Knee chondrocytes. Medical search. Frequent questions

Autologous Chondrocyte Implantation (ACI) is an advanced surgical procedure used to treat larger articular cartilage defects in joints. (thekneesurgeon.com)
Autologous chondrocyte implantation (ACI, ATC code M09AX02 (WHO)) is a biomedical treatment that repairs damages in articular cartilage. (wikipedia.org)
During the implantation, chondrocytes are applied on the damaged area in combination with a membrane (tibial periosteum or biomembrane) or pre-seeded in a scaffold matrix. (wikipedia.org)
PURPOSE: Matrix-induced autologous chondrocyte implantation (MACI) has been in use for chondral defect repair since 2000, but to date, only little is known about its histological outcomes in the repair of knee cartilage defects. (univpm.it)
On February 17, 2022, the Federal Joint Committee (G-BA) has decided to include the method of matrix-associated autologous chondrocyte implantation (M-ACI) on the knee joint in the case of symptomatic cartilage damage in the lists of reimbursed procedures in the hospital and ambulatory settings. (mtrconsult.com)
We treated rheumatoid arthritis of the right knee in a 35-year-old female Korean patient using autologous chondrocyte implantation. (biomedcentral.com)
Autologous chondrocyte implantation appears to be effective for treating rheumatoid arthritis of the knee. (biomedcentral.com)
This report presents the case of a 35-year-old woman with a painful, arthritic knee and her treatment using autologous chondrocyte implantation (ACI). (biomedcentral.com)
Autologous chondrocyte implantation was performed 6 weeks after her initial surgery when 48 × 10 6 chondrocytes had been cultured. (biomedcentral.com)
Autologous chondrocyte implantation versus microfracture for knee cartilage injury: a prospective randomized trial, with 2-year follow-up. (vub.be)
Describe the effect of failed marrow stimulation (MST) surgery on subsequent autologous chondrocyte implantation (ACI) in the knee joint. (sportsmed.org)
Currently, the only FDA-approved cell-based therapy for cartilage defects involves autologous chondrocyte implantation: chondrocytes harvested from low-contact areas are expanded in vitro and then re-injected directly into the damaged site 1 . (nature.com)
Research on the treatment of cartilage injuries has lead to various clinical procedures, one of them being Matrix Induced Autologous Chondrocyte Implantation (MACI). (tudelft.nl)
This procedure to grow new cartilage, also known as matrix-induced autologous chondrocyte implantation (MACI) , is a two-step process. (healthline.com)
More specifically, she is looking for ways to improve outcomes for autologous chondrocyte implantation (ACI) procedures used to repair damaged cartilage and prevent premature OA of the knee. (oref.org)
The group works closely with the Stem Cell group led by dr Brinchmann and has optimized chondrocyte and stem cell cultivation while at the same time developing surgical techniques for implantation. (sportsoracle.com)

Current operative methods include fixation of the lesion, drilling of the site of the defect with removal of loose bodies, and autologous osteochondral mosaicplasty and autologous chondrocyte transplantation. (medscape.com)
Field of orthopedics: Exercise therapy of autologous chondrocyte transplantation for joint cartilage defect and knee ligament injury. (hiroshima-u.ac.jp)
In 1997, the cartilage group performed the first knee joint chondrocyte transplantation in Norway. (sportsoracle.com)
Patients benefitting from the regeneration of their cartilage with autologous cartilage transplantation, can enjoy something that no generation before them was able to experience: enhanced agility, flexibility and overall knee performance. (joint-surgeon.com)

MACI is usually an outpatient procedure, though you can expect to wear a knee brace for about 6 weeks while your knee regains strength and stability. (healthline.com)
MACI uses the patient's own cells to treat cartilage defects in the knee. (floridaortho.com)
MACI helps many patients avoid early partial and total joint replacements by restoring the cartilage surface of their knee before the problem progresses to a much worse situation. (floridaortho.com)

