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LactoferrinLactoglobulinsEncyclopedias as TopicColostrumMilk, HumanTransferrinTransferrins
LysozymeColostrumAntimicrobialSalivaProteinTransferrin familySecretionSalivaryProteinsAntiviralExocrineCow's milkMoleculeHumansInteractsBovineWheySpecificityAntibacterialImmunoelectrophoresisMilkSupplementsAntioxidantHighBacterialNasalInhibitionHumanGenesInfectionPreventsChronicCellsHighestSignificantly higherSpeciesFunctionalIronFractionsFormBenefitsSourcePotentialForms
Lysozyme7
  • The association between caries experience/activity and the electrophoretic profiles of salivary proteins lactoferrin and lysozyme was evaluated. (pucrs.br)
  • There was a slight association between lysozyme concentrations and DMFT. (pucrs.br)
  • Conclusion: The quantification of lactoferrin and lysozyme enabled an assessment of possible associations with caries status, thus improving the understanding of the biological and etiological aspects of caries. (pucrs.br)
  • There are various infection inhibitors in saliva, the top one being IgA, and others such as IgG, lactoferrin, lysozyme, and several protease inhibitors that inhibit the function of TMPRSS2, some of which have synergistic effects. (lion.co.jp)
  • The low concentration of protein in human milk, the presence of specific anti-infective proteins such as immunoglobulin A, lactoferrin, lysozyme, and oligosacharides (prebiotics), as well as production of lactic acid, cause an acid milieu and are the main reasons for its bifidogenic charachtersitics. (customprobiotics.com)
  • Our analysis shows that although HTNV is sensitive to the overall antiviral capacity of human saliva from healthy donors, it is insensitive to the antiviral effects of certain salivary components, i.e., histatin 5, lactoferrin, lysozyme, and secretory leukocyte protease inhibitor ( 9 ), which are known to have antiviral effects against other viruses. (cdc.gov)
  • Saliva contains a number of components, including various electrolytes, glycoproteins, enzymes, and mucus, as well as secretory immunoglobulin A, lactoferrin, lysozyme, and peroxidase-with the latter 4 components important in that they exhibit antibacterial activity. (medscape.com)
Colostrum7
  • Concentration of lactoferrin in the milk varies from 7 g/L in the colostrum to 1 g/L in mature milk. (wikipedia.org)
  • Lactoferrin has its highest content in mother's first milk from human breast feeding or colostrum (first milk) from cows. (naturalnews.com)
  • So if obtaining colostrum or raw milk is prohibitive for financial or legal reasons, you can order lactoferrin contained in capsules from your favorite online supplement source, where better prices are available. (naturalnews.com)
  • Colostrum has the highest concentration of Lactoferrin, followed by human milk, then cow's milk. (diaryofafirstchild.com)
  • The highest concentration is found in colostrum, the pre-milk that is only available from the breast the first three to five days of the baby's life. (drgreene.com)
  • Moreover, the live yeast-supplemented ewes showed significantly higher IgG concentrations in their colostrum when compared to the control group, which ensures improved immune transfer to the lambs. (lallemandanimalnutrition.com)
  • In addition, there was a higher concentration of the bioactive antimicrobial molecules lactoferrin and sialic acids in the colostrum, which could also benefit the newborn robustness and digestive system development. (lallemandanimalnutrition.com)
Antimicrobial3
  • As an antimicrobial and antiviral agent, lactoferrin is especially important in establishing an infant's immune system. (nbc29.com)
  • Lactoferrin is one of the components of the immune system of the body, and has antimicrobial activity meaning it's a bacteriocide and a fungicide. (diaryofafirstchild.com)
  • Due to the well-known broad-spectrum antimicrobial activity of the lactoferrin protein, we sought to verify whether its bovine form (bLf) would also be effective in vitro against SARS-CoV-2. (biorxiv.org)
Saliva7
  • In view of the morphological and functional similarities between the pancreatic and parotid glands, we have measured the immunoreactive lactoferrin concentration in pure parotid saliva of 30 patients with chronic calcific pancreatitis, 26 controls, 5 patients with proven pancreatic cancer, 2 patients with Sjögren's disease and 2 patients with chronic recurrent parotitis. (karger.com)
  • Lactoferrin is a globular glycoprotein with a molecular mass of about 80 kDa that is widely represented in various secretory fluids, such as milk, saliva, tears, and nasal secretions. (wikipedia.org)
  • however, lactoferrin is a rare molecule in that it has a much higher concentration in saliva. (lion.co.jp)
