Chaperonin 60 (Cpn60) protein has been known to control the folding of several chloroplast protein polypeptides. (isaaa.org)
In chloroplasts, Cpn60 has two subunit types-Cpn60α and Cpn60β and the rice genome encodes three α and three β plastid chaperonin subunits. (isaaa.org)
Around two thirds of genome sequenced bacteria encode one chaperonin 60 protein with the other third encoding between two and eight chaperonin 60 paralogues. (sciencecentral.in)
Group II Heat Shock Protein 60 chaperonins which catalyses the cytoplasmic ATP-dependent folding of newly synthesized proteins. (yeastgenome.org)
Stable cotransformants were created in which NDPK expression was knocked down by antisense inhibition, and AMPK activity was chronically elevated either by constitutive overexpression of its active, catalytic domain (AMPK alpha T) or as a result of mitochondrial dysfunction (created by antisense inhibition of expression of a mitochondrial chaperone protein, chaperonin 60). (dundee.ac.uk)
Subsequent to GroEL binding, there is a transient expansion of the protein upon binding of ATP to GroEL, followed by compaction when GroES triggers the encapsulation of the protein inside the chaperonin cage. (uni-muenchen.de)
In summary, this study revealed significant novel aspects of the GroEL folding mechanism and provided insights into the basis of rate acceleration of the substrate protein by the chaperonin. (uni-muenchen.de)
This work may thus contribute to advance our fundamental knowledge of the chaperonin system and the basic mechanism of protein folding. (uni-muenchen.de)
Interestingly, an increase in expression of the mitochondrial stress protein chaperonin 60 was also observed, confirming a marked effect of C5a on mitochondrial functions. (edu.au)
Here, we show that heat-shock protein 60 (hsp60) is required for blastema formation and maintenance. (elsevierpure.com)
Heat shock protein (HSP) 60 is a mitochondrial and cytosolic protein. (houstonmethodist.org)
Induction of heat shock protein 60 expression in human monocytic cell lines infected with Mycobacterium leprae. (ox.ac.uk)
In this study, an immunochromatographic antigen detection test kit (ICT AgTK) that targets the highly conserved O. tsutsugamushi 60 kDa GroEL chaperonin (heat shock protein 60) was developed. (jsce-ip.com)
GroES2
This study has demonstrated that expressed Hsp60- Hsp10 was able to carry out all essential in vivo functions of GroEL and its co-chaperonin, GroES. (enzolifesciences.com)
GroEL-GroES, the Hsp-60 of E.coli, is one of the best studied chaperone systems. (uni-muenchen.de)
HSP601
also called mitochondrial HSP60 chaperonopathy or MitCHAP-60 disease. (abcam.cn)
In the absence of GroEL, the enzyme became completely inactive in about 45-60 hours when kept at 25 degrees C, while in the presence of an equimolar amount of GroEL, the enzyme remained approximately 80% active even after 75 hours. (birmingham.ac.uk)
Proteins1
Results: Retrospective evaluation of 819 patients with anti-retinal AAbs showed that 29% patients had AAbs targeted proteins between 60-70-kDa. (elsevierpure.com)
Gene5
To that effect, partial chaperonin 60 gene sequences were determined for the 35 serotype reference strains of S. suis. (canada.ca)
The chaperonin 60 gene phylogenetic tree was similar to the previously published tree based on 16S rRNA sequences, and it was also observed that strains with identical chaperonin 60 gene sequences tended to have identical 16S rRNA sequences. (canada.ca)
The chaperonin 60 gene sequences provided a higher level of discrimination between serotypes than the 16S RNA sequences provided and could form the basis for a diagnostic protocol. (canada.ca)
This gene encodes a member of the chaperonin family. (thermofisher.com)
Greek students were pathogen: specific identification by the chaperonin 60 gene identification method. (cdc.gov)
Chaperones1
As a nascent chain leaves the ribosome, it is captured first by the upstream chaperones and then possibly transferred to the downstream chaperonins. (uni-muenchen.de)
Cytosolic1
The crystal structure of yeast CCT reveals intrinsic asymmetry of eukaryotic cytosolic chaperonins. (yeastgenome.org)
Molecular weight2
Detects a band of approximately 60 kDa (predicted molecular weight: 60 kDa). (abcam.cn)
The goal was to identify frequently targeted retinal autoantigens within the 60-70-kDa molecular weight range. (elsevierpure.com)
Proteins2
The reported inventory of interactors can form the basis for interrogating which proteins are especially dependent on the chaperonin. (rug.nl)
This chaperonin complex facilitates folding of proteins to their native state in the mitochondrial matrix space. (scientificlabs.co.uk)
Bacterial chaperonin1
The bacterial chaperonin, GroEL, forms two large rings arranged back-to-back and each ring consists of heptameric 57-kDa subunits. (scirp.org)
GroEL-GroES2
The crystal structure of the asymmetric GroEL-GroES-(ADP)7 chaperonin complex. (nih.gov)
Application of fluorescence resonance energy transfer to the GroEL-GroES chaperonin reaction. (tamu.edu)
Heat1
The relaxed state of DNA topology was maintained for 60 min after heat shock. (elsevierpure.com)
Peptides3
We have also tested a number of synthetic Cpn 60 peptides for cytokine-inducing activity. (vittori-lab.com)
TABLE 1 Chaperonin 60 peptides used in this study Cpn 60.184C95Cpn 60.2195C219amoebocyte lysate (LAL) test. (vittori-lab.com)
PPBMC (2 106 cells/ml) were exposed to a range of concentrations of recombinant chaperonins or peptides. (vittori-lab.com)
Transient1
We suggest that transient ring separation is an integral part of the chaperonin mechanism. (bvsalud.org)
Reaction1
GroEL Ring Separation and Exchange in the Chaperonin Reaction. (bvsalud.org)
Range2
Endogenous PARG associated with the mitochondrial fraction migrated in the range of 60 kDa. (nih.gov)
20,000 contemporary and historical (up to 60 years of preservation) tick samples representing a wide range of tick biodiversity across diverse geographic regions in China. (biomedcentral.com)
Years1
Symptoms of HSP may begin at any age, from infancy to older than 60 years. (wikipedia.org)