Large cell anaplastic carcinomas carcinoma large cell. Medical search. Frequent questions

PURPOSE: The role of adjuvant external-beam radiotherapy (EBRT) in the treatment of locally advanced papillary thyroid carcinoma (PTC) remains controversial due to the lack of prospective data and the conflicting retrospective data. (bvsalud.org)
others include papillary, medullary, and metaplastic carcinomas as well as malignant phyllodes tumors. (radiopaedia.org)
Although this most common gynecologic cancer carries the best prognosis, it is important to differentiate between the classic endometrioid tumors that tend to be estrogen dependent and well differentiated, from other less common high-risk uterine malignancies, such as uterine papillary serous carcinomas (UPSCs), clear cell carcinomas, mixed mullerian tumors (MMTs), or sarcomas, which appear to have a different biology. (medmuv.com)
Immunohistochemical studies using specific monoclonal antibodies for cMYC and BRAF V600E were performed on tissue microarrays built from follicular cell-derived thyroid carcinomas (25 papillary, 24 follicular, 24 oncocytic variant of follicular, and 21 undifferentiated). (biomedcentral.com)
Carcinomas derived from thyroid follicular epithelium comprise papillary, follicular, poorly differentiated, and undifferentiated (anaplastic) carcinomas. (biomedcentral.com)
Herein, we utilized IHC for cMYC in a tissue microarray (TMA) study performed on a spectrum of follicular cell-derived thyroid carcinomas, including papillary ( n = 25), follicular ( n = 25), oncocytic variant of follicular ( n = 25), and undifferentiated ( n = 22) carcinomas. (biomedcentral.com)

As with all tumors, whether benign or malignant, identification of the cell or cell layer of origin is of the utmost importance. (medscape.com)
Solitary tumors of the uterus which arise de novo from the mesenchymal cells of the myometrium. (brainscape.com)
Independent of HPV copy number, most tumors had either a small or a very large deletion in the viral genome. (biomedcentral.com)
There is a currently accepted model for HPV-driven carcinogenesis which was derived from several decades of work examining several cervical cancer cell lines and primary tumors. (biomedcentral.com)
As with all tumors, whether benign or malignant, the paradigm of comprehension depends on identifying the cell or cell layer of origin. (medscape.com)
Skin malignancies, Merkel cell carcinoma and rare appendageal tumors. (medscape.com)
Future development of effective treatment strategies for large metastatic lymph nodes, gross residual tumors, and high serum thyroglobulin levels is warranted. (bvsalud.org)
A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (lookformedical.com)
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease. (lookformedical.com)
B-cell lymphoid tumors that occur in association with AIDS. (lookformedical.com)
Reports discussing cMYC protein expression in thyroid carcinomas are limited, and controversies exist pertaining to cMYC expression patterns (nuclear versus cytoplasmic immunoreactivity) in these tumors. (biomedcentral.com)
MCPyV in tumor cell genomes, tumor-associated mutations search Ethics Board, Halifax, Nova Scotia, Canada, and in the large T-antigen (T-ag) gene, and large T-ag expres- by the Baylor College of Medicine Institutional Review sion in tumors suggest that MCPyV is not only associated Board, Houston. (cdc.gov)
Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution. (lu.se)

Differentiating between low-grade lymphoma and reactive lymphocytes is often difficult by morphology alone as reactive lymphoid cells may acquire activation morphology from being exposed to different cytokines within the body fluid. (cytojournal.com)
In large cell lymphoma and leukemia cells involvement of body fluid this concept becomes less challenging. (cytojournal.com)
Large cell lymphoma and leukemia cells tend to have large size nuclei, less mature chromatin, and visible nucleoli with and without cytoplasmic vacuoles. (cytojournal.com)
Risk of breast implant associated anaplastic large cell lymphoma (BIA-ALCL) in a cohort of 3546 women prospectively followed long term after reconstruction with textured breast implants. (realplasticsurgeon.eu)
Lymphoma b cell. (lookformedical.com)
B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. (lookformedical.com)
Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)
Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. (lookformedical.com)
A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. (lookformedical.com)
Over 80 cases of anaplastic lymphoma kinase-negative anaplastic large cell lymphoma have been reported in patients with silicone breast implants and have been accepted as a new clinical entity. (biomedcentral.com)
To the best of our knowledge, an intravascular large B-cell lymphoma associated with a silicone breast implant has not been reported previously. (biomedcentral.com)
However, the histological examination unexpectedly also revealed an intravascular large B-cell lymphoma. (biomedcentral.com)
The genetic background of our patient with silicone breast implants might have predisposed her to three rare and difficult to diagnose syndromes/diseases: macrophage activation syndrome/hemophagocytic lymphohistiocytosis, autoimmune/inflammatory syndrome induced by adjuvants, and intravascular large B-cell lymphoma. (biomedcentral.com)
GzB expression is also a hallmark of the non-Hodgkin lymphoma, anaplastic lymphoma kinase-positive, anaplastic large cell lymphoma (ALK+ ALCL). (biomedcentral.com)
BK virus, simian munohistochemical testing showed that 1 T-cell lymphoma virus 40, and JC virus DNA sequences have been detected expressed MCPyV T-antigen. (cdc.gov)
The NHL samples were classifi ed as B- as previously described ( 20 ), omitting the deparaffi niza- cell lymphoma (n = 133), NK/T-cell lymphoma (n = 18), or tion step. (cdc.gov)

