Rectifier potassium channelSubfamilySubunitShakerVoltage-gated poBlockersSubunitsGenesNEURONMolecularSubfamiliesGeneTransmembraneCyclicCurrentsAxonAntibodiesBelongsKv1.3MembraneHumanCloningRegulationProteinInhibitionModulationFunctionalCellQuantitativeNodalDiseasesPropertiesActivityComplexModelsSpikePhysiologicalDirectCellsProgram
Rectifier potassium channel2
- Predicted to enable delayed rectifier potassium channel activity. (mcw.edu)
- 8. Paulmichl M, Nasmith P, Hellmiss R, Reed K, Boyle WA, Nerbonne JM, Peralta EG, and Clapham DE (1991) Cloning and expression of a rat cardiac delayed rectifier potassium channel. (aspetjournals.org)
Subfamily4
- Potassium voltage-gated channel subfamily A member 2 also known as Kv1.2 is a protein that in humans is encoded by the KCNA2 gene. (wikipedia.org)
- This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. (wikipedia.org)
- Kv1.1 belongs to the Kv1 subfamily, consisting of eight members (Kv1.1 to Kv1.8). (biomedcentral.com)
- 3. Neither are the Shaker (Kv1), Shab (Kv2) & Shaw (Kv3) subfamilies of currents, nor HERG, KvLQT1/IsK, inhibited by phrixotoxins which appear specific of the Shal (Kv4) subfamily of currents & also block I(to1) in isolated murine cardiomyocytes. (smartox-biotech.com)
Subunit3
- 10. Scott VE, Rettig J, Parcej DN, Keen JN, Findlay JB, Pongs O, and Dolly JO (1994) Primary structure of a β subunit of α-dendrotoxin-sensitive K + channels from bovine brain. (aspetjournals.org)
- 11. Rettig J, Heinemann SH, Wunder F, Lorra C, Parcej DN, Dolly JO, and Pongs O (1994) Inactivation properties of voltage-gated K + channels altered by presence of β-subunit. (aspetjournals.org)
- 13. Rhodes KJ, Keilbaugh SA, Barrezueta NX, Lopez KL, and Trimmer JS (1995) Association and colocalization of K + channel α-and β-subunit polypeptides in rat brain. (aspetjournals.org)
Shaker2
- Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). (wikipedia.org)
- 12. Kim E, Niethammer M, Rothschild A, Jan YN, and Sheng M (1995) Clustering of Shaker-type K + channels by interaction with a family of membrane-associated guanylate kinases. (aspetjournals.org)
Voltage-gated po1
- 3. Stuhmer W, Ruppersberg JP, Schroter KH, Sakmann B, Stocker M, Giese KP, Perschke A, Baumann A, and Pongs O (1989) Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain. (aspetjournals.org)
Blockers4
- Treatment with potassium channel blockers have been shown to block apoptosis in various cell types [ 11 ]. (biomedcentral.com)
- 6. It was concluded that phrixotoxins, are new & specific blockers of Kv4.3 & Kv4.2 potassium currents, & hence of I(to1) that will enable further studies of Kv4.2 & Kv4.3 channel &/or I(to1) expression. (smartox-biotech.com)
- Cell Biosci (2017) 7:Web page 4 ofis reasonable to assume that KTX-Sp4 adopts the wellknown cysteine-stabilized / scaffold, which can be related towards the scorpion classical K+-channel blockers. (adenylate-cyclase.com)
- In this work, we developed an efficient system for the production of three potent Kv1.3 channel blockers from different scorpion venoms: Vm24, AnTx, and Ts6. (mdpi.com)
Subunits7
- TITLE Voltage-gated low threshold potassium current from Kv1 subunits COMMENT NEURON implementation of a potassium channel from Kv1.1 subunits Kinetical scheme: Hodgkin-Huxley m^4, no inactivation Experimental data taken from: Human Kv1.1 expressed in xenopus oocytes: Zerr et al. (yale.edu)
- Therefore, we hypothesized that the truncated Kv1.1 would be expressed and dysregulate other Kv1 subunits in the mceph/mceph mice. (biomedcentral.com)
- Interactions between MCEPH and other Kv1 subunits were studied in cell culture, Xenopus oocytes and the brain. (biomedcentral.com)
- The channels are hetero- or homotetramers, formed by a great variety of subunits, classified in 12 subfamilies [ 5 ]. (biomedcentral.com)
- Kv1.1, Kv1.2 and Kv1.4 are the most abundant Kv1 subunits expressed in the brain [ 6 ]. (biomedcentral.com)
- brush resides in a cluster of redundant CNGCs encoding subunits which resemble metazoan voltage-gated potassium (Kv1-Kv4) channels in assembly and gating properties. (elifesciences.org)
- The results reveal a mechanism by which quantitative competition between channel subunits for tetramer assembly can impact the phenotype of the mutation carrier. (elifesciences.org)
Genes2
- 2. Kamb A, Weir M, Rudy B, Varmus H, and Kenyon C (1989) Identification of genes from pattern formation, tyrosine kinase, and potassium channel families by DNA amplification. (aspetjournals.org)
- 5. Chandy KG, Williams CB, Spencer RH, Aguilar BA, Ghanshani S, Tempel BL, and Gutman GA (1990) A family of three mouse potassium channel genes with intronless coding regions. (aspetjournals.org)
NEURON3
- MicrocircuitDB: Na+ channel dependence of AP initiation in cortical pyramidal neuron (Kole et al. (yale.edu)
- Na+ channel dependence of AP initiation in cortical pyramidal neuron (Kole et al. (yale.edu)
