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  • mouse laminin
  • A highly pure preparation of mouse laminin that is devoid of the bridging entactin molecule. (corning.com)
  • In mouse laminin gamma-1 chain, the seventh LE domain has been shown to be the only one that binds with a high affinity to nidogen [ PMID: 7781764 ]. (ebi.ac.uk)
  • We studied the reaction of different polyclonal antibodies including those against a Drosophila laminin B2-lac fusion protein, the entire Drosophila laminin complex, or against the mouse laminin complex and against laminin A and B1 chains with specific structures in developing male germ cells of Drosophila. (rupress.org)
  • It has been inferred by analogy with the strikingly similar 3' UTR sequence in mouse laminin gamma 1 cDNA, that multiple polyadenylation sites are utilized in human to generate the 2 different sized mRNAs (5.5 and 7.5 kb) seen on Northern analysis. (genetex.com)
  • The assay shows no cross-reactivity with human IL-28A, IL-29, and Mouse Laminin. (perkinelmer.com)
  • Corning BioCoat™ Laminin Cellware offers tissue-culture vessels with a uniform application of mouse laminin. (krackeler.com)
  • junctional epiderm
  • Eighty-three percent of patients with Herlitz junctional epidermolysis bullosa (H-JEB), an inherited, incurable skin disease, harbor nonsense mutation(s) in genes encoding a structural protein (laminin 332) responsible for skin adherence. (pnas.org)
  • Junctional epidermolysis bullosa (JEB) is an autosomal recessive skin blistering disease with both lethal and nonlethal forms, with most patients shown to have defects in laminin-5. (rupress.org)
  • Fibronectin
  • Laminin and fibronectin scaffolds enhance neural stem cell transplantation into the injured brain. (nih.gov)
  • In this study, neural stem cells were transplanted into the traumatically injured mouse brain within a tissue-engineered construct containing either a laminin- or fibronectin-based scaffold. (nih.gov)
  • Survival was more enhanced with the laminin-based scaffold compared to the fibronectin-based scaffold. (nih.gov)
  • 1990 ). We have previously shown that myoblast survival and fusion into myotubes depends on laminin 111 (which is made up of α1, β1 and γ1 chains), and not on fibronectin or vitronectin (Clark et al. (springer.com)
  • Recent studies, on cells cultured in 3D collagen gels, have shown that, beside from their well known biochemical role, fibronectin (FN) and laminin (LM) affect cell functions via a modification of mechanical and structural properties of matrix due to interaction with collagen molecules. (springer.com)
  • LAMA2
  • 1997 ). However, the major constituent of the basal lamina of adult skeletal muscle is not laminin 111, but laminin 211 (Sanes 2003 ), in which the α chain is LAMA2 (α2). (springer.com)
  • Mapping studies have shown that the α-chain of laminin 211 (LAMA2) binds to α-dystroglycan through its lamin G (LG) domains: LG1-3 and LG4-5 (Talts et al. (springer.com)
  • The incidence of CMDs has been estimated to be approximately one in 21,500 ( 2 ), with laminin α2- (LAMA2) deficient CMD (MDC1A) accounting for ≈40-50% of the CMD cases in European countries ( 3 ). (pnas.org)
  • subunits
  • Prior studies have found that loss of laminin subunits from vertebrate Schwann cells causes loss of myelination and neuropathies, results attributed to loss of laminin-receptor signaling. (sdbonline.org)
  • However, whereas invertebrates possess one to two laminin heterotrimers, mammals possess at least 15, which are formed through combinations of 5α, 4β and 3γ subunits (Aumailley, 2005). (sdbonline.org)
  • Laminin 5 is an isoform composed of three distinct subunits, alpha 3, beta 3 and gamma 2, which are bound to each other in a cross-shaped molecule by disulphide bonds. (abcam.com)
  • Aberdam D, Aguzzi A, Baudoin C, Galliano M-F, Ortonne J-P, Meneguzzi G (1994) Developmental expression of nicein adhesion protein (Laminin-5) subunits suggests multiple morphogenic roles. (springer.com)
  • Laminin a2 is present in the basal lamina of skeletal muscle, as well as other cell types and combines with ß and g subunits to form laminin 2. (fitness-vip.com)
  • function of laminin
  • The RNA analysis from adult and fetal tissues revealed developmental regulation of expression, however, the exact function of laminin, alpha 4 is not known. (wikipedia.org)
  • Structure and function of laminin: anatomy of a multidomain glycoprotein. (ebi.ac.uk)
  • Peptides
  • We focused on specific short peptides from α-laminin-2 (IKVSV, VQLRNGFPYFSY and GLLFYMARINHA) as well as residues 15-155 from FGF1. (springer.com)
