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Tissue DonorsLiving DonorsKidney TransplantationHeelPeriodicals as TopicTissue and Organ ProcurementDirected Tissue DonationGraft SurvivalCadaverBlood Specimen CollectionTransplantation, HomologousHistocompatibility TestingAuthorshipLasers, GasHistocompatibilityBibliometricsJournal Impact FactorGraft vs Host DiseaseGraft RejectionBone Marrow TransplantationImmunosuppressive AgentsPublishingPeer Review, ResearchUnrelated DonorsWaiting ListsHematopoietic Stem Cell TransplantationTransplantation ConditioningTreatment OutcomeAntilymphocyte SerumBlood DonorsWhole-Body IrradiationRetrospective StudiesTransplantsTime FactorsRandomized Controlled Trials as TopicSurvival RateHeart TransplantationSurvival AnalysisTransplantationLung TransplantationRisk FactorsResearch DesignCyclosporineTacrolimusPostoperative ComplicationsImmunosuppressionCytomegalovirus InfectionsTransplantation ImmunologyFetal Tissue TransplantationMycophenolic AcidLiver FailureKidney Failure, ChronicImmunocompromised HostFollow-Up StudiesHLA AntigensBrain DeathHeart-Lung TransplantationTransplantation, AutologousTransplantation ToleranceTransplantation, HeterotopicBrain Tissue TransplantationTissue and Organ HarvestingBronchiolitis ObliteransIsoantibodiesRecurrenceCytomegalovirusHematologic NeoplasmsKidneyOpportunistic InfectionsBiopsyTransplantation, IsogeneicBK VirusProspective StudiesLiver DiseasesIslets of Langerhans TransplantationGanciclovirLiver TransplantationEnd Stage Liver DiseaseLymphoproliferative DisordersCreatinineAcute DiseaseCorneal TransplantationPrimary Graft DysfunctionPolyomavirus InfectionsIncidenceSkin TransplantationPostoperative PeriodKidney DiseasesStem Cell TransplantationT-LymphocytesLeukemiaCord Blood Stem Cell TransplantationDeathBlood Group IncompatibilityPatient SelectionCold IschemiaFatal OutcomeMycosesAntiviral AgentsCohort Studies
TransplantationOrgansRecipientsKidneysUterusRecipientWombKidney transplantsAllogeneic transplantLive donorRejectionGraftTissuesAdultTissueCentersImmunosuppressionAcuteBirths1984BoneDonor'sOrgan donationPatientsSurgeryDialysisPatientDaysBloodHumanUterusesStudyYearsHeartWomanWomenPreviousMedicalDeadEarly
Transplantation19
  • We identified West Nile virus (WNV) RNA in skin, fat, muscle, tendon, and bone marrow from a deceased donor associated with WNV transmission through solid organ transplantation. (cdc.gov)
  • We evaluated tissues collected from a deceased donor who was associated with transmission of WNV through solid organ transplantation to determine if WNV RNA, viral antigen, or infectious viral particles could be detected in postmortem tissues. (cdc.gov)
  • LD kidney transplantation (LDKT) is preferred over DD kidney transplantation (DDKT), because of superior quality kidneys that result in improved patient and graft survival ( 2 ), greater flexibility for transplantation across the ABO ( 3 , 4 ) and HLA ( 5 , 6 ) barriers, and the possibility for kidney exchange ( 7 ) including chains initiated by unspecified donors ( 8 ). (frontiersin.org)
  • Even though each cadaveric organ donor can often supply multiple organs for transplantation, many patients still die before a suitable organ becomes available. (scialert.net)
  • 1999). Majority of the organs for transplantation are donated from patients in whom brain-stem death has been diagnosed and who are then ventilated to maintain adequate oxygenation and circulation-the so called non-heart-beating donors (NHBDs) (D Allessandro et al . (scialert.net)
  • 1995). Though this speaks volumes about the improvement in the level of health-care being provided, it also points to the important fact that the number of potential donors may be decreasing, which in turn is seriously limiting the transplantation programs. (scialert.net)
  • OBM Transplantation is committed to rapid review and publication, and we aim at serving the international transplant community with high accessibility as well as relevant and high quality content. (lidsen.com)
  • Donor cell-derived leukaemia (DCL) is an uncommon complication of allogeneic hematopoietic stem cell transplantation (HSCT). (lidsen.com)
