• Activated satellite cells initially proliferate as skeletal myoblasts before undergoing myogenic differentiation. (wikipedia.org)
  • Three different cellular models were used: micro-dissected human skeletal tissues, human myoblasts/myotubes and human skeletal muscle cells differentiated from urine stem cells of healthy donors. (bvsalud.org)
  • We find that C/EBPβ can regulate Notch2 expression and that restoration of Notch activity in myoblasts lacking C/EBPβ prevents precocious differentiation. (biomedcentral.com)
  • When overexpressed in the murine myoblast cell line C2C12 or in primary myoblasts, C/EBPβ reduced MyoD and other myogenic protein levels during differentiation, in addition to reducing myoblast fusion. (biomedcentral.com)
  • We also demonstrate that the transcriptional regulator PRDM16 (PRD1-BF1-RIZ1 homologous domain containing 16) controls a bidirectional cell fate switch between skeletal myoblasts and brown fat cells. (bioseek.eu)
  • 2000 On the other hand the transgene isn't portrayed in myoblasts but is normally up-regulated in differentiated multinucleated skeletal myotubes (Wang et al. (healthandwellnesssource.org)
  • These monocyte myoblasts proliferate and differentiate, following which, they fuse with existing muscle fibers to form multinucleated myotubes and myofibers. (kosfaj.org)
  • Overall, we used transdifferentiation to achieve the robust derivation of human skeletal myotubes and have described the signalling pathways and mechanisms regulating this process. (duke.edu)
  • We used regulated MyoD expression to reprogram urine-derived cells into myotubes. (jci.org)
  • Greater activation also results in increased expression of myogenic basic helix-loop-helix transcription factors MyoD, myogenin, and MRF4 - all responsible for the induction of myocyte-specific genes. (wikipedia.org)
  • Expression of muscle growth related genes was quantified with qPCR. (nature.com)
  • Overall, Gln supplementation stimulated cell proliferation in muscle tissue and in vitro in myogenic cell culture, whereas muscle growth regulatory genes were barely altered. (nature.com)
  • Here we reveal the expression patterns of the two MyoD genes in Oreochromis ( Alcolapia) alcalica using in situ hybridisation. (mdpi.com)
  • Among these, EZH2 that mediates repressive histone H3 lysine 27 trimethylation (H3K27me3) is upregulated and binds to muscle specific genes in ERMS. (elifesciences.org)
  • Finally, Prdm16-deficient brown fat displays an abnormal morphology, reduced thermogenic gene expression and elevated expression of muscle-specific genes. (bioseek.eu)
  • DDX5 is required for cell proliferation by controlling the transcription of genes expressing DNA replication proteins in cancer cells in which the DDX5 locus is amplified, and this has uncovered a dependence on DDX5 for cell proliferation. (aacrjournals.org)
  • In addition, the expression levels of genes related to muscle differentiation and atrophy were confirmed through qRT-PCR. (kosfaj.org)
  • However, demonstration of whether and how these genes cause pathology is largely lacking. (sdbonline.org)
  • Fibroblasts within the muscle deposit scar tissue, which can impair muscle function, and is a significant part of the pathology of muscular dystrophies. (wikipedia.org)
  • Scholars@Duke publication: Efficient transdifferentiation of human dermal fibroblasts into skeletal muscle. (duke.edu)
  • Here we used MYOD1 to establish its capacity to induce skeletal muscle transdifferentiation of human dermal fibroblasts under baseline conditions. (duke.edu)
  • 1996 1999 Although pRb-deficient fibroblasts transfected with MyoD become myogenic and communicate early muscle mass markers such as myogenin expression of late markers such as myosin heavy chain (MHC) is reduced. (healthandwellnesssource.org)
  • All superior and inferior rectus muscles from both globes were examined for BrdU incorporation, MyoD expression, neonatal and developmental myosin heavy chain (MyHC) isoform expression, and myofiber cross-sectional area alterations. (arvojournals.org)
  • Both active and passive stretch of the rectus muscles produced by strabismus surgery dramatically upregulated the processes of satellite cell activation, integration of new myonuclei into existing myofibers, and concomitant upregulation of immature myosin heavy chain isoforms. (arvojournals.org)
  • These cells represent the oldest known adult stem cell niche, and are involved in the normal growth of muscle, as well as regeneration following injury or disease. (wikipedia.org)
  • The process of muscle regeneration involves considerable remodeling of extracellular matrix and, where extensive damage occurs, is incomplete. (wikipedia.org)
