In muscle, it binds to alpha-dystroglycan and integrin alpha7-beta1 via the G domain, and via the other end, it binds to the extracellular matrix. (wikipedia.org)
Mutations in all sarcoglycans, dysferlin, and caveolin-3, as well as mutations that cause abnormal glycosylation of alpha-dystroglycan can result in limb-girdle muscular dystrophy syndrome. (medscape.com)
Dystroglycan is a highly glycosylated extracellular matrix receptor with essential functions in skeletal muscle and the nervous system. (nature.com)
Normally, dystrophin serves as the bridge in the dystrophin-associated glycoprotein complex (DAPC), connecting the cytoskeleton, via attachments to subsarcolemmal F-actin, to the extracellular matrix through an association with plasma membrane bound β-dystroglycan[ 4 ]. (biomedcentral.com)
Integrin1
Neurons of the peripheral nervous system express integrin receptors that attach to laminins and promote neuroregeneration after injury. (wikipedia.org)
Skeletal muscle2
Disruption of DAG1 in differentiated skeletal muscle reveals a role for dystroglycan in muscle regeneration. (nature.com)
[ 1 , 2 ] Although the chief target of the autoimmune attack in most cases is the skeletal muscle nicotinic acetylcholine receptor (nAChR), other antigenic targets that are components of the neuromuscular junction (NMJ) have also been implicated. (medscape.com)
Neuronal3
Distinct functions of glial and neuronal dystroglycan in the developing and adult mouse brain. (nature.com)
Dystrophin also serves a signaling role through mechanotransduction of forces and localization of neuronal nitric oxide synthase (nNOS), which produces nitric oxide (NO) to facilitate vasorelaxation. (biomedcentral.com)
Dystrophin also serves signaling roles, including mechanotransduction of forces and localization of signaling proteins, such as neuronal nitric oxide synthase (nNOS), which synthesizes nitric oxide (NO) to facilitate vasorelaxation[ 5 - 7 ]. (biomedcentral.com)
Plasma membrane1
The proteins also bind to cell membranes through integrins and other plasma membrane molecules, such as the dystroglycan glycoprotein complex and Lutheran blood group glycoprotein. (wikipedia.org)
Endothelial4
For example, the peptide sequence [GTFALRGDNGDNGQ], which is located on the alpha-chain of laminin, promotes the adhesion of endothelial cells. (wikipedia.org)
P-selectin, soluble endothelial protein C receptor, soluble thrombomodulin, plasminogen activator inhibitor 1, ADAMTS-13, von Willebrand factor, tissue factor, soluble intercellular adhesion molecule 1, and vascular cell adhesion molecule 1 were more elevated in LF patients than in controls. (cdc.gov)
Endothelial protein C receptor, thrombomodulin, intercellular adhesion molecule 1, plasminogen activator inhibitor 1, D-dimer, and hepatocyte growth factor were higher in fatal than nonfatal LF cases. (cdc.gov)
Another approach increases the density of the underlying vascular network by inducing angiogenesis, and this has been accomplished through either direct delivery of vascular endothelial growth factor (VEGF) or by downregulating the VEGF decoy-receptor type 1 (VEGFR-1 or Flt-1). (biomedcentral.com)
Proteins2
Laminins are heterotrimeric proteins with a high molecular mass (~400 to ~900 kDa) and possess three different chains (α, β and γ) encoded by five, four, and three paralogous genes in humans, respectively. (wikipedia.org)
progenitors signal the non-motile mechanisms and proteins considered by the photosynthetic canonical conference-goers remain I and II plus conformational human cations of TGF-beta-mediated granulocyte( Bruckner 2010). (familie-vos.de)
Abnormal1
Abnormal laminin-332, which is essential for epithelial cell adhesion to the basement membrane, leads to a condition called junctional epidermolysis bullosa, characterized by generalized blisters, exuberant granulation tissue of skin and mucosa, and pitted teeth. (wikipedia.org)
Glycosylation1
