Additionally, we detected increased levels of active glycogen synthase kinase 3 β, a physiological kinase of TAU, in neurons derived from AD iPSCs, as well as significant upregulation of amyloid precursor protein (APP) synthesis and APP carboxy-terminal fragment cleavage. (biomedcentral.com)
Most cases of early-onset AD are linked to autosomal dominant inherited mutations in the genes encoding amyloid precursor protein ( APP ), presenilin 1 ( PSEN1 ), and presenilin 2 ( PSEN2 ). (biomedcentral.com)
Gold nanoparticles4
Kattesh V. Katti, M.D., Ravi Shukla, M.D., and colleagues detail their studies in a paper titled "Laminin receptor specific therapeutic gold nanoparticles ( 198 AuNP-EGCg) show efficacy in treating prostate cancer. (genengnews.com)
Interaction of biocompatible EGCg with 198 Au precursor affords the production of inherently therapeutic gold nanoparticles through a novel synthetic route, effectively eliminating toxic chemicals that are routinely utilized in pharmaceutical formulations," the authors conclude. (genengnews.com)
In our continued efforts to apply Green Nanotechnology for the development of therapeutic radioactive gold nanoparticles, recently we have discovered that the high antioxidant capacity of Epigallocatechin gallate (EGCG), which is the most abundant catechin polyphenol in tea, can be used to convert radioactive Gold-198 precursor to the corresponding biocompatible radioactive gold nanoparticles functionalized with Laminin receptor specific EGCG. (sbbn.org.br)
Laminin receptors are overexpressed in a large number of human tumors and the high in vivo affinity of EGCG toward Laminin receptors has allowed to develop Laminin receptor specific radioactive gold nanoparticles to achieve tumor specificity (14). (sbbn.org.br)
Glycoprotein3
The process of thrombus formation is considered to be initiated by von Willebrand factor (VWF) binding to exposed collagen or laminin in the damaged vessel wall, followed by shear-dependent platelet binding to VWF through the glycoprotein (GP)Ib-V-IX complex ( 1 , 3 , 4 ). (frontiersin.org)
The flow-dependent adhesion of platelets to those and other extracellular matrix components is stabilized by a panel of integrins, including integrin α 2 β 1 , α IIb β 3 , and α 6 β 1 (adhesive platelet population), while the initial activation of platelets is achieved by signaling via the collagen/laminin receptor, glycoprotein VI (GPVI). (frontiersin.org)
Collagen receptors are cell surface receptors that modulate signal transduction between cells and the EXTRACELLULAR MATRIX. (lookformedical.com)
It first binds with high affinity to specific cell-surface receptors and then induces their dimerization, which is essential for activating the tyrosine kinase in the receptor cytoplasmic domain, initiating a signal transduction that results in DNA synthesis and cell proliferation. (embl.de)
Collagen1
A biosynthetic precursor of collagen containing additional amino acid sequences at the amino-terminal and carboxyl-terminal ends of the polypeptide chains. (lookformedical.com)
Synthesis1
Currently, 18 subtypes have been reported: 12 are type I (dysfunctional lipid-linked oligosaccharide precursor synthesis), and 6 are type II (dysfunctional trimming/processing of the protein-bound oligosaccharide), including leukocyte adhesion deficiency II (CDG-IIc). (medscape.com)
Proteins2
The filtered light-chain proteins, reabsorbed by the proximal tubular cells via the tandem megalin/cubilin receptors, are catabolized by lysosomal enzymes. (medscape.com)
Several ECM proteins such as laminin, tenascin and thrombospondin contain domains with homology to epidermal growth factor (EGF) and exhibit growth promoting activity. (embl.de)
Extracellular matrix1
WAT is characterised by its capacity to adapt and expand in response to surplus energy through processes of adipocyte hypertrophy and/or recruitment and proliferation of precursor cells in combination with vascular and extracellular matrix remodelling. (springer.com)
Binds1
Secondly, the green tea extract directly and selectively binds with laminin67R receptors that are overexpressed in prostate tumor cells. (genengnews.com)
Mechanism2
The colocalisation with laminin indicates a mechanism of interaction between smooth muscle cells and mast cells that may be important in the role of mast cells in the process of fibrosis. (bmj.com)
De Felice FG, Velasco PT, Lambert MP, Viola K, Fernandez SJ, Ferreira ST and Klein WL: Abeta oligomers induce neuronal oxidative stress through an N- methyl- d - aspartate receptor- dependent mechanism that is blocked by the Alzheimer drug memantine. (spandidos-publications.com)
Amino1
The present study aimed to establish an AD cell model overexpressing the 695‑amino‑acid Swedish mutant of Aβ precursor protein (APP695swe) in order to observe the effects of memantine on the cell viability, autophagy and apoptosis of SH‑SY5Y cells in the AD model, and to investigate the associated underlying mechanisms. (spandidos-publications.com)
Regulation4
Here, we summarise the mechanisms contributing to adipose tissue (AT) plasticity and function including characteristics and cellular complexity of the various adipose depots and we discuss recent insights into AT origins, identification of adipose precursors, pathophysiological regulation of adipogenesis and its relation to WAT/BAT expandability in obesity and its associated comorbidities. (springer.com)
An important way of regulation is provided by proteolytic cleavage of several of these receptors, leading to either a gain or a loss of platelet function. (frontiersin.org)
Imaging P2X4 receptor subcellular distribution, trafficking, and regulation using P2X4-pHluorin. (tamu.edu)
