• The World Health Organization classification of lung tumors recognizes a variant of LCNEC, namely "combined large-cell neuroendocrine carcinoma" (c-LCNEC). (wikipedia.org)
  • Neuroendocrine carcinomas are extremely rare in the esophagus as they represent less than 0.04% of all neuroendocrine tumors. (biomedcentral.com)
  • Standardized guidelines for the treatment of these neoplasms remain lacking as the rarity of these tumors hinders the development of large cohort studies that provide evidence-based recommendations. (biomedcentral.com)
  • Large cell neuroendocrine carcinoma (LCNEC) is part of the neuroendocrine spectrum of pulmonary tumors. (johnshopkins.edu)
  • Therefore, debate has emerged regarding whether the tumors should be classified and treated as NSCLC or small-cell lung cancer. (johnshopkins.edu)
  • Carcinoids (2 types of bronchial neuroendocrine tumors) account for 85% of bronchial gland tumors and 1-2% of all lung malignancies. (medscape.com)
  • Bronchial carcinoids are part of a spectrum of neuroendocrine tumors (see below), of which only the first 2 are considered bronchial adenomas. (medscape.com)
  • Adenoid cystic carcinoma behaves very similarly to major and minor salivary gland tumors. (medscape.com)
  • Neuroendocrine tumors of the gynecologic tract: A Society of Gynecologic Oncology (SGO) clinical document. (sagepub.com)
  • Neuroendocrine tumors are unique and rare tumors originating from neuroendocrine cells. (nel.edu)
  • Large cell neuroendocrine tumors have been found. (nel.edu)
  • Carcinoma of cervix is classified as per the WHO classification into primary tumors which are predominantly epithelial tumors, mesenchymal tumors and tumor like lesions, mixed epithelial stromal tumors, melanocytic, germ cell, and lymphoid tumors. (cytojournal.com)
  • Squamous cell carcinoma (SCC) in various morphological forms needs to be separated from other epithelial tumors for treatment modality selection. (cytojournal.com)
  • Background/aim: Large-cell neuroendocrine carcinoma (LCNEC) of the lung is a relatively uncommon and aggressive subset of pulmonary neuroendocrine tumors, which include typical and atypical carcinoid, and small-cell lung cancer. (tubitak.gov.tr)
  • LCNECs show features of high-grade neuroendocrine tumors and patients with LCNEC have a very poor prognosis. (tubitak.gov.tr)
  • Traditionally, bile duct tumors located within the liver had been classified with hepatocellular carcinoma as primary liver tumors. (tri-kobe.org)
  • Tumors of the intrahepatic bile ducts originate in small intrahepatic ductules or large intrahepatic ducts that are proximal to the bifurcation of the right and left hepatic ducts. (tri-kobe.org)
  • Heterogeneous Tumor-Immune Microenvironments between Primary and Metastatic Tumors in a Patient with ALK Rearrangement-Positive Large Cell Neuroendocrine Carcinoma. (go.jp)
  • Pherochromocytoma (PH) and paraganglioma (PG) are neuroendocrine tumors arising in cromaffin cells in the adrenal medulla or extra adrenal paraganglia respectively. (enets.org)
  • In this document, we review the literature on the use of 177 Lu-DOTATATE in neuroendocrine tumors (NETs) of different primary origin, discuss issues of controversy, and review potential contraindications to treatment. (snmjournals.org)
  • Neuroendocrine Tumors of the Bronchopulmonary System (Typical and Atypical Carcinoid Tumors): Current Strategies in Diagnosis and Treatment. (karger.com)
  • Because CXCR2 is ubiquitously expressed by neuroendocrine cells in prostate cancer of all stages, targeting CXCR2 may particularly benefit patients whose tumors are advanced, recurrent, and resistant to currently available therapies," Huang says. (futurity.org)
  • Pancreatic neuroendocrine tumors may be functional or nonfunctional. (medscape.com)
  • Although nonfunctional islet cell tumors are not uncommon at autopsy, most islet cell tumors with clinical manifestations are functional. (medscape.com)
  • Pancreatic islet cell tumors may secrete 2 or more polypeptide hormones. (medscape.com)
  • Nonfunctioning tumors usually are larger and present because of their size or metastatic spread. (medscape.com)
