GO analysis shows that the differential abundant proteins are associated with cell junction and signal transducer activity from extracellular to intracellular. (nature.com)
citation needed] This effect of laminin-111 probably occurs through a lowering of intracellular cyclic AMP. (wikipedia.org)
Through interactions with cell surface receptors, laminins stimulate intracellular signaling cascades which direct specific survival and differentiation outcomes. (bvsalud.org)
Isoforms3
We further found that the pericytic laminin isoforms differentially regulate mouse β-cells. (nature.com)
In metabolic tissues such as the pancreas, adipose, muscle, and liver, laminin isoforms are expressed in discrete temporal and spatial patterns suggesting that certain isoforms may support the development and function of particular metabolic cell types. (bvsalud.org)
This review focuses on the research to date detailing the expression of laminin isoforms, their potential function, as well as known pathways involved in laminin signaling in metabolic tissues. (bvsalud.org)
Integrin1
Neurons of the peripheral nervous system express integrin receptors that attach to laminins and promote neuroregeneration after injury. (wikipedia.org)
Subunit1
Laminin subunit beta 1 (LAMB1) is involved in attachment, migration, and organization during development, and its elevated expression has been associated with several cancers. (bvsalud.org)
Extracellular matrix3
KEGG pathways enrichment and PPI network indicate four major pathways, including extracellular matrix -receptor interaction, focal adhesion, phosphatidylinositol 3-kinase (PI3K)-Protein kinase B (Akt), and Ras signaling pathways were involved in the degeneration of cartilage. (nature.com)
Laminins form independent networks and are associated with type IV collagen networks via entactin, fibronectin, and perlecan. (wikipedia.org)
For example, growth cones are repelled by netrin when grown on laminin-111 but are attracted to netrin when grown on fibronectin. (wikipedia.org)
Molecules3
Moreover, integrins, laminins, NF-κB and other regulative molecules were found as crucial proteins. (nature.com)
The laminin molecules are named according to their chain composition, e.g. laminin-511 contains α5, β1, and γ1 chains. (wikipedia.org)
The three short arms have an affinity for binding to other laminin molecules, conducing sheet formation. (wikipedia.org)
Pathways2
This study was designed to identify signaling pathways and crucial proteins involved in the pathological mechanism of KBD compared with osteoarthritis (OA). (nature.com)
In conclusion, our results demonstrated that compared with OA, the differential abundance proteins and signaling pathways may contribute to the occurrence and development of joint damage in KBD. (nature.com)
Collagen1
BMs are specialized structures that underlie epithelia and surround organs and mainly comprise collagen IV, laminins, and heparan sulfate proteoglycans (HSPG). (nature.com)
Basement membrane1
Abnormal laminin-332, which is essential for epithelial cell adhesion to the basement membrane, leads to a condition called junctional epidermolysis bullosa, characterized by generalized blisters, exuberant granulation tissue of skin and mucosa, and pitted teeth. (wikipedia.org)
Interactions2
Through these interactions, laminins critically contribute to cell attachment and differentiation, cell shape and movement, maintenance of tissue phenotype, and promotion of tissue survival. (wikipedia.org)
The roles and possible interactions of the Wnt/beta-catenin signaling pathway, FGF signaling, and lama5 in the branching process were investigated by morphogenesis assays and gene expression patterns. (bvsalud.org)
Substrate1
Laminin-111 is a major substrate along which nerve axons will grow, both in vivo and in vitro. (wikipedia.org)
Proteins1
Laminins are heterotrimeric proteins with a high molecular mass (~400 to ~900 kDa) and possess three different chains (α, β and γ) encoded by five, four, and three paralogous genes in humans, respectively. (wikipedia.org)
Regulates1
Finally, we show that Wnt/beta-catenin signaling regulates branching morphogenesis through Lama5. (bvsalud.org)
Tissues1
We will also discuss the current biomedical therapies involving laminins in these tissues in addition to prospective applications, with the goal being to encourage future investigation of laminins in the context of metabolic disease. (bvsalud.org)
Gene2
Whereas α2 laminins promoted islet cell clustering, they did not affect gene expression. (nature.com)
Congenital muscular dystrophy (CMD) with merosin deficiency (MDC1A) is an autosomal recessive disorder due to mutations in the laminin alpha-2 gene (LAMA2). (fsrmm.ch)
Chains3
The laminins are combinations of different alpha-, beta-, and gamma-chains. (wikipedia.org)
Laminin-211 is composed of an α2, β1 and γ1 chains. (wikipedia.org)
Compared to ECs, pancreatic pericytes produce significantly higher levels of α2 and α4 laminin chains, which constitute the peri-islet and vascular BM. (nature.com)
Promotes1
For example, the peptide sequence [GTFALRGDNGDNGQ], which is located on the alpha-chain of laminin, promotes the adhesion of endothelial cells. (wikipedia.org)
Experiments1
Further experiments indicated that FGF signaling most likely acts upstream as a negative regulator of the canonical Wnt pathway during the branching process, whose effect could be partially reversed by Wnt3a. (bvsalud.org)
LAMB11
U0126, an extracellular signal-regulated kinase (ERK) inhibitor, regulated the expression of LAMB1 in gastric cancer cells. (bvsalud.org)
ELISA3
Description: A sandwich ELISA kit for detection of Toll Like Receptor 9 from Rabbit in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (2sars.com)
Description: Quantitativesandwich ELISA kit for measuring Human Receptor-type tyrosine-protein phosphatase F (PTPRF) in samples from serum, plasma, urine, tissue homogenates, cell lysates. (scalegen.com)
Description: A sandwich ELISA kit for detection of Interleukin 8 Receptor Beta from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (scalegen.com)
Cell6
Laminins are integral to the structural scaffolding of almost every tissue of an organism-secreted and incorporated into cell-associated extracellular matrices. (wikipedia.org)
In contrast, culturing on Laminin-421 induced the expression of β-cell genes, including Ins1 , MafA , and Glut2 , and significantly improved glucose-stimulated insulin secretion. (nature.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rabbit Toll Like Receptor 9 (TLR9) in Tissue homogenates, cell lysates and other biological fluids. (2sars.com)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rabbit Toll Like Receptor 9 (TLR9) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (2sars.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Interleukin 8 Receptor Beta (IL8Rb) in serum, plasma, tissue homogenates, cell lysates and other biological fluids. (scalegen.com)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Interleukin 8 Receptor Beta (IL8Rb) in samples from Serum, plasma, tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (scalegen.com)
Mechanism1
We conclude that the Wnt/beta-catenin signaling pathway acting downstream of FGF signaling can serve as a negative regulatory mechanism in the process of SMG branching morphogenesis through Lama5. (bvsalud.org)
Specific1
Some of these biological functions of laminin have been associated with specific amino-acid sequences or fragments of laminin. (wikipedia.org)
Addition1
In addition, many laminins had common names before either laminin nomenclature was in place. (wikipedia.org)
Growth1
The presence of laminin-1 can influence how the growth cone responds to other cues. (wikipedia.org)
Cells1
citation needed] Laminins are enriched at the lesion site after peripheral nerve injury and are secreted by Schwann cells. (wikipedia.org)
Beta1
Here, we have investigated whether cross-talk may exist between the Wnt/beta-catenin signaling pathway and lama5 during the branching process in SMG development. (bvsalud.org)