.ir)
  • Results: The rates of revision in general, and due to dislocation or infection, were similar for DMC and cTHA in the different approach groups during the follow-up. (lu.se)
  • Corresponding results for lateral approach was 0.4% (0-0.8) for DMC and 0.7% (0.4-1) for cTHA. (lu.se)
  • Since then, several more approaches have been described, each with their own advantages and disadvantages, some of which will be described here. (asra.com)
  • The infraclavicular block has several advantages that make it a preferable approach to brachial plexus blockade: comprehensive upper extremity anesthesia, lower incidence of tourniquet pain and preferable site for catheter insertion. (asra.com)
  • However, as the lateral market cools down, it's essential to shift our focus to the next phase. (legalsales.org)
  • The dissection consists of a direct approach to the subcutaneous bone. (orthofixar.com)
  • The technique is effective for approaching the posterolateral mesencephalon. (barrowneuro.org)
  • As some compression persisted clinically and radiologically, the patient was re-operated via a lateral approach. (springer.com)
  • This approach however was also not without its own limitations, namely a higher likelihood of pneumothorax as the needle is directed superiorly and medially, near the apex of the lung. (asra.com)
  • Recent review articles have addressed the use of patient history, differential diagnosis, and physical examination in the diagnosis of lateral epicondylitis. (aafp.org)
  • Place the patient in the lateral position on the operating table. (orthofixar.com)
  • For the lateral thigh flap, when the patient is positioned, secure the foot and leg in a padded stirrup, shown below. (medscape.com)
  • From patient zero, threat actors begin lateral movement in earnest. (scmagazine.com)