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  • membrane
  • We show here that the cementoin domain adopts an α-helical conformation both by circular dichroism and nuclear magnetic resonance analyses in the presence of membrane mimetics, a characteristic shared with a large number of linear polycationic antimicrobial peptides. (beds.ac.uk)
  • However, pre-elafin/trappin-2 and its domains display only weak lytic properties, as assessed by scanning electron micrography, outer and inner membrane depolarization studies with P. aeruginosa and leakage of liposome-entrapped calcein. (beds.ac.uk)
  • The strong adhesive interactions of lipid membrane onto the silica nanoparticle triggered liposome deformation until the formation of a curved neck. (archives-ouvertes.fr)
  • As the pH naturally neutralizes within the liposome (protons can pass through some membranes), the drug will also be neutralized, allowing it to freely pass through a membrane. (wikipedia.org)
  • tumor
  • The first was used to quantify the amount of technetium-99m-labeled liposomes within the tumor under normothermic conditions. (aacrjournals.org)
  • Planar scintigraphy was used to measure the activity of technetium-99m-labeled liposomes within the tumor at predetermined times up to 18 h after injection. (aacrjournals.org)
  • In the remaining 14 cats, hyperthermia resulted in a significant increase in liposome accumulation in the tumor ( P = 0.001). (aacrjournals.org)
  • Tumor volume ranged from 1.2 to 236.2 cm 3 , and thermal dose ranged from 2.0 to 243.3 CEM43CT90 (equivalent time that the 10th percentile temperature was equal to 43°C). There was not a relationship between either tumor volume or hyperthermia dose on the magnitude of increased liposome accumulation, suggesting that this method has application across a range of tumor volumes and degrees of heatibility. (aacrjournals.org)
  • If hyperthermia was capable of enhancing liposome accumulation, it is expected that if the liposome contained a drug that the drug will eventually leak out and increase the intracellular concentration of drug in the tumor cells themselves. (aacrjournals.org)
  • These pores are heterogeneously distributed throughout the tumor vasculature and provide a heterogeneous route for liposome accumulation into the tumor extravascular tissue. (aacrjournals.org)
  • Once in the tumor interstitial space, liposomes, because of their relatively large size, tend to reside preferentially in the perivascular space just outside the blood vessels and do not become homogeneously distributed throughout the tumor. (aacrjournals.org)
  • Antitumor effect of taxol-containing liposomes in a taxol-resistant murine tumor model. (pubmedcentralcanada.ca)
  • dispersion
  • 8. A dispersion comprising liposomes which include a nucleotide or nucleotide sequence and a divalent cation contained in an internal aqueous phase of a given osmolarity within the liposomes, the liposomes being dispersed in a solution having anosmolarity of less than 50% of that of the internal aqueous phase. (patentgenius.com)
  • phase
  • Sankhala KK et al (2009) A phase I pharmacokinetic (PK) study of MBP-426, a novel liposome encapsulated oxaliplatin. (springer.com)
  • and causing the loading of nucleotides into intact liposomes thus formed by suspending the liposomes in a solution containing a nucleotide or nucleotidesequence and having an osmolarity of less than 50% of that of the internal aqueous phase. (patentgenius.com)
  • release
  • The data are consistent with paclitaxel release from circulating liposomes, but with efflux delayed sufficiently to retain drug to a greater extent in the central (blood) compartment and reduce penetration into peripheral tissues. (pubmedcentralcanada.ca)
  • complex
  • In many cases, a large number of upstream signals are funneled to a master regulator of cellular behavior, but it remains unclear how individual proteins can rapidly integrate a complex array of signals within the appropriate spatial niche within the cell. (pnas.org)
  • We reconstituted the DivL-CckA complex on liposomes in vitro and found that DivL directly controls the CckA kinase/phosphatase switch, and that stimulation of either CckA catalytic activity depends on the second of its two PAS domains. (pnas.org)
  • However, the enzyme complex is possible because of the presence of large molecular subunits within the enzyme. (omicsonline.org)
  • increase
  • In this study, we tested whether hyperthermia could be used to augment delivery of liposomes to tumors, specifically to increase intratissue concentration of the liposome. (aacrjournals.org)
  • The productivity increase results from the fact that laboratory, bench and industrial-scale ultrasonic processor systems incorporate progressively larger ultrasonic horns, able to generate progressively larger high-intensity cavitation zones and, therefore, to process more material per unit of time. (wikipedia.org)