• These factors cause inflammation, apoptosis and eventually fibrosis of liver cells. (wikipedia.org)
  • Cirrhosis is a late stage of serious liver disease marked by inflammation (swelling), fibrosis (cellular hardening) and damaged membranes preventing detoxification of chemicals in the body, ending in scarring and necrosis (cell death). (wikipedia.org)
  • Because ER stress is known to induce M2 macrophage polarization, we examined whether Nogo-B regulates M1/M2 polarization of Kupffer cells and alters the pathogenesis of alcoholic liver disease (ALD). (elsevier.com)
  • Subsequently, the higher levels of fatty acids signal the liver cells to compound it to glycerol to form triglycerides. (wikipedia.org)
  • We previously reported that gadolinium chloride (GdCl), an agent that depletes the liver of phagocytically active Kupffer cells, enhances hepatic expression of TNF messenger RNA (mRNA) and promotes liver regeneration after subsequent PH. (wiley.com)
  • Here, we demonstrate that galectin-9, the natural ligand for the T cell immunoglobulin domain and mucin domain protein 3 (Tim-3), circulates at very high levels in the serum and its hepatic expression (particularly on Kupffer cells) is significantly increased in patients with chronic HCV as compared to normal controls. (sigmaaldrich.com)
  • Uptake and killing of Lyme disease and relapsing fever borreliae in the perfused rat liver and by isolated Kupffer cells. (prohealth.com)
  • The in vitro uptake of B. burgdorferi IRS by isolated rat Kupffer cells was rapid, and within 30 min of the infection, large intracellular aggregates of amorphous material were detectable by immunofluorescence with specific anti-B. burgdorferi antibody. (prohealth.com)
  • This study has been performed to examine which cells are responsible for the hepatic clearance of the new ultrasound contrast agent Sonazoid and to study whether uptake of these gas microbubbles disturbs the function of the cells involved. (biomedsearch.com)
  • In conclusion, galectin-9 production by Kupffer cells links the innate and adaptive immune response, providing a potential novel immunotherapeutic target in this common viral infection. (sigmaaldrich.com)
  • In 1874 he was the first to describe the bacillus that causes typhoid fever, later to be known as Salmonella typhi, and in 1898 was the first to correctly identify the liver's Kupffer cells as specialized macrophages. (wikipedia.org)
  • This can lead to oxidative stress, lipid peroxidation, and DNA damage, which may result in cell death. (wikipedia.org)
  • The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. (wikipedia.org)
  • Inhibition or destruction of Kupffer cells (KC) may protect against ischemia-reperfusion (IR) induced primary graft nonfunction (PNF) in liver transplantation. (sigmaaldrich.com)
  • Baer K, Roosevelt M, Clarkson AB Jr, van Rooijen N, Schnieder T, Frevert U (2007) Kupffer cells are obligatory for Plasmodium yoelii sporozoite infection of the liver. (springer.com)
  • Even though CLEC4F is not detectable in tissues outside liver, both residential Kupffer cells and infiltrating mononuclear cells surrounding liver abscesses are CLEC4F-positive upon Listeria monocytogenes (L. monocytogenes) infection. (nih.gov)
  • From 1880 until his retirement in 1901, Kupffer held the chair of anatomy at the University of Munich. (wikipedia.org)
  • When Kupffer cells were inhibited, the increase in serum TNF-α levels and the infiltration of neutrophils in the lung were prevented, but P-selectin expression remained unmodified. (csic.es)
  • Rats were given ethanol (4 g/kg body wt) intragastrically, and Kupffer cells were isolated 0-48 hours later. (nih.gov)
  • Kupffer cells isolated from rats early after ethanol exhibited tolerance to LPS, whereas sensitization was observed later. (nih.gov)
  • This response decreases liver parasite load possibly because type I IFN signaling in myeloid cells contributes to the recruitment of immune cells to the inflammatory foci around infected hepatocytes ( 6 ). (frontiersin.org)
  • Liver Kupffer cells have crucial roles in mediating the inflammatory processes that promote liver cancer, but the mechanistic basis for their contributions are not fully understood. (aacrjournals.org)
  • However, in some cell types it is detectable only when up-regulated, such as activated but not quiescent microglia, and can thus be used as a marker of inflammatory conditions and immune reactions in those instances. (wikipedia.org)
  • Burgio VL, Ballardini G, Artini M, Caratozzolo M, Bianchi FB, Levrero M (1998) Expression of co-stimulatory molecules by Kupffer cells in chronic hepatitis of hepatitis C virus etiology. (springer.com)
  • We verified that therapeutic treatment of acute viral hepatitis with type I interferon is reasonable, since it activates local immune cells and helps to eliminate the virus," concludes institute director Prof. Ulrich Kalinke. (eurekalert.org)
  • The muscular pulmonary arteries become fibrotic and hypertrophy while the smaller arteries lose smooth muscle cells and their elastic intima. (wikipedia.org)
  • Beschin A, De Baetselier P, Van Ginderachter JA (2013) Contribution of myeloid cell subsets to liver fibrosis in parasite infection. (springer.com)