  • Islet cell tumors in this group are often multiple and malignant. (medscape.com)
  • Overall, the age-adjusted incidence of neuroendocrine tumors increased sixfold from 1973 (1.09 per 100,000) to 2012 ((6.98 per 100,000), possibly because of increased early detection. (medscape.com)
  • This article reviews the role of imaging in the management of islet cell tumors. (medscape.com)
  • No universally agreed-upon algorithm exists in the radiologic investigation of pancratic neuroendocrine (islet cell) tumors of the pancreas. (medscape.com)
  • Neuroendocrine lung tumors can be grouped into four epithelial and one mesenchymal tumor. (deepdyve.com)
  • The epithelial neuroendocrine tumors are further divided into two high-grade carcinomas, large and small cell neuroendocrine carcinomas, and into low-grade typical and intermediate grade atypical carcinoid. (deepdyve.com)
  • In this short review, we will focus on the low and intermediate grade neuroendocrine tumors only. (deepdyve.com)
  • Pancreatic neuroendocrine neoplasms (PanNENs) fall into two subclasses: the well-differentiated, low- to high-grade pancreatic neuroendocrine tumors (PanNETs), and the poorly-differentiated, high-grade pancreatic neuroendocrine carcinomas (PanNECs). (biomedcentral.com)
  • With this approach, PanNENs fall into two basic subtypes: well-differentiated pancreatic neuroendocrine tumors (PanNETs) and poorly differentiated pancreatic neuroendocrine carcinomas (PanNECs) [ 4 ]. (biomedcentral.com)
  • Objectives Granular cell tumors are rare neoplasms of neural origin. (medscape.com)
  • We present the largest case series to date comprising 50 patients with benign and atypical soft tissue granular cell tumors in an effort to better define the pathologic features in this subset of lesions. (medscape.com)
  • Methods All cases of soft tissue granular cell tumors from the Ohio State Medical Center and the Medical College of Wisconsin over a 10-year period were reviewed for histologic and clinical findings. (medscape.com)
  • Conclusions Compared with granular cell tumors overall, the soft tissue subset shows a larger average size and higher propensity for incomplete resections, with atypical features being relatively common. (medscape.com)
  • Our findings suggest that soft tissue granular cell tumors may be slightly more aggressive than their dermal or organ-confined counterparts. (medscape.com)
  • Granular cell tumors (GCTs) are rare lesions believed to be of neural origin. (medscape.com)
  • Pauniaho SL, Salonen J, Helminen M, Vettenranta K, Heikinheimo M, Heikinheimo O. The incidences of malignant gonadal and extragonadal germ cell tumors in males and females: a population-based study covering over 40 years in Finland. (cancercentrum.se)
  • Mayr D, Hirschmann A, Marlow S, Horvath C, Diebold J. Analysis of selected oncogenes (AKT1, FOS, BCL2L2, TGFbeta) on chromosome 14 in granulosa cell tumors (GCTs): a comprehensive study on 30 GCTs combining comparative genomic hybridization (CGH) and fluorescence-in situ-hybridization (FISH). (cancercentrum.se)
  • Mutation of FOXL2 in granulosa-cell tumors of the ovary. (cancercentrum.se)
  • CpG methylation of the FHIT, FANCF, cyclin-D2, BRCA2 and RUNX3 genes in Granulosa cell tumors (GCTs) of ovarian origin. (cancercentrum.se)
  • The prevalence and prognostic impact of lymph node metastasis in malignant germ cell tumors of the ovary. (cancercentrum.se)
  • Conservative surgery to preserve ovarian function in patients with malignant ovarian germ cell tumors. (cancercentrum.se)
  • Bjorkholm E, Silfversward C. Granulosa- and theca-cell tumors. (cancercentrum.se)
  • Retroperitoneal nodal metastasis in primary and recurrent granulosa cell tumors of the ovary. (cancercentrum.se)
  • Ayhan A, Salman MC, Velipasaoglu M, Sakinci M, Yuce K. Prognostic factors in adult granulosa cell tumors of the ovary: a retrospective analysis of 80 cases. (cancercentrum.se)
  • Surgical staging and adjuvant chemotherapy in the management of patients with adult granulosa cell tumors of the ovary. (cancercentrum.se)
  • Large-cell neuroendocrine carcinoma of the lung (LCNEC of the lung), or pulmonary large-cell neuroendocrine carcinoma (PLCNC), is a highly malignant neoplasm arising from transformed epithelial cells originating in tissues within the pulmonary tree. (wikipedia.org)