Nicotine exploits a COPI-mediated process for chaperone-mediated up-regulation of its receptors. (tamu.edu)
Specific1
Although these platelet activation processes are relatively well-studied as a function of the platelet environment, only since recently it is becoming clear that a multitude of proteases present in plasma or produced by platelets themselves are important for the distinct properties of platelet populations, often by cleaving specific receptors. (frontiersin.org)
Origins1
The proteases involved are of different origins and types: (i) present as precursor in plasma, (ii) secreted into the plasma by activated platelets or other blood cells, or (iii) intracellularly activated and cleaving cytosolic receptor domains. (frontiersin.org)
Cells4
All mast cells in the muscularis propria were colocalised with patches of laminin. (bmj.com)
In contrast, in the submucosa, laminin was exclusively found in the basal lamina of blood vessels where many adherent mast cells were seen. (bmj.com)
The cells embedded within it interact with the matrix as well as with other cells due to the presence of specialized matrix receptor molecules. (biologywise.com)
These 2 members mediate leukocyte adhesions to endothelial cells but they also serve as receptors for iC3b (inactivated C3b). (medscape.com)
Cell1
are laminin-like diffusible chemotactic protein involved with pancreatic morphogenesis and are likely involved in the legislation of duct-cell and foetal GSK1838705A islet cell migration. (immune-source.com)
Directly1
Texidó L, Martín-Satué M, Alberdi E, Solsona C and Matute C: Amyloid β peptide oligomers directly activate NMDA receptors. (spandidos-publications.com)
Effects1
The Effects of NLY01, a Novel Glucagon-Like Peptide-1 Receptor Agonist, on Cuprizone-Induced Demyelination and Remyelination: Challenges and Future Perspectives. (neurotree.org)
High-affinity3
The high-affinity cellular receptor for the basement membrane component laminin is differentially expressed during tumor invasion and metastasis. (nih.gov)
It first binds with high affinity to specific cell-surface receptors and then induces their dimerization, which is essential for activating the tyrosine kinase in the receptor cytoplasmic domain, initiating a signal transduction that results in DNA synthesis and cell proliferation. (embl-heidelberg.de)
We hypothesize that androgen action on the eye involves the local, intracrine synthesis of this sex steroid from adrenal precursors (e.g., dehydroepiandrosterone), binding to saturable, high-affinity and androgen-specific receptors, control of gene transcription, and ultimately modulation of translation. (molvis.org)
MRNA3
Primer extension experiments demonstrated that the clone contained the complete 5' sequence of the murine laminin receptor mRNA. (nih.gov)
RNA blot data demonstrated a single-sized laminin receptor mRNA, approximately 1400 bases long, in human, mouse, and rat. (nih.gov)
The apparent molecular weight on SDS-polyacrylamide gels of the rabbit reticulocyte cell-free translation product of selectively hybridized laminin receptor mRNA is 37,000. (nih.gov)
Dimerization1
The relationship between the 67 LR and its precursor 37 LRP is not completely understood, but previous observations have suggested that 37 LRP can undergo homo- and/or hetero- dimerization with Galectin-3 (Gal-3) to form mature 67 LR. (nottingham.ac.uk)
Peptides1
Antisera to cDNA-deduced synthetic peptides of the receptor immunoprecipitated a 37-kilodalton band both from cell-free translation products and from pulse-labeled cell extracts. (nih.gov)
Protein3
The precursor of the laminin receptor is apparently smaller than the 67-kilodalton protein isolated from tissue. (nih.gov)
Microbial infection) Acts as a receptor for the pathogenic prion protein. (nih.gov)
Currently, 18 subtypes have been reported: 12 are type I (dysfunctional lipid-linked oligosaccharide precursor synthesis), and 6 are type II (dysfunctional trimming/processing of the protein-bound oligosaccharide), including leukocyte adhesion deficiency II (CDG-IIc). (medscape.com)
Soluble2
In particular, experimental and clinical trials performed in emergency departments highlight the validity of soluble urokinase plasminogen activator receptor (suPAR) as a predictive and prognostic biomarker in patients with sepsis. (bvsalud.org)
Concentrations of N 6 -Carboxymethyllysine (CML), N 6 -Carboxyethyllysine (CEL), and Soluble Receptor for Advanced Glycation End-Products (sRAGE) Are Increased in Psoriatic Patients. (nih.gov)
Tyrosine1
Recent clinical trials have targeted specific pathways implicated in the pathogenesis of IPF and these have included γ-interferon, endothelin receptor antagonists, antioxidants, etanercept, pirfenidone and tyrosine kinase inhibitors 1 - 6 . (ersjournals.com)
Neural1
Neural crest precursors do not exist as a segregated population in the ectoderm. (silverchair.com)
Molecules1
It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. (nih.gov)
Human1
A cDNA clone encoding the murine laminin receptor was isolated and identified on the basis of sequence homology to the human laminin receptor [Wewer et al. (nih.gov)
Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. (nih.gov)
Relationship1
Antisera to three different domains of the cDNA-predicted receptor were used to study the relationship between the 37- and 67-kilodalton polypeptides. (nih.gov)
Domains1
The mitogenic activity of laminin is restricted to a fragment which consists of about 25 repeating domains with partial homology to EGF and comprises the rod-like inner regions of the three short arms of the four armed molecule. (embl-heidelberg.de)
Activity1
the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). (nih.gov)