  • Additionally, organs from animal sources could be transplanted into patients currently excluded from the human organ transplantation list. (medscape.com)
  • They developed the buttonhole technique for anastomosis of donor and recipient vessels in kidney transplantation to prevent thrombus formation. (medscape.com)
  • The transplanted kidneys were functional between 72 hours and one week after transplantation in 34.4% of the patients. (brieflands.com)
  • Despite the benefits of receiving a kidney transplant for CKD patients, sometimes this approach can be unsuccessful (i.e., the loss or rejection of the graft in less than 31 days after transplantation, a condition known as early graft loss (EGL). (brieflands.com)
  • Early in the pandemic, Swisstransplant, the Swiss National Foundation for Organ Donation and Transplantation, set up a national stepwise shutdown approach to avoid a collapse of transplant activities during phases of the pandemic with sufficient available healthcare capacities. (smw.ch)
  • A retrospective nationwide study was conducted to evaluate donor procurement and solid organ transplantation activity in Switzerland during the COVID-19 pandemic (1 January to 31 May 2020). (smw.ch)
  • To assess the impact of the flexible stepwise shutdown plan on overall transplantation activity in Switzerland, we compared total and individual numbers of transplanted organs during the first wave of the pandemic with the transplant activity immediately before the pandemic. (smw.ch)
  • In May 2020, solid organ transplantation activity in Switzerland again exceeded the average of pre-pandemic months (January and February), with 35 transplanted organs, but the increase from April to May 2020 was exclusively driven by liver and kidney transplants. (smw.ch)
  • The Swiss stepwise shutdown approach in organ donation and transplantation helped to maintain a limited national organ procurement and vital organ transplant activity, avoiding a complete nationwide shutdown of organ donation and transplant activity. (smw.ch)
  • The ISN-TTS Sister Transplant Centers Program is a joint partnership set up between ISN and The Transplantation Society (TTS) to create new kidney transplant centers and develop existing kidney transplant programs in emerging countries. (tts.org)
  • The TTS-ILTS Paired Transplant Centers Program is a collaboration between The Transplantation Society (TTS) and the International Liver Transplantation Society (ILTS) supporting new liver transplant programs in emerging countries. (tts.org)
Organs5
  • Scientists from Bristol helped grow the cells for the transplant and the European team believes such tailor-made organs could become the norm. (bbc.co.uk)
  • Usually organs are retrieved from only about 15-20% of the eligible cadaveric donors available each year. (scialert.net)
  • The concept was pioneered a century ago, when transplanting human organs was considered ethically controversial. (medscape.com)
  • Xenografts have been proposed as appropriate for infants who are physically too small to accommodate organs retrieved from adult or pediatric donors. (medscape.com)
  • Sept. 3 - As many as 2,500 more organs could be made available for transplant in the UK if families spoke more openly about donating after death, says the NHS Blood and Transplant organisation. (tts.org)
Recipients10
  • In 6 clusters of organ transplant-transmitted WNV infections reported to public health agencies in the United States, 12 (75%) of 16 recipients were infected ( 5 ). (cdc.gov)
  • Subsequently, all 4 organ donor recipients were tested and had positive results for WNV RNA. (cdc.gov)
  • [11] About one-third to one-half of allogeneic transplant recipients will develop acute GvHD. (wikipedia.org)
  • The leukemogenesis of DCL is not well understood due to the limited numbers of cases reported and lack of detailed molecular genetic information from recipients and donors. (lidsen.com)
  • Several factors play a role in the occurrence of EGL in kidney transplant recipients, which must be identified and limited. (brieflands.com)
  • This ten-year retrospective study was conducted in a single center on 32 kidney transplant recipients with EGL to determine the reasons for and risk factors of kidney transplant rejection in Iran. (brieflands.com)