  • Consequently, skeletal muscle models are being developed to study human pathophysiology and regeneration. (duke.edu)
  • Using genetic tools to conditionally abrogate C/EBPβ expression in Pax7 + cells, we examined the role of C/EBPβ in self-renewal of satellite cells during muscle regeneration. (biomedcentral.com)
  • After a single muscle injury, C/EBPβ-deficient satellite cells fail to self-renew resulting in a reduction of satellite cells available for future rounds of regeneration. (biomedcentral.com)
  • After a second round of injury, muscle regeneration is impaired in C/EBPβ conditional knockout mice compared to wild-type control mice. (biomedcentral.com)
  • These findings demonstrate that C/EBPβ is a novel regulator of satellite cell self-renewal during muscle regeneration acting at least in part through Notch2. (biomedcentral.com)
  • Further, C/EBPβ-deficient SCs are unable to self-renew after muscle injury leading to a reduction in the SC pool such that it cannot efficiently support muscle regeneration after a second round of injury. (biomedcentral.com)
  • The dystrophin-deficiency leads to severe muscle lesions including necrosis, regeneration, inflammation, fibrosis and fatty degeneration. (researchsquare.com)
  • 1 2 Residing outside the sarcolemma but within the basal lamina of individual myofibers is a population of cells that are responsible for muscle repair and regeneration, the satellite cells. (arvojournals.org)
  • 6 These manipulations result in satellite cell activation and proliferation, which in turn are responsible for muscle repair and regeneration. (arvojournals.org)
  • Changes in gene expression can cause defects in myogenesis and muscle regeneration, apoptosis, and sensitivity to oxidative stress. (comprehensivephysiology.com)
  • Therefore, promotion of myoblast proliferation and differentiation and induction of myotube hypertrophy should be beneficial for muscle regeneration and control of muscle mass. (kosfaj.org)
  • We previously demonstrated expression and activity of the subtype hTAS2R46 in human airway smooth muscle and broncho-epithelial cells, and here we show its expression and functionality in human skeletal muscle cells. (bvsalud.org)
  • We show, for the first time, experimentally the presence and functionality of a type 2 bitter receptor in human skeletal muscle cells. (bvsalud.org)
  • Differential splicing of the titin gene results in numerous species- and muscle-specific titin isoforms. (frontiersin.org)
  • More proliferation was observed in muscle tissue of LBW-GLN than LBW-ALA piglets at 5 dpn, but there was no clear effect of supplementation on related gene expression. (nature.com)
  • The MyoD gene was duplicated during the teleost whole genome duplication and, while a second MyoD gene ( MyoD2 ) was subsequently lost from the genomes of some lineages (including zebrafish), many fish lineages (including Alcolapia species) have retained both MyoD paralogues. (mdpi.com)
  • MYOD1, a master gene regulator, induces transdifferentiation of a variety of cell types into skeletal muscle, although inefficiently in human cells. (duke.edu)
  • We used qPCR, immunohistochemistry and immunofluorescence analysis to evaluate gene and protein hTAS2R46 expression. (bvsalud.org)
  • We herein demonstrated that circadian clock network in the intestines plays pivotal roles in skeletal metabolism such that the lack of Bmal1 gene in the intestines (Bmal1Int-/- mice) caused bone loss with bone resorption being activated and bone formation suppressed. (jci.org)
  • Gene expression of AMP-activated protein kinase (AMPK), MyoD1, and myogenin, along with the muscle atrophy factors muscle RING finger-1 (MuRF-1) and forkhead box O3a (FoxO3a) upon addition of deer antler extracts to muscle-atrophied C2C12 cells was determined by qRT-PCR after treatment with AICAR. (kosfaj.org)
  • In addition, gene expression of MyoD1 and myogenin in the muscle atrophy cell model was significantly increased compared that into the CON. (kosfaj.org)
  • Their physiological accuracy, however, is hampered by the lack of an easily accessible human cell source that is readily expandable and capable of efficient differentiation. (duke.edu)
  • The balance between differentiation and self-renewal is critical to maintain muscle tissue homeostasis, and alterations in this equilibrium can lead to chronic muscle degeneration. (biomedcentral.com)
  • The transcription factor CCAAT/enhancer binding protein beta (C/EBPβ) is expressed in Pax7 + satellite cells of healthy muscle and is downregulated during myoblast differentiation. (biomedcentral.com)