  • LCNEC is often generically grouped among the non-small-cell lung carcinomas. (wikipedia.org)
  • Introduction: To treat LCNEC with non-small cell lung carcinoma type chemotherapy (NSCLC-ct, i.e. gemcitabine/taxanes or pemetrexed) or small cell lung carcinoma type (SCLC-ct, i.e. platinumetoposide) is subject of debate. (nrs-science.nl)
  • Large cell neuroendocrine carcinoma (LCNEC) is a rare type of lung cancer that accounts for approximately 3% of lung cancers. (e-acfs.org)
  • Large cell neuroendocrine carcinoma (LCNEC) is a rare subtype of lung cancer, accounting for 1% to 3% of all lung cancers, and is known for its aggressive behavior [ 1 ]. (e-acfs.org)
  • Discriminating small-cell lung carcinoma (SCLC) from large-cell neuroendocrine carcinoma (LCNEC) rests on morphological criteria, and reproducibility has been shown to be poor. (warwick.ac.uk)
  • Large cell neuroendocrine carcinoma (LCNEC) is now recognized as a histologically high grade non small cell carcinoma showing histopathological features of neuroendocrine differentiation as well as immunohistochemical neuroendocrine markers. (ersjournals.com)
  • The large cell carcinoma class has been enriched with several variants, including the LCNEC and the basaloid carcinoma, both with a dismal prognosis. (ersjournals.com)
  • As compared to the previous edition, changes include a better definition of pre-invasive lesion, a reclassification of adenocarcinoma, the description of two new tumour types as variants of large cell carcinoma, large cell neuroendocrine carcinoma (LCNEC) and basaloid carcinoma, and a new class called pleomorphic carcinoma. (ersjournals.com)
  • The terms related to NETs, including "carcinoid", "endocrine", "neuroendocrine", "small cell carcinoma" and "large cell neuroendocrine carcinoma (LCNEC)", were searched among histopathological diagnoses of all neoplasm specimens obtained during surgical procedures at Tokyo Medical University Hospital during the 6 years between January 2008 and December 2013. (biomedcentral.com)
  • Pancreatic neuroendocrine neoplasms (PanNENs) have undergone several classification changes according to consensus guidelines [ 1 ]. (biomedcentral.com)
  • A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal. (who.int)
  • SFTs of the pleura are localized mesenchymal neoplasms composed of fibroblastlike cells believed to arise from the subpleural connective tissue. (medscape.com)
  • Gastroenteropancreatic High-Grade Neuroendocrine Neoplasms: Histology and Molecular Analysis, Two Sides of the Same Coin. (cdc.gov)
  • Pulmonary carcinoids are well differentiated low to intermediate grade lung neuroendocrine tumours (LNETs), that belong to the group of lung neuroendocrine neoplasms which also include highly aggressive lung neuroendocrine carcinomas (LNECs). (who.int)
  • These data have been combined with previously published LNET data to perform integrative analysis using multi-omics factor analysis (MOFA), resulting in a molecular map of lung neuroendocrine neoplasms for exploration. (who.int)
  • Methods: For this population based retrospective cohort study all diagnoses of stage IV ct treated high grade neuroendocrine carcinomas (NEC, not being SCLC) were retrieved from the Netherlands Cancer Registry and Pathology Registry (PALGA) (2003-2012). (nrs-science.nl)
  • SCLC accounts for approximately 15% of bronchogenic carcinomas. (cancer.gov)
  • Compare the progression-free survival of patients with previously treated small cell lung cancer (SCLC) treated with ZD6474 vs placebo. (knowcancer.com)
  • Zepzelca is indicated for the treatment of adult patients with metastatic small cell lung cancer (SCLC) with disease progression on or after platinum-based chemotherapy. (pharmaceutical-technology.com)
  • Small cell lung cancer (SCLC), previously known as oat cell carcinoma, is considered distinct from other lung cancers, which are called non-small cell lung cancers (NSCLCs) because of their clinical and biologic characteristics. (medscape.com)
