• We demonstrate that UCN-01, at concentrations lower than those necessary to inhibit cancer cell growth, inhibit proliferation of human endothelial cells in vitro. (karger.com)
  • The ability of lovastatin, mevastatin and simvastatin to inhibit the melanoma cell proliferation was examined using cytotoxicity and apoptosis assays. (biomedcentral.com)
  • The concentrations required to inhibit proliferation of melanoma cells (0.8-2.1 μM) have previously been achieved in a phase I clinical trial of lovastatin in patients with solid tumours, (45 mg/kg/day resulted in peak plasma concentrations of approximately 3.9 μM). (biomedcentral.com)
  • Tan IIA inhibited proliferation of mouse keratinocytes in a dose- and time-dependent manner and induced apoptosis, resulting in S phase arrest accompanied by down-regulation of pCdk2 and cyclin A protein expression. (hindawi.com)
  • Previous studies have demonstrated that glycolysis inhibitors reduce the proliferation of non‑small cell lung cancer (NSCLC) cells by interfering with the aerobic glycolytic pathway. (spandidos-publications.com)
  • Furthermore, we identified 5-iodotubercidin as a potent ERK2 inhibitor, which may help reveal the role of ERK2 in cell proliferation. (rcsb.org)
  • Sesamin (75 and 150 μM) clearly inhibited SiHa and HeLa cell proliferation in a dose-dependent fashion, but did not affect the proliferation of Hs68 cells. (medsci.org)
  • These findings indicate that sesamin inhibits cervical cancer cell proliferation, and its mechanism may be attributed to the induction of p53/PTEN-mediated apoptosis. (medsci.org)
  • Protein tyrosine kinase inhibitors inhibit both proliferation and chemotaxis of vascular smooth muscle cells. (researchmap.jp)
  • Protein kinase C-mediated inhibition of vascular smooth muscle cell proliferation : The isoform that may mediate G1/S inhibition. (researchmap.jp)
  • Is classified as a tyrosine kinase inhibitor. (pharmacology2000.com)
  • Entrectinib is a selective tyrosine kinase inhibitor designed to inhibit the kinase activity of the tropomyosin receptor kinase (TRK) A/B/C and ROS1 proteins. (medscape.com)
  • We have focused on the study of two families of proteins, kinases and histone modifying enzymes (HMEs). (bibalex.org)
  • HME inhibitors affect parasite survival and we explored these enzymes as anti-schistosome targets. (bibalex.org)
  • Topoisomerase inhibitors block cancer cells from dividing and spreading by interfering with enzymes called topoisomerases. (healthline.com)
  • Miotic inhibitors prevent cancer cells from replicating by inhibiting enzymes the cells needs to make certain proteins. (healthline.com)
  • Sorafenib is available in 200-mg tablets for oral administrationand is used in the treatment of RCC and colon cancer.The agent is classified as a multikinase inhibitor because ofits action on numerous kinase enzymes including thePDGF-R, VEGF-R, Kit, and Raf. (guidechem.com)
  • The first group of herbicides inhibits different enzymes in the carotenoid biosynthetic pathway that protects chlorophyll from excessive light and photo-oxidation. (ufl.edu)
  • PARP enzymes are drug targets: Drugs that inhibit PARP activity are already in use today in treatment of certain forms of cancer. (lu.se)
  • OPV to prevent the risk for vaccine-associated paralytic have been reported as potent inhibitors of the replication of picornaviruses in vitro ( 8 ). (cdc.gov)
  • When only 1 or a few of antipicornavirus drugs for their ability to inhibit PV rep- compounds had been described for a particular target (for lication in vitro. (cdc.gov)
  • The investigators moved on to think about evaluating the therapeutic potential of pharmacologically inhibiting Cx32, using 2-aminoethoxy-dipenyl-borate (2APB), a compound previously shown to transiently inhibit Cx32 gap junctions in vitro, and which they confirmed was specific to the Cx32 gap junction protein. (genengnews.com)
  • Anle138b is an oligomeric aggregation inhibitor that inhibits formation of pathological prion protein (PrP Sc ) and α-synuclein aggregates in vitro . (tocris.com)
