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  • neuronal
  • Members of this channel family play critical roles in cellular signaling processes regulating neurotransmitter release , heart rate , insulin secretion , neuronal excitability , epithelial electrolyte transport, smooth muscle contraction, and cell volume regulation. (axonmedchem.com)
  • vascular
  • Our study also suggests a therapeutic strategy to improve ischemic vascular occlusion by lowering 15-HETE level and preventing Kv channel down-regulation which makes 15-LOX as a new target for the treatment of cerebral hypoxia. (welbourneprimary.com)
  • Keywords: 15-lipoxygenase (15-LOX) 15 acid (15-HETE) hypoxia Kv1.5 Kv2.1 Introduction Cerebral vascular disease is MP470 one of diseases with high morbidity and mortality 75 of which is caused by ischemic cerebrovascular. (welbourneprimary.com)
  • However, until now the in vivo pharmacology of the involved vascular K V channels with regard to XE991 remains undetermined, since XE991 effects may involve Ca 2+ activated BK Ca channels and/or voltage-dependent K V 1.5 channels sensitive to diphenyl phosphine oxide-1 (DPO-1). (frontiersin.org)
  • Our study was also aimed at extending our current knowledge on the in situ vascular pharmacology of DPO-1 and XE991 regarding K V 1.5 and BK Ca channels, in helping to identify the nature of K + channels that could contribute to PVAT-mediated relaxation. (frontiersin.org)
  • We conclude that K V channels are involved in the control of arterial vascular tone by PVAT. (frontiersin.org)
  • Over the past decade, various potassium (K + ) channels have been implicated as important players in the regulation of arterial vascular tone and its control by perivascular adipose tissue (PVAT). (frontiersin.org)
  • Opening of vascular smooth muscle cell (VSMC) K + channels causes K + efflux and membrane hyperpolarization, which leads to reduced Ca 2+ influx though L-type Ca V 1.2 channels and consequently arterial relaxation ( Nelson and Quayle, 1995 ). (frontiersin.org)
  • transient
  • TCR ligation is followed by a transient release of calcium from intracellular stores, which precedes a sustained calcium influx through Ca 2+ release-activated Ca 2+ channels that is required for complete activation. (jimmunol.org)
  • suppresses
  • β1-adrenoceptor stimulation suppresses endothelial IKCa-channel hyperpolarization and associated dilatation in resistance arteries. (bath.ac.uk)
  • calcium
  • For calcium-dependent K + and similar channels, the model must account for the molecular species to which the channels are sensitive. (jneurosci.org)
  • Voltage-independent calcium channels mediate lipopolysaccharide-induced hyporeactivity to endothelin-1 in the rat aorta. (bath.ac.uk)
  • Potassium channels play a fundamental role in modulating calcium signaling by providing the counterbalancing cation flux to promote calcium entry through Ca 2+ release-activated Ca 2+ channels ( 1 - 3 ). (jimmunol.org)
  • repeats
  • The alpha subunits of these channels contain four repeats of a core motif, which consists of six predicted transmembrane regions, S1-S6. (axonmedchem.com)
  • variety
  • SGK1-regulated channels include the Ca2+ channel TRPV6, which is expressed in a variety of epithelial and nonepithelial cells including tumor cells. (deepdyve.com)