  • SCLC is a neuroendocrine carcinoma that exhibits aggressive behavior, rapid growth, early spread to distant sites, exquisite sensitivity to chemotherapy and radiation, and frequent association with distinct paraneoplastic syndromes, including hypercalcemia, Eaton-lambert syndrome, syndrome of inappropriate diuretic hormone, and many others. (medscape.com)
  • Small cell lung carcinoma (SCLC) arises in peribronchial locations and infiltrates the bronchial submucosa. (medscape.com)
  • The predominant cause of small cell lung cancer (SCLC) (and non-SCLC) is tobacco smoking. (medscape.com)
  • Of all histologic types of lung cancer, SCLC and squamous cell carcinoma have the strongest correlation to tobacco. (medscape.com)
  • The incidence of small cell lung cancer (SCLC) has declined over the last few years. (medscape.com)
  • Approximately 60-70% of patients with small cell lung cancer (SCLC) have clinically disseminated or extensive disease at presentation. (medscape.com)
  • Large cell neuroendocrine carcinoma of the ileocecal junction with well differentiation adenocarcinoma. (nel.edu)
  • Wang X, Li Y, Feng H, Wang C, Chen J, Liu L. Large cell neuroendocrine carcinoma of the ileocecal junction with well differentiation adenocarcinoma. (nel.edu)
  • Another change is the subclassification of adenocarcinoma: the definition of bronchioalveolar carcinoma has been restricted to noninvasive tumours. (ersjournals.com)
  • They established which miRNAs were differentially expressed regardless of cancer subtype, as well as signatures for both adenocarcinoma and squamous cell carcinoma specifically, after finding that the miRNAs strongly differed between those two groups. (genomeweb.com)
  • The researchers also identified a 27-miRNA predictive signature from only the adenocarcinoma samples, and a 17-miRNA signature from only those with squamous cell carcinoma. (genomeweb.com)
  • PanNECs can occur with admixed components of other carcinoma types of non-neuroendocrine origin, this can be either ductal adenocarcinoma (PDAC) or acinar cell carcinoma (ACC). (biomedcentral.com)
  • He underwent an en bloc resection, and pathological findings concluded to a metastasis of a pulmonary combined small cell carcinoma and adenocarcinoma. (hindawi.com)
  • In this present case, we report the observation of a patient who presented with an acute intestinal intussusception caused by a jejunal metastasis of pulmonary combined small cell carcinoma and adenocarcinoma and we present a review of the literature. (hindawi.com)
  • [ 3 , 4 ] The term "pseudomesotheliomatous carcinoma" was first applied by Harwood and colleagues in 1976 to 6 cases of peripheral lung adenocarcinoma that closely mimicked mesothelioma. (medscape.com)
  • The present consensus statement was developed collaboratively by the North American Neuroendocrine Tumor Society (NANETS) and the Society of Nuclear Medicine and Molecular Imaging (SNMMI). (snmjournals.org)
  • It was also under development for the treatment of epithelial ovarian cancer peritoneal cancer, fallopian tube cancer, metastatic pancreatic cancer, hepatocellular carcinoma, bone cancer and bladder cancer. (pharmaceutical-technology.com)
  • It is characterized by a mixture of mucus-producing, glandular, and squamous epithelial cells, as well as intermediate cells with both properties at various percentages, and by various growth patterns such as cystic, papillary, and solid structures. (medscape.com)
  • Finally, a new class was defined called carcinoma with pleomorphic, sarcomatoid, or sarcomatous elements, which brings together a number of proliferations characterized by a spectrum of epithelial to mesenchymal differentiation. (ersjournals.com)
  • The only non-epithelial neuroendocrine tumor of the lung is pulmonary paraganglioma. (deepdyve.com)
  • By definition, pseudomesotheliomatous carcinoma refers to an epithelial neoplasm that secondarily involves the pleura and encases the lung, thereby simulating the radiologic and macroscopic appearance of malignant mesothelioma. (medscape.com)
  • Synovial sarcomas encompass both biphasic (epithelial and spindle cell components) and monophasic (purely spindle cell) variants. (medscape.com)
