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  • liver
  • It converts pyruvate, the final product of glycolysis , to lactate when oxygen is absent or in short supply, and it performs the reverse reaction during the Cori cycle in the liver . (wikipedia.org)
  • serum
  • There has therefore existed, for a substantial period of time, the need for a simple testing mechanism for the determination of the concentration of serum lactate dehydrogenase in body fluids, especially the blood, which long-felt need is satisfied by the instant invention more fully discussed hereinbelow. (freepatentsonline.com)
  • Clinical Significance
  • The book entitled "Lactate Dehydrogenase (LDH): Biochemistry, Functions and Clinical Significance" provides a broad and authoritative review of the lactate dehydrogenase enzyme, including its isoforms, catalytic functions, distribution in various tissues, involvement in cancer cell metabolism and tumorigenesis, involvement in the plasmodium enzyme, various small molecule inhibitors of hLDHA and pfLDH, and clinical significance. (novapublishers.com)
  • heart
  • The quantitative determination of lactate dehydrogenase is extremely important in the detection of heart diseases, especially heart attacks, in that, following heart attacks, the concentration of lactate dehydrogenase in the blood rises noticeably over its normal concentration. (freepatentsonline.com)
  • Refined crystal structure of mitochondrial malate dehydrogenase from porcine heart and the consensus structure for dicarboxylic acid oxidoreductases. (ebi.ac.uk)
  • body
  • Available tests for the detection of the concentration of lactate dehydrogenase in body fluids have, until now, consisted of extremely complex liquid systems whereby test tubes, measuring devices, ultraviolet light, standardization of instruments, correction factors depending upon temperature and false readings prevail. (freepatentsonline.com)
  • As mentioned briefly above, I have now discovered a novel test means for the determination of the concentration of lactate dehydrogenase in body fluids. (freepatentsonline.com)