• The laminins can self-assemble, bind to other matrix macromolecules, and have unique and shared cell interactions mediated by integrins, dystroglycan, and other receptors. (embl.de)
  • Moreover, integrins, laminins, NF-κB and other regulative molecules were found as crucial proteins. (nature.com)
  • Integrins are heterodimeric, transmembrane receptors that function as mechanosensors, adhesion molecules and signal transduction platforms in a multitude of biological processes. (thno.org)
  • Integrins are heterodimeric cell surface receptors found in nearly all metazoan cell types, composed of non-covalently linked α and β subunits. (thno.org)
  • Integrins are not constitutively active but rather exist in multiple activation states wherein ligand binding stability is related to the activation status of the receptor. (thno.org)
  • The region of sdc-1 that associates with 31 and 64 integrins is called the co-receptor binding website. (monossabios.com)
  • sdc-1 null fibroblasts AG-1478 enzyme inhibitor have reduced activation of v integrins on their surface (4) which may contribute to delayed wound healing in sdc-1 null mice since several v integrin heterodimers including v5, v6, and v8 mediate TGF1 activation. (monossabios.com)
  • To begin to build such an interaction map, we have initially focused on integrins, the major receptors for extracellular matrix proteins. (uiowa.edu)
  • Integrins mediate cell adhesion and migration during development, in homeostasis, and in a variety of pathological settings, including tumor cell metastasis. (uiowa.edu)
  • Thus at present there is no satisfactory explanation for how different integrins that share a common β subunit are able to mediate different cellular responses. (uiowa.edu)
  • For example, tumor cell motility mediated by α3β1 integrin on its ligand, laminin-332 (laminin-5), can be 3-4 fold faster than motility mediated by other β1 integrins, such as the collagen receptor, α2β1, or the fibronectin receptor, α5β1. (uiowa.edu)
  • We hypothesize that the diversity in the functions of different β1 integrins may derive in part from their differing patterns of lateral cell surface interactions. (uiowa.edu)
  • Another form of integrin functional diversity is the ability of individual integrins to mediate different responses in different cell types. (uiowa.edu)
  • These chondrocyte/ECM interactions are regulated by a large family of transmembrane glycoproteins whereby beta 1 integrins are the most widely expressed and interact with several matrix proteins such as collagen, fibronectin, vitronectin and laminin [ 4 ]. (biomedcentral.com)
  • Cell lines and transfected cell systems augment this study with particular emphasis on perturbations in the biology of selectins, integrins, matrix adhesion, and chemokine receptors. (stjude.org)
  • Rap-1 is an essential protein involved in signaling mediated by integrins. (medscape.com)
  • We studied human bone marrow cell adhesion to laminin-10/11 (alpha5beta1gamma1/alpha5beta2gamma1), laminin-8 (alpha4beta1gamma1), laminin-1 (alpha1beta1gamma1), and fibronectin. (ox.ac.uk)
  • About 35% to 40% of CD34(+) and CD34(+)CD38(-) stem and progenitor cells adhered to laminin-10/11, and 45% to 50% adhered to fibronectin, whereas they adhered less to laminin-8 and laminin-1. (ox.ac.uk)
  • Whereas endothelial cells plated on fibronectin or fibrinogen activate NF-κB in response to flow, cells on collagen or laminin do not. (rupress.org)
  • These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. (wikipedia.org)
  • Laminins are alphabetagamma heterotrimeric extracellular proteins that regulate cellular functions by adhesion to integrin and nonintegrin receptors. (ox.ac.uk)
  • Adhesion of CD34(+)CD38(-) cells to laminin-10/11 was maximal without integrin activation, whereas adhesion to other proteins was dependent on protein kinase C activation by 12-tetradecanoyl phorbol-13-acetate (TPA). (ox.ac.uk)
  • The cell surface receptors that interpret these cues engage cytoplasmic partners to transduce signals, but recent work reveals that many receptors also interact laterally with cell surface proteins that can be critical for proper receptor function. (uiowa.edu)
  • Integrin α3β1 strongly interacts with one particular tetraspanin, CD151, which in turn links α3β1 into larger cell surface complexes that may contain other tetraspanins, Ig superfamily (IgSF) proteins, growth factor receptors, membrane-bound growth factors, and novel proteins (Figure 1). (uiowa.edu)