  • Saliva in SS is characterized by the increased concentration of lactoferrin, potassium and cystatin C and the decreased concentration of amylase, carbonic anhydrase, mucins, histatines, IgA, statherins, proline-rich proteins, and the loss of salivary buffer properties. (intechopen.com)
  • Saliva from healthy persons with no evidence of seropositivity against hantavirus was pooled and preincubated at different concentrations with 10,000 focus-forming units of ANDV (strain Chile-9717869), HTNV (strain 76-118), or PUUV (strain Kazan E6) for 1 hr ( 9 ). (cdc.gov)
  • At a low concentration (12.5% saliva), we observed a slight effect on HTNV, even though we saw no effect on ANDV and PUUV. (cdc.gov)
  • ANDV was the only virus that resisted higher concentrations of saliva (25% and 50%), and an antiviral effect was clearly observed on HTNV and PUUV at these saliva concentrations ( Figure ). (cdc.gov)
Protein19
  • Lactoferrin (LF), also known as lactotransferrin (LTF), is a multifunctional protein of the transferrin family. (wikipedia.org)
  • Therefore, it was named lactoferrin in 1961, though the name lactotransferrin was used in some earlier publications, and later studies demonstrated that the protein is not restricted to milk. (wikipedia.org)
  • Similarity in the size of exons and their distribution in the domains of the protein molecule indicates that the evolutionary development of lactoferrin gene occurred by duplication. (wikipedia.org)
  • The degree of glycosylation of the protein may be different and therefore the molecular weight of lactoferrin varies between 76 and 80 kDa. (wikipedia.org)
  • The Formula has added lactoferrin, a key protein found in higher concentrations in human breast milk. (nbc29.com)
  • Lactoferrin is a 77-kDa iron-binding protein to which a wide variety of divergent biologic functions have been ascribed. (nih.gov)
  • Lactoferrin inhibited LPS priming of neutrophils if LPS contamination of the protein (provided by commercial suppliers) was first reduced. (nih.gov)
  • These results show that LPS should not be expected to affect the free radical biology of lactoferrin, which is a crucial physiologic function of this protein. (nih.gov)
  • Lactoferrin is a versatile, iron-binding protein which enhances the body's ability to utilize iron and also stimulates immune system cells. (integrativepsychiatry.net)
  • OBJECTIVE: Investigation of the inhibitory capacity on melanoma cells (B16F10) proliferation and the influence on % distribution of cell cycle phases, in the presence of various concentrations of whey protein isolate (WPI), bovine collagen hydrolysate (BCH) or its fractions. (greenmedinfo.com)
  • Whey protein is a rich source of the essential amino acids in higher concentrations compared with vegetable sources such as soy. (lifeextension.com)
  • Compared with other protein sources, whey contains a high concentration of branched-chain amino acids, which are important for tissue growth and repair. (lifeextension.com)
  • The purpose of this investigation was to study children with kwashiorkor and to relate the concentration of bleomycin detectable iron (BDI) and the iron binding protein, transferrin, to the severity of oedema on admission to hospital and during their nutritional rehabilitation. (bmj.com)
  • Milk Specialties Global, a leading international whey and milk protein producer, is entering the lactoferrin market following a multi-million-dollar investment at the company's Fond Du Lac, Wisconsin facility. (milkspecialties.com)
  • Lactoferrin is a unique protein fraction that occurs naturally in whey protein. (milkspecialties.com)
  • Lactoferrin comprises only a tiny portion of the overall whey protein but offers powerful health benefits when concentrated. (milkspecialties.com)
  • Valuable protein fractions that are lost during ion exchange (lactoferrin), glycomacropeptides and peptide fragments are thus preserved. (sharkfitness.ch)
  • Activated lactoferrin (ALF) is a new form of a naturally occurring protein from milk that acts as a powerful deterrent to pathogenic bacteria that may be present on a meat surface. (ift.org)
  • Pro-inflammatory biomarkers were measured before, 2 and 18 h postexposure, including cytokine IL-6 and IL-8, protein and lactoferrin in nasal lavage (NAL) as well as IL-6 in blood. (bmj.com)
Transferrin family1
  • Exons of the lactoferrin gene in oxen have a similar size to the exons of other genes of the transferrin family, whereas the sizes of introns differ within the family. (wikipedia.org)
Secretion3
  • These findings suggest that increased lactoferrin secretion is confined to the exocrine pancreas in patients with chronic pancreatitis and is thus probably a phenomenon secondary to the disease. (karger.com)