  • The author then comments on four meta-analyses performed on eight small studies, which showed that the survival of patients with disseminated non-small-cell lung cancer treated with supportive care is shorter than the survival of patients treated with combination chemotherapy. (cancernetwork.com)
  • Therefore, it is currently unresolved as to whether it is important to include cisplatin as one of the agents in chemotherapy regimens for patients with disseminated non-small-cell lung cancer. (cancernetwork.com)
  • I do agree with the author's assertions that (1) patients similar to those treated in the randomized studies should be offered combination chemotherapy, (2) a best regimen has not been identified, and (3) not all physicians agree that the magnitude of survival benefit makes combination chemotherapy a standard treatment for patients with disseminated non-small-cell lung cancer. (cancernetwork.com)
  • The current gold standard of care for first-line therapy in patients with nonsmall cell lung cancer (NSCLC) is a platinum-based doublet chemotherapy, which is recommended for a maximum of six cycles. (deepdyve.com)
  • Endoscopic ultrasound-guided biopsy revealed poorly differentiated neuroendocrine carcinoma of the esophagus with metastasis to a diaphragmatic lymph node. (biomedcentral.com)
  • atypical adenomatous hyperplasia and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia. (ersjournals.com)
  • In addition of the categories of squamous dysplasia and carcinoma in situ , two additional lesions were added to the group of pre-invasive lesions: atypical adenomatous hyperplasia (AAH) and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH). (ersjournals.com)
  • One example of this is diffuse idiopathic pulmonary neuroendocrine cell hyperplasia. (enets.org)
  • Diagnosis of acinic cell carcinoma of the salivary gland on cytology specimens: Role of NOR‐1 (NR4A3) immunohistochemistry Meiklejohn K, Hrones M, Wang M, Prasad M, Cai G , Adeniran A, Gilani S. Diagnosis of acinic cell carcinoma of the salivary gland on cytology specimens: Role of NOR‐1 (NR4A3) immunohistochemistry. (yale.edu)
  • Cytomorphologic, immunophenotypical and molecular features of pancreatic acinar cell carcinoma Sun T, Gilani S, Jain D, Cai G. Cytomorphologic, immunophenotypical and molecular features of pancreatic acinar cell carcinoma. (yale.edu)
  • Among 557 invasive oropharyngeal squamous cell carcinomas, 72% were positive for HPV and 62% for vaccine types HPV16 or 18. (cdc.gov)
  • most are classified histologically as squamous cell carcinoma (OPSCC). (cdc.gov)
  • Large cell esophageal NECs are typically associated with rapid growth and poor prognosis [ 5 ]. (biomedcentral.com)
  • Ji, Yong-Il 2018-01-01 00:00:00 Neuroendocrine carcinoma of the cervix is rare, and prognosis is very poor. (sagepub.com)
  • Researchers from the Medical College of Wisconsin, the Mayo Clinic, and Washington University in St. Louis have identified two microRNA expression signatures predictive of prognosis in patients with stage I non-small cell lung cancer. (genomeweb.com)
  • With several recent studies correlating miRNA expression with outcome in lung cancer, the investigators set out to try to identify miRNA signatures that could accurately predict prognosis in what they claim is the largest study of its kind to date. (genomeweb.com)
  • It is a high-grade and poorly differentiated neuroendocrine tumor, usually diagnosed in advanced stages, with a poor prognosis and few therapeutic options in that setting. (mdpi.com)
  • 20%) combined with poor differentiation of their cells, resulting in an aggressive phenotype and poor prognosis [ 7 ]. (biomedcentral.com)
  • In most people, the cancer has already spread by the time the diagnosis has been made, so the prognosis for Merkel cell carcinoma is poor. (msdmanuals.com)
  • Although pulmonary carcinoids show relatively good prognosis in comparison to carcinomas, metastatic disease and relapse do occur. (who.int)
  • We reviewed the medical records of neuroendocrine bladder carcinoma patients treated at the University of Nebraska Medical Center between 1996 and 2011. (nebraska.edu)
  • Dr. Vokes provides information about integrating a new chemotherapeutic agent, vinorelbine (Navelbine), into the current treatment regimens for patients with advanced-stage non-small-cell lung cancer. (cancernetwork.com)