  • Currently, our focus is to determine whether the interaction between NTHi surface proteins and CRL can trigger an immune response, as this information will be valuable in identifying potential vaccine candidates. (lu.se)
  • These properties will act mediating the action of cell adhesion proteins, regulating cell behavior and causing tissue regeneration. (bvsalud.org)
  • To occur the adhesion of CAMs to the biomaterial, it is necessary their interaction with some components of extracellular matrix, such as proteoglycans, collagen and proteins 23 . (bvsalud.org)
  • BMs are specialized structures that underlie epithelia and surround organs and mainly comprise collagen IV, laminins, and heparan sulfate proteoglycans (HSPG). (nature.com)
  • Otiz-Urda and colleagues (7) showed the development of human being epidermal squamous cell carcinomas required the interaction between the two extracellular matrix molecules laminin 332 (LM332) and type VII collagen and recent studies show that this interaction is definitely mediated by signaling through integrin mediated adhesions. (monossabios.com)
  • ii) Serial deletions of RPSA have shown that the segment of residues 236-262, included in the C-domain, is involved in the interaction between RPSA and the 40S subunit of ribosome. (wikipedia.org)
  • While both subunits contribute to ligand-binding specificity, the β subunit cytoplasmic tail mediates most of the established integrin signaling and cytoskeletal interactions that have been identified. (uiowa.edu)
  • Integrin-mediated interactions with the extracellular matrix (ECM) are required for the attachment, cytoskeletal organization, mechanosensing, migration, proliferation, differentiation and survival of cells in the context of a multitude of biological processes including fertilization, implantation and embryonic development, immune response, bone resorption and platelet aggregation. (thno.org)
  • Integrin mediated cellular adhesion is dynamic process that is both indicative of and influenced by cell status. (thno.org)
  • The biodirectional nature of integrin mediated signaling allows both extra- and intracellular cues to regulate activation [ 4 ] (Fig. 1 ). (thno.org)
  • In the absence of integrin ligation, these processes are abrogated therefore pharmacological inhibition of integrin ligation is of great interest for the therapy of numerous diseases resulting from abberant integrin mediated signaling. (thno.org)
  • Data from a radiolabeled ligand‑binding assay indicated that LGP exhibited apparent competing effects on thromboxane receptor (TP) and P2Y12 receptors. (spandidos-publications.com)
  • However, the specific ligand of NTHi responsible for this interaction remains unknown. (lu.se)
  • Laminin IV domain is also found in the perlecan protein, an integral component of basement membranes, which serves also as an attachment substrate for cells, but it is not found in short laminin chains (alpha4 or beta3). (embl.de)
  • Laminins containing alpha4 and alpha5 chains are expressed in bone marrow, but their interactions with hematopoietic progenitors are unknown. (ox.ac.uk)
  • We further found that the pericytic laminin isoforms differentially regulate mouse β-cells. (nature.com)
  • dGLYAT was found to regulate Gadd45 -mediated JNK pathway activation and cell invasion. (sdbonline.org)
  • Important biological events associated with plasma membranes, such as signal transduction, cell adhesion, and protein trafficking, are mediated through the membrane microdomains. (mdpi.com)
  • Cytokines bind to their receptors, activating signal transduction pathways such as adenylate cyclase/cAMP, phospholipase C/inositol trisphosphate, and Ca 2+ and tyrosine kinases. (biomedcentral.com)
  • RPSA is also a receptor for small molecules. (wikipedia.org)
  • Other unusual features of the receptor include its ability to engage classes of molecules, rather than individual ligands, and its enhanced surface expression in environments rich in RAGE ligands. (jci.org)
  • These cell adhesion molecules (CAM) will mediate the contact between two cells or between cells and the extracellular matrix, an essential process to the success of the implant. (bvsalud.org)
  • Notwithstanding, to achieve the effectiveness and integration of the grafted tissue to the receptor site, it is necessary a strong cell adhesion, so that it demands many molecules interaction to induce cell differentiation and the bone matrix mineralization formed onto the graft. (bvsalud.org)