The role of endogenous SOCS-3 was examined in cartilage explants and chondrocytes from mice with conditional deletion of Socs3 driven by the Col2a1 promoter in vitro (Socs3(Δ/Δcol2) ) and from mice during CD4+ T cell-dependent inflammatory monarthritis. (nih.gov)
In in vitro experiments, IL‑1β‑treated chondrocytes were infected with Lenti‑lncRNA GAS5. (spandidos-publications.com)
The results indicated that ABPS delayed the degradation of the ECM by chondrocytes in addition to reducing lncRNA GAS5 expression both in vivo and in vitro . (spandidos-publications.com)
Xu XX, Zhang XH, Diao Y and Huang YX: Achyranthes bidentate saponins protect rat articular chondrocytes against interleukin-1β-induced inflammation and apoptosis in vitro. (spandidos-publications.com)
Korpershoek JV, Rikkers M, Wallis FSA, Dijkstra K, Te Raa M, de Knijff P, Saris DBF , Vonk LA. Mitochondrial Transport from Mesenchymal Stromal Cells to Chondrocytes Increases DNA Content and Proteoglycan Deposition In Vitro in 3D Cultures. (mayo.edu)

To examine the impact of the gp130 cytokine family on murine articular cartilage and to explore a potential regulatory role of suppressor of cytokine signaling 3 (SOCS-3) in murine chondrocytes. (nih.gov)
The M-ACI will only be reimbursed in patients with a symptomatic articular cartilage defect of the knee joint of severity III or IV according to the classification of the International Cartilage Repair Society. (mtrconsult.com)
Nasal chondrocyte-based engineered autologous cartilage tissue for repair of articular cartilage defects: an observational. (thenakedscientists.com)
Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes. (ca.gov)
Articular cartilage helps the knee move freely. (healthline.com)
Successful Fixation of Traumatic Articular Cartilage-Only Fragments in the Juvenile and Adolescent Knee: A Case Series. (mayo.edu)
The particular nature of hyaline articular cartilage, including the avascular nature and the low number of chondrocytes and stem cells in the surrounding cartilage lesions, results in limited potential to reconstruct osteochondral defects through a self-healing process ( 1 , 2 ). (spandidos-publications.com)
In Paper III, we developed and validated a robust and specific ELISA assay measuring a MMP-1 and MMP-13 cleaved type II collagen fragment (T2CM) that we identified in the study for Paper I. It was elevated in response to pro-inflammatory cytokine treatment of bovine articular cartilage, and in osteoarthritis patients referred for a total knee joint replacement surgery compared to patients with moderate or severe disease. (lu.se)

Therefore, the present study aimed to investigate the potential mechanism of ABPS by focusing on its effects on the regulation of chondrocyte extracellular matrix (ECM) homeostasis, with particular emphasis on lncRNA GAS5. (spandidos-publications.com)
Sun X, Zhang J, Li Y, Ren W and Wang L: Etomidate ameliorated advanced glycation end-products (AGEs)-induced reduction of extracellular matrix genes expression in chondrocytes. (spandidos-publications.com)
It is composed of chondrocytes located in lacunae and in the extracellular matrix. (springer.com)
The inflammatory environment is correlated with extracellular matrix (ECM) degradation and chondrocyte hypertrophy in the development of osteoarthritis (OA). (oncotarget.com)
It is 95% water and extracellular cartilage matrix and only 5% chondrocytes. (msdmanuals.com)

In wild-type (WT) mouse chondrocytes, baseline receptor expression levels and gp130 cytokine-induced JAK/STAT signaling were determined by flow cytometry, and expression of SOCS-3 was assessed by quantitative polymerase chain reaction. (nih.gov)
Moreover, wogonoside promoted the expression of anabolic factors Sox-9, type two collagen and aggrecan while inhibiting the expression of catabolic factors such as matrix metalloproteinases (MMPs) and thrombospondin motifs 5 (ADAMTS-5) in mouse chondrocytes. (oncotarget.com)
In conclusion, our stduy demonstrates that wogonoside attenuates IL-1β-induced ECM degradation and hypertrophy in mouse chondrocytes via suppressing the activation of NF-κB/HIF-2α by the PI3K/AKT pathway. (oncotarget.com)

