Periodontitis is a highly prevalent chronic inflammatory bone disease and could destroy the periodontal structures, including alveolar bone, periodontal ligament, and root cementum, which eventually lead to tooth-loss [ 4 ]. (biomedcentral.com)
In the teeth, Sharpey's fibres are the terminal ends of principal fibres (of the periodontal ligament) that insert into the cementum and into the periosteum of the alveolar bone. (wikipedia.org)
A study on rats suggests that the three-dimensional structure of Sharpey's fibres intensifies the continuity between the periodontal ligament fibre and the alveolar bone (tooth socket), and acts as a buffer medium against stress. (wikipedia.org)
It affects the supporting structures of the teeth (root cementum, periodontal ligament and alveolar bone), causing irreversible attachment and bone loss, which are observed histologically and clinically. (encyclopedia.pub)
While the more severe forms of periodontal disease associated with alveolar bone loss are less frequent, gingivitis is widespread at all ages and is the most common form of periodontal disease. (encyclopedia.pub)
Periodontium is a complex and highly specialized pressure sensing system consisting of four components such as cementum, periodontal ligament, alveolar bone, junctional and sulcular epithelia supporting the teeth. (bvsalud.org)
Of these structures, periodontal ligament is a dynamic tissue with a high rate of remodeling and turnover, which connects the teeth to the alveolar bone [1]. (bvsalud.org)
However, microbial substances gain access to the gingival tissue and initiate and perpetuate an inflammatory reaction, which leads to the destruction of the periodontal ligament and alveolar bone, leading to chronic periodontitis and, finally, to tooth loss if left untreated [2]. (bvsalud.org)
The clinical symptoms of this disease include swollen red gingiva, gingival bleeding, suppuration, periodontal pocketing, gingival recession and loss of supporting alveolar bone. (bvsalud.org)
The present study demonstrates that MSE has antibacterial activity against two putative periodontal pathogens. (opendentistryjournal.com)
Periodontal pathogens can, thus, disseminate through the blood and can contribute to development of adverse systemic effects by direct (endothelial injury or dysfunction) indirect (through lipopolysaccharide (LPS) activated cytokine profiles) mechanisms [8]. (bvsalud.org)
PDLSCs3
Exploring the effects of lncRNA SNHG1 in the process of osteogenic differentiation of periodontal ligament stem cells (PDLSCs) would provide novel therapeutic strategies for tissue regeneration. (biomedcentral.com)
Periodontal ligament stem cells (PDLSCs) have demonstrated the potential for differentiation into many cell types, though the molecular mechanism of their neural differentiation in particular remains largely unknown. (edu.pl)
In our previous study, we found that periodontal ligament stem cells (PDLSCs) isolated from beagle dogs effectively differentiated into SCs with exposure to a combination of dimethyl sulfoxide (DMSO), basic fibroblast growth factor (bFGF), brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and forskolin. (edu.pl)
Stem cells1
Notch pathway activation promotes the differentiation of beagle dog periodontal ligament stem cells to Schwann cells. (edu.pl)
Gingival1
We put the link through the use of metronidazole for other diseases such as parasitic infections, which indirectly improves the periodontal and gingival health. (biomedgrid.com)
Diseases1
P. gingivalis LPS acts as a potent stimulus to a variety of host cells, which subsequently results in the expression of inflammatory cytokines leading to the development and progression of the related host immune response in periodontal diseases [ 6 ]. (opendentistryjournal.com)
Prevalence1
It was shown that 40-50% of plaque remains after tooth brushing, and the effects of biofilm retention are clearly evident in the prevalence of caries, gingivitis and periodontal disease. (encyclopedia.pub)
Severe forms1
In the industrialized countries, moderate or severe forms of destructive periodontal disease affect almost 40% of the adult population [3,4]. (bvsalud.org)
Teeth1
Periodontal ligament mesenchymal cells were obtained from two healthy human teeth (impacted third molars). (bvsalud.org)
Destruction1
IL-8) release which could further enhance inflammation [ 7 , 8 ] and finally leading to periodontal destruction via Matrix Metalloproteinases (MMPs) [ 9 ]. (opendentistryjournal.com)
Immune1
Trial: A phase 2 trial of an Ad5 vectored COVID-19 vaccine candidate, conducted in China, has found that the vaccine is safe and induces an immune response, according to new research published in The Lancet . (regenerativemedicine.net)
Inflammatory1
Evidence for the anti inflammatory activity of M. alba Stem Extract (MSE) in periodontal disease is limited. (opendentistryjournal.com)
Human5
To evaluate the proliferative capacity of mesenchymal cells derived from human periodontal ligament on polished and plasma-treated titanium surfaces. (bvsalud.org)
We concluded that plasma nitriding produced surfaces that permitted the proliferation of human periodontal ligament mesenchymal cells. (bvsalud.org)
In this respect, this study evaluated the proliferation of mesenchymal cells derived from the periodontal ligament of human third molars on polished and plasma-nitrided titanium surfaces. (bvsalud.org)
The study aimed to investigate the inhibitory effect of MSE on the growth of periodontopathic bacteria and expression of interleukin (IL)-6 and IL-8 in Porphyromonas gingivalis Lipopolysaccharide (LPS)-stimulated human Periodontal Ligament (hPDL) fibroblasts. (opendentistryjournal.com)
Canakci V, Canakci CF. Pain levels in patients during periodontal probing and mechanical non-surgical therapy. (ijold.com)
Common1
The most common etiology of periodontal disease is dental plaque, which consists of microbial flora containing more than 700 distinct microbial species cultivated from dental plaque [7]. (bvsalud.org)
Study1
The present study reviewed the literature regarding the impacts of using metronidazole for treating parasitic infections in improving the periodontal health. (biomedgrid.com)
Research1
1]K. Mahmoud Ababneh, "The Use of Metronidazole for Treating Parasitic Infections Improves the Periodontal Health," American Journal of Biomedical Science & Research, vol. 1, no. 5, pp. 226-227, Mar. 2019. (biomedgrid.com)