  • RESULTS: Chitosan inhibited fungal growth in vitro and, when sprayed on the susceptible wheat cultivar Remus 24 hours pre-inoculation with F. graminearum, it significantly reduced the number of infected spikelets at 7, 14 and 21 days post-inoculation. (bvsalud.org)
  • Proteins phosphorylation near the NLS is normally reported to try out a major function in modulating NLS-dependent nuclear import and will facilitate NLS identification with the NLS-binding importin-α subunit (23 27 28 Proteins kinases including PKA regulate the subcellular localization of several protein. (molecularcircuit.com)
  • Phosphorylation of S312 within the dorsal proteins of by PKA elevated its affinity for importin-α and was associated with enhanced nuclear deposition (21). (molecularcircuit.com)
  • Mechanistically, we found that lycopene and sorafenib could additively inhibit the mitogen-activated protein kinase (MAPK) pathways, as shown by the protein phosphorylation of ERK1/2, JNK1/2 and p38 were reduced additively. (frontiersin.org)
  • Protein expression and phosphorylation were determined using western blotting. (medsci.org)
  • Furthermore, sesamin induced p53 phosphorylation at serine-46 and serine-15 and upregulated the levels of PUMA, Bax, and PTEN, while inhibiting AKT phosphorylation at serine-473. (medsci.org)
  • Here, we confirmed that rutin can effectively inhibit biofilm formation in S. xylosus, of which the inhibition mechanism involves its ability to interact with imidazole glycerol phosphate dehydratase (IGPD), a key enzyme in the process of biofilm formation. (figshare.com)
  • The short-term protein trafficking inhibition and long-term effect on plant growth and survival caused by TE1 were fully reversible upon drug washout. (portlandpress.com)
  • Inhibition of autophagy with autophagy inhibitor 3-methyladenine (3-MA) potentiated the secretory function of glibenclamide further. (hindawi.com)
  • Protein kinase C-mediated inhibition of cyclin A expression in human vascular endothelial cells. (researchmap.jp)
  • The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. (tocris.com)
  • Glycogen Synthase Kinase Inhibitors " has 18 results in Products. (rndsystems.com)
  • Kinase inhibitors. (cancercare.org)
  • Kinase inhibitors block these proteins. (cancercare.org)
  • Pyridinyl imidazole compounds block pro-inflammatory cytokine production and are specific p38 kinase inhibitors. (rcsb.org)
  • It is clear that tyrosine kinase inhibitors do not simply inhibit the enzyme, but rather remodel the machine," Superti-Furga aid. (sciencedaily.com)
  • The toxicity data of protein kinase inhibitors in humans is also well established [5]. (who.int)
  • The involvement of p53 in the apoptotic cascade was assessed by a specific inhibitor. (medsci.org)
  • PKC-specific inhibitor or PKCaDN cells abolish this HDE-mediated effect. (cdc.gov)
  • Based on these data and expected tissue concentrations of inhibitors, we predict that a p.o. administered curcuminoid/piperine combination is most likely to inhibit CYP3A, CYP2C9, UGT, and SULT metabolism within the intestinal mucosa. (aspetjournals.org)
  • Glibenclamide is a second-generation SU drug that inhibits SUR1 at nanomolar concentrations and targets K ATP (Sur1-Kir6.2) channels for the treatment of T2DM [ 7 ]. (hindawi.com)
  • GRFT can inhibit human immunodeficiency virus (HIV) infection at picomolar concentrations, surpassing the ability of most anti-HIV agents. (mdpi.com)
  • Previous studies have shown that apratoxins can target a human protein called Sec61, which ensures that certain proteins are properly glycosylated and folded correctly. (sciencedaily.com)
  • Researchers such as Superti-Furga are taking a taking a 'proteomics' approach to understanding precisely how certain proteins that are key drug targets organise themselves in the cell, and how they make complex interactions with often dozens of other proteins. (sciencedaily.com)
  • We implemented a rational design approach to identify potent and selective ACE2 inhibitors. (acs.org)