- In this simulation action potential initiation, action potential properties and the role of axon initial segment Na+ channels are investigated in a realistic model of a layer 5 pyramidal neuron axon initial segment. (yale.edu)
Molecular1
- The molecular weight of KTX-Sp4 was determined by matrix assisted-laser-desorption/ionization time-of-flight mass spectrometry (MALDI-TOF S). Benefits showed that the measured value of KTX-Sp4was 4545.3 Da (Fig. 2c), which confirmed the theoretical molecular weight of 4547.three Da.Modulation of KTXSp4 on endogenous voltagegated potassium channelsexamined no matter if KTX-Sp4 could block endogenous Kv1.three expressed by human Jurkat T cells. (adenylate-cyclase.com)
Subfamilies1
- K v 1, K v 2 and K v 3 channel subfamilies are insensitive to this toxin. (smartox-biotech.com)
Gene3
- The responsible mutation was recently revealed to be an eleven base pair deletion, leading to a frame shift, in the gene encoding the potassium channel Kv1.1. (biomedcentral.com)
- 9. Grissmer S, Dethlefs B, Wasmuth JJ, Goldin AL, Gutman GA, Cahalan MD, and Chandy KG (1990) Expression and chromosomal localization of a lymphocyte K + channel gene. (aspetjournals.org)
- Ion channels, located on the membrane of T cells, are the effectors which link antigen recognition to T cell function and gene regulation by controlling calcium homeostasis. (uc.edu)
Transmembrane2
- Myelin is a continuous structure with intermittent gaps called nodes of Ranvier, which are the sites enriched with ion channels, transmembrane, scaffolding, and cytoskeletal proteins. (bvsalud.org)
- Predicted to be involved in potassium ion transmembrane transport. (mcw.edu)
Cyclic1
- Cyclic nucleotide-gated channel (CNGC) family members mediate Ca 2+ influx from cellular stores in plants (Charpentier et al. (elifesciences.org)
Currents1
- In the present study, two new peptides, phrixotoxins PaTx1 & PaTx2 (29-31 amino acids), which potently block A-type potassium currents, have been purified from the venom of the tarantula Phrixotrichus auratus. (smartox-biotech.com)
Axon3
- The main Na+ channel properties were constrained by experimental data and the axon initial segment was reconstructed. (yale.edu)
- 1 . Kole MH, Ilschner SU, Kampa BM, Williams SR, Ruben PC, Stuart GJ (2008) Action potential generation requires a high sodium channel density in the axon initial segment. (yale.edu)
- To better understand how mild demyelination gives rise to the early symptoms of demyelinating diseases, one approach is to build mathematical models of the axon and study the link between demyelination patterns and axonal conduction properties [ 2 , 3 , 4 , 5 ]. (springeropen.com)
Antibodies2
- This group of diseases behaves like the target-specific antibodies-the effect of autoantibodies on potassium channels was described by Hart et al. (touchneurology.com)
- 4 The new class of antibodies is directed against the neuropil-in particular against synaptic surface antigens such as N-methyl-D-aspartic acid (NMDA), gamma-aminobutyric acid (GABA), and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA). (touchneurology.com)
Belongs1
- TWIK-related acid-sensitive potassium channel 1 (TASK-1 encoded by KCNK3) belongs to the family of two-pore domain potassium channels. (ersjournals.com)
Kv1.34
- The Kv1.3 channel has become a therapeutic target for the treatment of various diseases. (mdpi.com)
- Targeted knockdown of Kv1.3 channels in T lymphocytes corrects the disease manifestations associated with systemic lupus erythematosus. (uc.edu)
- Kv1.3 Channels Mark Functionally Competent CD8+ Tumor-Infiltrating Lymphocytes in Head and Neck Cancer. (uc.edu)
- The C-terminus SH3-binding domain of Kv1.3 is required for the actin-mediated immobilization of the channel via cortactin. (uc.edu)
Membrane3
- A paranodal membrane barrier has long been described as the boundary separating nodal and juxtaparanodal ion channels. (rupress.org)
- My laboratory is interested in ion channels and the membrane mechanisms that regulate the activation and function of T lymphocytes. (uc.edu)
- We have identified a critical role of the phospholipid phosphatidylinositol (4,5) bisphosphate in coordinating the actin-mediated recruitment of secretory vesicles to the plasma membrane. (edu.au)
Human1
- Potassium (K + ) channels constitute the largest group of ion channels in the human genome. (ersjournals.com)
Cloning1
- 7. Roberds SL and Tamkun MM (1991) Cloning and tissue-specific expression of five voltage-gated potassium channel cDNAs expressed in rat heart. (aspetjournals.org)
Regulation4
- As the specific mechanisms behind this phenomenon are unknown, spermatozoa from mice were screened for sensitivities to inhibitors known to affect specific channels involved in volume regulation of somatic cells. (smartox-biotech.com)
- These results imply that channels potentially involved in volume regulation of murine spermatozoa include the voltage-dependent Kv1.4 (also known as KCNA1), Kv1.5 (KCNA5), Kv4.1 (KCND1), Kv4.2 (KCND2), Kv4.3 (KCND3), mink (KCNE1), & acid-sensitive TASK2 (KCNK5) & TASK3 (KCNK9). (smartox-biotech.com)
