Lactotroph adenoma (prolactinoma) typically exhibits strong cytoplasmic prolactin immunoreactivity. (cap.org)
Tumor formation is due to neoplastic transformation of anterior pituitary lactotrophs, resulting in excess synthesis and secretion of prolactin (PRL). (medscape.com)
Results of in vitro studies demonstrate that cabergoline exerts a direct inhibitory effect on the secretion of prolactin by rat pituitary lactotrophs. (drugs.com)
Since neurophysin does not stimulate prolactin release from the ectopic pituitary under the kidney capsule nor from lactotrophs in a primary monolayer culture system, neurophysin is believed to act indirectly on the pituitary, presumably through a neurotransmitter and/or hypothalamic releasing (or inhibiting) factor. (wikigenes.org)
In women, during pregnancy, elevated levels of estrogen stimulate the lactotrophs to produce large amounts of prolactin which stimulates alveolar cells in the breasts. (osmosis.org)
Intracellular calcium concentration and hormone secretion are controlled differently by TRH in rat neonatal lactotrophs and somatotrophs. (nih.gov)
The model behavior resembles that seen in somatotrophs, lactotrophs, and corticotrophs. (nih.gov)
At the pituitary level, follistatin signals could be located in carp somatotrophs, gonadotrophs, and lactotrophs. (frontiersin.org)
Somatotrophs and lactotrophs are acidophils that secrete GH and PRL, respectively, whereas mammosomatotrophs secrete both GH and PRL. (oncohemakey.com)
Hormone secreted from lactotroph cells of the anterior pituitary gland with an essential role in lactation. (citizendium.com)
Lactation1
Pituitary haemorrhage causing death of the lactotrophs results in failure of lactation (Sheehan's syndrome). (brainkart.com)
SF3B11
Prevalence and clinical correlations of SF3B1 variants in lactotroph tumours. (cdc.gov)
Hormone2
Thyrotropin-releasing hormone (TRH) acts via a G-protein-coupled receptor on lactotrophs to increase the intracellular free calcium ion concentration, [Ca(2+)](i). (nih.gov)
Control of Ca2+ entry into rat lactotrophs by thyrotrophin-releasing hormone. (nih.gov)
We recently reported that estrogen receptor alpha (ERalpha), even in absence of estrogen (E2), plays a critical role in lactotroph homeostasis. (nih.gov)
However, all three ER antagonists suppressed PRL release, suggesting that receptor occupation is sufficient to inhibit prl gene expression whereas receptor degradation is required to suppress lactotroph proliferation. (nih.gov)
Outcome2
In this study our objective was to determine whether ERalpha degradation versus occupation, differentially modulates the biological outcome of anti-estrogens.Using the rat lactotroph cell line, GH3 cells, we report that ICI induced proteosome mediated degradation of ERalpha. (nih.gov)
This really is likely mediated by an immediate outcome on the lactotroph. (llclinic.com)
Previously1
These results provide a cellular mechanism that can account for the previously demonstrated potentiation of secretion from lactotrophs by cAMP- and PKC-dependent pathways. (rupress.org)