  • Development of Potent and Selective Phosphinic Peptide Inhibitors of Angiotensin-Converting Enzyme 2. (acs.org)
  • The Hh pathway inhibitors bind to and inhibit Smoothened, a transmembrane protein involved in Hh signal transduction. (rxlist.com)
  • One of these is CSMD1, a large transmembrane protein deleted in number of tumors but also acting as classical complement inhibitor targeting complement convertases. (lu.se)
  • A monoclonal antibody against protein C is employed as the tracer. (lu.se)
  • Both IL-6 and IL-8 release are likewise diminished under these conditions compared with normal HBE, and treatment with TNF-a neutralizing antibody does not further inhibit cytokine release. (cdc.gov)
  • These findings provide insight into the molecular basis for human antibody recognition of paramyxovirus surface proteins and the mechanisms of SOSV neutralization. (cdc.gov)
  • The aim of the present study was to determine whether BAY11‑7082, an inhibitor of the NF‑κB pathway, inhibits the expressions of tissue factor (TF) and plasminogen activator inhibitor‑1 (PAI‑1) in AECⅡ in response to TNF‑α. (spandidos-publications.com)
  • Our previous studies indicated that knockdown of the p65 gene or IKKβ inhibited lipopolysaccharide (LPS)-induced upregulation of TF and PAI-1 in rat AECII ( 15 , 16 ), indicating that the NF-κB signaling pathway participates in coagulation and fibrinolysis regulation in LPS-treated AECⅡ cells. (spandidos-publications.com)
  • How Do Antineoplastic Hedgehog Pathway Inhibitors Work? (rxlist.com)
  • Hh pathway inhibitors are drugs designed to selectively inhibit abnormal signaling in the Hh pathway that plays an essential role in cell growth and differentiation in the developing embryo. (rxlist.com)
  • Hh pathway inhibitors are administered orally once daily with or without food. (rxlist.com)
  • Herein, we showed that glibenclamide promoted insulin release and further activated autophagy through the adenosine 5′-monophosphate (AMP) activated protein kinase (AMPK) pathway in MIN-6 cells. (hindawi.com)
  • Autophagy is a self-protective pathway of cell catabolism that allows cells to degrade misfolded proteins or damaged organelles, providing energy for cells and maintaining their homeostasis [ 10 , 11 ]. (hindawi.com)
  • Autophagy is either positively mediated by the adenosine 5′-monophosphate (AMP) activated protein kinase (AMPK) pathway [ 12 ], or negatively mediated by the mammalian target of rapamycin (mTOR) pathway [ 13 ]. (hindawi.com)
  • Protein and gene expression of apoptotic signaling pathway-related proteins such as caspase-3, cytochrome c, and PARP were determined to provide evidence for the mechanisms of action of Tan IIA in the treatment of psoriasis. (hindawi.com)
  • To identify targets of interest genes were invalidated by RNAi, protein structures were determined and enzymatic assays developed to test new compounds. (bibalex.org)
  • We report enzymatic analyses of wild-type ERK2 and the mutant proteins, and the crystal structure of a pyridinyl imidazole, SB203580, bound to an ERK2 pentamutant, I103L, Q105T, D106H, E109G. (rcsb.org)
  • Enzymatic removal of accumulated extracellular ATP (eATP) or pharmacological blockage of the eATP-P2Y2 purinergic receptor inhibited the ShlA-promoted autophagic response in CHO cells. (bvsalud.org)
  • The enzymatic activity of NA is inhibited by one class of antiviral drugs that are FDA-approved for treatment of in uenza (i.e. (cdc.gov)
  • We want to understand enzymatic mechanisms and improve the fit of PARP inhibitors to their enzymatic pockets. (lu.se)
  • Apoptosis was partially blocked by the caspase-3 inhibitor Ac-DEVD-CHO. (hindawi.com)
  • Here, we explored whether sesamin activates p53, which is widely inhibited in cervical cancer cells, thereby inducing p53-mediated apoptosis. (medsci.org)
  • Autocrine FGF-2 is responsible for the cell density-dependent susceptibility to apoptosis of HUVEC : a role of a calpain inhibitor-sensitive mechanism. (researchmap.jp)
  • Kinase proteins send signals to the cell's control center to help tumor cells grow. (cancercare.org)
