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  • tumor cell
  • In the human tumor cell lines compound 1 showed ED,o values of 2.19 pg cmW3 in the colon adenocarcinoma, 1.63 pg cm-3 in the HeLa-S3 and 3.67 pg cm-, in the KB nasopharynx, and it was not active against bronchogenic lung, osteosarcoma or glioma growth. (docme.ru)
  • 1210
  • Significant differences in binding of Con A were revealed between NK/Ly (67 % Con A+) and L-1210 (7,2 % Con A+) cells, while the differences in binding of other lectins with both types of tumor cells were not significant. (cytgen.com)
  • Lutsyk M.M., Yashchenko A.M., Kovalyshyn V.I., Prydatko O.E., Stoika R.S., Lootsik M.D. Hete- rogeneity of cell population of lymphoma NK/Ly and leukemia L-1210 according to carbohydrate structure of cell surface : immunocytochemical analysis of lectin binding, Tsitol Genet. (cytgen.com)
  • vitro
  • These results indicate that siRNA targeted to ABCB1 can sensitize paclitaxel-resistant ovarian cancer cells in vitro and suggest that siRNA treatment may represent a new approach for the treatment of ABCB1 -mediated drug resistance. (aacrjournals.org)
  • camptothecin
  • The plant alkaloid camptothecin (CPT) has demonstrated the ability to inhibit replication of the equine anemia virus (E1AV) and the human immunodeficiency virus (HIV) in infected cells in culture. (springer.com)
  • drugs
  • The ability of combination chemotherapy to cure acute childhood leukemia and advanced Hodgkin's disease in the 1960s and early 1970s overcame the prevailing pessimism about the ability of drugs to cure advanced cancers, facilitated the study of adjuvant chemotherapy, and helped foster the national cancer program. (aacrjournals.org)
  • The ABCB1 gene encodes a membrane-bound P-glycoprotein (P-gp), which has been shown to transport a variety of chemotherapeutic drugs out of the cell in an energy-dependent process. (aacrjournals.org)
  • extracts
  • the Km values for deoxycytidine and cytosine arabinoside were increased in the extracts from the dGuo-R cells. (ecu.edu)
  • By use of high-performance liquid chromatography, the kinase activities in the extracts from the wild-type and resistant cells could be resolved. (ecu.edu)
  • resistance
  • A mouse leukemia L1210 cell line was selected for resistance to deoxyguanosine. (ecu.edu)
  • The dGuo-R cell line showed an increased level of resistance to 2-fluoro-2'-deoxyadenosine and 2-fluoroadenine arabinoside (11-14-fold), but essentially no increase in resistance to deoxyadenosine or adenine arabinoside. (ecu.edu)
  • 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays of siRNA-treated cells demonstrated 7- to 12.4-fold reduction of paclitaxel resistance in the lines treated with the synthesized siRNA of ABCB1 and 4.7- to 7.3-fold reduction of paclitaxel resistance in the cell lines transfected with siRNA of ABCB1 expressing vectors. (aacrjournals.org)
  • ABCB4 siRNA-treated cell lines showed minor reduction in paclitaxel resistance. (aacrjournals.org)
  • In brief, cell culture, animal, and clinical studies strongly suggest that overexpression of the ABCB1 gene may be the single most important determinant of drug resistance in some cancers. (aacrjournals.org)
  • cancers
  • In laboratory studies, isoflavones slowed down the growth of several different types of cancer cells, including breast and prostate cancers. (mskcc.org)
  • Paclitaxel, originally isolated from Taxus brevifolia (the Pacific yew), is a microtubule stabilizing chemotherapeutic drug used in the treatment of ovarian, breast, and nonsmall cell lung cancers ( 1 , 2 ). (aacrjournals.org)
  • receptor
  • p-Anilinoaniline enhancement of dioxin-induced CYP1A1 transcription and aryl hydrocarbon receptor occupancy of CYP1A1 promoter: role of the cell cycle. (nih.gov)
  • membrane
  • A relatively high percentage of PNA+ cells was registered that can indicate a high degree of desialization of membrane glycoproteins. (cytgen.com)
  • values
  • The IC50 values for araC and araG were increased, but only 10-12-fold in the dGuo- R cells when compared with the wild-type cells. (ecu.edu)