The risk of this side effect is so low that doctors rarely see it, but if you do develop lactic acidosis as a result of taking metformin, you may need more intensive care than usual. (news.edu.ge)
Phenformin and Buformin1
Other biguanides, such as phenformin and buformin, were withdrawn from the U.S. market because of their higher risk of serious adverse effects (increased risk of lactic acidosis).1 Metformin has also been studied in cats as a potential treatment for diabetes mellitus.2,3 Most cases of metformin toxicosis reported to the ASPCA Animal Poison Control Center (APCC) involve dogs that have ingested their owners' medication. (dvm360.com)
Hydrochloride2
Buformin hydrochloride is a fine, white to slightly yellow, crystalline, odorless powder, with a weakly acidic bitter taste. (wikipedia.org)
Buformin is still available and prescribed in Romania (timed release Silubin Retard is sold by Zentiva), Hungary, Taiwan and Japan (sold by Nichi-Iko Pharmaceutical Co., Ltd as "DIBETOS" tablets, each containing 50 mg buformin hydrochloride). (wikipedia.org)
Metformin6
Buformin (1-butylbiguanide) is an oral antidiabetic drug of the biguanide class, chemically related to metformin and phenformin. (wikipedia.org)
Buformin decreased cancer incidence, multiplicity, and burden in chemically induced rat mammary cancer, whereas metformin and phenformin had no statistically significant effect on the carcinogenic process relative to the control group. (wikipedia.org)
Metformin (Glucophage) may be the best choice for patients who also have heart failure,[5] but it should be temporarily discontinued before any radiographic procedure involving intravenous iodinated contrast, as patients are at an increased risk of lactic acidosis. (glucophagemetformin.com)
Buformin was withdrawn from the market in many countries due to an elevated risk of causing lactic acidosis (although not the US, where it was never sold). (wikipedia.org)
Biguanides1
Buformin and the other biguanides are not hypoglycemic, but rather antihyperglycemic agents. (wikipedia.org)
Liver1
Its Atmospheric -OH rate constant is 1.60E-10 cm3/molecule-sec at 25 °C. Buformin delays absorption of glucose from the gastrointestinal tract, increases insulin sensitivity and glucose uptake into cells, and inhibits synthesis of glucose by the liver. (wikipedia.org)
Patients2
The lactic acidosis occurred only in patients with a buformin plasma level of greater than 0.60 µg/mL and was rare in patients with normal renal function. (wikipedia.org)
In one report, the toxic oral dose was 329 ± 30 mg/day in 24 patients who developed lactic acidosis on buformin. (wikipedia.org)
Effects2
Buformin also exhibits anti-proliferative and anti-invasive effects in endometrial cancer cells, lung cancer cells and cervical cancer cells. (wikipedia.org)
There are others like phenformin, buformin and bufezin that are very similar in their effects on the body and may also be helpful for weight loss. (news.edu.ge)
Phenformin8
Buformin (1-butylbiguanide) is an oral antidiabetic drug of the biguanide class, chemically related to metformin and phenformin. (wikipedia.org)
Buformin decreased cancer incidence, multiplicity, and burden in chemically induced rat mammary cancer, whereas metformin and phenformin had no statistically significant effect on the carcinogenic process relative to the control group. (wikipedia.org)
Phenformin, the other previously available biguanide, was withdrawn from the market in 1977 because of an association with lactic acidosis. (medscape.com)
Metformin, phenformin, and buformin are derivatives of guanidine, which was extracted from the plant isoamylene in the 1920s ( Bailey and Day, 1989 ). (frontiersin.org)
Phenformin (DBI) was used from 1960s through 1980s, but was withdrawn due to lactic acidosis risk. (allaboutheaven.org)
The FDA's initial rationale behind the label was due to resilient evidence that phenformin caused lactic acidosis (another biguanide which has been removed from the US market). (diabetestalk.net)
Biguanide1
Buformin, another biguanide, is not available in the United States. (medscape.com)
Incidence2
The incidence of lactic acidosis with metformin at therapeutic doses is rare (less than three cases per 100,000 patient-years) and is not greater than with nonmetformin therapies ( 3 ). (diabetesjournals.org)
Although it is generally considered to be associated with an unacceptably high incidence of lactic acidosis, often fatal, it is still available in some countries. (nih.gov)
Anti-proliferative2
Buformin also exhibits anti-proliferative and anti-invasive effects in endometrial cancer cells, lung cancer cells and cervical cancer cells. (wikipedia.org)
As our data shown, buformin exhibited significant anti-proliferative effects in a dose-dependent manner in 4 cervical cancer cell lines. (bvsalud.org)
Hypoglycemic1
The aim of the present study was to explore whether buformin (BF), a hypoglycemic agent, could alleviate sepsis-induced ALI by inhibiting pyroptosis. (bvsalud.org)
Doses1
In addition, low doses of buformin synergized with routine chemotherapeutic drugs (such as paclitaxel, cisplatin, and 5-FU) to achieve more significant anti-tumor effects. (bvsalud.org)
Inhibits3
Its Atmospheric -OH rate constant is 1.60E-10 cm3/molecule-sec at 25 °C. Buformin delays absorption of glucose from the gastrointestinal tract, increases insulin sensitivity and glucose uptake into cells, and inhibits synthesis of glucose by the liver. (wikipedia.org)
Buformin is a metabolic antiviral that inhibits the mTOR pathway used by influenza and Middle East respiratory syndrome-related coronavirus. (wikipedia.org)
Take together, we are the first to demonstrate that buformin suppresses cellular proliferation and invasion through the AMPK/S6 signaling pathway, which arrests cell cycle and inhibits cellular invasion. (bvsalud.org)
Lactate2
[ 72 , 82 ] Furthermore, diabetes itself may increase the risk of lactic acidosis in these patients, secondary to the abnormal lactate metabolism that is part of the disease. (medscape.com)
Moreover, we found that buformin enhanced glucose uptake and LDH activity, increased lactate level, while decreased ATP production in cervical cancer cells. (bvsalud.org)
Renal2
The lactic acidosis occurred only in patients with a buformin plasma level of greater than 0.60 µg/mL and was rare in patients with normal renal function. (wikipedia.org)
There is now an overwhelming two decades' worth of research and evidence showing no serious increased risks for lactic acidosis in patients with mild-to-moderately impaired renal function. (diabetestalk.net)
Control1
Compared to the control, buformin notably suppressed colony formation and increased ROS production in C33A, Hcc94 and SiHa cells. (bvsalud.org)
Greater1
In vivo, a single use of buformin exerted moderate anti-tumor effects, and the combination with buformin and paclitaxel exhibited even greater suppressive effects. (bvsalud.org)
Cells1
The invasion of C33A and SiHa cells sharply declined with buformin treatment. (bvsalud.org)