  • function of several poorly characterized proteins expressed in tumor cells and which are structurally related to known complement inhibitors but also suggested to act as tumor suppressors. (lu.se)
  • Antiviral agents do not confer ecules that have previously been reported to be inhibitors immunity but could be used prophylactically as well as of picornavirus replication and discuss their potential use, therapeutically. (cdc.gov)
  • Scientists report that apratoxin S4, an anticancer drug candidate that targets a human protein, can interfere with the replication of many viruses, including SARS-CoV-2 and influenza A, offering a possible pan-viral therapy. (sciencedaily.com)
  • Further testing revealed that Apra S4 didn't prevent SARS-CoV-2 from entering cells, but it reduced the amount of viral protein that was produced and transported in cells, especially the spike protein, and it decreased viral RNA replication. (sciencedaily.com)
  • overexpressed SIRT5 can effectively inhibit virus replication. (bvsalud.org)
  • In addition to the HA and NA, the RNA transcription and replication complex (PB2, PB1, PA, NP) also have species-speci c determinants that impact e cient replication in humans and other mammals, particularly polymerase basic protein 2 (PB2). (cdc.gov)
  • An Active Site Inhibitor Induces Conformational Penalties for ACE2 Recognition by the Spike Protein of SARS-CoV-2. (acs.org)
  • Furthermore, the Food & Drug Administration (FDA)-approved mIDH1 inhibitor ivosidenib (AG-120) dramatically inhibited tumor growth in preclinical models of pancreatic cancer, highlighting this approach as a potential therapeutic strategy against wild-type IDH1 cancers. (nature.com)
  • The biotin carboxyl carrier protein is an Acetyl CoA subunit that allows for Acetyl CoA to be catalyzed and converted to malonyl-CoA. (wikipedia.org)
  • Nuclear importation of proteins is really a two-step procedure relating to the dimeric importin-α/β where the α-subunit straight binds the NLS theme and acts as an adaptor for importin-β. (molecularcircuit.com)
  • This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. (nih.gov)
  • A-inhibited guanine nucleotide-exchange protein BIG1 and BIG2 are activators of ADP-ribosylation SNS-314 aspect GTPases which are needed for regulating vesicular visitors among intracellular organelles. (molecularcircuit.com)
  • Small G-proteins, monomeric GTPases, or the RAS (Rat sarcoma) superfamily are a large family of small guanine nucleotide-binding proteins with molecular weights ranging from 20 to 30 kDa [ 1 , 2 ]. (oncotarget.com)
  • Lovastatin, mevastatin and simvastatin inhibited the growth, cell migration and invasion of HT144, M14 and SK-MEL-28 melanoma cells. (biomedcentral.com)
  • However, higher doses of statins may have a role to play in adjuvant therapy by inhibiting growth and invasion of melanoma cells. (biomedcentral.com)
  • Herein, we also demonstrate that compounds developed to target mutant IDH1 can be repurposed as wild-type IDH1 inhibitors, because these drugs surprisingly become potent inhibitors of wtIDH1 in cancer cells under conditions present in tumors: specifically, we found that wtIDH1 is critical for PDAC cell survival under low-glucose conditions, and allosteric IDH inhibitors effectively block wtIDH1 activity under low magnesium. (nature.com)
  • In anti-metastatic studies, lycopene has been found to inhibit the metastasis of human hepatoma SK-Hep-1 cells in athymic nude mice ( 17 ). (frontiersin.org)
  • Moreover, we recently reported that lycopene inhibits the metastasis of human liver adenocarcinoma SK-Hep-1 cells by downregulation of the NADPH oxidase 4 (NOX4) proteins ( 18 ). (frontiersin.org)
  • TNF‑α significantly promoted TF and PAI‑1 expression either at the mRNA or protein level in AECII cells. (spandidos-publications.com)
  • Pulmonary inflammation can damage pulmonary vascular endothelial cells and type-II alveolar epithelial cells (AECII), which further increases the expression of tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) in these cells, thus activating the exogenous coagulation system. (spandidos-publications.com)
