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  • amino acids
  • Katayama Y, Cheung MK, Alves A, Becker DP (1989) Ion fluxes and cell swelling in experimental traumatic brain injury: The role of excitatory amino acids. (springer.com)
  • Ewmswie KS, Yoshikami D. (1985) Effects of kynurenate on root potentiaws evoked by synaptic activity and amino acids in de frog spinaw cord. (appspot.com)
  • Moreover, as a major storage site for glucose, lipids and amino acids, muscle is an essential coordinator of whole-body energy metabolism. (frontiersin.org)
  • synthesis
  • Among these features are deficits of working memory and decreased levels of glutamic acid decarboxylase 67, one of the enzyme isoforms that catalyzes the synthesis of GABA, and parvalbumin, a Ca 2+ -binding protein expressed by interneurons, primarily in the stratum pyramidale. (aspetjournals.org)
  • sodium
  • Specifically the wells were incubated with peroxidase-labeled streptavidin which binds to biotin followed by incubation having a peroxidase substrate consisting of peroxide and 2 2 azinobis (3-ethylbenzthiazoline sulfonic acid) in sodium citrate buffer ph 4.2. (exposed-skin-care.net)
  • urine
  • The aim of this pilot study is to evaluate sarcosine, uracil, and kynurenic acid in urine as potential biomarkers in prostate cancer detection and progression monitoring. (mdpi.com)
  • Sarcosine, uracil, and kynurenic acid were measured in urine samples of 32 prostate cancer patients prior to radical prostatectomy, 101 patients with increased prostate-specific antigen prior to ultrasonographically-guided prostatic biopsy collected before and after prostatic massage, and 15 healthy volunteers (controls). (mdpi.com)
  • In contrast to total PSA values, kynurenic acid was found a promising biomarker for the detection of prostate cancer particularly in cases where collection of urine samples was performed after prostatic massage. (mdpi.com)
  • Kynurenic acid was discovered in 1853 by de German chemist Justus von Liebig in dog urine , which it was apparentwy named after. (appspot.com)
  • High wevews of kynurenic acid have been identified in human urine in certain metabowic disorders, such as marked pyridoxine deficiency and deficiency/absence of kynureninase . (appspot.com)
  • For the in vitro determination of kynurenic acid in urine. (iristechnologies.net)
  • enzyme
  • Indoleamine 2, 3-dioxygenase (IDO) is an interferon (IFN)-γ-inducible, enzyme that catalyses the initial and rate-limiting step in the degradation of the essential amino acid tryptophan via. (arvojournals.org)
  • 3. The method according to claim 1, characterized in that the activity is derived from a kynurenine-converting enzyme and/or a kynurenic-acid-producing enzyme of a tissue sample, preferably a liver-tissue sample, more preferred an isolated or synthesized liver-tissue sample. (patentsencyclopedia.com)
  • 7. The method according to any one of claim 1, comprising the step of comparing the activity to the activity of the kynurenine-converting enzyme and/or the kynurenic-acid-producing enzyme, preferably derived from a tissue sample, as described in claim 3, in the absence of the interfering sample or by using a different amount of the interfering sample or the enzyme. (patentsencyclopedia.com)
  • The method according to claim 1 for measuring the activity of a kynurenine-converting enzyme and/or a kynurenic-acid-producing enzyme, characterized in that the conversion of kynurenine and/or kynurenic acid is detected. (patentsencyclopedia.com)
  • 13. A kit, comprising a biological sample that includes a kynurenine-converting enzyme and/or a kynurenic-acid-producing enzyme, preferably together with a tissue sample or a homogenate, in particular a liver homogenate or synthesized liver, appropriate buffers and kynurenine, preferably L-kynurenine, and optionally also comprising pyridoxal-5'-phosphate. (patentsencyclopedia.com)
  • serum
  • 25 μg of membranes is incubated at room temperature for 1 h in assay buffer (20 mM HEPES, 5 m MMgCl 2 , 0.1% bovine serum albumin (pH 7.5)) containing 3 μM GDP and 0.1 nM[ 35 S]GTPγS in the absence or presence of kynurenic acid. (medchemexpress.com)
  • Effect
  • Kynurenic acid affects the activity of leukocytes in the peripheral blood of mice, although the lowest one (2.5 mg/L) has the most profound influence in contrast to the highest one (250 mg/L), which produces the weakest effect. (medchemexpress.com)
  • Effect of oral administration of kynurenic acid on the activity of the peripheral blood leukocytes in mice. (medchemexpress.com)
  • range
  • Kynurenic acid, with a shallower inhibition curve and non-competitively, antagonizes α7nAChRs on cultured hippocampal neurons with an IC 50 in the low micromolar range . (medchemexpress.com)
  • cells
  • Antal O, Hackler JL, Shen J, Mán I, Hideghéty K, Kitajka K, Puskás LG (2014) Combination of unsaturated fatty acids and ionizing radiation on human glioma cells: cellular, biochemical and gene expression analysis. (springer.com)