An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. (lookformedical.com)

Primary cutaneous CD30+ anaplastic large cell lymphomas mimicking KAs have been reported. (medscape.com)
In addition, cytoplasmic vacuoles are not uncommon in large cell lymphomas involving body cavities. (cytojournal.com)
On 8th September of 2022, the U.S. Food and Drug Administration (FDA) posted a Safety Communication on their website ( https://www.fda.gov/medical-devices/safety-communications/breast-implants-reports-squamous-cell-carcinoma-and-various-lymphomas-capsule-around-implants-fda ), informing the public about reports of cancers, including breast implant associated squamous cell carcinoma (BIA-SCC) and various lymphomas (besides BIA-ALCL) in the capsule surrounding breast implants. (realplasticsurgeon.eu)
The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1). (lookformedical.com)
For example, GzB expression in urothelial carcinoma was implicated in promoting tumour cell invasion, whereas its expression in nasal-type NK/T lymphomas was found to correlate with increased apoptosis. (biomedcentral.com)
These fi ndings suggest that in human lymphoid tissues, blood cells, and lymphomas the lymphoid system plays a role in MCPyV infection and ( 17 - 20 ). (cdc.gov)
In this study, we investigated the presence of Merkel cell polyomavirus (MCPyV) was fi rst described MCPyV in benign lymph nodes and malignant lymphomas in 2008 ( 1 ) as a new human virus associated with in patients from Canada. (cdc.gov)

Histologically, the fully formed domelike lesion reveals a mass of proliferating squamous epithelial cells, which created the central core of keratin. (medscape.com)
[ 7 ] In KAs, cells that stain positive with proliferating-cell nuclear antigen immunostaining are distributed only in the outer edges of the tumor, corresponding to the proliferating squamous epithelial cells. (medscape.com)
On the other hand, clear cell acanthoma is a rare, benign epithelial cutaneous tumor. (medscape.com)
Clear cell acanthoma usually stains positively for epithelial membrane antigen and negatively for carcinoembryonic antigen. (medscape.com)
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. (lookformedical.com)
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. (lookformedical.com)
A primary malignant neoplasm of epithelial liver cells. (lookformedical.com)
It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)
A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (lookformedical.com)
It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA . (lookformedical.com)
An epithelial neoplasm characterized by unusually large anaplastic cells. (uchicago.edu)

A metastatic thyroid tumor (MTT) arising from breast carcinoma (BC) is rare and sometimes difficult to diagnose. (bvsalud.org)
we suspected anaplastic thyroid carcinoma at initial presentation. (bvsalud.org)
Reports discussing cMYC protein expression in thyroid carcinomas are limited, with controversies pertaining to cMYC expression patterns noted in the literature. (biomedcentral.com)
The aims of the current study were to clarify patterns and intensities of cMYC expression in follicular cell-derived thyroid carcinomas across a spectrum of cancer morphologies and disease aggressivities, to correlate cMYC with BRAF V600E expression, and to evaluate the potential role of cMYC in progression of well-differentiated thyroid carcinomas into less well-differentiated carcinomas. (biomedcentral.com)
cMYC was expressed almost exclusively in a nuclear fashion in both thyroid carcinomas and nodular hyperplasias. (biomedcentral.com)
UDC cases that developed out of well-differentiated thyroid carcinomas showed frank overexpression of cMYC in the undifferentiated tumor components. (biomedcentral.com)
Our study suggests that nuclear overexpression of cMYC correlates with tumorigenesis / dedifferentiation in follicular cell derived thyroid carcinomas, a concept that has not been shown before on whole tissue sections. (biomedcentral.com)
The pituitary gland produces thyroid stimulating hormone (TSH) that goes into the blood stream to activate thyroid cells, which then secrete T3 and T4 into the peripheral tissues. (cdc.gov)
The thyroid hormone exerts negative feedback on cells that produce TSH, causing them to shut down production. (cdc.gov)
On a portion of thyroid cell facing the blood stream there is a protein called sodium iodine symporter that transports iodine into the thyroid cell. (cdc.gov)
The iodine is what the cells need to make the thyroid hormone. (cdc.gov)
In the normal U.S. diet, iodine intake is about 250 micrograms or ¼ milligram (mg) of iodine per day, which goes into the thyroid cells and is incorporated into amino acids called tyrosine (in a large thyroglobulin molecule). (cdc.gov)

