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  • cutaneous
  • Canine cutaneous histiocytoma (derived from specialised epidermic dendritic cells, the Langerhans cells) 2. (wikipedia.org)
  • Elevated numbers of FXIIIa positive cells can be found in a host of cutaneous inflammatory conditions including lichen planus and psoriasis. (leicabiosystems.com)
  • Due to its rareness in skin, the accurate diagnosis of cutaneous LCS could be difficult to be made because similar microscopic features may be encountered in metastatic cancer, malignant melanoma, anaplastic large cell lymphoma and myeloid sarcoma. (biomedcentral.com)
  • Nonmelanoma skin cancers consisting of basal cell carcinomas (BCC) and squamous cell carcinomas (SCC) are, however, the most frequently diagnosed cutaneous malignancies and account for 80% and 16% of all skin cancers, respectively, whereas malignant melanomas account for 4% of all skin cancers. (redorbit.com)
  • immune
  • Their approach, published in Proceedings of the National Academy of Sciences, uses transfusions of engineered red blood cells to re-train the immune system. (childrenshospital.org)
  • Tumour Microenvironment and Metabolic Plasticity in Cancer and Cancer Stem Cells: Perspectives on Metabolic and Immune Regulatory Signatures in Chemoresistant Ovarian Cancer Stem Cells. (fecri.org.au)
  • Acute exercise leads to regulation of telomere-associated genes and microRNA expression in immune cells. (fecri.org.au)
  • Dendritic cells (DC) and tumour-associated macrophages (TAM) are essential in linking the innate and adaptive immune response against tumour cells and tumour progression. (biomedcentral.com)
  • These cells are also potential target for immunotherapy as well as providing a handle to investigate immune status in the tumour microenvironment. (biomedcentral.com)
  • Kaplan-Meier and Cox regression analyses were applied to determine the impact of immune cell infiltration on 5-year overall survival (OS). (biomedcentral.com)
  • The prognostic value of the other investigated immune cells did not differ significantly in strata according to adjuvant chemotherapy. (biomedcentral.com)
  • 2013). IDCS is derived from normal interdigitating dendritic cells (IDCs), whose role consists to present antigens to T cells and regulate cellular immune response (Saygin C et al. (atlasgeneticsoncology.org)
  • Dendritic cells are highly adapted to their role of presenting antigen and directing immune responses. (biomedsearch.com)
  • Over the years, the skin was proven to have a crucial immunological role, not only being a passive protective barrier but a network of effector cells and molecular mediators that constitute a highly sophisticated compound known as the "skin immune system" (SIS). (hindawi.com)
  • Far from being a simple mechanical barrier, the skin constitutes a network of effector cells and molecular mediators that constitute a highly sophisticated "skin immune system" (SIS) as described by Bos and Kapsenberg in 1986 [ 1 ]. (hindawi.com)
  • Taken together, the total skin environment favors the interaction between the immune cells and the host microbial community. (hindawi.com)
  • The skin is a highly active immunological organ that contains a multitude of specialized immune cells. (rupress.org)
  • These BMCs express scavenger receptor, macrophage mannose receptor, TLR2, and TLR4 and may play a role in adaptive and innate immune responses in the human ocular surface. (arvojournals.org)
  • Among potential UV-R targets, skin resident memory T cells (T RM ) stand as well positioned immune cells at the forefront within the skin. (frontiersin.org)
  • and moreover, whether UV-R alters barrier function, leading to microbial-specific skin T RM , disrupting the healthy balance between skin microbiome and skin immune cells, and resulting in chronic inflammation and diseased skin. (frontiersin.org)
  • Dendritic cells (DCs) are known sentinels of the immune system entrusted with the chief task of antigen recognition, presentation, and T cell activation. (hindawi.com)
  • Dendritic cells (DCs) and natural killer (NK) cells are both part of the innate immune system, also playing crucial functions in the regulation of adaptive immune responses. (intechopen.com)
  • In recent years, numerous works have demonstrated that DCs and NK cells mutually influence each other with major consequences in the type and effectiveness of elicited immune responses. (intechopen.com)
  • Dendritic cells (DCs) are a heterogeneous population of innate immune cells with unique capacity to process and present antigens to naïve T cells. (intechopen.com)
  • In fact, it is known that an optimal antitumor immune response depends on a complex interplay between CD8 + T cells, CD4 + T cells and NK cells [ 4 ]. (intechopen.com)
  • NK cells are large granular innate immune cells with cytotoxic functions. (intechopen.com)
  • Absence of a clear T cell infiltrate has been linked to an apparent inability to respond to an immune checkpoint blockade [ 3 ]. (pubmedcentralcanada.ca)