  • Some of these molecules are glycoproteins expressed on the cell surface, socalled cell adhesion molecules (CAM), which mediate either the contact between two cells or the contact among cells and the extracellular matrix, being therefore of fundamental importance for adhesion 3 . (bvsalud.org)
  • Finally, interaction with the basal lamina during radial sorting is mediated by laminin receptors 7, but what controls their expression is also not known. (holyexperiment.org)
  • In contrast, in the submucosa, laminin was exclusively found in the basal lamina of blood vessels where many adherent mast cells were seen. (bmj.com)
  • Currently, a major focus in the lab is determining (i) the extent to which assembly into tetraspanin complexes can help to explain α3β1 integrin's ability to mediate unusually rapid tumor cell migration, and (ii) the implications of tetraspanin association for the role of α3β1 in metastatic tumor cell spread. (uiowa.edu)
  • A tumor microenvironment that is altered (such as by frontline treatment) can mediate tumor cell entrance into, maintenance, and exit from dormancy through interaction with cells at niches, such as endothelial cells, stroma, or immune cells. (biomedcentral.com)
  • Microglia strongly enhanced glioma invasiveness in the co-culture system, but this invasion-promoting activity was lost in glioma cells stably expressing shTbetaRII, indicating a crucial role of microglia-derived TGF-beta in tumor-host interactions. (dbcls.jp)
  • These 2 members mediate leukocyte adhesions to endothelial cells but they also serve as receptors for iC3b (inactivated C3b). (medscape.com)
  • The interactions with the various BM components differentially affect β-cells, although the underlying mechanism is largely unknown. (nature.com)
  • The colocalisation with laminin indicates a mechanism of interaction between smooth muscle cells and mast cells that may be important in the role of mast cells in the process of fibrosis. (bmj.com)
  • In functional assays, both laminin-8 and laminin-10/11 facilitated stromal-derived factor-1alpha (SDF-1alpha)-stimulated transmigration of CD34(+) cells, by an integrin alpha6 receptor-mediated mechanism. (ox.ac.uk)
  • Conformational changes in the GM-CSF receptor suggest a molecular mechanism for affinity conversion and receptor signaling. (cusabio.com)
  • Binding of these ligands to RAGE does not accelerate clearance or degradation but rather begins a sustained period of cellular activation mediated by receptor-dependent signaling. (jci.org)
  • In this study, we found that activation of Toll-like receptor 3 (TLR3) signaling rather than type I IFN stimulation led to the upregulation of SOCS1 during DTMUV infection. (bvsalud.org)
  • 2006) Combined integrin activation and intracellular cAMP cause Rho GTPase dependent growth cone collapse on laminin-1. (assumption.edu)
  • Upon cellular activation, the bacteria then adhere to chemokine receptors, particularly the platelet-activating factor receptor. (stjude.org)
  • The 1,384-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein,' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. (nih.gov)
  • Su YC, Mattsson E, Singh B, Jalalvand F, Murphy TF, Riesbeck K. The Laminin Interactome: A Multifactorial Laminin-Binding Strategy by Nontypeable Haemophilus influenzae for Effective Adherence and Colonization. (lu.se)
  • It also acts as a cell surface receptor, in particular for laminin, and is involved in several pathogenic processes. (wikipedia.org)
  • Many of the effects of laminin are mediated through interactions with cell surface receptors. (wikipedia.org)
  • Each laminin is a heterotrimer assembled from alpha, beta and gamma chain subunits, secreted and incorporated into cell-associated extracellular matrices. (embl.de)
  • Whereas α2 laminins promoted islet cell clustering, they did not affect gene expression. (nature.com)
  • In contrast, culturing on Laminin-421 induced the expression of β-cell genes, including Ins1 , MafA , and Glut2 , and significantly improved glucose-stimulated insulin secretion. (nature.com)
  • We show that the absence of Yap and Taz causes a severe peripheral neuropathy due to a developmental impairment in axonal sorting, and that Yap/Taz-Tead1 are required for the transcriptional regulation of laminin receptors in Schwann cell. (holyexperiment.org)
  • Integrin alpha6 and beta1 chains were involved in binding of both cell fractions to laminin-10/11 and laminin-8. (ox.ac.uk)
  • Laminin-10/11 was highly adhesive to lineage-committed myelomonocytic and erythroid progenitor cells and most lymphoid and myeloid cell lines studied, whereas laminin-8 was less adhesive. (ox.ac.uk)
