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  • amides
  • The research presented herein describes the development of synthetic methods to one-carbon bridged twisted amides and the study of properties of one-carbon bridged lactams. (ku.edu)
  • One-carbon bridged lactams display superior to other bridged amides levels of hydrolytic stability. (ku.edu)
  • monobactams
  • In fact, during the last two decades medicinal chemists have convincingly demonstrated that structural modifications of monocyclic β-lactams (monobactams) is an effective protocol for the discovery of new derivatives with novel pharmacological profiles. (omicsonline.org)
  • efficacy
  • 6 Of the three pharmacodynamic parameters described with antimicrobials, optimal efficacy with beta-lactams is achieved when free drug concentrations stay above the minimum inhibitory concentration (MIC) for an extended duration of the recommended dosing interval ( FIGURE 1 ). (uspharmacist.com)
  • bacterial
  • This quantitative correlation lays the foundation for predicting bacterial population dynamics during β-lactam treatments. (pnas.org)
  • This notion serves as the foundation for the concept of bacterial persistence: dormant bacterial cells that do not grow are phenotypically tolerant against β-lactam treatment. (pnas.org)
  • Due to the lack of thorough quantification, however, it is unclear whether and to what extent the bacterial growth rate can predict the lysis rate upon β-lactam treatment under diverse conditions. (pnas.org)
  • Inhibitors
  • Therefore the novel β-lactams were found to be stable, potent and specific inhibitors of elastase that may of therapeutic use in the treatment of many inflammatory conditions. (bl.uk)
  • broad-spectrum
  • We conducted a retrospective multicenter survey of carbapenem and broad-spectrum noncarbapenem beta-lactam consumption between January 2011 and December 2013. (asm.org)
  • The broad-spectrum beta-lactams cefepime, meropenem, and piperacillin-tazobactam are the agents most studied for this dosing strategy, as they have reliable activity against most gram-negative organisms, including Pseudomonas aeruginosa. (uspharmacist.com)
  • bacteria
  • Because of the popularity of beta-lactam drugs, certain bacteria have been able to develop counter-measures to traditional drug therapies. (princeton.edu)
  • An enzyme called beta-lactamase is present in many different types of bacteria, which serves to 'break' the beta lactam ring, which effectively nullifies the antibiotic's effectiveness. (princeton.edu)
  • With precise measurements and analyses enabled by experimental automation, we found a robust relationship between growth and lysis rates that is generally applicable to diverse pairs of β-lactams and bacteria. (pnas.org)
  • patient
  • Understanding the possible cross-reactivity will help a provider assess the risk to the patient and ultimately decide whether a nonpenicillin beta-lactam should be used. (pharmacytimes.com)
  • In vitro data, skin tests, and patient challenge studies found no risk of cross-reactivity to other beta-lactam allergies. (pharmacytimes.com)
  • found
  • Electrospray ionisation mass spectrometry (ESI-MS) identified a novel mode of inhibition, for β-lactams which possess a hydroxyl group present at the C3 position, resulting in the formation of an acyl-enzyme intermediate which was found to be extremely stable. (bl.uk)
  • form
  • and hydrolyzing the distilled aminonitrile with water in the vapor phase in the presence or the absence of a catalyst to form said lactam. (patentgenius.com)
  • drugs
  • They also strongly suggest that most reactions reported in children are attributable to infectious diseases or interactions between drugs and infectious agents rather than to β-lactam HS. (aappublications.org)
  • studies
  • In these studies, immediate HS to β-lactams was diagnosed by skin tests in 4.9% to 40% of children. (aappublications.org)
  • Enzyme kinetic studies demonstrated that the β-lactams had k ass values ranging from 1000 - 10,000 M -1 s -1 . (bl.uk)
  • target
  • citation needed] Antiproliferative agents that target tubulin with β-lactams in their structure have also been reported. (wikipedia.org)
  • higher
  • Prolonged (3-4 hours) or continuous infusion of IV beta-lactams has a higher probability of achieving pharmacodynamic goals compared with standard 30-minute intermittent infusions. (uspharmacist.com)
  • rate
  • That is, the growth rate of population serves as a reliable predictor for the lysis rate in response to a β-lactam. (pnas.org)
  • similar
  • Based on skin tests and OC, the prevalences of immunoglobulin E-dependent and of semi-late or delayed sensitizations to β-lactam assessed were similar (6.8% vs 5.2%, respectively). (aappublications.org)