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  • osmotic
  • In the colon, lactulose is broken down primarily to lactic acid, and also to small amounts of formic and acetic acids, by the action of colonic bacteria, which results in an increase in osmotic pressure and slight acidification of the colonic contents. (nih.gov)
  • bowel movement
  • Since lactulose does not exert its effect until it reaches the colon, and since transit time through the colon may be slow, 24 to 48 hours may be required to produce the desired bowel movement. (nih.gov)
  • doses
  • As a result, oral doses of lactulose reach the colon virtually unchanged. (nih.gov)
  • In studies of mice, rats, and rabbits, doses of lactulose solution up to 6 or 12 mL/kg/day produced no deleterious effects in breeding, conception, or parturition. (nih.gov)
  • Reproduction studies have been performed in mice, rats, and rabbits at doses up to 3 or 6 times the usual human oral dose and have revealed no evidence of impaired fertility or harm to the fetus due to lactulose. (nih.gov)
  • disaccharide
  • Lactulose is poorly absorbed from the gastrointestinal tract and no enzyme capable of hydrolysis of this disaccharide is present in human gastrointestinal tissue. (nih.gov)
  • solution
  • A theoretical hazard may exist for patients being treated with lactulose solution who may be required to undergo electrocautery procedures during proctoscopy or colonoscopy. (nih.gov)
  • Although this complication has not been reported with lactulose, patients on lactulose therapy undergoing such procedures should have a thorough bowel cleansing with a non-fermentable solution. (nih.gov)
  • Therefore, a possible lack of desired effect of treatment should be taken into consideration before such drugs are given concomitantly with lactulose solution. (nih.gov)
  • Administration of lactulose solution in the diet of mice for 18 months in concentrations of 3 and 10 percent (v/w) did not produce any evidence of carcinogenicity. (nih.gov)
  • Because many drugs are excreted in human milk, caution should be exercised when lactulose solution is administered to a nursing woman. (nih.gov)
  • elderly
  • Elderly, debilitated patients who receive lactulose for more than six months should have serum electrolytes (potassium, chloride, carbon dioxide) measured periodically. (nih.gov)
  • diarrhea
  • Unless you are a diabetic lactulose is a safe medication, however, like anything else if you are taking too much, especially if not necessary (having normal BM or diarrhea) it can cause issues. (healthtap.com)