  • As such, patients with "cold" tumors (i.e., those lacking an effector T cell infiltrate) could benefit from therapeutic vaccination with neo- or shared tumor Ags to induce, recruit, and maintain an anticancer cytotoxic T cell response, which might then render those tumors responsive to immune checkpoint blockade. (pubmedcentralcanada.ca)
  • Therapeutic vaccination against cancer will have to rely on efficient Ag loading and activation of DCs to prime powerful antitumor T cell immunity, even in the face of the various immune-suppressive barriers put up by the tumor. (pubmedcentralcanada.ca)
  • immature
  • The density of tolerogenic immature CD1a + dendritic cells (DC), and MARCO + , CD68 + and CD163 + tissue-associated macrophages (TAM) was analysed by immunohistochemistry in tissue micro arrays with tumours from 175 consecutive cases of periampullary adenocarcinoma who had undergone pancreaticoduodenectomy, 110 with pancreatobiliary type (PB-type) and 65 with intestinal type (I-type) morphology. (biomedcentral.com)
  • This result contrasted with the marked preferential fusion of the laboratory-adapted 81A over NL4-3 in immature MDDCs and in ex vivo Langerhans cells, indicating that these laboratory-adapted HIV strains do not fully recapitulate all of the properties of primary HIV isolates. (pubmedcentralcanada.ca)
  • tumor cells
  • Unique proteome signature of post-chemotherapy ovarian cancer ascites-derived tumor cells. (fecri.org.au)
  • Histologically, typical large and pleomorphological tumor cells with epithelioid appearance and significantly malignant cytological features were observed to infiltrate in dermis and subcutaneous tissue. (biomedcentral.com)
  • By immunohistochemistry, the tumor cells were positive for CD1a, S-100 protein and largerin strongly and diffusely. (biomedcentral.com)
  • vivo
  • In vivo, this process is paralleled by DC migration to the lymphoid organs, where the mature DCs efficiently present processed antigenic peptides to interacting T cells (for a review see reference 5 ). (pubmedcentralcanada.ca)
  • This property may be tested directly by explanting tissue in vitro , and is mirrored by significant differences in turnover between DCs and macrophages after stem cell transplantation in vivo . (biomedsearch.com)
  • This review will focus on the advantages of using the unique in vivo Ag-capturing, -processing, and -presenting abilities of APCs, specifically DCs and macrophages, by targeting vaccine formulations to CLRs expressed on their cell surface. (pubmedcentralcanada.ca)
  • Likewise, members of the integrin family, such as the α 4 β 1 and the α L β 2 integrins, proved to be important for progenitor cell trafficking both in vitro and in vivo ( 14 , 15 ). (jimmunol.org)
  • In one embodiment, human dendritic cells, after exposure to a prostate cancer antigen or specific antigenic peptide, are administered to a prostate cancer patient to activate the relevant T cell responses in vivo. (patentsencyclopedia.com)
  • macrophage
  • Cytokine conditions favoring outgrowth of DCs in vitro have been well defined in mouse and human cells, most commonly culture of bone marrow progenitors with granulocyte-macrophage colony-stimulating factor (GM-CSF), CD34 + progenitors with GM-CSF and tumor necrosis factor α (TNFα), or stimulation of blood monocytes with GM-CSF and interleukin-4 (IL-4). (bloodjournal.org)
  • dermis
  • F and G ) Electron micrograph (EM) of the skin with markers denoting epithelium (E), Langerhans cell (LC), and dermis (D). The arrows point at morphological structures consistent with Birbeck granules (BG). (jci.org)
  • Pathology
  • This study highlights the critical and proximal role of T cell activation through the B7-CD28/CD152 costimulatory pathway in maintaining the pathology of psoriasis, including the newly recognized accumulation of mature DCs in the epidermis. (rupress.org)
  • Lineage
  • Both TCR s and CD3 are specific features of cel l s belonging to the T cell lineage. (immbio.hu)
  • reactivity
  • House dust mite and bee and wasp venom extracts were found to generate CD1a reactivity, but paradoxically this function was within the protein and not lipid fraction. (ox.ac.uk)
  • This antibody shows no reactivity with B-cells making it a good marker for T-cell tumors. (immbio.hu)
  • inflammation
  • The lipids then bind to CD1a on Langerhans cells which are recognised by T cells, which in turn contribute to skin inflammation. (ox.ac.uk)
  • This use of CTLA4Ig in psoriasis patients provides a unique opportunity to ascertain the contribution of ongoing T cell costimulation to the persistence of chronic cell-mediated inflammation in a human disease ( 16 ). (rupress.org)
  • mast
  • Gene inactivation studies in mice have revealed that PU.1 is required for the correct development of both the lymphoid and the myeloid lineages, including neutrophils, macrophages, osteoclasts, DCs, and mast cells. (bloodjournal.org)