In fact, clear cell acanthoma possesses a similar staining pattern to inflammatory dermatoses such as psoriasis vulgaris, lichen planus, and discoid lupus erythematosus and might be a localized form of inflammatory eruption rather than a neoplasm. (medscape.com)

A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane. (lookformedical.com)
An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST. (lookformedical.com)
Mucinous carcinoma of the breast , also known as colloid breast carcinoma , is a subtype of invasive ductal carcinoma (IDC). (radiopaedia.org)
Overall the tendency to metastasize is less than for other types of cancer (e.g. invasive carcinoma of no special type ). (radiopaedia.org)

Red, scaly plaque, microscopically characterized by the spread of malignant cells within the epithelium, occasionally with invasion of underlying dermis. (brainscape.com)
Among sporadic endometrial cancers, when present, the microsatellite instability is confined to the malignant cells, and is not seen in the adjacent normal epithelium. (medmuv.com)

Fields et al reviewed 500 patients with Merkel cell carcinoma in a single-institution study. (medscape.com)
Merkel cell carcinoma (MCC), an uncommon but aggressive form of skin cancer. (cdc.gov)

Kirsten (Ki)-ras activating point mutations in codons 12 and 13 have been implicated in the development of atypical endometrial hyperplasias and endometrioid carcinomas in Japanese women, as well as in colon cancers. (medmuv.com)
cMYC expression was weakly positive in both nodular hyperplasias and well-differentiated carcinomas. (biomedcentral.com)

A cell line derived from cultured tumor cells. (lookformedical.com)

Cancers of both lymphoid and non-lymphoid origin also express GzB, and in some cases this expression has been linked to pathogenesis or sensitizing tumour cells to cell death. (biomedcentral.com)

Carcinoma, Large Cell" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)

test is associated with proinflammatory reactants and clinical outcome in non-small cell lung cancer patients. (rush.edu)
Shin JY, Yoon JK, Marwaha G. Progress in the Treatment and Outcomes for Early-Stage Non-Small Cell Lung Cancer. (rush.edu)
Patterns of locoregional failure in stage III non-small cell lung cancer treated with definitive chemoradiation therapy. (rush.edu)
Randomized phase II study of cetuximab and bevacizumab in combination with two regimens of paclitaxel and carboplatin in chemonaive patients with stage IIIB/IV non-small-cell lung cancer. (rush.edu)
Herbst RS, O'Neill VJ, Fehrenbacher L, Belani CP, Bonomi PD, Hart L, Melnyk O, Ramies D, Lin M, Sandler A. Phase II study of efficacy and safety of bevacizumab in combination with chemotherapy or erlotinib compared with chemotherapy alone for treatment of recurrent or refractory non small-cell lung cancer. (rush.edu)
Kasuganti D, Cimbaluk D, Gattuso P. Lymph node metastasis of large-cell carcinoma of the lung in a seventeen-year-old patient: diagnosis by fine-needle aspiration. (rush.edu)
Administration of pemetrexed immediately following gemcitabine as front-line therapy in advanced non-small cell lung cancer: a phase II trial. (rush.edu)

Lesion of the female vulva characterized by thinning of the epidermis and disappearance of rete pegs, hydropic degeneration of basal cells, superficial hyperkeratosis, dermal fibrosis with scant perivascular, mononuclear inflammatory cell infiltrate. (brainscape.com)
The mucin to cell ratio can vary from lesion to lesion. (radiopaedia.org)
It is commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. (lookformedical.com)