  • Inhibiting gap junctions in liver cells could provide a feasible strategy to preventing drug-induced liver injury (DILI), investigators claim. (genengnews.com)
  • Since viruses don't have their own machinery to do this, they hijack the process and force human cells to make functional viral proteins. (sciencedaily.com)
  • Venetoclax (Venclexta) targets the B-cell lymphoma 2 (BCL-2) protein, leading to the death of CLL cells. (cancercare.org)
  • The ank gene that the team found produces a protein that spans the membrane surrounding cells. (stanford.edu)
  • This protein is believed to shuttle pyrophosphate - a strong inhibitor of calcification and bone mineralization - into and out of cells. (stanford.edu)
  • Moreover, after PCAIs treatment, migration, and invasion of A549 cells were inhibited by 72 and 70%, respectively while the levels of vinculin and fascin dropped by 33 and 43%, respectively. (oncotarget.com)
  • Tyrosine kinase ingibitors inhibit multiple steps of the cell cycle of vascular smooth muscle cells. (researchmap.jp)
  • New research into how proteins in human cells interact and 'talk' to each other is leading to a better understanding of how drug molecules work and should result in more effective therapies, according to scientist. (sciencedaily.com)
  • Functional genomics describes the way in which genes and their products, proteins, interact together in complex networks in living cells. (sciencedaily.com)
  • Here we show a quantitative mass spectrometry-based succinylproteomics analysis of SARS-CoV-2 infection in Caco-2 cells, revealing dramatic reshape of succinylation on host and viral proteins. (bvsalud.org)
  • This flags these target proteins for specific activities in our cells. (lu.se)
  • Another is SUSD4, which we recently showed to be bind and inhibit C1 and which we found on T cells infiltrating various solid tumors. (lu.se)
  • Blocking α5ß1 integrin highly inhibited ShlA-dependent autophagy, a result consistent with α5ß1 transactivation by the P2Y2 receptor. (bvsalud.org)
  • They are also known to possess anti-nutritional elements, to inhibit trypsin ( a digestive enzyme), and depress growth in animals. (usda.gov)
  • G-Protein Signaling Protein-17 (RGS17) Is Upregulated and Promotes Tumor Growth and Migration in Human Colorectal Carcinoma. (nih.gov)
  • The RNase Inhibitor is intended for molecular biology applications. (qiagen.com)
  • Sorafenib Tosylate (Bay 43-9006, Nexavar) is a small molecular inhibitor of VEGFR, PDGFR, c-Raf and B-Raf with IC50s of 18 nM, 10 nM, 3 nM and 15 nM, respectively. (guidechem.com)
  • Can we understand the 3-d protein as a molecular machine much better? (sciencedaily.com)
  • They discovered that the protein exists as a complex of some 46 separate components and operates as a giant molecular machine, with each part in close communication with the others. (sciencedaily.com)
  • Collectively, our results uncover a regulatory mechanism of host protein posttranslational modification and cellular pathways mediated by SARS-CoV-2, which may become antiviral drug targets against COVID-19. (bvsalud.org)
  • Ritonavir is a potent inhibitor of CYP3A4- and CYP2D6- mediated drug metabolism. (who.int)
  • Complete plasminogen activator inhibitor 1 deficiency (complete PAI-1 deficiency) is a disorder that causes abnormal bleeding. (medlineplus.gov)
  • This gene provides instructions for making a protein called plasminogen activator inhibitor 1 (PAI-1). (medlineplus.gov)
  • The PAI-1 protein blocks (inhibits) the action of other proteins called plasminogen activators. (medlineplus.gov)
  • By inhibiting plasminogen activators, the PAI-1 protein helps ensure that clots remain intact until they are no longer needed to stop bleeding. (medlineplus.gov)
  • Absence of functional PAI-1 protein allows plasminogen activators to dissolve blood clots prematurely, resulting in the abnormal bleeding associated with this disorder. (medlineplus.gov)
