ExtracellularMerosinStructuralProteoglycansChainGeneMigrationComponentGenesStructureDomainActiveFamiliesGlycoproteinsExtracellular matrix pSubunits of lamininOrganization of basement membranesMutationsIsoformsIntegrinReceptorsCollagenAminoSignal transductionNidogenPhenotypeGammaStructuresRegulateTranscript variantsExpressionMiceMetastasisGliomaInflammationHumanCellFunctionCellsLungAssemblyRoleStudiesWorkSkin
Extracellular6
- Laminin, an extracellular matrix protein, is a major component of the basement membrane. (wikipedia.org)
- Functional analyses indicated that some of the genes induced by dragonfly larvae caused an increase in laminins necessary for cell adhesion in the extracellular matrix. (biomedcentral.com)
- An Illustration of the Laminin-111 complex depicting the domain organization Laminins are high-molecular weight (~400 to ~900 kDa) proteins of the extracellular matrix. (pearltrees.com)
- The laminin globular (G) domain can be found in one to several copies in various laminin family members, including a large number of extracellular proteins. (embl.de)
- Merging extracellular domains: fold prediction for laminin G-like and amino-terminal thrombospondin-like modules based on homology to pentraxins. (embl.de)
- There are a number of families of extracellular matrix (ECM) proteins including collagens, proteoglycans and laminins (LM). (urosario.edu.co)
Merosin1
- This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). (wikipedia.org)
Structural3
- 3] They are composed of a family of related proteins sharing common structural and sequence features. (pearltrees.com)
- Using a series of fusion proteins corresponding to the different structural domains of TSP, binding of [125I]DCN to TSP was found to be dependent of the N-terminal domain and, to a lesser extent, of the type 1 repeats and the C-terminal domain of TSP. (embl.de)
- Here is how wikipedia describes them :'Laminins are a family of proteins that are an integral part of the structural scaffolding of basement membranes in almost every animal tissue. (apostolic.edu)
Proteoglycans1
- Other than water, the mesoglea is composed of several substances including fibrous proteins like collagen and heparan sulphate proteoglycans. (pearltrees.com)
Chain1
- the tadpoles showed reduced expression of cα(E)-catenin , small muscle protein, dystrophin , and myosin light chain genes. (biomedcentral.com)
Gene3
- Laminin subunit alpha-2 is a protein that in humans is encoded by the LAMA2 gene. (wikipedia.org)
- Two transcript variants encoding different proteins have been found for this gene. (wikipedia.org)
- Thrombospondin 1, abbreviated as THBS1, is a protein that in humans is encoded by the THBS1 gene. (pearltrees.com)
Migration2
- The laminins are an important and biologically active part of the basal lamina, influencing cell differentiation, migration, and adhesion. (pearltrees.com)
- Laminin G-containing proteins appear to have a wide variety of roles in cell adhesion, signalling, migration, assembly and differentiation. (embl.de)
Component3
- He is known for his work on laminins - huge proteins that are a key component of all basement membranes. (imperial.ac.uk)
- They are a major component of the basal lamina (one of the layers of the basement membrane), a protein network foundation for most cells and organs. (pearltrees.com)
- The conserved patterns correspond mainly to hydrophobic core residues located in central beta strands of the known three-dimensional structures of two pentraxins, the human C-reactive protein and the serum amyloid P-component. (embl.de)
Genes1
- ELAV - like1 , methyltransferase like 7A , dolichyl-phosphate mannosyltransferase , laminin subunit beta-1 , gremlin 1 , BCL6 corepressor-like 1 , and three genes of unknown identity. (biomedcentral.com)
Structure1
- Here is what the structure of laminin looks l! (apostolic.edu)
Domain3
- Taxonomic distribution of proteins containing TSPN domain. (embl.de)
- The complete taxonomic breakdown of all proteins with TSPN domain is also avaliable . (embl.de)
- Click on the protein counts, or double click on taxonomic names to display all proteins containing TSPN domain in the selected taxonomic class. (embl.de)
Active1
- Predicted to be active in basement membrane. (nih.gov)
Families1
Glycoproteins3
- Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. (nih.gov)
- Laminins are heterotrimeric glycoproteins of the extracellular matrix that are secreted by epithelial cells and which are crucial for the normal structure and function of the basement membrane. (nih.gov)
