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  • lama5
  • Lack of laminin-10 in lama5 -/- mice results in aberrant tissue development. (stanford.edu)
  • Here, we examined the role of podocyte-derived laminin α5 via podocyte-specific inactivation of Lama5 and podocyte-specific rescue of the Lama5 neo mutation. (asnjournals.org)
  • Podocyte-specific restoration of laminin α5 production using two distinct strategies in Lama5 neo/neo mice resulted in the resolution of proteinuria, hematuria, and PKD. (asnjournals.org)
  • Laminin α5 is widely expressed, 17 and Lama5 −/− mice die at late fetal stages with multiple developmental defects. (asnjournals.org)
  • Here we manipulated Lama5 expression in vivo specifically in podocytes in three different ways to investigate the function of laminin α5 in the GBM. (asnjournals.org)
  • Hydrogels
  • In this study, laminin-derived peptides were conjugated to poly(ethylene glycol) (PEG) monoacrylate and covalently incorporated into degradable PEG diacrylate (PEGDA) hydrogels to investigate the influence of these peptides on endothelial cellular adhesion and function in organizing into tubule networks. (rice.edu)
  • Degradable PEGDA hydrogels were synthesized by incorporating a matrix metalloproteinase (MMP)-sensitive peptide, GGGPQGIWGQGK (abbreviated PQ), into the polymer backbone. (rice.edu)
  • Tubules formed in the matrix of metalloproteinase sensitive hydrogels were visualized from 7 days to 4 weeks in response to different combination of peptides. (rice.edu)
  • Moreover, hydrogels functionalized with laminin peptides and transplanted in a mouse cornea supported the ingrowth and attachment of endothelial cells to the hydrogel during angiogenesis. (rice.edu)
  • epithelial
  • ABSTRACT The body wall of Hydra is organized as an epithelial bilayer (ectoderm and endoderm) with an intervening extracellular matrix (ECM), termed mesoglea by early biologists. (ehu.es)
  • Morphological studies have determined that Hydra ECM is composed of two basal lamina layers positioned at the base of each epithelial layer with an intervening interstitial matrix. (ehu.es)
  • whereas
  • T-cell lines with a capacity to infiltrate produced matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinases-1 (TIMP-1), whereas non-infiltrating cell lines did not produce MMP-9. (diva-portal.org)
  • mice
  • These results suggest that the development of normal GBM structure and function requires podocyte-derived laminin α5 during and after glomerulogenesis and present a unique mechanism for the pathogenesis of PKD in these mice. (asnjournals.org)
  • role
  • Redox signaling and increased oxidative stress play a significant role in regulating normal wound healing by facilitating hemostasis, inflammation, angiogenesis, granulation tissue formation, wound closure, and development and maturation of the extracellular matrix [ 3 ]. (mdpi.com)
  • Taken together, our data indicate that P. aeruginosa and S. aureus may benefit each other by coinfecting wounds and that the host-derived matrix may serve as important a role as the bacterium-derived matrix in protecting bacteria from some antibiotics. (asm.org)
  • extract
  • 10. A pharmaceutical composition according to any one of the preceding claims wherein the cell extract is selected from the group consisting of a cytosolic extract, a cytoplasmic extract, a nuclear extract, a whole cell lysate, extracellular extract, whole tissue extract and mixtures thereof. (google.es)
  • Results
  • Mutation of the mouse laminin α5 gene results in a variety of developmental defects, including defects in kidney structure and function. (asnjournals.org)
  • major
  • 13 The major laminin in mature GBM is laminin-521 (α5β2γ1), but during glomerulogenesis there are developmental transitions in which laminin-111 (α1β1γ1) is replaced by laminin-511 (α5β1γ1), which is then joined and eventually replaced by laminin-521. (asnjournals.org)
  • growth
  • Determination of Cellular Shape by the Extracellular Matrix and Its Correlation with the Control of Cellular Growth", Cancer Research, vol. 38, Nov. 1978, pp. 4155-4171. (patentgenius.com)
  • Endothelial Growth Factors and Extracellular Matrix Regulate DNA Synthesis Through Modulation of Cell and Nuclear Expansion", In Vitro Cellular & Developmental Biology, vol. 23, No. 5, May 1987, pp. 387-394. (patentgenius.com)