  • Persistent expression of C/EBPβ upregulates Pax7, inhibits MyoD, and blocks myogenic differentiation. (biomedcentral.com)
  • CCAAT/enhancer binding proteins (C/EBPs) are a family of transcription factors that regulate cellular growth and differentiation, metabolism, and inflammation [ 18 ]. (biomedcentral.com)
  • As we age, Myostatin increases while its inhibitors like follistatin and myogenin/MyoD (the latter two are responsible for regulating muscle cell differentiation) tend to decrease. (mrsupps.com)
  • Loss of PRDM16 from brown fat precursors causes a loss of brown fat characteristics and promotes muscle differentiation. (bioseek.eu)
  • Moreover forced appearance of MyoD in a number of in provoking cell loss of life in allele was removed either before or after differentiation. (healthandwellnesssource.org)
  • Hematoxylin and eosin staining of mix areas … The serious deficit in muscle mass advancement Carfilzomib led us to query if the residual muscle tissue materials were undergoing suitable differentiation. (healthandwellnesssource.org)
  • The effect of deer antler extract on muscle differentiation and muscle atrophy were evaluated to minimize muscle loss following aging. (kosfaj.org)
  • Morphological changes according to the effect of antler extracts on muscle differentiation were confirmed by Jenner-Giemsa staining. (kosfaj.org)
  • Therefore, our findings indicate that antler extract can increase the expression of MyoD1, Myf5 and myogenin, inhibit muscle atrophy, and promote muscle differentiation. (kosfaj.org)
  • NF-B signaling in skeletal muscle upregulates the muscle-specific E3 ligase MURF-1 and induces a loss of proteins integral for muscle fiber formation and maintenance, such as MyoD and Myogenin7,9,11,13. (sdfca.org)
  • To better understand the inclusion of the specific ingredients in the formula, it is important to have a little bit of background on the ways the body upregulates muscle growth. (mrsupps.com)
  • In skeletal muscles, the Dp71 isoform was ectopically expressed as a probable consequence of the mutation. (researchsquare.com)
  • Results mice expire at delivery with serious muscles deficits To research the necessity for pRb in myogenesis mice having a floxed allele (Marino et al. (healthandwellnesssource.org)
  • The two DUX4‐fl isoforms produce the same protein sequence and differ only in the splicing of the 3′UTR. (comprehensivephysiology.com)
  • Feeding with amino acids can stimulate protein synthesis in all tissues, especially in skeletal muscle as reviewed by Davis et al. (nature.com)
  • Glucose homeostasis is tightly controlled by the regulation of glucose production in the liver and glucose uptake into peripheral tissues, such as skeletal muscle and adipose tissue. (e-enm.org)
  • Under prolonged fasting, hepatic gluconeogenesis is mainly responsible for glucose production in the liver, which is essential for tissues, organs, and cells, such as skeletal muscle, the brain, and red blood cells. (e-enm.org)
  • is essential for both MyoD and MEF2 transcriptional activity as well as keeping the terminally differentiated state (Schneider et al. (healthandwellnesssource.org)
  • HS causes poor meat quality by impairing protein synthesis and augmenting undesirable fat in meat. (frontiersin.org)
  • Considered the master regulator of protein synthesis in muscle, MTOR is the key player in this cascade. (mrsupps.com)
  • In isolated HEK293 cells, Benfotiamine at 20-40ug/mL is able to attenuate the glucose-induced increase in β-amyloid protein synthesis and theoretically aid the pathology of Alzheimer's disease. (examine.com)
  • Inspired by the extraordinary wet adhesion properties of mussel byssus proteins resulting from interaction of catechol and amino residues, hydrogels from soy protein isolate (SPI) and selected polyphenols i.e. caffeic acid (CA), chlorogenic acid (CGA) and gallic acid (GA) under mild aerial oxidative conditions were prepared. (bvsalud.org)
  • Protein arginine methyltransferases (PRMTs) comprise a group of enzymes that catalyze the transfer of methyl groups to the amino acid arginine or the arginine residues of proteins in eukaryotic species. (e-enm.org)
  • While all three types of PRMTs are capable of catalyzing monomethylation of arginine residues, type I PRMTs can transfer a second methyl group to the monomethylated nitrogen atom of the guanidino group of monomethyl arginine, resulting in the formation of proteins containing one or more asymmetric dimethylarginine residues. (e-enm.org)
