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  • antigen
  • An immunoassay method utilizes antigen tagged, enzyme encapsulating liposomes which are immunospecifically ruptured in the presence of cognate antibody and active complement. (google.com)
  • A homogeneous phase reaction occurs with the antibody and complement acting to release the enzyme if an immunospecific antigen-antibody complex is formed at the surface of the liposome. (google.com)
  • 1. An immunoreactive, stable liposome labeled with one of an antigen or its cognate antibody said liposome sequestering an enzyme carried within it, and having a signal to noise ratio of no less than 5 to 1. (google.com)
  • 7. An immunoreactive, stable liposome in accordance with claim 1 and having in combination therewith the other of said antigen or cognate antibody. (google.com)
  • 10. A liposome in accordance with claim 8 wherein said antigen is of use in clinical diagnostics. (google.com)
  • 12. A liposome in combination as set forth in claim 8 and further comprising said liposomes being labeled with an antigen. (google.com)
  • formulation
  • The efficiency of encapsulating a drug into a liposomal formulation is increased by use of a lipid having a carbon chain containing from about 13 to about 28 carbons during preparation of the liposomes. (google.com)
  • A novel liposomal irinotecan formulation with significant anti-tumour activity: Use of the divalent cation ionophore A23187 and copper-containing liposomes to improve drug retention" Eur J Pharm Biopharm. (patentgenius.com)
  • Irinophore C: A Liposome Formulation of Irinotecan with Substantially Improved Therapeutic Efficacy against a Panel of Human Xenograft Tumors" Clin Cancer Res. (patentgenius.com)
  • enzymes
  • Because both MMP-2 (20 , 21) and MMP-9 (22 , 23 , 24) are bound by specific cell-surface receptors, these enzymes represent potential receptors for liposome targeting to invasive cells, such as tumor cells and angiogenic endothelial cells. (aacrjournals.org)
  • Secretory vesicles hold the enzymes that are used to make the cell walls of plants, protists, fungi, bacteria and Archaea cells as well as the extracellular matrix of animal cells. (wikipedia.org)
  • wherein
  • 3. An immunoreactive, stable liposome in accordance with claim 1 wherein said signal to noise ratio is no less than 60 to 1. (google.com)
  • 5. A liposome in accordance with claim 1 wherein said enzyme is selected from the group consisting of oxidoreductases, hydrolases and mixtures thereof. (google.com)
  • 9. A liposome in accordance with claim 8 wherein said signal to noise ratio is in the range of from 5-1000:1. (google.com)
  • naturally
  • As the pH naturally neutralizes within the liposome (protons can pass through some membranes), the drug will also be neutralized, allowing it to freely pass through a membrane. (wikipedia.org)
  • vivo
  • Coencapsulation of irinotecan and floxuridine into low cholesterol-containing liposomes that coordinate drug release in vivo" Biochim Biophys Acta. (patentgenius.com)
  • therapeutic
  • The liposome may comprise an interior buffer solution containing the therapeutic agent, the solution having a pH less than 6.5 and most preferably approximating pH 3.5. (patentgenius.com)
  • presence
  • We show here that the cementoin domain adopts an α-helical conformation both by circular dichroism and nuclear magnetic resonance analyses in the presence of membrane mimetics, a characteristic shared with a large number of linear polycationic antimicrobial peptides. (beds.ac.uk)
  • cell
  • These liposomes work to deliver drug by diffusion rather than by direct cell fusion. (wikipedia.org)
  • The use of liposomes for transformation or transfection of DNA into a host cell is known as lipofection. (wikipedia.org)
  • Vesicles can also fuse with other organelles within the cell. (wikipedia.org)
  • The 2013 Nobel Prize in Physiology or Medicine was shared by James Rothman, Randy Schekman and Thomas Südhof for their roles (building upon earlier research, some of it by their mentors) on the makeup and function of cell vesicles, especially in yeasts and in humans, including information on each vesicle's parts and how they are assembled. (wikipedia.org)
  • Plant cells have a large central vacuole in the center of the cell that is used for osmotic control and nutrient storage. (wikipedia.org)
  • These proteins travel within the cell inside of transport vesicles. (wikipedia.org)
  • highly
  • It has been a highly effective drug for over fifty years in large part because it has a low incidence of drug resistance in the pathogens it treats. (wikipedia.org)