- Volume regulation of spermatozoa may involve novel voltage-gated & pH-sensitive potassium channels, which could be valuable targets for the development of a posttesticular male contraceptive. (smartox-biotech.com)
- K+ channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons. (modeldb.science)
Protein3
- 2,3,5,4′-Tetrahydroxystilbene 2-O-��-D-glucoside COA Expression, purification and characterization of KTXSp4 peptideThe expressed GST-KTX-Sp4 fusion protein was purified on GSH affinity column and then desalted using centrifugal filter devices. (adenylate-cyclase.com)
- Further experiments found that the channel formed by the mutated CNGC protein is leaky and allows calcium ions to enter the cell in the absence of any cue from the environment. (elifesciences.org)
- These findings provide important insights into the function of CNGCs and reveal how a small change in a channel protein can have far reaching effects on an organism. (elifesciences.org)
Inhibition1
- 4. In order to evaluate the physiological consequences of the Ito1 inhibition, mice were injected intravenously with PaTx1, which resulted in numerous transient cardiac adverse reactions including the occurrence of premature ventricular beats, ventricular tachycardia & different degrees of atrioventricular block. (smartox-biotech.com)
Modulation1
- Recent studies show that modulation of TASK-1 channels, either directly or indirectly by targeting their regulatory mechanisms, has the potential to control pulmonary arterial tone in humans. (ersjournals.com)
Functional3
- Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. (wikipedia.org)
- 4. Yokoyama S, Imoto K, Kawamura T, Higashida H, Iwabe N, Miyata T, and Numa S (1989) Potassium channels from NG108-15 neuroblastoma-glioma hybrid cells: primary structure and functional expression from cDNAs. (aspetjournals.org)
- This review summarises our current state of knowledge of the functional role of TASK-1 channels in the pulmonary circulation in health and disease, with special emphasis on current advancements in the field. (ersjournals.com)
Cell2
- These proteins act as channels and allow ions to move across cell membranes. (elifesciences.org)
- 1. Role of ion channels in T cell response and adaptation to hypoxia. (uc.edu)
Quantitative1
- 2007). Here, we report the unusual genetic behavior of a quantitative gain-of-function CNGC mutation ( brush ) in Lotus japonicus resulting in a leaky tetrameric channel. (elifesciences.org)
Nodal1
- In addition, we model sodium channel remodeling as a homeostatic control of nodal excitability. (springeropen.com)
Diseases1
- The classic syndromes are antigen-target-oriented syndromes such as myasthenia gravis (MG), Lambert-Eaton myasthenic syndrome (LEMS), and ion channel-mediated diseases. (touchneurology.com)
Properties2
- It does so by altering the gating properties of the channels. (smartox-biotech.com)
- 70 nM, by altering the gating properties of these channels. (smartox-biotech.com)
Activity3
- TASK-1 channels are sensitive to a wide array of physiological and pharmacological mediators that affect their activity such as unsaturated fatty acids, extracellular pH, hypoxia, anaesthetics and intracellular signalling pathways. (ersjournals.com)
- PD1 blockade enhances K+ channel activity, Ca2+ signaling, and migratory ability in cytotoxic T lymphocytes of patients with head and neck cancer. (uc.edu)
- A defect in KCa3.1 channel activity limits the ability of CD8+ T cells from cancer patients to infiltrate an adenosine-rich microenvironment. (uc.edu)
Models1
- Adaptation was predicted by parameter optimization in detailed computational models based on available knowledge on GrC ionic channels. (yale.edu)
Spike1
- Simulations showed that fine-tuning of pre- and post-synaptic parameters generated effective MF-GrC transmission channels, which could enrich the processing of input spike patterns and enhance spatio-temporal recoding at the cerebellar input stage. (yale.edu)
Physiological1
- Mutations in K + channel sequences can lead to a variety of clinical disorders exemplifying their physiological importance [ 3 ]. (ersjournals.com)
Direct1
- A direct link between potassium channel dysfunction and apoptosis is that reduced intracellular potassium levels appear to promote critical events early in the suicide program. (biomedcentral.com)
Cells2
- The cells were incubated at 37°C for 24h in media containing different concentrations of ab120017 (CNQX) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. (abcam.com)
- Staining of the treated cells with ab96379 (1/100 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. (abcam.com)
Program1
- Head wear is an severe disease that quickly progresses to loss of life within six months (4), whereas Head wear has a even more chronic program with the average length of three years (5). (healthanddietblog.info)