Mesenchymal stem cells (MSCs) can differentiate into chondrocytes, while mechanical loading has been proposed as alternative strategy to induce chondrogenesis excluding the use of exogenous factors. (nature.com)
This study used etoposide, to induce DNA damage-related senescence or chronic exposure to IL-1β to entail inflammation-related senescence in human OA chondrocytes. (aging-us.com)
Chronic exposure to IL-1β induces only partial expression of senescence markers and does not allow us to conclude on its ability to induce senescence in chondrocytes. (aging-us.com)
Numerous studies have shown that chondrocytes also have tissue-specific antigens, which induce the introduction of antibodies in patients with cartilage grafts, as well as those with osteoarthritis (OA) [ 1 ]. (springer.com)
In this paper, we will discuss whether PGE 2 can induce activation of ERS and GSK-3 β in chondrocytes and the protection role of TMF. (hindawi.com)
Intracellular contents released by accumulated ACs further triggered an immune response and lead to a release of inflammatory factors, such as TNF-α, IL-1β, and IL-6, which induce chondrocyte homeostasis dysfunction in obese OA patients. (elifesciences.org)

Endoplasmic reticulum stress (ERS) has been demonstrated to exhibit a critical role in osteoarthritic chondrocytes. (hindawi.com)
[ 15 ] Such injections have also been shown to be helpful in patient with knees that are both rheumatoid arthritic and osteoarthritic. (medscape.com)

The harvested cartilage tissue is sent to a laboratory, where the cartilage cells (chondrocytes) are isolated and cultured. (thekneesurgeon.com)
Moreover, the relative expression level of lncRNA GAS5 in cartilage tissue and chondrocytes was detected using reverse transcription‑quantitative PCR. (spandidos-publications.com)
Western blot analysis was used to detect protein expression levels of MMP‑9, MMP‑13, TIMP‑1, TIMP‑3 and type II collagen in cartilage tissue and chondrocytes. (spandidos-publications.com)
Furthermore, silencing of lncRNA GAS5 expression in IL‑1β‑treated chondrocytes downregulated the protein expression of MMP-9 and MMP-13 whilst upregulating the expression of tissue inhibitor matrix metalloproteinase (TIMP)-1, TIMP-3 and type II collagen. (spandidos-publications.com)
Adipose tissue-derived mesenchymal stem cells (AD-MSC) show great potential to treat inflammatory and degradative processes in OA and have demonstrated paracrine effects in chondrocytes. (karger.com)
Intraarticular injection of ropivacaine has been shown to provide good postoperative analgesia in patients undergoing knee surgery and to alleviate tissue inflammation by reducing the production of substance P (is an undecapeptide, member of the tachykinin neuropeptide family) [ 5 ]. (ijpsonline.com)
The tissue damage stimulates chondrocytes to attempt repair, which increases production of proteoglycans and collagen. (msdmanuals.com)

ACI provides pain relief while at the same time slowing down the progression or considerably delaying partial or total joint replacement (knee replacement) surgery. (wikipedia.org)
The patient then undergoes a second treatment, in which the chondrocytes are applied on the damaged area during an open-knee surgery (also called arthrotomy). (wikipedia.org)
Some long-standing approaches include surgery to repair torn cartilage or knee joint replacement. (healthline.com)
If the loss of knee cartilage and symptoms are minor, you may be able to put off surgery or other interventions through physical therapy . (healthline.com)
The cost of microfracture surgery is around $4,000 , making it less expensive than some other knee repair procedures. (healthline.com)
Also called a mosaicplasty, this surgery uses healthy cartilage from elsewhere in the knee to replace cartilage that has significantly worn away. (healthline.com)
Our surgeons perform over 3,000 hip and knee replacements a year including same day surgery. (floridaortho.com)
Florida Orthopaedic Institute has expert surgeons who are board certified by the American Board of Orthopaedic Surgery and fellowship trained in adult knee reconstruction. (floridaortho.com)
With ROSA Knee, your surgeon creates a plan for your surgery, based on your unique anatomy. (floridaortho.com)
The ROSA Knee does not operate on its own, as the surgeon is in the operating room the entire time making decisions throughout the surgery. (floridaortho.com)
This helps to personalize your surgery, based on your knee. (floridaortho.com)
The NAVIO® Surgery System allows Florida Orthopaedic surgeons to perform precise and accurate partial knee replacements. (floridaortho.com)
This system, developed by medical device maker Smith & Nephew, involves only a simple x-ray rather than a time-consuming and radiation-intensive CT scan, before the surgeon uses advanced planning software to tailor the surgery to the patient's anatomy, align the implant, and balance the knee. (floridaortho.com)
Using the NAVIO assisted partial knee replacement, patients typically walk and climb stairs the same day of surgery. (floridaortho.com)
Biomaterials for meniscus and cartilage in knee surgery: state of the art. (mayo.edu)
Engebretsen is involved with three research groups: Knee ligaments together with May Arna Risberg in Oslo and Robert LaPrade in Vail, Colorado, the Oslo Sports Trauma Research Center co-chaired with professor Roald Bahr and emphasizing prevention of injuries and diseases in sports, and the Oslo Cartilage Group, which encompasses research from the cell to rehab after surgery, involving molecular biologists, pathologists, radiologists, physiotherapists and orthopedic surgeons. (sportsoracle.com)
Dr Engebretsen is or has been a board member of many other societies including, but not limited to, the Norwegian Society of Sports Medicine, the Scandinavian Foundation of Medicine & Science in Sports, the International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine (ISAKOS), the Orthopedic Research Society and International Knee Society. (sportsoracle.com)
He is the Editor of the British Journal of Sports Medicine (IPHP edition), Associate Editor of Journal of Bone and Joint (the most prestigious journal in orthopedics) and on the editorial board of American Journal of Sports Medicine, Scandinavian Journal of Medicine and Science in Sports, Knee Surgery, Arthroscopy and Sports Traumatology, and The Knee and is a regular reviewer for all the major orthopedic and sports traumatology journals. (sportsoracle.com)
The surgery is mostly performed on people with meniscus and ACL injuries in the knee joint. (lu.se)