Reduced matrix binding by α-dystroglycan (α-DG) due to perturbed glycosylation is a pathological feature of several forms of muscular dystrophy. (nature.com)
Congenital3
Dysfunctional structure of one particular laminin, laminin-211, is the cause of one form of congenital muscular dystrophy. (wikipedia.org)
Deletion of brain dystroglycan recapitulates aspects of congenital muscular dystrophy. (nature.com)
Localization2
Dystroglycan organizes axon guidance cue localization and axonal pathfinding. (nature.com)
Palmitoylation regulates neuropilin-2 localization and function in cortical neurons and conveys specificity to semaphorin signaling via palmitoyl acyltransferases. (harvard.edu)
Binds1
forces are distinct, encoding development to incoming parts with responses under IL7 groups of receptors or binds. (familie-vos.de)
Structural1
Laminins are integral to the structural scaffolding of almost every tissue of an organism-secreted and incorporated into cell-associated extracellular matrices. (wikipedia.org)
Interactions1
Through these interactions, laminins critically contribute to cell attachment and differentiation, cell shape and movement, maintenance of tissue phenotype, and promotion of tissue survival. (wikipedia.org)
Basement1
Yurchenco, P.D. Basement membranes: cell scaffoldings and signaling platforms. (nature.com)
Bound2
The atomic details of matrix binding were revealed by a high-resolution crystal structure of laminin-G-like (LG) domains 4 and 5 (LG4 and LG5) of laminin-α2 bound to a LARGE-synthesized oligosaccharide. (nature.com)
Figure 3: Crystal structure of laminin-α2 LG4-5 bound to oligosaccharide G6/7. (nature.com)
Promotes1
SLC1A1 is an intact SLC5A7 phosphorylation 1( EAAC1, regardless was EAAT3) and promotes free either in demand but ever in receptor, initiative, evidence, envelope, development and in electricity wind signatories. (familie-vos.de)
Occurs2
citation needed] This effect of laminin-111 probably occurs through a lowering of intracellular cyclic AMP. (wikipedia.org)
The autoimmune attack occurs when autoantibodies form against the nicotinic acetylcholine postsynaptic receptors at the neuromuscular junction of skeletal muscles (see the image below). (medscape.com)
Biological1
Some of these biological functions of laminin have been associated with specific amino-acid sequences or fragments of laminin. (wikipedia.org)
Protein1
Malfunctional laminin-521 in the kidney filter causes leakage of protein into the urine and nephrotic syndrome. (wikipedia.org)
Tissue1
In DMD, the signaling defects produce inadequate tissue perfusion caused by functional ischemia due to a diminished ability to respond to shear stress induced endothelium-dependent dilation. (biomedcentral.com)
Complex3
Ervasti, J.M. & Campbell, K.P. A role for the dystrophin-glycoprotein complex as a transmembrane linker between laminin and actin. (nature.com)
A stoichiometric complex of neurexins and dystroglycan in brain. (nature.com)
2017. Ryanodine receptors are part of the myospryn complex in cardiac muscle . (cardiff.ac.uk)
Essential1
Pikachurin, a dystroglycan ligand, is essential for photoreceptor ribbon synapse formation. (nature.com)
Human2
Barresi, R. & Campbell, K.P. Dystroglycan: from biosynthesis to pathogenesis of human disease. (nature.com)
75NTR digitalis Indeed suggests in ligase to MAG in human laminin complexes. (familie-vos.de)
Type1
Laminins form independent networks and are associated with type IV collagen networks via entactin, fibronectin, and perlecan. (wikipedia.org)
Cells1
citation needed] Laminins are enriched at the lesion site after peripheral nerve injury and are secreted by Schwann cells. (wikipedia.org)
Formation1
The three short arms have an affinity for binding to other laminin molecules, conducing sheet formation. (wikipedia.org)
Growth1
The presence of laminin-1 can influence how the growth cone responds to other cues. (wikipedia.org)
Shape1
Mechanoreceptor signal convergence and transformation in the dorsal horn flexibly shape a diversity of outputs to the brain. (harvard.edu)