  • The cell-adhesive laminins affected migration of hematopoietic progenitors, suggesting a physiologic role for laminins during hematopoiesis. (ox.ac.uk)
  • Syndecan-1 (sdc-1) is a cell surface proteoglycan that mediates the connection of cells with their matrix, influencing attachment, migration and response to growth factors. (monossabios.com)
  • Evidence for the importance of sdc-1 in epithelial homeostasis is definitely shown by the fact that sdc-1 manifestation in epithelial cells is definitely controlled via TGF1 mediated cell signaling AG-1478 enzyme inhibitor (16). (monossabios.com)
  • Thus, a more sophisticated understanding of cell migration will require a "cell surface interaction map" describing the physical and functional connections between receptors and their cell surface partners. (uiowa.edu)
  • It also has been shown that cell surface glypicans are low-affinity endostatin receptors (Karumanchi et al. (justia.com)
  • On the other hand, the heparin binding properties of endostatin manifest themselves in its interaction with the cell surface. (justia.com)
  • Detta steg är nödvändigt för att virus ska kunna föröka sig i en infekterad cell och sprida sig vidare till intilliggande celler och vidare till andra människor. (umu.se)
  • P-selectin, soluble endothelial protein C receptor, soluble thrombomodulin, plasminogen activator inhibitor 1, ADAMTS-13, von Willebrand factor, tissue factor, soluble intercellular adhesion molecule 1, and vascular cell adhesion molecule 1 were more elevated in LF patients than in controls. (cdc.gov)
  • The RPSA gene encodes a multifunctional protein, which is both a ribosomal protein and a high-affinity, non-integrin laminin receptor. (wikipedia.org)
  • Proteomic results were analyzed with gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and protein-protein interactions (PPI). (nature.com)
  • Our results demonstrate a successful targeting of TGF-beta-dependent invasiveness and tumorigenicity of glioblastoma cells by RNAi-mediated gene silencing. (dbcls.jp)
  • The different laminin chains share a 600-residue domain I/II which oligomerises into a rod-like coiled-coil structure forming the long arm of laminins. (embl.de)
  • Compared to ECs, pancreatic pericytes produce significantly higher levels of α2 and α4 laminin chains, which constitute the peri-islet and vascular BM. (nature.com)
  • The C-Type Lectin receptor (CRL) is known as the major β-glucan receptor expressed in myeloid cells and is responsible for targeting respiratory fungal pathogens. (lu.se)
  • Mutations in GPR56 , an orphan G-protein-coupled receptor (GPCR), cause bilateral frontoparietal polymicrogyria (BFPP), a disorder characterized by mental retardation, seizures, motor developmental delay, and ataxia. (jneurosci.org)
  • However, while many studies demonstrated the importance of the ECM, its interactions with β-cells are still not fully understood. (nature.com)
  • All mast cells in the muscularis propria were colocalised with patches of laminin. (bmj.com)
  • Laminin isoform-specific promotion of adhesion and migration of human bone marrow progenitor cells. (ox.ac.uk)
  • In conclusion, we demonstrate laminin isoform-specific adhesive interactions with human bone marrow stem, progenitor, and more differentiated cells. (ox.ac.uk)
  • Interference RNA-mediated knockdown of GPR56 recapitulates the loss of adhesion seen in knock-outs, and reexpression of GPR56 rescues the adhesion defect in knock-out granule cells. (jneurosci.org)
  • Expanded manifestation of 64 within papillomas undergoing premalignant progression arising from 2-stage chemical carcinogenesis is associated with variations AG-1478 enzyme inhibitor in the connection of cells with laminin in their matrix (5,6). (monossabios.com)
  • CD11a/CD18 (LFA-1) expressed on lymphocytes is known to play an important role in lymphocyte trafficking (adhesion to vascular endothelium), as well as interactions to antigen presenting cells (APC). (medscape.com)
  • We developed plasmid-transcribed small hairpin RNAs (shRNAs) to downregulate the TGF-beta type II receptor (TbetaIIR) expression, which effectively inhibited cytokine-induced signaling pathways and transcriptional responses in transiently transfected human glioblastoma cells. (dbcls.jp)
  • This interaction allows bacterial entry into cells and results in transmigration. (stjude.org)
  • Sdc-1 null keratinocytes are more adhesive and less migratory as they rely primarily on 64 to mediate their migration. (monossabios.com)
  • Both recombinant N-domain and C-domain of RPSA bind laminin in vitro, and they bind with similar dissociation constants (300 nM). (wikipedia.org)