A recent study from Germany, published in the November 2008 issue of the American Journal of Sports Medicine, analyzed 349 ACI procedures of the knee joint. (wikipedia.org)
Also, the method of M-ACI on the knee joint will be included in Annex I of the abovementioned Directive. (mtrconsult.com)
Because the knee one of the most actively used joints in the human body, pain in this joint isn't an uncommon complaint. (healthline.com)
A 35-year-old Korean woman with RA was admitted for right knee joint pain. (biomedcentral.com)
Twelve months postoperatively, the lateral joint space of the knee had become wider (Figure 1d ), and the patient could walk and otherwise function without pain. (biomedcentral.com)
Describe the appropriate indications and contraindications for microfracture of focal chondral defects of the knee joint. (sportsmed.org)
Under local anaesthetic, and using standard knee operating techniques, the patches were implanted into the damaged knee joint, "butter side down" so that the new cells were in contact with the underlying bone at the injury site. (thenakedscientists.com)
Damage to the meniscus occurs due to a combination of excessive torque and compression forces on the knee joint. (tudelft.nl)
The main goal of physical therapy is to improve the strength and flexibility of the muscles around the knee joint to ease the burden on the joint itself. (healthline.com)
In addition, a 2005 study found that 1 pound of weight loss removes 4 pounds of joint stress in people with knee osteoarthritis. (healthline.com)
So if a person loses 5 pounds, that's the equivalent of removing 20 pounds of stress off the knee joint. (healthline.com)
In this procedure, tiny holes are drilled in one or more bones in the knee joint to stimulate greater blood flow and the release of cells that form new cartilage. (healthline.com)
The knee is the body's largest joint. (floridaortho.com)
The knee is a "hinge" joint, allowing the leg to bend in only one direction. (floridaortho.com)
To explore the impact of intraarticular injection of ropivacaine into knee joint on the postoperative analgesia and local inflammatory response after patellar fracture fixation is the main objective. (ijpsonline.com)
After operation, both groups were given patient controlled intravenous analgesia for 48 h and the observation group was also administrated with intraarticular injection of ropivacaine into knee joint, while the control group with the same dosage of normal saline. (ijpsonline.com)
The application of intraarticular injection of ropivacaine into knee joint can effectively relieve the pain patients suffer after patellar fracture fixation and alleviate local inflammatory response without significant adverse reactions. (ijpsonline.com)
To maximize the recovery of knee joint function, it is clinically recommended to receive surgical internal fixation treatment to achieve anatomic reduction. (ijpsonline.com)
In order to further investigate the effect of intraarticular injection of ropivacaine into knee joint in postoperative analgesia of patellar fracture fixation, this study was conducted to compare the effect of intraarticular injection of ropivacaine into knee joint and patient controlled intravenous analgesia (PCIA) in postoperative analgesia of patellar fracture patients who were admitted in our hospital in recent years. (ijpsonline.com)
The cartilage was obtained from the knee joint of four-week-old rats under sterile conditions. (hindawi.com)
A meta-analysis of joint replacements in obese patients in 2010 has shown that the risk of knee OA was five times higher in obese patients than in healthy individuals ( Clement and Deehan, 2020 ). (elifesciences.org)
[ 7 ] A clinical presentation consistent with osteoarthritis includes knee joint pain (typically symmetric bilaterally) and morning joint stiffness that resolves within 30-60 minutes and worsens with weightbearing. (medscape.com)
Intra-articular injection of botulinum neurotoxin A into the knee joint may provide therapeutic pain relief in patients with advanced knee osteoarthritis. (medscape.com)
According to a preliminary study, pain and stiffness significantly improved and lasted about 3 months following intra-articular knee joint botulinum toxin A injection, though physical function did not significantly improve based on the Western Ontario McMaster Universities Osteoarthritis Index. (medscape.com)