  • Human plasminogen activator inhibitor-1 (PAI-1) deficiency: characterization of a large kindred with a null mutation in the PAI-1 gene. (medlineplus.gov)
  • Flevaris P, Vaughan D. The Role of Plasminogen Activator Inhibitor Type-1 in Fibrosis. (medlineplus.gov)
  • We found succinylation inhibitors possess significant antiviral effects. (bvsalud.org)
  • The protein content was determined by BCA assay. (abcam.com)
  • A trypsin inhibitor assay reveals that Ara h 3 allergen protein has trypsin inhibitory activity. (usda.gov)
  • Effect of an Inhibitor on the ACE2-Receptor-Binding Domain of SARS-CoV-2. (acs.org)
  • To try to identify these proteins the research team has developed a technique to test which proteins in a cell bind specifically to foreign nucleic acids. (sciencedaily.com)
  • They have also observed which genes in the cell are switched on or 'up regulated' when foreign genetic material is present - and whether the proteins that are encoded by these genes are the same as those that bind to the material. (sciencedaily.com)
  • Overall, the present study demonstrates that lycopene in combination with sorafenib additively inhibits the lung metastasis of tumor, indicating lycopene has potential as an adjuvant for sorafenib in cancer treatment. (frontiersin.org)
  • Therefore, inhibiting cancer metastasis can be one of the strategies to effectively treat lung cancer. (frontiersin.org)
  • Screen Targeting Lung and Prostate Cancer Oncogene Identifies Novel Inhibitors of RGS17 and Problematic Chemical Substructures. (nih.gov)
  • The National Institute for Health and Care Excellence (NICE) is approving entrectinib ( Rozlytrek , Roche) as a treatment option for ROS1-positive, advanced non-small cell lung cancer (NSCLC) not previously treated with ROS1 inhibitors. (medscape.com)
  • Griffithsin (GRFT), an algae-derived lectin, is one of the most potent viral entry inhibitors discovered to date. (mdpi.com)
  • Each of these four structural classes has not been reported as FIH1 inhibitor, and therefore can be considered for further development by structure-activity relationship or denovo design methods. (nih.gov)
  • At the protein level, it is demonstrated that peanut allergen Ara h 3 also has trypsin inhibitory activity. (usda.gov)
  • As a consequence there is significant effort towards developing drug that inhibit HME activity. (bibalex.org)
  • Irreversibly inhibits kinase activity. (pharmacology2000.com)
  • The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. (nih.gov)
  • High-resolution structure of RGS17 suggests a role for Ca(2+) in promoting the GTPase-activating protein activity by RZ subfamily members. (nih.gov)
  • The compound is an inhibitor of mammalian protein kinase and has been applied topically for the treatment of skin metastasis showing good local tolerability [5]. (who.int)
  • Ribavirin was included as a ref- never been evaluated for their ability to block PV replica- erence standard, since it was regarded as a broad-spectrum tion and 2) the selected compounds have never been com- inhibitor of positive-strand RNA viruses. (cdc.gov)
  • The potential to inhibit other viruses as well as parasites has also been demonstrated. (mdpi.com)
  • Metformin, a known inhibitor of mitochondrial OXPHOS, has been indicated to reduce NSCLC morbidity and mortality in clinical studies. (spandidos-publications.com)
  • To this end, picomolar inhibitors of ACE2 were designed and synthesized. (acs.org)
  • The unique aspect of this report lies in the example, with enviroxime, the sole protein 3A-targeting fact that 1) certain drugs (e.g., rupintrivir) were specifi cally drug reported so far), the impact in the clinical setting was developed to treat rhinovirus and other infections and have considered less important. (cdc.gov)
  • Their experiments demonstrated that treating mice with a small molecule inhibitor that specifically target the hepatic gap junction protein connexion 32 (Cx32) provides significant protection against liver damage and death resulting from subsequent or simultaneous challenge with known hepatotoxic drugs such as acetaminophen. (genengnews.com)