  • 15. Jens Hegnhøj, Ove Schaffalitzky de Muckadell, Jes Lauritzen, Jens Rikardt Andersen & Erik Magid: Duodenal output and concentration of lactoferrin in chronic pancreatitis: Correlation to amylase secretion and duct morphology. (ku.dk)
  • Humans, through secretion of lactoferrin, maintain an iron concentration of 10^(-18) M within macrophages, and the bacterium has evolved the siderophores mycobactin T and exomycobactin T (formerly exochelin) to cope with this shortage. (reactome.org)
Salivary1
  • Objective: This study compared the concentration of salivary lactoferrin in patients with and without chronic periodontitis and investigated correlations with clinical variables of the disease. (bvsalud.org)
Proteins5
  • Lactoferrin is one of the transferrin proteins that transfer iron to the cells and control the level of free iron in the blood and external secretions. (wikipedia.org)
  • Lactoferrin belongs to the basic proteins, its isoelectric point is 8.7. (wikipedia.org)
  • Whey proteins (mainly lactoferrin) have been investigated for cancer prevention and treatment. (greenmedinfo.com)
  • RESULTS: The inhibitory concentrations for 50% of B16F10 cells (IC(50)) ranged from 0.19 to 156.9 mg/mL for all these proteins evaluated. (greenmedinfo.com)
  • The production by Cross Flow Micro- filtration (micro- and subsequent ultrafiltration, no ion exchange) guarantees the highest possible preservation and concentration of the valuable, non-denatured whey proteins. (sharkfitness.ch)
Antiviral2
  • 2) Concentrated enough in one's blood, lactoferrin is antiviral, antibacterial (to only the bad bacteria), and anti-fungal. (naturalnews.com)
  • Using an antiviral assay based on quantitative reverse transcription-polymerase chain reaction (qRT-PCR), we found that bLf reduced progeny virus yield by up to ∼84,6% in African green monkey kidney epithelial cells (Vero E6) and ∼68,6% in adenocarcinomic human alveolar basal epithelial cells (A549) at 1 mg/mL, a concentration previously shown to have low cytotoxicity. (biorxiv.org)
Exocrine1
  • Lactoferrin (Lf) is a cationic glycoprotein synthetized by exocrine glands and is present in all human secretions. (frontiersin.org)
Cow's milk1
  • Lactoferrin remains in cow's milk after the baby calf's early nursing period, but in lower concentrations. (naturalnews.com)
Molecule2
  • Oral-Relax is made from high concentration small-molecule Lactoferrin, which forms a protective layer on the oral mucosa, assists in relieving inflammation, inhibiting infection, and promoting wound recovery. (barkmall.com)
  • As it can bind iron with higher affinity than lactoferrin, it frequently scavenges iron ions from this molecule (Miethke & Marahiel 2007). (reactome.org)
Humans1
Interacts2
  • Lactoferrin interacts with DNA and RNA, polysaccharides and heparin, and shows some of its biological functions in complexes with these ligands. (wikipedia.org)
  • It has recently been reported that lactoferrin interacts with bacterial lipopolysaccharide (LPS) in such a fashion as to affect the binding of lactoferrin to myeloid cells. (nih.gov)
Bovine1
  • 1) As "first milk" for human and bovine infants, lactoferrin confers increased immunity protection to support their not fully developed immune systems. (naturalnews.com)
Whey1
  • 2 Other constituents of whey include beta-lactoglobulin, lactoferrin, and immunoglobulins, which hold important benefits for immune support. (lifeextension.com)
Specificity1
  • The anti-human lactoferrin was solid phase absorbed against human serum to ensure specificity. (leebio.com)
Antibacterial2
  • Lactoferrin provides antibacterial activity to human infants. (wikipedia.org)
  • The antibacterial action of lactoferrin was also documented in 1961, and was associated with its ability to bind iron. (wikipedia.org)
Immunoelectrophoresis2
Milk5
  • Lactoferrin can be purified from milk or produced recombinantly. (wikipedia.org)
  • Lactoferrin supplements are even approved by the same FDA that attacks raw milk production and sales. (naturalnews.com)
  • And if you're not in a raw milk loop, or if the FDA and USDA get their way eventually, at least we all know there is one option left: Lactoferrin supplements. (naturalnews.com)
  • The research around the health and immune benefits of lactoferrin is very compelling," says David Lenzmeier, CEO of Milk Specialties Global. (milkspecialties.com)
  • Lactoferrin is part of Milk Specialties' NutriPRO™ family of products and comes in a wide range of concentration options - from 0.15 percent purity up to 95 percent purity. (milkspecialties.com)
Supplements2
  • Lactoferrin supplements reduce the risk of respiratory tract infections, based on a recent meta-analysis of randomized controlled trials. (wikipedia.org)