  • Type II PRMTs transfer a methyl group to the unmodified nitrogen atom of the guanidine group of monomethyl arginine to form proteins with symmetric dimethylarginine residues. (e-enm.org)
  • Post-translational modification of proteins at lysine residues by reversible acetylation is catalyzed by the opposing activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs), which act on both histone and non-histone substrates despite their names. (biomedcentral.com)
  • Catabolic Signaling is multifaceted and complex, but a couple of key players in the triggering of muscle protein degradation are MuRF1 and MAFbx (3-5). (mrsupps.com)
  • DUX4‐fl transcription factor misexpression in skeletal muscle leads to disrupted RNA splicing, nonsense mediated decay (NMD), and protein degradation, possibly causing damaged associated molecular pattern (DAMP) release, which may elicit an immune response to targeted damaged muscles. (comprehensivephysiology.com)
  • Insulin Like Growth Factor 1 (IGF1) activates Phosphoinositide 3-Kinase (PI3K), which activates Protein Kinase B (Akt), which then activates the Mechanistic Target of Rapamycin (MTOR, also known as the mammalian Target of Rapamycin). (mrsupps.com)
  • Liver kinase B1 inhibits smooth muscle calcification via high mobility group box 1. (omicsdi.org)
  • The insertional 6 mm of the superior rectus muscles of adult rabbits were resected and reattached to the original insertion site. (arvojournals.org)
  • It is considered postmitotic, in that the myonuclei residing within these myofibers do not divide in adult muscle. (arvojournals.org)
  • There are a number of factors that initiate myofiber remodeling in adult skeletal muscles. (arvojournals.org)
  • 10 Even more compelling is a recent study that subjected individual quiescent satellite cells isolated from adult limb muscle to stretching in vitro, and showed that direct stretching of the satellite cells themselves results in activation and bromodeoxyuridine (BrdU) incorporation. (arvojournals.org)
  • however, its impacts on skeletal metabolism remain largely unknown. (jci.org)
  • Muscle atrophy with aging is accompanied by muscle damage caused by oxidative damage and malnutrition caused by lack of muscle metabolism. (kosfaj.org)
  • Glutamine is regarded as the most abundant amino acid in the body, is mainly synthesized in skeletal muscle 10 , and muscle tissue is the most important site for Gln storage 11 . (nature.com)
  • Skeletal muscle holds significant regenerative potential but is incapable of restoring tissue loss caused by severe injury, congenital defects or tumour ablation. (duke.edu)
  • Given the tendentially protective role of the bitter receptors starting from the oral cavity and following also in the other ectopic sites, and given its expression already at the myoblast level, we hypothesize that the bitter receptor can play an important role in the development, maintenance and in the protection of muscle tissue functions. (bvsalud.org)
  • Skeletal muscle is a complex tissue composed of thousands of individual multinucleated myofibers. (arvojournals.org)
  • The hormone resistin is a member of a novel family of cysteine-rich secreted proteins associated with pulmonary inflammation (FIZZ3) and expressed in the murine small bowel and adipose tissue ( 1 ). (diabetesjournals.org)
  • The mammalian genome comprises nuclear DNA (nDNA) derived from both parents and mitochondrial DNA (mtDNA) that is maternally inherited and encodes essential proteins required for oxidative phosphorylation. (regenerativemedicine.net)
  • Protein arginine methyltransferases (PRMTs) were recently added to the list of enzymes that are critical for regulating transcription in hepatic gluconeogenesis. (e-enm.org)
  • It is estimated that microRNAs regulate production of approximately 60% of all human proteins and enzymes that are responsible for major physiological processes. (archivesofmedicalscience.com)
  • The delayed growth of LBW piglets is mainly due to a slower development of skeletal muscle as the myogenic activity is usually impaired in these animals during the fetal and early postnatal period 3 , 4 . (nature.com)
  • Postnatal growth and repair of skeletal muscle relies upon a population of quiescent muscle precursor cells, called satellite cells that can be activated to proliferate and differentiate into new myofibers, as well as self-renew to replenish the satellite cell population. (biomedcentral.com)
  • Proliferating, BrdU-positive cells in muscle sections were detected with immunohistochemistry indicating different cell types and decreasing proliferation with age. (nature.com)
