• As part of the Tulane research project, which was designed to identify diagnostics and treatment for Lassa, researchers support the Kenema facility, which has a 5,500 square foot laboratory and similarly sized hospital ward. (reuters.com)
  • The Lassa ward at Kenema has been funded by the United States for more than a decade through a variety of grants and contracts, Garry said. (reuters.com)
  • Both isolates and sequences are important for the development and evaluation of medical countermeasures to treat and prevent Lassa fever, such as diagnostics, therapeutics, and vaccines. (nih.gov)
  • These data are integral for the development of humoral-based vaccines that mimic the mature Lassa virion. (pnas.org)
  • Emerging and re-emerging infectious diseases like Lassa fever are global health challenges, and the NIH has a long history of investing in global research to improve the health of people in the United States and around the world,' says NIAID director Anthony S. Fauci, MD. 'The new Lassa virus data set will be valuable for understanding Lassa virus and developing medical countermeasures such as diagnostics, therapies and vaccines. (infectioncontroltoday.com)
  • There are no treatments or vaccines targeted to Nipah virus, but it is a priority disease on the World Health Organization (WHO) research and development blueprint. (umn.edu)
  • On Apr 11 CEPI announced support for Lassa and MERS-CoV vaccines that are in development at Inovio Pharmaceuticals. (umn.edu)
  • A 10-year Lassa virus research project has yielded structural and functional details of a key viral surface protein that could help advance development of Lassa vaccines and antibody-based therapeutics, which are currently lacking. (scienceandtechnologyresearchnews.com)
  • There are currently no approved Lassa fever vaccines. (nih.gov)
  • If a company like Themis went to venture capitalists and asked for investment to develop vaccines for Lassa or MERS, chances are nobody would pay us money to develop those vaccines because they are commercial risks. (endpts.com)
  • With its measles virus platform, Themis is also developing vaccines against Zika, RSV, and norovirus, among other areas. (endpts.com)
  • At the same time, they will begin studying the natural animal reservoirs of the viruses in an attempt to try and predict which strains are likely to cause future outbreaks, information that will be essential for creating effective vaccines. (cam.ac.uk)
  • The new genomic catalog contains nearly 200 viral genomes collected from patient samples in Sierra Leone and Nigeria, as well as field samples from the major animal reservoir, or host, of Lassa virus--the rodent Mastomys natalensis, also called the multimammate rat. (infectioncontroltoday.com)
  • The natural host of Lassa virus is the rodent Mastomys natalensis , otherwise known as the Natal multimammate mouse or rat. (cepi.net)
  • He says, "The reservoir or host of the Lassa virus is a rodent known as the Multimammate rat of the genus Mastomys. (punchng.com)
  • Most human Lassa virus outbreaks are caused by multiple exposures to urine or feces from the multimammate mouse, Mastomys natalensis, which is the reservoir of the virus in nature. (virology.ws)
  • People contract Lassa virus through contact with infected Mastomys rats and through exposure to an infected person's bodily fluids. (nih.gov)
  • Human beings become infected with the Lassa virus from exposure to urine or feces of infected mastomys rats. (xinhuanet.com)
  • The virus was discovered as part of a plan to identify unknown viruses from Africa by collecting serum specimens from patients with fevers of unknown origin. (cdc.gov)
  • The most efficient way to get Lassa is through a rodent bite. (mirznanii.com)
  • Scientists state that individuals can contract the virus if they inhale air from an environment that is contaminated by rodent excretions. (punchng.com)
  • Most Lassa virus infections are a consequence of multiple, independent transmissions from the rodent reservoir. (virology.ws)
  • Sierra Leone's Health Minister Zainab Bangura said that eradicating the rodent that carries the virus was "almost impossible. (medindia.net)
  • Most of this data originated from Lassa fever patients diagnosed at Irrua Specialist Teaching Hospital, Edo State, Nigeria. (nih.gov)
  • Only about 1% of Lassa virus infections result in death. (mnn.com)