  • Along with being a core ingredient in infant formula, lactoferrin is ideally suited for health supplements, medical nutrition products, ready-to-mix drinks and functional foods. (milkspecialties.com)
Antioxidant1
High7
  • It is not known whether these high levels of lactoferrin represent a genetically determined defect predisposing to the later development of chronic pancreatitis or are simply a consequence of the disease. (karger.com)
  • The stability of lactoferrin has been associated with the high glycosylation degree. (wikipedia.org)
  • Apoptosis was extremely high at low concentration (400 microg/mL) of the F1-F3 fractions. (greenmedinfo.com)
  • We previously determined, first, that metabolic endotoxemia controls the inflammatory tone, body weight gain, and diabetes, and second, that high-fat feeding modulates gut microbiota and the plasma concentration of lipopolysaccharide (LPS), i.e., metabolic endotoxemia. (diabetesjournals.org)
  • Sucrose permeability was unaffected by high concentrations of aprotinin, indicating that transcytosis of aprotinin was unrelated to changes in the BBCEC monolayer integrity. (aspetjournals.org)
  • and lactoferrin was associated with all PM characteristics that were high at the underground site. (bmj.com)
  • Blue-Green Algaes that have very high concentrations of chlorophyll. (drjonritz.com)
Bacterial1
  • However, we have recently reported that moderate increase of plasma concentration of the inflammatory reagent, the bacterial lipopolysaccharide (LPS), increased during a fat-enriched diet, and defined metabolic endotoxemia ( 4 ). (diabetesjournals.org)
Nasal1
  • Conclusions We observed no consistent effects in two-pollutant models for PM mass concentration and OP. Instead, we found consistent associations with nasal inflammatory markers for other PM characteristics, specifically OC, endotoxin and NO 2 . (bmj.com)
Inhibition1
  • Inhibition of LPS priming was observed whether apolactoferrin or iron-saturated lactoferrin was used. (nih.gov)
Human2
Genes2
  • Study of polymorphism of genes that encode lactoferrin helps selecting livestock breeds that are resistant to mastitis. (wikipedia.org)
  • Therefore, the purpose of this study was twofold: (i) to perform a global microarray analysis and (ii) to investigate the role of lactoferrin (LTF), one of the most altered genes, in relation to obesity in Latino youth. (syr.edu)
Infection1
  • This activity varied according to concentration (100/500 μg/ml), multiplicity of infection (0.1/0.01), and cell type (Vero E6/Caco-2 cells). (frontiersin.org)
Prevents2
Chronic2
  • Lactoferrin is present in pancreatic juice, and greatly increased concentrations are found in the pancreatic juice of patients with chronic pancreatitis. (karger.com)
  • No difference in the lactoferrin concentration was detected between control subjects and patients with chronic pancreatitis or pancreatic cancer. (karger.com)
Cells1
  • Lactoferrin is also present in secondary granules of PMNs and is secreted by some acinar cells. (wikipedia.org)
Highest2
  • IgG is found in the highest concentration and helps to neutralize toxins. (integrativepsychiatry.net)
  • 0.001)Lactoferrin levels were highest in participants with 'poor' oral hygiene [6.85(0.60) mg/l] and lowest in those with 'good' oral hygiene [6.65(0.83) mg/l]. (bvsalud.org)
Significantly higher1
  • RESULTS BDI was significantly higher in the patients with severe oedema (20.5 v 6.75 μmol/l) whereas the albumin concentrations were similar (16 v 17 g/l). (bmj.com)
Species3
Functional2
Iron4
  • Lactoferrin inhibited iron-catalyzed formation of hydroxyl radical in the presence of LPS at pH 7.4 and 4.5. (nih.gov)
  • AIMS To relate the plasma concentration of radical promoting 'free' iron to the degree of oedema in patients with kwashiorkor. (bmj.com)
  • METHODS Plasma 'free' iron was measured as bleomycin detectable iron (BDI) and related to severity of oedema and plasma albumin concentration. (bmj.com)
  • There is a growing body of research around the benefits of concentrated lactoferrin for all life stages including enhanced immune system support, promotion of "good" prebiotic bacteria for positive gut health and improved iron status. (milkspecialties.com)
Fractions1
  • The most inhibitory fractions of the BCH hydrolysate were BCH-P1 and F1-F4 with IC(50) concentrations below 1mg/mL. (greenmedinfo.com)
Form1
Benefits1
  • Circa 1960, a method of extracting pure lactoferrin was created, and the studies began, which have led to finding a plethora of health benefits. (naturalnews.com)
Source1
Potential1
Forms1
  • X-ray diffraction reveals that lactoferrin is based on one polypeptide chain that contains about 700 amino acids and forms two homologous globular domains named N-and C-lobes. (wikipedia.org)