  • This descriptive-analytical study's population included 605 kidney transplant recipients receiving kidneys during the last ten years in our center. (brieflands.com)
  • In this study, 32 out of 605 kidney transplant recipients (5.28%) experienced EGL (53.1% male and 46.9% female, average age of 41.12 years). (brieflands.com)
  • In this prospective, longitudinal 2-centre study of 864 kidney transplant (KT) recipients with a median follow up of 3.3 (2.9-5.2) years, Thomas and colleagues examined whether cognitive impairment is associated with an increased risk of all-cause graft loss (ACGL). (tts.org)
  • In deceased donor KT recipients this difference in ACGL was not observed, however when these patients were stratified by those with severe cognitive impairment versus those without, ACGL was 53.0% at 5 years versus 24.2% (p=0.046). (tts.org)
Kidneys3
  • Donor kidneys could be from a deceased donor (DD) or a living donor (LD). (frontiersin.org)
  • Chimpanzee kidneys have been transplanted into patients with renal failure. (medscape.com)
  • Recently, research has increased in the area of transplanting embryonic cells across species and growing kidneys and endocrine pancreas cells in situ. (medscape.com)
Uterus9
  • The transplanted uterus was removed in two cases, in one case due to a serious infection and in the other due to blood clots in the transplanted blood vessels. (sciencedaily.com)
  • The seven remaining women have in 2014 tried to become pregnant through a process where their own embryos, produced through IVF, are reintroduced to the transplanted uterus. (sciencedaily.com)
  • In early September, the woman successfully delivered a baby by caesarean section, making her the first woman in the world to deliver a child from a transplanted uterus. (sciencedaily.com)
  • This Dec. 15, 2017 photo provided by transplant surgeon Dr. Wellington Andraus shows the baby girl born to a woman with a uterus transplanted from a deceased donor at the Hospital das Clinicas of the University of Sao Paulo School of Medicine, Sao Paulo, Brazil, on the day of her birth. (apnews.com)
  • LONDON (AP) - Brazilian doctors are reporting the world's first baby born to a woman with a uterus transplanted from a deceased donor. (apnews.com)
  • The baby girl was born in Sao Paulo, Brazil, late last year following a successful 10 hour uterus transplant to a patient who had been born without a womb. (herfamily.ie)
  • The Lancet reports that the mother had Mayer-Rokitansky-Küster-Hauser syndrome, a condition that causes the uterus and vagina to not develop properly. (herfamily.ie)
  • It was then transplanted to the woman who was given medication to weaken her immune system so her body would not reject the uterus. (herfamily.ie)
  • The first uterus transplants from live donors were a medical milestone, creating the possibility of childbirth for many infertile women with access to suitable donors and the needed medical facilities. (herfamily.ie)
Recipient3
  • However, EGL heralds adverse physical and emotional consequences for both the tissue recipient and the transplant team. (brieflands.com)
  • Aug. 27 - Surgeons at UC San Diego Health have transplanted the kidney of a deceased donor with HIV into a recipient with a pre-existing HIV infection. (tts.org)
  • However, the risk of primary cancer clinically as an immunosuppressant maceutical drugs ciclosporin and in the transplant recipient increases to treat certain autoimmune diseas- azathioprine. (who.int)
Womb4
  • Nine women in the project have received a womb from live donors -- in most cases the recipient's mother but also other family members and close friends. (sciencedaily.com)
  • Eleven previous births have used a transplanted womb but from a living donor, usually a relative or friend. (apnews.com)
  • The first ever baby has been born through a womb transplant from a deceased donor. (herfamily.ie)
  • The transplant womb was taken from a mother-of-three who had died from bleeding on the brain. (herfamily.ie)
Kidney transplants1
  • In comparison, 50% of kidney transplants in the Netherlands in 2021 were from LDs and a greater proportion of these patients (44%) were pre-emptive ( 25 ). (frontiersin.org)