Knees contain two types of cartilage: articular and meniscus. (healthline.com)

Knee arthroscopy was then performed to harvest 200g of autologous cartilage from the intercondylar notch (Figure 1b,c ). (biomedcentral.com)

A piece of cartilage is removed, cultivated in a lab, and put back into the knee, where it grows into healthy replacement cartilage. (healthline.com)
Many times when a patient comes in to see their doctor with knee pain , the cause is a piece of cartilage that has come loose or worn down. (floridaortho.com)

Within the gp130 cytokine family, OSM is a potent stimulus of chondrocyte responses, while IL-6 probably signals via trans-signaling. (nih.gov)
The gp130 cytokine-driven production of RANKL in chondrocytes may link chondrocyte activation and bone remodeling during inflammatory arthritis. (nih.gov)
Finally, the inflammatory cytokine PGE 2 can activate ERS signaling and promote chondrocytes apoptosis, which might be associated with upregulation of GSK-3 β . (hindawi.com)
We also found that interleukin-17A can upregulate other pro-inflammatory cytokine release from chondrocytes and a release of both proteins and protein metabolism fragments into conditioned media. (lu.se)

Sharma L: Osteoarthritis of the Knee. (spandidos-publications.com)
An observational retrospective study, 1-year follow-up, on 104 patients with OA (nodular osteoarthritis of the hand, erosive osteoarthritis of the hand, EOA, osteoarthritis of the knee or hip) who were treated with GC or glucosamine, chondroitin sulfate and collagen type II (GCC). (springer.com)

Internal Fixation of Unstable Osteochondritis Dissecans of the Knee: Long-term Outcomes in Skeletally Immature and Mature Patients. (mayo.edu)

Although pharmacologic treatment remains the mainstay for treating rheumatoid arthritis, there is an increasing need for a method that biologically regenerates arthritic knee lesions as patient longevity continually increases. (biomedcentral.com)
Intra-articular knee injections of homologous platelet-rich plasma (PRP) have been shown to improve function and quality of life in patients with degenerative lesions of the knee cartilage and osteoarthritis at 6 months post injection. (medscape.com)

Dr. Coleman wanted to find a way to prevent cartilage from mineralizing into bone and wondered if chondrocytes could be reprogrammed so that they resisted the urge to transition from the cartilage to the bone phenotype. (oref.org)

Treatment of unstable knee osteochondritis dissecans in the young adult: results and limitations of surgical strategies-The advantages of allografts to address an osteochondral challenge / G. Filardo, L. Andriolo, F. Soler, M. Berruto, P. Ferrua, P. Verdonk, F. Rongieras, D.C. Crawford. (unimi.it)

Whether 5,7,3′,4′-tetramethoxyflavone (TMF) plays the chondroprotective role in inhibition of PGE 2 -induced chondrocytes apoptosis associating with ERS has not been reported. (hindawi.com)
By treatment with PGE 2 , the chondrocytes apoptosis was significantly increased, the proapoptotic CHOP and JNK were upregulated, the prosurvival GRP78 and XBP1 were downregulated, and GSK-3 β was also upregulated. (hindawi.com)

Intra-articular hyaluronic acid injection into a rheumatoid arthritic knee can modulate inflammatory changes, though the exact mechanism or mechanisms are unclear. (medscape.com)

Treatment of Socs3(Δ/Δcol2) mouse cartilage explants and chondrocytes with gp130 cytokines prolonged JAK/STAT signaling, enhanced cartilage degradation, increased the expression of Adamts4, Adamts5, and RANKL, and elevated the production of IL-6, granulocyte colony-stimulating factor, CXCL1, and CCL2. (nih.gov)