  • He reviews the phase II activity of vinorelbine and summarizes the large phase III studies showing a prolongation of survival in patients treated with vinorelbine in combination with cisplatin (Platinol). (cancernetwork.com)
  • However, a study comparing survival of patients with disseminated non-small-cell lung cancer treated with cisplatin-containing combinations and those given regimens not containing cisplatin showed similar median survivals [2]. (cancernetwork.com)
  • It is worth noting that the Japanese phase II study of vinorelbine in patients with disseminated non-small-cell lung cancer (objective response rate of 32%) [3] confirms the objective response rate of 29% quoted for the other phase II study. (cancernetwork.com)
  • However, the effect of vinorelbine/cisplatin shown in this large trial was not great (prolongation of median survival of 2 months) and did not appear to influence the outcome of patients after 1 year. (cancernetwork.com)
  • This regimen had previously been shown to prolong survival in patients with disseminated non-small-cell lung cancer compared to supportive care in the National Cancer Institute of Canada study [5]. (cancernetwork.com)
  • However, even these patients are at risk of dying from lung cancer (both small and non-small cell types). (cancer.gov)
  • Here we analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 patients with non-small cell lung cancer prospectively enrolled into the TRACERx study. (researchgate.net)
  • Age 10years, alveolar histology, FOXO1 fusion presence, unfavorable primary location, higher Oberlin score, and lack of radiation were identified as poor prognostic/predictive characteristics.This study represents the largest analysis of RMS metastatic to bone marrow, defining the poor prognostic outcome for these patients. (stanfordchildrens.org)
  • The majority of patients with non-small-cell lung cancer (NSCLC) present with advanced disease, with targeted therapies providing some improvement in clinical outcomes. (bmj.com)
  • CXCR2 is also expressed by immune cells and involved in inflammation, and scientists are developing a drug that inhibits its function for patients with chronic obstructive pulmonary disease (COPD). (futurity.org)
  • Pathological classification of the primary lesion was NET Grade 2 (Ki-67: 3 to 20 %) in 3 patients and neuroendocrine carcinoma (NEC, Ki-67: ≥21 %) in 26 patients. (biomedcentral.com)
  • Extrapulmonary small-cell carcinoma (SCC) is a rare neoplasm that shares certain features with its pulmonary counterpart and occurs predominantly in the gastrointestinal tract (GIT). (mdpi.com)
  • Synovial sarcoma is a malignant soft-tissue neoplasm that most commonly affects the extremities near to, but not in continuity with, large joints. (medscape.com)
  • Here, we describe the case and management of a previously healthy 67-year-old male in his fifth year of remission after treatment for poorly differentiated large cell neuroendocrine carcinoma of the esophagus. (biomedcentral.com)
  • Extracellular circulating miRNAs are also observed outside the cell, but their origin is poorly understood. (frontiersin.org)
  • Pleomorphic Carcinoma Versus Sarcomatoid Malignant Mesothelioma Baine M, Cai G , Zhang X. Pleomorphic Carcinoma Versus Sarcomatoid Malignant Mesothelioma. (yale.edu)
  • Pathologic examination revealed a pT2 undifferentiated carcinoma with a sarcomatoid component involving all layers of the jejunum and expressing only cytokeratin 7. (hindawi.com)
  • Histological examination revealed a combined lung tumor appearance with a predominant component (80%) consisting of a small cell neuroendocrine carcinoma associated with a solid adenocarcinomatous component, with massive infiltration of the lung, rupture of the visceral pleura, and extension to parietal fat tissue but with free surgical margin at this level and without sarcomatoid component. (hindawi.com)
  • Analysis of these large in multiple cancerS - a mendelian through the study of genetic susceptibility genome-wide studies also includes a randomization approach variants of various cancer sites, and also Mendelian randomization approach that patterns of genetic mutations that are aims to understand how lifestyle factors Elevated body mass index (BMI) and observed in tumours. (who.int)