Allogeneic transplant1
  • Dr Roger Owen (Leeds General Infirmary) gives his opinion on the place of allogeneic transplant in myeloma following the debate. (medicalupdateonline.com)
Live donor2
  • It also shows that transplants with a live donor are possible, including if the donor is past menopause,' says Brännström. (sciencedaily.com)
  • However, the need for a live donor is a major limitation as donors are rare, typically being willing and eligible family members or close friends. (herfamily.ie)
Rejection3
  • The woman has had three mild rejection episodes since the transplant, one of which occurred during the pregnancy. (sciencedaily.com)
  • The rejection episodes, which are often seen also in other types of transplants, could be stopped with immunosuppressive treatment. (sciencedaily.com)
  • The groundbreaking technology also means for the first time tissue transplants can be carried out without the need for anti-rejection drugs. (bbc.co.uk)
Graft2
  • Risk Factors and Causality of Early Graft Loss in Kidney Transplanted Patie. (brieflands.com)
  • The efficacy of allo-SCT in MM relies on the transplanted immune system having an anti-tumour effect on the host bone marrow, the so-called graft-versus-myeloma (GvM) effect. (medicalupdateonline.com)
Tissues1
  • none of the donor tissues were transplanted. (cdc.gov)
Adult2
  • The adult male donor had a history of cerebral palsy, seizures, and blindness. (cdc.gov)
  • Between April 2021 and March 2022, only 40% of adult kidney only transplants were from LDs ( 22 ) and only 35% of these transplants were pre-emptive ( 24 ). (frontiersin.org)
Tissue5
  • The white blood cells present within the transplanted tissue then attack the recipient's body's cells, which leads to GvHD. (wikipedia.org)
  • In contrast to organ/tissue transplant associated GvHD, the incidence of TA-GvHD is increased with HLA matching (first-degree or close relatives). (wikipedia.org)
  • Surgeons in Spain have carried out the world's first tissue-engineered whole organ transplant - using a windpipe made with the patient's own stem cells. (bbc.co.uk)
  • Then they used strong chemicals and enzymes to wash away all of the cells from the donor trachea, leaving only a tissue scaffold made of the fibrous protein collagen. (bbc.co.uk)
  • Between 50,000 and 60,000 people are diagnosed with cancer of the larynx each year in Europe, and scientists say about half them may be suitable candidates for tissue engineering transplants. (bbc.co.uk)
Centers1
  • This initiative encourages transplant centers to work together to increase opportunities for kidney transplant patients in developing countries. (tts.org)
Immunosuppression1
Acute1
  • The acute or fulminant form of the disease (aGvHD) is normally observed within the first 10 to 100 days post-transplant, [9] [10] and is a major challenge to transplants owing to associated morbidity and mortality. (wikipedia.org)
Births1
  • 11 other births have resulted from living donors, including women who donated their uteruses to their daughters. (herfamily.ie)
19841
  • [ 1 ] In 1984, a baboon heart was transplanted into a newborn infant, Baby Fae, who had hypoplastic left heart syndrome and lived 20 days after heart surgery. (medscape.com)
Bone2
Donor's1
  • Five weeks after the donor's death, frozen spleen/lymph node homogenate from the donor that had been used for human leukocyte antigen testing was sent from the transplant center to CDC, and initial WNV PCR testing was performed as part of the transplant-transmission investigation ( 7 ). (cdc.gov)
Organ donation1
  • The main reason for the very low rate of organ donation in Germany has been reported to be the refusal of the consent by the donor/relatives (Kleidienst et al . (scialert.net)
Patients5
  • [10] It is less common in younger patients and in those with closer human leukocyte antigens (HLA) matches between donor and the patient. (wikipedia.org)
  • The European research team, which also includes experts from the University of Padua and the Polytechnic of Milan in Italy, is applying for funding to do windpipe and voice box transplants in cancer patients. (bbc.co.uk)