  • KEGG pathways enrichment and PPI network indicate four major pathways, including extracellular matrix -receptor interaction, focal adhesion, phosphatidylinositol 3-kinase (PI3K)-Protein kinase B (Akt), and Ras signaling pathways were involved in the degeneration of cartilage. (nature.com)
  • In OA, cartilage damage is the outcome of an abnormal extra-cellular matrix (ECM) remodelling leading to an overwhelm of tissue breakdown mediated by metalloproteinases (MMPs). (biomedcentral.com)
  • PMID- 17684491 OWN - NLM STAT- MEDLINE DCOM- 20080304 LR - 20220309 IS - 1476-5594 (Electronic) IS - 0950-9232 (Linking) VI - 27 IP - 7 DP - 2008 Feb 7 TI - Microglia-derived TGF-beta as an important regulator of glioblastoma invasion--an inhibition of TGF-beta-dependent effects by shRNA against human TGF-beta type II receptor. (dbcls.jp)
  • While SOCS1 acts as a negative regulator of cytokines, we found that DTMUV utilized SOCS1 to mediate the ubiquitination and proteasomal degradation of IRF7 and ultimately inhibit type I IFN production, thereby promoting its proliferation. (bvsalud.org)
  • Finally, SOCS1 acts as an E3 ubiquitin ligase that binds to IFN regulatory factor 7 (IRF7) through its SH2 domain and mediates K48-linked ubiquitination and proteasomal degradation of IRF7, ultimately inhibiting type I IFN production mediated by IRF7 and promoting viral proliferation. (bvsalud.org)
  • Taken together, these features of RAGE allow the receptor to propagate cellular dysfunction in a number of pathophysiologically relevant situations, most often dictated by the formation and persistence of ligands in the tissues. (jci.org)
  • This finding suggests that this receptor may have the ability to detect ligands from a broader spectrum of pathogens, not limited to fungal origins. (lu.se)
  • Endothelial protein C receptor, thrombomodulin, intercellular adhesion molecule 1, plasminogen activator inhibitor 1, D-dimer, and hepatocyte growth factor were higher in fatal than nonfatal LF cases. (cdc.gov)
  • To this end, molecular and cellular interactions may influence the tissue reactions to biomaterials. (bvsalud.org)
  • Likely other tissues, many events occur when a given biomaterial is in contact with the biological bone environment, with molecular and cellular interactions influencing on the tissue features surrounding the biomaterial. (bvsalud.org)
  • The N-terminal short arms consist of rod-like elements (domain III and V) formed by tandem arrays of laminin-type EGF modules and several globular domains: domains IV and domain VI (laminin N-terminal). (embl.de)
  • The heparin binding property of endostatin is mediated by noncontiguous arginines clustered over the three dimensional globular surface of the molecule (Sasaki et al. (justia.com)
  • RPSA is a ribosomal protein which has acquired the function of laminin receptor during evolution. (wikipedia.org)
  • This study demonstrated that the Receptor for Activated C-Kinase 1 (RACK1) is important in SC function. (sdbonline.org)
  • Further studies found that RNF123 promoted the proteasomal degradation of SOCS1 and promoted Toll-like receptor 3 (TLR3)- and interferon (IFN) regulatory factor 7 (IRF7)-mediated type I IFN production during duck Tembusu virus (DTMUV) infection through SOCS1, ultimately inhibiting DTMUV replication. (bvsalud.org)
  • In this project, our aim is to identify the molecule responsible for the interaction between NTHi and CRL, with the goal of finding a promising target for vaccine development to treat NTHi infections. (lu.se)
  • Moreover, the C-domain of RPSA and heparin compete for binding to laminin, which shows that the highly acidic C-domain of RPSA mimicks heparin (and potentially heparan sulfates) for the binding to laminin. (wikipedia.org)
  • Den återstående sjukdomar beskrivs som "Disease X" och som representeras av kunskapen att en allvarlig internationell epidemi kan orsakas av ett smittämne som för närvarande är okänt som sjukdomsframkallande hos människor. (umu.se)
  • Further studies revealed that JOSD1 stabilized SOCS1 expression by binding to the SH2 domain of SOCS1 and mediating its deubiquitination. (bvsalud.org)
  • Further studies showed that JOSD1 stabilized SOCS1 expression by mediating the deubiquitination of SOCS1. (bvsalud.org)
  • Anatomical profiling of G protein-coupled receptor expression. (guidetopharmacology.org)
  • It is likely that endostatin has a number of biological functions mediated by different regions of the protein. (justia.com)