  • A current perspective on the pathological assessment of FOXL2 in adult-type granulosa cell tumours of the ovary. (cancercentrum.se)
  • Due to its rarity, no standardized guidelines have been proposed to treat esophageal neuroendocrine carcinoma, although general recommendations suggest surgery with adjuvant chemoradiotherapy as the treatment of choice. (biomedcentral.com)
  • We report a 50-year-old woman who was diagnosed with large cell neuroendocrine carcinoma of the cervix and underwent radical surgery followed by adjuvant chemoradiation therapy. (sagepub.com)
  • Background This review describes a new therapeutic landscape in the adjuvant treatment of resectable non-small cell lung cancer (NSCLC) and discusses the role of the surgeon in ensuring best outcomes within this treatment paradigm. (researchgate.net)
  • SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a, member 4 (SMARCA4)- deficient non-small cell lung cancer (SMARCA4-dNSCLC) is an uncommon yet notable malignancy originating within the lung. (spandidos-publications.com)
  • Adenoid cystic carcinoma (ACC), which commonly arises in a salivary gland, accounts for 10% of bronchial adenomas (0.04-0.2% of all lung cancers). (medscape.com)
  • This increasingly recognized tumor has been reported to have 5-year actuarial survival rates following resection that are worse than those described for other variants of non-small cell lung cancer (NSCLC). (johnshopkins.edu)
  • Fernandez, FG & Battafarano, RJ 2006, ' Large-Cell Neuroendocrine Carcinoma of the Lung: An Aggressive Neuroendocrine Lung Cancer ', Seminars in thoracic and cardiovascular surgery , vol. 18, no. 3, pp. 206-210. (johnshopkins.edu)
  • In addition to smoking, for the first time, our study indicates that the personal or family history of cancer may increase risk to neuroendocrine bladder cancer. (nebraska.edu)
  • Metastatic large cell neuroendocrine carcinoma of the lung arising from the uterus: A pitfall in lung cancer diagnosis. (sagepub.com)
  • Carcinoma cervix is not the only cancer caused by HPV. (cytojournal.com)
  • Dr. Vokes is careful about applying this information and appropriately concludes that vinorelbine in combination with cisplatin should be considered as the initial therapy for stage IV non-small-cell lung cancer. (cancernetwork.com)
  • The bulk of the article deals with studies of vinorelbine as an agent for non-small-cell lung cancer. (cancernetwork.com)
  • Vinorelbine is the fourth drug to be approved by the Food and Drug Administration for the treatment of non-small-cell lung cancer. (cancernetwork.com)
  • Clinical Implications and Molecular Characterization of Drebrin-Positive, Tumor-Infiltrating Exhausted T Cells in Lung Cancer. (go.jp)
  • SWI/SNF‑related, matrix‑associated, actin‑dependent regulator of chromatin, subfamily a, member 4 (SMARCA4)‑deficient non‑small cell lung cancer (dNSCLC) is a rare malignant tumor that originates in the lungs. (spandidos-publications.com)
  • Neuroendocrine carcinoma (NEC) is an extremely rare subtype of endometrial cancer which is usually seen among perimenopausal or postmenopausal women. (enets.org)
  • Lung cancer is the most prevalent life-threatening cancer worldwide 1 with more than 80% being non-small-cell lung cancer (NSCLC). (bmj.com)
  • Targeting a cell surface receptor essential for the function and survival of resistant prostate cancer cells can halt tumor growth, researchers report. (futurity.org)
  • Resistance occurs because a small percentage of prostate cancer cells are completely impervious to the therapies, and actually thrive when the drugs are used. (futurity.org)
  • We noticed in prostate cancer there are two types of cells," says senior author Jiaoti Huang, chair of the pathology department at Duke University. (futurity.org)
  • The researchers isolated the neuroendocrine cells from fresh human prostate cancer tissue and studied them in the lab. (futurity.org)