  • In the resected muscle and in the passively stretched antagonist muscle, there was a dramatic increase in the number of myofibers positive for neonatal MyHC and in the number of BrdU- and MyoD-positive satellite cells. (arvojournals.org)
  • The addition of BrdU-positive myonuclei increased from 1 per 1000 myofibers in cross sections of control muscles to 2 to 3 per 100 myofibers in the resected muscles. (arvojournals.org)
  • In addition, IGF-1 expression in skeletal muscle extends the capacity to activate satellite cell proliferation (Charkravarthy, et al. (wikipedia.org)
  • The decreased activation of STAT3, which resulted from a decrease in STAT3 protein expression, was due to the inhibition of STAT3 translation as there were no changes in STAT3 mRNA levels. (sdfca.org)
  • As well, MyoStatin expression is one of the major limiting factors in muscle growth for people of all ages. (mrsupps.com)
  • We serially evaluate several facets of the recovery process, including α V β 3 -integrin expression (a marker of angiogenesis), blood perfusion, and muscle function. (thno.org)
  • In one study, when researchers tried to fatten rats up and give them diabetes, AM was able to ameliorate "glucose toxicity", improve insulin sensitivity, and increase glucose uptake in the muscle cells (10). (mrsupps.com)
  • Better skeletal muscle insulin sensitivity and more glucose uptake = bigger muscles. (mrsupps.com)
  • C and D) Trichrome‐stained biopsies isolated from the biceps of an unaffected (C) or FSHD affected (D) subjects showing characteristic muscle pathology. (comprehensivephysiology.com)
  • DUX4 misexpression dysregulates diverse cellular activities that may contribute to FSHD muscle pathology. (comprehensivephysiology.com)
  • Myosatellite cells, also known as satellite cells, muscle stem cells or MuSCs, are small multipotent cells with very little cytoplasm found in mature muscle. (wikipedia.org)
  • Myosatellite cells are located between the basement membrane and the sarcolemma of muscle fibers, and can lie in grooves either parallel or transversely to the longitudinal axis of the fibre. (wikipedia.org)
  • Satellite cells are able to differentiate and fuse to augment existing muscle fibers and to form new fibers. (wikipedia.org)
  • Activated satellite cells also begin expressing muscle-specific filament proteins such as desmin as they differentiate. (wikipedia.org)
  • When muscle cells undergo injury, quiescent satellite cells are released from beneath the basement membrane. (wikipedia.org)
  • Satellite cells proliferate following muscle trauma and form new myofibers through a process similar to fetal muscle development. (wikipedia.org)
  • Muscle samples were collected and myogenic cells were isolated and cultivated. (nature.com)
  • Irradiation treatment, which eliminates satellite cells from these muscles, prevents the compensatory hypertrophy in these types of experiments. (arvojournals.org)
  • Another stimulus that activates satellite cells is stretching of the muscle. (arvojournals.org)
  • 7 8 9 In fact, passive stretching alone can activate limb muscle satellite cells. (arvojournals.org)
  • We find that the DDX5 locus is frequently amplified in breast cancer and that breast cancer-derived cells with amplification of DDX5 are much more sensitive to its depletion than breast cancer cells and a breast epithelial cell line that lacks DDX5 amplification. (aacrjournals.org)
  • Understanding the effects of strabismus surgery on muscle cell biological reactions and myofiber remodeling may suggest new approaches for improving surgical outcomes. (arvojournals.org)
  • Therefore, we complemented our investigations into the cellular development of the skeletal muscle of neonatal piglets with in vitro studies using a primary porcine myogenic cell culture model with Gln supplementation. (nature.com)
  • Fig. 2 review A and C with E and G). Oddly enough MHC manifestation was considerably reduced in limb musculature but was much less affected in intercostal muscle groups (Fig. 2 H) and F. The histological and immunofluorescent Collectively. (healthandwellnesssource.org)
  • The poultry sector is noted to make a considerable contribution to global nutrition and food security, which helps in the provision of cheap protein, essential micronutrients, and energy to humans ( 1 ). (frontiersin.org)
  • Silent information regulator 2 (Sir2) proteins, or sirtuins, are protein deacetylases dependent on nicotine adenine dinucleotide (NAD) and are found in organisms ranging from bacteria to humans. (biomedcentral.com)
  • We report our analysis of MyoD1 and MyoD2 protein sequences from 54 teleost species, and show that O. alcalica , along with some other teleosts, include a polyserine repeat between the amino terminal transactivation domains (TAD) and the cysteine-histidine rich region (H/C) in MyoD1. (mdpi.com)