  • Mast cells contain basophilic granules and originate from the same precursor as basophils but are not the same cell type. (brainscape.com)
  • progenitors
  • 11 , 12 Constitutive overexpression of myeloid transcription factors in heterogeneous populations of hematopoietic progenitors also has defined factors incompatible with alternative Langerhans cell or granulocyte fates under GM-CSF differentiation conditions. (bloodjournal.org)
  • Transendothelial migration of hemopoietic progenitor cells occurs during mobilization from bone marrow in response to cytokines and during homing of circulating progenitors ( 10 ). (jimmunol.org)
  • CD14
  • All the CD68 + cells expressed HLA-DR and CD14. (arvojournals.org)
  • These findings demonstrated that the main population of BMCs in the substantia propria of normal human conjunctiva is CD68 + CD14 + HLA-DR + cells. (arvojournals.org)
  • We describe a subset of peripheral CD14 + cells, coexpressing the CD34 progenitor marker and able to migrate across endothelial cell monolayers. (jimmunol.org)
  • The CD14 + CD34 + population expressed higher levels of platelet endothelial cell adhesion molecule-1 (PECAM-1) and α 4 β 1 integrin than the CD14 + CD34 − counterpart, being dull positive for other integrins. (jimmunol.org)
  • Using stably transfected PECAM-1 + , VCAM-1 + , or ICAM-1 + cells, we found that PECAM-1 and, to a lesser extent, VCAM-1, could support transmigration of CD14 + CD34 + cells, whereas the αL-ICAM-1 interaction was involved in cell adhesion. (jimmunol.org)
  • We suggest that a subset of CD14 + CD34 + circulating leukocytes can localize to peripheral tissues and differentiate into functional dendritic cells, thus representing a functional reservoir of potential APC. (jimmunol.org)
  • Transmigration of mature Mo, expressing CD14, is a multistep process that follows the well-known stepwise model of rolling, mediated by selectins ( 3 ), cell adhesion, involving integrins ( 4 , 5 ), and migration ( 3 , 6 ). (jimmunol.org)
  • tissues
  • To provide the essential functions in priming naive T cells in lymphoid tissues, PDCs require CD40 ligands (CD40L), which are delivered from T cells and cause the terminal maturation of DCs ( 3 , 4 ). (jimmunol.org)
  • CD68 + cells were separated from the conjunctival tissues by using magnetic beads, and the expression of toll-like receptor (TLR) 2 and TLR4 was examined. (arvojournals.org)
  • CD68 + cells isolated from conjunctival tissues expressed TLR2 and TLR4 on flow cytometry. (arvojournals.org)
  • Langerhans cells (LCs) are likely among the first targets of HIV-1 infection due to their localization in mucosal tissues. (jci.org)
  • This antibody intensely stains germinal center cells and B immunoblasts in lymphoid tissues. (immbio.hu)
  • namely
  • To establish infection, HIV-1 must infect cells that support high-level replication, namely CD4+ T cells, which are absent from the outermost genital epithelium. (jci.org)
  • bone
  • 2 Cells of the bone marrow origin are believed to be the primary site for the synthesis of the subunit A in plasma FXIII, hepatocytes in the liver have been also implicated. (leicabiosystems.com)
  • To characterize the main population of bone marrow-derived cells (BMCs) in human normal subconjunctiva and make a comparison with BMCs in the corneal stroma and epithelium. (arvojournals.org)
  • In addition to the existence of bone marrow-derived cells (BMCs) in normal mouse cornea, 2 3 4 we have previously characterized BMCs that reside in the normal human corneal stroma and epithelium. (arvojournals.org)
  • Originates from stem cells in bone marrow and matures in marrow. (brainscape.com)
  • stem cell transplant
  • Early treatment intensification with R-ICE and 90Y-ibritumomab tiuxetan (Zevalin)-BEAM stem cell transplantation in patients with high-risk diffuse large B-cell lymphoma and positive interim PET after 4 cycles of R-CHOP-14. (fecri.org.au)
  • progenitor cells
  • Recently, PECAM-1/CD31 has been reported to enhance the adhesivity of α 4 β 1 integrin expressed by hemopoietic progenitor cells ( 16 ). (jimmunol.org)
  • immunology
  • 2 Correspondence: Department of Molecular Cell Biology and Immunology, Cancer Center Amsterdam, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands. (pubmedcentralcanada.ca)
  • expression
  • Amongst leukocytes, E-cadherin expression is unique to Langerhans cells. (wikipedia.org)
  • Expression of CD23 has been detected in neoplastic cells from cases of B cell CLL and some cases of centroblastic/centrocytic lymphoma. (immbio.hu)
  • Furthermore, we report an induction of Cx43 expression in astrocytes following injury to the mouse motor cortex and demonstrate for the first time CX43 expression at the interface between implanted AF cells and host brain cells. (biomedsearch.com)
  • peptides
  • Frequency of molecular mimicry among T-cell peptides as the basis for autoimmune disease and autoantibody induction. (springer.com)