  • [ 5 ] and pig neuronal cells have been transplanted into patients with Parkinson (Parkinson's) disease and Huntington (Huntington's) disease . (medscape.com)
  • [ 8 ] In 2009, 28,464 patients had transplants, and approximately 40% of listed candidates on waiting list were younger than 50 years. (medscape.com)
  • 2 The Blood and Marrow Transplant Clinical Trials Network (BMT CTN) 0102 study showed that patients receiving an autologous SCT (ASCT) followed by an allo-SCT had significantly higher CR rates that patients receiving double ASCTs. (medicalupdateonline.com)
Surgery2
  • Professor Martin Birchall, professor of surgery at the University of Bristol who helped grow the cells for the transplant, said: "This will represent a huge step change in surgery. (bbc.co.uk)
  • Our findings supported previous studies' results, suggesting that EGL is associated with receiving an incompatible kidney transplant and surgery-related complications, including bleeding and thrombosis. (brieflands.com)
Dialysis2
  • Perhaps the most important advantage of LDKT is the ability to plan the transplant and hence avoid dialysis, thereby offering the most secure way to achieve pre-emptive KT (PKT). (frontiersin.org)
  • In the UK, median waiting time from start of dialysis to DDKT was 1,044 days for adults transplanted between April 2021 and March 2022 ( 22 ). (frontiersin.org)
Patient3
  • Five months on the patient, 30-year-old mother-of-two Claudia Castillo, is in perfect health, The Lancet reports. (bbc.co.uk)
  • To make the new airway, the doctors took a donor windpipe, or trachea, from a patient who had recently died. (bbc.co.uk)
  • [ 2 ] A baboon liver was transplanted to a patient with hepatic failure. (medscape.com)
Days1
  • After four days of growth in the lab in a special rotating bioreactor, the newly-coated donor windpipe was ready to be transplanted into Ms Castillo. (bbc.co.uk)
Blood1
  • After a month, a biopsy of the site proved that the transplant had developed its own blood supply. (bbc.co.uk)
Human1
  • He said it looked and behaved identically to a normal human donor trachea. (bbc.co.uk)
Uteruses1
Study2
  • Two more transplants are planned as part of the Brazilian study. (apnews.com)
  • The aim of this study was to describe the stepwise shutdown approach and to determine whether this flexible approach would be helpful for avoiding complete cessation of transplant activities during a pandemic. (smw.ch)
Years1
  • He said that in 20 years time, virtually any transplant organ could be made in this way. (bbc.co.uk)
Heart1
  • J Heart Lung Transplant. (smw.ch)
Woman4
  • Now the first transplanted woman has delivered a baby - a healthy and normally developed boy. (sciencedaily.com)
  • The woman - a 32-year-old psychologist - was initially apprehensive about the transplant, said Dr. Dani Ejzenberg, the transplant team's lead doctor at the University of Sao Paulo School of Medicine. (apnews.com)
  • The woman became pregnant through in vitro fertilization seven months after the transplant. (apnews.com)
  • The donor was a 45-year-old woman who had three children and died of a stroke. (apnews.com)
Women2
  • Seven Swedish women have had embryos reintroduced after receiving wombs from living donors. (sciencedaily.com)
  • In a ground-breaking research project at the University of Gothenburg, seven Swedish women have had embryos reintroduced after receiving wombs from living donors. (sciencedaily.com)
Previous2
  • Ten previous attempts using deceased donors in the Czech Republic, Turkey and the U.S. have failed. (apnews.com)
  • The 10 previous pregnancies from deceased donors have failed. (herfamily.ie)
Medical1
  • Details of the first case were published Tuesday in the medical journal Lancet. (apnews.com)
Dead1
  • The transplant lobby considers this a big problem because administering anesthesia is perceived as an additional difficulty in telling the relatives that the donor is not actually dead but in an unsurvivable coma. (scialert.net)
Early1
  • In its early era allo-SCT was associated with transplant-related mortality (TRM) rates of around 40%, 1 and in Dr Cook's opinion this has left a lingering perception in many MM clinicians' minds that allo-SCT outcomes are poor. (medicalupdateonline.com)