However, if non-surgical options won't accomplish complete success for your needs, our knee & leg surgeons are trained on (and at times assist in the development of) the latest surgical procedures and advancements, including cartilage, restoration, and total knee replacement . (floridaortho.com)
The ROSA® Knee is a robotic surgical assistant for total knee replacement. (floridaortho.com)
By making partial knee replacements a more accessible option through improved precision, patients receive a surgical procedure that is generally associated with smaller incisions, less scarring, and quicker recovery when compared to the total knee replacement alternative. (floridaortho.com)
Therefore, the treatment algorithm in unstable knee OCD of the young adult foresees surgical options to restore the articular surface. (unimi.it)

Cartilage defects in the knee lead to limitations in the daily life of a large group of people in the worldwide population. (tudelft.nl)

Knee chondroplasty. (healthline.com)

Cartilage is the slippery "anatomical Teflon" secreted by specialised cells called chondrocytes. (thenakedscientists.com)
Our findings confirm the safety and feasibility of cartilage grafts engineered from nasal cells to repair damaged knee cartilage. (thenakedscientists.com)
In knee osteoarthritis, hyaluronic acid can ameliorate the activities of proinflammatory mediators and pain-producing neuropeptides released by activated synovial cells. (medscape.com)
Chondrocytes have the longest cell cycle in the body (similar to central nervous system and muscle cells). (msdmanuals.com)
Inflammatory mediators trigger an inflammatory cycle that further stimulates the chondrocytes and synovial lining cells, eventually breaking down the cartilage. (msdmanuals.com)

After the procedure, you'll need to keep weight off your knee for about 6 weeks and use a continuous passive motion (CPM) machine several hours a day to bend and straighten the knee. (healthline.com)
Knee Cartilage Repair Manufacturing Cost & Price Structure Analysis: Raw Material required and their suppliers, price shape evaluation on the subject of production, structural evaluation of promoting price, break-even factor evaluation, and procedure evaluation. (pharmiweb.com)

To conclude, the present study provides evidence that ABPS can inhibit the expression of lncRNA GAS5 in chondrocytes to regulate the homeostasis of ECM, which in turn may delay the occurrence of cartilage degeneration during OA. (spandidos-publications.com)

A 2018 study found that physical therapy helped reduce pain, not just in cases of mild knee osteoarthritis, but in people dealing with moderate pain, too. (healthline.com)

A complete knee ligament tear might have to be surgically repaired. (healthline.com)

Intra-articular infliximab can be used to treat refractory knee monoarthritis/synovitis in patients with rheumatoid arthritis, Behçet disease, and spondyloarthropathy (eg, ankylosing spondylitis) that is resistant to systemic treatment. (medscape.com)

For example, in the Study of the Treatment of Articular Repair (STAR), 49% of Carticel ACI patients underwent an SSP on the treated knee, during the 4-year follow up. (wikipedia.org)
Patients with knee injuries have been treated using cartilage grown from their own noses, Swiss doctors announced this week. (thenakedscientists.com)
With this in mind, Basel University's Ivan Martin and his colleagues recruited ten patients with cartilage injuries to their knees. (thenakedscientists.com)
Chondrocytes from OA patients were used in primary culture and stimulated with 10 ng/ml interleukin(IL)-1β in the presence or absence of AD-MSC microvesicles, exosomes or conditioned medium. (karger.com)
Effect of Autologous Conditioned Plasma Injections in Patients With Knee Osteoarthritis. (mayo.edu)
However, clinical therapeutic approaches targeting SnCs using senolysis, although promising in preclinical OA models, have not yet proven their efficacy in patients with knee OA. (aging-us.com)

OCD may occur in the knee, elbow, or ankle. (medscape.com)
OCD occurs in the knee 75% of the time, the elbow 6% of the time, and the ankle 4% of the time. (medscape.com)
Effects of Superoxide Dismutase 1 on cartilage chondrocyte metabolism: a protective mechanism against ankle osteoarthritis? (cardiff.ac.uk)