  • The evolutionary history of MyoD1 and MyoD2 is compared to the presence of this polyserine region using phylogenetics, and its functional relevance is tested using overexpression in a heterologous system to investigate subcellular localisation, stability, and activity of MyoD proteins that include and do not include the polyserine region. (mdpi.com)
  • The backbone of the sarcomere is composed of three filament systems: the myosin-based thick filament, the actin-based thin filament, supplemented with the regulatory protein tropomyosin and the troponin complex, and the titin filament. (frontiersin.org)
  • Protein-interactions e.g., with muscle ankyrin repeat proteins or muscle LIM-protein link titin to hypertrophic signaling and via p62 and Muscle Ring Finger proteins to mechanisms that control protein quality control. (frontiersin.org)
  • Also, other DUX4‐fl protein interactions may affect muscle function. (comprehensivephysiology.com)
  • They have the potential to provide additional myonuclei to their parent muscle fiber, or return to a quiescent state. (wikipedia.org)
  • Our previous studies showed that Gln had the potential to increase muscle fiber size in piglets 16 , but the mechanism was not clear. (nature.com)
  • Studies previously conducted show that HS negatively affects the skeletal muscle growth and development by changing its effects on myogenic regulatory factors, insulin growth factor-1, and heat-shock proteins. (frontiersin.org)
  • This boost in insulin sensitivity and increased muscle glycogen storage has been corroborated by other studies as well (9,11,12). (mrsupps.com)
  • Moreover, we have shown that NF-B can also mediate muscle wasting by collaborating with STAT3 to markedly increase the transcription of inducible nitric oxide synthase (iNOS), an enzyme that catalyzes the conversion of L-arginine to citrulline resulting in the release of nitric oxide (NO)7,9,10,12. (sdfca.org)
  • A family of cellular proteins that mediate the correct assembly or disassembly of polypeptides and their associated ligands. (lookformedical.com)
  • We determined that the angiogenic activity one week after mMSC treatment was enhanced by approximately 80% relative to the saline group, which resulted in relative increases in blood perfusion and muscle strength of approximately 42% and 1.7-fold, respectively. (thno.org)
  • In the I-band part skeletal muscle titin is composed of a series of proximal Ig-domains, the N2A-domain (including the N2-A unique sequence), the PEVK domain [high abundance of proline (P), glutamic acid (E), valine (V), and lysine (K)] and the distal Ig-domains. (frontiersin.org)
  • For example, the concurrent signaling of interferon (IFN) and tumor necrosis factor (TNF) (IT) can synergistically elicit muscle wasting by stimulating the activity of transcription factors including STAT3 and the heterodimeric NF-B9C12. (sdfca.org)
  • Epicatechin is an exciting ingredient with potential to stimulate muscle growth through multiple avenues. (mrsupps.com)
  • Muscle growth of low birth weight (LBW) piglets may be improved with adapted nutrition. (nature.com)
  • The specific combination and dosages of these novel ingredients should allow users to tap into a previously unattainable level of muscle growth. (mrsupps.com)
  • In fully-grown adults, IGF1 is no longer responsible for bone growth, as it shifts its focus to other duties like muscle growth. (mrsupps.com)
  • FINDINGS: The decrease of free NH2 and SH groups of SPI, the EPR features, the good cohesive strength and excellent underwater resistance (15â ¯days for SPI/GA) under conditions relevant to their use as surgical glues indicated an efficient interaction of the polyphenols with the protein in the hydrogels. (bvsalud.org)
  • Myotonic dystrophy (DM) is the most common autosomal dominant muscular dystrophy and encompasses both skeletal muscle and cardiac complications. (jci.org)
  • 3 When a muscle is injured, this specialized cell population becomes activated, divides, and either repairs damaged fibers or forms new myofibers. (arvojournals.org)
  • and nonhistone proteins (CHROMOSOMAL PROTEINS, NON-HISTONE) found within the nucleus of a cell. (lookformedical.com)
  • Small chromosomal proteins (approx 12-20 kD) possessing an open, unfolded structure and attached to the DNA in cell nuclei by ionic linkages. (lookformedical.com)
  • Proteins that control the CELL DIVISION CYCLE. (lookformedical.com)
  • Proteins found in the nucleus of a cell. (lookformedical.com)