High risk human papillomaviruses (HPVs) are known to be involved in the development of cervical cancers, a number of other anogenital cancers and they are increasingly involved in oropharyngeal squamous cell carcinoma (OPSCC) [ 1 , 2 , 3 ]. (biomedcentral.com)
Recent advancements in next generation sequencing (NGS) technologies and their utilization to examine large numbers of primary cervical cancers has revealed that the overall model for HPV-driven carcinogenesis needs to be rethought. (biomedcentral.com)
An examination of a large number of HPV16 and HPV18-positive cervical cancers has revealed that while most HPV18-positive cervical cancers have HPV integrated somewhere within the human genome, this only occurs in about 75% of HPV16-positive cervical cancers [ 8 ]. (biomedcentral.com)
Chromosome 17p is frequently involved, which contains the p53 gene known to confer a poor prognosis in endometrial cancers when mutated or deleted, and which plays an important role in the transition to carcinoma from atypical hyperplasia. (medmuv.com)
While no mutations were found in the exons of the DCC gene in endometrial cancers, chromosome 18 was found to be capable of suppressing tumorigenicity of endometrial cancer cells in nude mice by the procedure of microcell fusion, with DCC expression elevated in most of the suppressed hybrids. (medmuv.com)

Recurrent giant cell carcinoma of the bladder. (uchicago.edu)

Horrifying giant basal cell carcinoma of the face--a case report. (uchicago.edu)

Lymphoid cells concerned with humoral immunity. (lookformedical.com)

Thus far, there is no science based rationale for advising explanting unaffected breast implants based upon these new reported case reports of breast implant associated squamous cell carcinomas. (realplasticsurgeon.eu)
Primary Squamous Cell Carcinoma Arising From a Breast Implant Capsule: A Case Report and Review of the Literature. (realplasticsurgeon.eu)
Squamous Cell Carcinoma Arising in Breast Implant Capsules. (realplasticsurgeon.eu)
Breast implant capsule-associated squamous cell carcinoma: a report of 2 cases. (realplasticsurgeon.eu)
Possible origins of squamous cell carcinoma associated with a breast implant capsule. (realplasticsurgeon.eu)
Satgunaseelan L, Cheung D, Reddy, J. Breast Implant-Associated Squamous Cell Carcinoma - A Rare Long Term Complication. (realplasticsurgeon.eu)

Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. (lookformedical.com)

In general, hematolymphoid cells manifest as dyshesive cells in cytological specimens. (cytojournal.com)

These proliferating cells exhibit no cytologic abnormalities and have a normal nuclear-to-cytoplasmic ratio. (medscape.com)
In order to distinguish between KA and SCC, further histologic studies can be used, including proliferating-cell nuclear antigen immunostaining. (medscape.com)
In contrast, cells within an SCC that stain positive with proliferating-cell nuclear antigen immunostaining are more diffusely distributed. (medscape.com)
The majority of undifferentiated carcinomas (UDCs) showed strong nuclear cMYC positivity. (biomedcentral.com)

KA lesions can easily be mistaken for squamous cell carcinoma (SCC). (medscape.com)
Case reports in the literature report clear cell acanthomas with multiple lesions, (ie, polypoid clear cell acanthoma). (medscape.com)

High risk human papillomaviruses (HPV) plays important roles in the development of cervical cancer, a number of other anogenital cancer and they are increasingly found in oropharyngeal squamous cell carcinoma (OPSCC), however there has not been comprehensive analysis about the role how these viruses play in the development of OPSCC. (biomedcentral.com)
At pathological examination, the dominant feature is the presence of mucin within and surrounding cancer cells. (radiopaedia.org)
Microscopically, it is formed by large mucin lakes surrounded by mucus-producing cancer cells. (radiopaedia.org)

The cells within the acanthotic epidermis stain faintly because of the overload of glycogen content in the keratinocytes. (medscape.com)

This presence of melanin provides pigmentation to the benign tumor, and this occurrence has been termed pigmented clear cell acanthoma. (medscape.com)

Cells grown in vitro from neoplastic tissue. (lookformedical.com)

Granzyme B (GzB) is a serine protease found in the cytoplasmic granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. (biomedcentral.com)

Distal enhancement and microlobulated margins are also commonly found in mucinous carcinomas. (radiopaedia.org)

A histological examination of the capsule tissue showed an extensive lymphohistiocytic/giant cell foreign body reaction suggestive of autoimmune/inflammatory syndrome induced by adjuvants. (biomedcentral.com)

Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. (lookformedical.com)

Whole genome sequencing has revealed the complexity of the HPV18 integration event in the HeLa cell line and this integration occurs within an HPV18-specific hot-spot near the c-MYC oncogene. (biomedcentral.com)
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). (lookformedical.com)

Their cells are translucent because of the presence of glycogen, which can be demonstrated by a periodic acid-Schiff (PAS) stain (and eliminated with diastase) or electron microscopy. (medscape.com)
With antikeratin antibodies, the clear cell acanthomas stain for AE1 and AE3, but did not stain for CAM5.2. (medscape.com)

A classification of B-lymphocytes based on structurally or functionally different populations of cells. (lookformedical.com)

Anatomy16

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Highly malignant1

Lymphomas7

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