  • In early-stage prostate cancer, they constitute no more than 1% of all tumor cells, but their numbers are much larger in late-stage and metastatic disease, and they make up almost all of a particularly lethal form of prostate cancer called small cell neuroendocrine carcinoma. (futurity.org)
  • Current prostate cancer treatments exclusively target the majority population of luminal tumor cells, and they do that job well. (futurity.org)
  • Jimmy Buffett died of a rare form of skin cancer: What is Merkel cell carcinoma? (yahoo.com)
  • Jimmy Buffett died on Friday due to a rare form of skin cancer called Merkel cell carcinoma. (yahoo.com)
  • According to the Canadian Cancer Society , Merkel cell carcinoma is a rare type of non-melanoma skin cancer. (yahoo.com)
  • This disease is also sometimes called neuroendocrine cancer of the skin or trabecular carcinoma. (yahoo.com)
  • While many factors play a role in survival rates for the cancer, experts estimate that three out of four people who have Merkel cell carcinoma that hasn't spread are alive five years after their diagnosis . (yahoo.com)
  • See Small Cell Lung Cancer: Beating the Spread, a Critical Images slideshow, to help identify the key clinical and biologic characteristics of small cell lung cancer, the staging criteria, and the common sites of spread. (medscape.com)
  • See Clinical Presentations of Lung Cancer: Slideshow , a Critical Images slideshow, to help efficiently distinguish lung carcinomas from other lung lesions, as well as how to stage and treat them. (medscape.com)
  • Ovarian granulosa cell tumor and increased risk of breast cancer. (cancercentrum.se)
  • Larger lesions are easily identifiable by modern cross-sectional imaging techniques. (medscape.com)
  • There has been substantial evolution of concepts in neuroendocrine lung tumour classification. (ersjournals.com)
  • Correlation between PD-L1 expression of the tumour cells and lymphocytes infiltration in the invasive front of urothelial carcinoma Chen X, Chen H, Lin R, Li Y, Guo Y, Chen Q, Zhang Y, Cai G , Hu M, Chen G. Correlation between PD-L1 expression of the tumour cells and lymphocytes infiltration in the invasive front of urothelial carcinoma. (yale.edu)
  • An immunofluorescent staining of a Merkel cell carcinoma tumour tissue. (yahoo.com)
  • Prognostic impact of lymphadenectomy in clinically early stage malignant germ cell tumour of the ovary. (cancercentrum.se)
  • They are characterized by a clinical course that is usually more benign than that of bronchogenic carcinoma. (medscape.com)
  • Eleven (21.6%) cases showed evidence of cytologic atypia and fulfilled the criteria for a diagnosis of atypical giant cell tumor. (medscape.com)
  • is done to confirm the diagnosis of Merkel cell carcinoma. (msdmanuals.com)
  • A neuroendocrine tumor (NET) can develop anywhere in the body, but is mainly found in the pancreas, gastrointestinal tract, and lungs. (biomedcentral.com)
  • DNA alterations and immunohistochemistry of cell-type markers PDX1, ARX, and SOX9 were utilized to further characterize PanNECs and their cell of origin in the pancreas. (biomedcentral.com)
  • PDACs have been shown to originate from normal ductal or acinar cells [ 20 , 21 ], while G1 and G2 PanNETs have been shown to originate from endocrine cells of the pancreas [ 22 , 23 , 24 ]. (biomedcentral.com)
  • Merkel cell carcinoma arises from uncontrolled growth of cells in the skin that share some characteristics with normal Merkel cells. (msdmanuals.com)
  • Because of its rarity, effective treatment of neuroendocrine carcinoma of the cervix has not been established. (sagepub.com)
  • American Journal Of Respiratory Cell And Molecular Biology 2023, 68: 75-89. (yalemedicine.org)
  • The risk factors, the optimal therapy and prognostic factors contributing to poor outcomes of neuroendocrine urinary bladder carcinoma are not fully elucidated because of its rarity. (nebraska.edu)
  • Endometrial small-cell neuroendocrine carcinoma (ESCNEC) is extremely rare. (enets.org)
  • High-power photomicrograph of small cell carcinoma on the left side of the image with normal ciliated respiratory epithelium on the right side of the image. (medscape.com)
  • Separate worldwide data for small cell carcinoma are not available. (medscape.com)