  • They thus postulated that liver-specific gap junction inhibitors might act to protect the liver if they could be co-formulated with hepatotoxic drugs. (genengnews.com)
  • Drugs that fall in the subgroup called topoisomerase II inhibitors can increase your risk of developing a second cancer. (healthline.com)
  • Therapy should involve combinations of drugs-two nucleoside-analogue reverse-transcriptase inhibitors combined with either a protease inhibitor (PI) or a non-nucleoside-analogue reverse-transcriptase inhibitor. (medscape.com)
  • We hope to create inhibitors also for their activities, with the aim of creating new anti-infective drugs. (lu.se)
  • The biosynthesis performed by the BCCP protein allows for the transfer of CO2 within active sites of the cell. (wikipedia.org)
  • The NLS within a proteins destined for nuclear localization includes a unipartite or even a bipartite simple amino acidity cluster such as for example KKKRK in SV40 huge tumor antigen (25) or RKR-Xn-RKRKR in T cell proteins tyrosine phosphatase (26) that is acknowledged by an importin-α/β heterodimer. (molecularcircuit.com)
  • It is thought that proteins in the human cell can tell if a sequence of nucleic acids is from an invading organism. (sciencedaily.com)
  • PKCa and PKCe activities were inhibited using isoform-specific pharmacologic inhibitors and genetically modified dominant-negative (DN) expressing cell lines. (cdc.gov)
  • However, most studies of this protein have been conducted on the E. coli form of the enzyme, where all three components exist as three separate complexes rather than being united on one polypeptide chain. (wikipedia.org)
  • Structure-Guided Chemical Optimization of Bicyclic Peptide (Bicycle) Inhibitors of Angiotensin-Converting Enzyme 2. (acs.org)
  • RNase Inhibitor is an acidic, 52 kDa protein that is a potent non-competitive inhibitor of pancreatic-type ribonucleases such as RNase A, RNase B and RNase C. The enzyme is provided as a fusion of the porcine RNase Inhibitor gene with a proprietary 22.5 kDa protein tag. (qiagen.com)
  • The enzyme specifically inhibits RNases A, B and C. It inhibits RNases by binding noncovalently in a 1:1 ratio with high affinity. (qiagen.com)
  • Dilutions of the enzyme were made in 1X RNase Inhibitor Reaction Buffer and added to 1000 μL reactions containing 1mM cytidine 2',3'-cyclic monophosphate, 1μg RNase A in a 1X reaction buffer containing 100mM Tris-Acetate, 1mM EDTA, pH 6.5. (qiagen.com)
  • Protein concentration was determined using a 2.0 μL sample of enzyme analyzed at OD 280 using a nanodrop ND-1000 spectrophotometer standardized using a 2.0 mg/mL BSA sample and blanked with product storage solution. (qiagen.com)
  • Topoisomerase inhibitors can be divided into topoisomerase I and topoisomerase II depending on which enzyme they affect. (healthline.com)
  • The researchers say more studies are needed, but these results suggest that Apra S4 and other inhibitors of the human Sec61 protein are broadly acting antivirals that could help in the fight against future pandemics. (sciencedaily.com)
  • The researchers found the human version of the protein using the mouse ank protein as a guide. (stanford.edu)
  • Levels of p‑IκBα, p65 and p‑p65 in the cytoplasm also decreased, and translocation of p65 from cytoplasm into the nucleus was inhibited by BAY11‑7082 pretreatment. (spandidos-publications.com)
  • Polyisoprenylated cysteinyl amide inhibitors (PCAIs) are agents that mimic the essential posttranslational modifications of G-proteins. (oncotarget.com)
  • The interactions with the amino acid residues responsible for the stabilizations of the inhibitors in the active site are addressed in detail. (nih.gov)
  • In conclusion, putative peanut trypsin inhibitors have been isolated and reveal high similiarity at the nucleotide and amino acid level to peanut allergen Ara h 3 and Ara h 4. (usda.gov)
  • This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. (nih.gov)