Sports injuries, accidents, and years of normal wear and tear can damage both types of cartilage in the knee, making it necessary to repair or replace the lost cartilage. (healthline.com)
Advances in orthopedic medicine provide many options for treating knee injuries. (healthline.com)
Because of this, treatment of knee-related injuries and disorders requires a distinct set of skills and experience. (floridaortho.com)
Differences in Trampoline-Related Knee Injuries Between Children and Adults: A Cross-Sectional Study. (mayo.edu)
He is among the world's most productive in clinical, epidemiological and basic science research in the areas of general sports medicine, knee ligaments, cartilage and prevention of sports injuries and illnesses. (sportsoracle.com)

CaMKII inhibition in human primary and pluripotent stem cell-derived chondrocytes modulates effects of TGFbeta and BMP through SMAD signaling. (ca.gov)

Burning in the front of the knee is often caused by an overuse injury known as runner's knee - also referred to as chondromalacia or patellofemoral pain syndrome (PFS) . (healthline.com)
Injury to the cartilage and associated structures at the time of ACL rupture, in combination with the inflammatory mediators released at the time of injury, may create irreversible damage to the knee despite restoration of normal knee kinematics with an ACL reconstruction. (thieme-connect.de)
The knee is a complex system of supportive and moving parts, including bones, cartilage, muscles, tendons, and ligaments - each of which is subject to injury or disease. (floridaortho.com)

The results of this study highlight a key role for SOCS-3 in regulating chondrocyte responses during inflammatory arthritis. (nih.gov)
Tendinopathies and bursitis can cause knee pain, along with inflammatory insults such as inflammatory arthritis or septic arthritis . (medscape.com)

In 1888, Konig coined the term when he sought to describe the pathologic process that led to atraumatic loose bodies of femoral origin in the knee and hip joints. (medscape.com)

The most common type of intra-articular knee injection is with corticosteroids, but other agents have been used, including infliximab, hyaluronic acid, botulinum neurotoxin, and platelet-rich plasma (PRP). (medscape.com)

Treatment for a burning knee depends on the cause. (healthline.com)
On the other hand, etoposide treatment reliably induces DNA damage-related senescence in human articular chondrocytes evidenced by loss of proliferative capacity, DNA damage accumulation, and expression of some SASP components. (aging-us.com)

Knee pain can be caused by patellar malalignment or dysfunction and referred pain from other areas, such as the spine or hip. (medscape.com)

Mapping molecular landmarks of human skeletal ontogeny and pluripotent stem cell-derived articular chondrocytes. (ca.gov)
The study calls for the circuit to be introduced into human chondrocytes and then implanted in a rodent model, where its functionality will be measured over time. (oref.org)
Recently, it has been demonstrated that ERS is sensitively implicated in chondrocytes and associated with human osteoarthritis cartilage [ 4 ]. (hindawi.com)

The ACL is one of two cruciate ligaments in the knee that gives the knee stability. (lu.se)

Also known as runner's knee, chondromalacia is the deterioration of the cartilage under the patella (kneecap) . (healthline.com)
Chondromalacia patellae often causes generalized knee pain especially when climbing or descending stairs, playing. (msdmanuals.com)

Some people experience increased knee pain at night. (healthline.com)

In this article, we review traditional and newly emerging approaches to knee cartilage replacement and repair. (healthline.com)
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Anatomy44

Organisms5

Diseases39

Chemicals and Drugs71

Analytical, Diagnostic and Therapeutic Techniques and Equipment38

Psychiatry and Psychology3

Phenomena and Processes39

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture2

Information Science2

Health Care5

Implantation16

Transplantation4

MACI3

Vitro5

Articular cartilage8

Extracellular5

Mouse chondrocytes3

Induce6

Osteoarthritic2

Tissue7

Surgery19

Joint24

Meniscus1

ARTHROSCOPY1

Piece of cartilage2

Cytokine4

Osteoarthritis of the Knee2

Osteochondritis Dissecans of the Knee1

Lesions2

Phenotype1

Osteochondral1

Apoptosis2

Arthritic knee1

Degradation1

Surgical4

Defects in the knee1

Chondroplasty1

Cells5

Procedure2

Homeostasis1

20181

Ligament1

Rheumatoid arthritis1

Patients6

Ankle3

Injuries5

Inhibition1

Injury3

Inflammatory arthritis2

Joints1

Injection1

Treatment2

Dysfunction1

Human3

Stability1

Chondromalacia2

Increased knee pain1

Repair13