- The laminins are a family of extracellular matrix glycoproteins that have a heterotrimeric structure consisting of an alpha, beta and gamma chain. (utsouthwestern.edu)
Extracellular matrix p2
- Studies on extracellular matrix proteins, cells, and genetically modified animals have converged to reveal mechanisms of basement membrane self-assembly as mediated by γ1 subunit-containing laminins, the focus of this chapter. (nih.gov)
- Extracellular matrix proteins, including those of the laminin family, formed regions within the LN that were permissive for colocalization of alloantigen-presenting cells, alloreactive T cells, and Tregs. (jci.org)
Subunits of laminin2
- This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). (wikipedia.org)
- This gene encodes one of the alpha 1 subunits of laminin. (utsouthwestern.edu)
Organization of basement membranes1
- They are also involved in the formation and organization of basement membranes, which are thin, sheet-like structures that separate and support cells in many tissues. (medlineplus.gov)
Mutations7
- Mutations in laminin subunits, affecting expression or LN domain-specific functions, are a cause of human diseases that include those of muscle, nerve, brain, and kidney. (nih.gov)
- The more serious form of the disease, known as JEB generalized severe, usually results from mutations that prevent the production of functional laminin 332. (medlineplus.gov)
- Most of these mutations lead to a premature stop signal in the instructions for making the gamma subunit of laminin 332, which prevents the assembly of this protein. (medlineplus.gov)
- Some of these mutations alter single protein building blocks (amino acids) in the gamma subunit of laminin 332. (medlineplus.gov)
- Muhle C, Jiang QJ, Charlesworth A, Bruckner-Tuderman L, Meneguzzi G, Schneider H. Novel and recurrent mutations in the laminin-5 genes causing lethal junctional epidermolysis bullosa: molecular basis and clinical course of Herlitz disease. (nih.gov)
- Scope includes mutations and abnormal protein expression. (cancerindex.org)
- However, the changes Asn802 to Ser or Val804 to Ser, both known to exist in the laminin gamma 2 chain, were deleterious mutations. (uea.ac.uk)
Isoforms4
- Heterogeneity of function is created in part by the isoforms of laminin that vary in their ability to polymerize and to interact with integrins, dystroglycan, and other receptors. (nih.gov)
- Through combination, laminin chains constitute 15 laminin isoforms. (icosagen.com)
- Laminin isoforms and their integrin receptors in glioma cell migration and invasiveness: Evidence for a role of alpha5-laminin(s) and alpha3beta1 integrin. (icosagen.com)
- This demonstrated conservation of binding structures in laminins of distantly related species, but not between homologous chains of laminin isoforms. (uea.ac.uk)
Integrin1
- These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. (nih.gov)
Receptors2
- Many of the effects of laminin are mediated through interactions with cell surface receptors. (nih.gov)
- Laminins are a family of large heterotrimeric proteins that promote cell adhesion and migration via integrins and other cell-surface receptors. (icosagen.com)
Collagen3
- Immunostaining and confocal fluorescence microscopy show that the ECM proteins fibronectin, collagen I, and laminin are deposited throughout the entire 3D structure. (nature.com)
- TGF-β1 is a multifunctional cytokine that has been shown to promote fibroblast proliferation and drive the stable accumulation of ECM proteins particularly collagen and fibronectin in vivo 14 , 15 . (nature.com)
- Rather, the loss of α3 laminin was associated with a significant increase in the collagen content of the lungs. (nih.gov)
Amino1
Signal transduction1
- The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. (cancerindex.org)
Nidogen2
- The basic model is as follows: A member of the laminin family adheres to a competent cell surface and typically polymerizes followed by laminin binding to the extracellular adaptor proteins nidogen, perlecan, and agrin. (nih.gov)
- High affinity binding of nidogen to laminin is mediated by an EGF-like repeat gamma 1III4 of the mouse laminin gamma 1 chain and has now been restricted to two short noncontiguous regions of its 56 residue sequence by use of synthetic peptides and recombinant mutants. (uea.ac.uk)
Phenotype1