  • receptors
  • Integrins, dystroglycan, syndecans, and several other cell surface molecules are cellular receptors for laminins. (amsbio.com)
  • In addition to their structural role, laminins also act as signaling molecules through receptors such as integrins ( 8 ). (pnas.org)
  • molecule
  • Similarly, there is a molecule called Laminin within the extracellular matrix which forms the components of our bodies structure. (imagekind.com)
  • The reason being is that the photograph of an actual laminin molecule is simply a scattering of black dots with a cluster of more black dots in the center and all of that, displayed upon a white background. (imagekind.com)
  • The current nomenclature of the laminin molecule family is presented. (springer.com)
  • zebrafish
  • To characterize morphologic and physiological alterations in the retina of three laminin mutant zebrafish, bashful ( bal , lama1), grumpy ( gup , lamb1), and sleepy ( sly , lamc1), which were identified in forward genetic screens and were found to be impaired in visual functions. (arvojournals.org)
  • surfaces
  • The distribution of gamma 3-containing laminins along ciliated epithelial surfaces suggests that the apical laminins are important in the morphogenesis and structural stability of the ciliated processes of these cells. (nih.gov)
  • Here we show that chondroitin 4-sulfate (CS4), chondroitin 6-sulfate (CS6), and keratan sulfate (KS) inhibit neurite growth from both cerebellar and DRG neurons on laminin-coated surfaces. (jneurosci.org)
  • On laminin surfaces, DS and HS had no effect on neurite growth from both cerebellar and DRG neurons. (jneurosci.org)
  • structural
  • Few patients with laminin alpha2 deficiency have been described with seizures and structural brain abnormalities. (biomedsearch.com)
  • METHODS: A patient with CMD with partial laminin alpha2 presenting with brain structural abnormalities and untreatable generalized and partial complex seizure was studied. (biomedsearch.com)
  • survival
  • Furthermore, behavioural analyses indicated that mice receiving neural stem cells within the laminin-based scaffold performed significantly better than untreated mice on a spatial learning task, supporting the notion that functional recovery correlates positively with donor cell survival. (nih.gov)
  • Laminin 211 has also been reported to be important for myoblast fusion and myotube survival (Vachon et al. (springer.com)
  • neurite
  • To resolve the controversy concerning the ability of exogenous GAGs to modulate neurite growth, we examined the effects of a panel of structurally different GAGs on the growth of postnatal rat cerebellar granule neurons and embryonic rat dorsal root ganglia (DRG) neurons on substrates of either laminin or the L1 glycoprotein. (jneurosci.org)
  • nidogen
  • Crystal structure of three consecutive laminin-type epidermal growth factor-like (LE) modules of laminin gamma1 chain harboring the nidogen binding site. (ebi.ac.uk)
  • Structure of the nidogen binding LE module of the laminin gamma1 chain in solution. (ebi.ac.uk)
  • Low nidogen affinity of laminin-5 can be attributed to two serine residues in EGF-like motif gamma 2III4. (ebi.ac.uk)
  • glycoprotein
  • They suggest that while CS and KS GAGs may not exert strong negative influences over axonal growth in regions of the developing CNS where the L1 glycoprotein is abundant, these GAGs are capable of inhibiting the growth of axons that extend within an environment rich in laminin. (jneurosci.org)
  • human
  • Full length native protein (purified) corresponding to Human Laminin 5. (abcam.com)
  • 3D culture - Laminin I promotes attachment and growth of a human epithelial cell line derived from mammary gland (MCF-10A) and human prostate (PC-3), and in the presence of assay medium, these cell lines differentiate into acinar structures. (sigmaaldrich.com)
  • Synthetic peptide within Human 67kDa Laminin Receptor aa 250 to the C-terminus (C terminal). (abcam.com)
  • Recombinant protein encompassing a sequence within the C-terminus region of human Laminin alpha 4. (genetex.com)
  • chain
  • Transcripts of laminin B2 were detected in the RNA of male germ cells with the polymerase chain reaction and by in situ hybridization. (rupress.org)
  • skeletal
  • Defect of laminin M in skeletal and cardiac muscles and peripheral nerve of the homozygous dystrophic dy/dy mice. (springer.com)
  • physiological
  • The physiological consequences of disruption of laminin secretion in glia included decreased larval locomotion and ultimately lethality. (sdbonline.org)