  • We modified and purified a safe drug from natural sources and discovered how it can protect against deadly virus infections," said Ghislain Opdenakker, MD, a researcher involved in the study from the Laboratory of Immunobiology at the Rega Institute for Medical Research and the University of Leuven in Belgium. (infectioncontroltoday.com)
  • A major factor impeding the development of antiviral compounds to treat these infections is the need to manipulate the virus under BSL-4 containment, limiting research to a few institutes worldwide. (cdc.gov)
  • Authorities in a second Indian state are investigating two suspected Nipah virus infections, both of them in people who had traveled to Kerala state where they had contact with infected patients, Reuters reported today, citing a health official in Karnataka state. (umn.edu)
  • Both patients' infections resulted from contact with the same individual at a missionary hospital in Togo, who died from Lassa fever after evacuation to Germany. (emory.edu)
  • One in five infections results in severe disease, where the virus affects several organs such as the liver, spleen and kidneys. (sunnewsonline.com)
  • This story starts with a young graduate student in San Diego and leads all the way to Sierra Leone, to a unique hospital where Lassa fever victims arrive by the thousands every year. (news-medical.net)
  • As Hastie tackled those challenges from her lab bench in San Diego, staff at the Kenema Government Hospital in Sierra Leone labored on the front lines of the ongoing fight against Lassa. (news-medical.net)
  • Epidemics of Lassa fever have occurred in countries such as Sierra Leone, Congo (formerly Zaire), Liberia and Nigeria. (academic.ru)
  • Modern-day Lassa virus strains probably originated at least 1,000 years ago in Nigeria, then spread to Sierra Leone as recently as 150 years ago. (virology.ws)
  • Since there are no designated laboratories in Liberia that can test samples for Lassa fever by PCR, specimens are currently sent for testing to Kenema, Sierra Leone. (who.int)
  • In some areas of Liberia and Sierra Leone, approximately 10 to 16 per cent of those admitted to hospitals each year have Lassa fever, which indicates the serious impact of the virus on the population of these areas. (sunnewsonline.com)
  • The field performance of recombinant antigen-based Lassa fever immunoassays was compared to that of quantitative polymerase chain assays (qPCRs) using samples from subjects meeting the case definition of Lassa fever presenting to Kenema Government Hospital in Sierra Leone. (nih.gov)
  • We know that, Favipiravir, also known as T-705 or Avigan, is an experimental antiviral drug being developed by Toyama Chemical of Japan with activity against many RNA viruses. (med-chemist.com)
  • We sequenced and isolated 77 Lassa virus strains from 16 Nigerian states. (nih.gov)
  • The majority of sequences clustered with the main Nigerian lineages II and III, while a few sequences formed a new cluster related to Lassa virus strains from Hylomyscus pamfi Within lineages II and III, seven and five sublineages, respectively, were distinguishable. (nih.gov)
  • Virus-specific primers are however biased towards known strains and variants and do not capture divergent or unknown viruses in the sample. (biomedcentral.com)
  • Science writer David Quammen ventured deep into the forest of central Africa to try to find out for his latest book "Ebola: The Natural and Human History of a Deadly Virus. (pri.org)
  • This study , which presents the crystal structure of Lassa GCP bound to a human neutralizing antibody, is therefore a huge breakthrough. (id-hub.com)
  • Their research provides the first detailed view of the Lassa GPC bound to a human neutralizing antibody from an African survivor. (scienceandtechnologyresearchnews.com)
  • The investigational vaccine, called LASSARAB, includes inactivated genetic material from Lassa virus and a rabies virus vector. (upi.com)
  • Although Lassa fever is often a mild illness, some people experience serious symptoms, such as hemorrhage (severe bleeding) and shock. (nih.gov)
  • Novel therapeutic strategies for the treatment of Lassa fever are therefore urgently needed. (asm.org)
  • A novel vaccine designed to protect people from both Lassa fever and rabies showed promise in preclinical testing, according to new research published in Nature Communications . (nih.gov)