- PHENOTYPE: Homozygous null mice display embryonic lethality before somite formation with impaired formation of Reichert's membrane. (utsouthwestern.edu)
Gamma1
Structures1
- This is, at least in part, attributable to the release and intercellular trafficking of extracellular vesicles (EVs), heterogeneous membrane structures containing multiple bioactive macromolecules. (cancerindex.org)
Regulate1
- Laminins are a group of proteins that regulate cell growth, cell movement (motility), and the attachment of cells to one another (adhesion). (medlineplus.gov)
Transcript variants2
- Two transcript variants encoding different proteins have been found for this gene. (wikipedia.org)
- Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. (cancerindex.org)
Expression2
- We identified unique expression patterns of laminin proteins in high endothelial venule basement membranes and the cortical ridge that correlated with alloantigen-specific immunity or immune tolerance. (jci.org)
- We observed that EGFRvIII expression alters the expression of EV-regulating genes (vesiculome) and EV properties, including their protein composition. (cancerindex.org)
Mice2
- At 60 days after intratracheal treatment of adult Lama3(fl/fl) mice with an adenovirus encoding Cre recombinase (Ad-Cre), the protein abundance of α3 laminin in whole lung homogenates was more than 50% lower than that in control-treated mice, suggesting a relatively long half-life for the protein in the lung. (nih.gov)
- Upon exposure to an injurious ventilation strategy (tidal volume of 35 ml per kg of body weight for 2 hours), the mice with a knockdown of the α3 laminin subunit had less severe injury, as shown by lung mechanics, histology, alveolar capillary permeability and survival when compared with Ad-Null-treated mice. (nih.gov)
Metastasis3
- Cell-adhesive protein LAMR1 plays an important role in the processes of cancer proliferation, invasion and metastasis. (nih.gov)
- This protein enhances cell motility, invasion and metastasis of cancer cells. (cancerindex.org)
- These proteins make up a major component of the basement membrane and have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. (utsouthwestern.edu)
Glioma2
- Among them, we validated the association of pro-invasive proteins (CD44, BSG, CD151) with EVs of EGFRvIII expressing glioma cells, and downregulation of exosomal markers (CD81 and CD82) relative to EVs of EGFRvIII-negative cells. (cancerindex.org)
- Nano-flow cytometry revealed that the EV output from individual glioma cell lines was highly heterogeneous, such that only a fraction of vesicles contained specific proteins (including EGFRvIII). (cancerindex.org)
Inflammation1
Human1
- Hartwig B, Borm B, Schneider H, Arin MJ, Kirfel G, Herzog V. Laminin-5-deficient human keratinocytes: defective adhesion results in a saltatory and inefficient mode of migration. (medlineplus.gov)
Cell5
- The ratio of laminin α4 to laminin α5 was greater in domains within tolerant LNs, compared with immune LNs, and blocking laminin α4 function or inducing laminin α5 overexpression disrupted T cell and DC localization and transmigration through tolerant LNs. (jci.org)
- It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. (nih.gov)
- Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. (cancerindex.org)
- This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. (cancerindex.org)
- They are major components of basement membranes of blood vessels and other tissue compartments, and are synthesized by numerous cell types. (icosagen.com)
Function1
- The genetic changes responsible for JEB generalized intermediate usually lead to the production of a laminin 332 protein that retains some of its function. (medlineplus.gov)
Cells1
- A special type of ECM is the basal membrane, which supports epitelial cells. (uncommondescent.com)
Lung2
Assembly1
- Laminins in basement membrane assembly. (nih.gov)
Role1
- Laminin 332 has a particularly important role in the basement membrane that underlies the top layer of skin (the epidermis). (medlineplus.gov)
Studies1
- Studies suggest that laminin 332 also has several other functions. (medlineplus.gov)
Work1
- This work identifies laminins as potential targets for immune modulation. (jci.org)
Skin2
- This membrane gives strength and resiliency to the skin and creates an additional barrier between the body and its surrounding environment. (medlineplus.gov)
- Without laminin 332, the epidermis is only weakly connected to the underlying layers of skin. (medlineplus.gov)