• The other physical changes associated with Klinefelter syndrome are usually subtle. (medlineplus.gov)
  • Having Klinefelter syndrome can be a challenge, especially during puberty and young adulthood. (mayoclinic.org)
  • Even if the problem is male-factor infertility, the chances of a man having Klinefelter syndrome are relatively low. (wdxcyber.com)
  • The chances of you actually having Klinefelter syndrome are very small (somewhere between 1 in 500 and 1 in 1000 men have the condition). (sharedjourney.com)
  • [ 1 ] The etiology was thought to be due to an endocrine disorder of unknown cause, until 1959, when Jacobs et al recognized that Klinefelter syndrome was a chromosomal disorder in which there is an extra X chromosome, resulting in the karyotype 47,XXY. (medscape.com)
  • Today, the term Klinefelter syndrome (KS) refers to a group of chromosomal disorders in which the normal male karyotype, 46,XY, has at least one extra X chromosome. (medscape.com)
  • Klinefelter males are born with at least one extra X chromosome in each of their cells. (wdxcyber.com)
  • In a nutshell, men with Klinefelter syndrome have an extra X chromosome. (sharedjourney.com)
  • Klinefelter syndrome occurs when a boy has one extra X chromosome. (msdmanuals.com)
  • Klinefelter syndrome (or 47,XXY or XXY syndrome) is a condition in which males have an extra X chromosome. (clinicalpub.com)
  • But what happens when a biological male has an extra X chromosome (Klinefelter syndrome), and a biological female is missing an X chromosome (Turner syndrome)? (hellovaia.com)
  • The symptoms of Klinefelter syndrome stem from a lower-than-normal production of testosterone , and the effects the extra X chromosome(s) have on the body's development and function. (healthymale.org.au)
  • Klinefelter syndrome is a problem in which male babies are born with an extra X chromosome (XXY). (epnet.com)
  • Klinefelter syndrome is a rare genetic condition in which a male has an extra X chromosome. (cdc.gov)
  • The name may refer to: Harry Klinefelter (1912-1990), an American endocrinologist Klinefelter syndrome Kleinfeltersville, Pennsylvania Kleinfeld Dictionary of American Family Names. (wikipedia.org)
  • The syndrome is named after Harry Klinefelter, the endocrinologist who first identified it in 1942. (sharedjourney.com)
  • Klinefelter syndrome was first identified by DR. Harry Klinefelter in 1940. (difference.wiki)
  • These treatments can help boys with Klinefelter syndrome who have problems with speech, language and muscle weakness. (mayoclinic.org)
  • Some boys with Klinefelter syndrome have trouble learning and socializing and can benefit from extra assistance. (mayoclinic.org)
  • Most boys with Klinefelter syndrome have normal or slightly decreased intelligence. (msdmanuals.com)
  • Frequency of XY sperm increases with age in fathers of boys with Klinefelter syndrome. (medscape.com)
  • Boys with Klinefelter syndrome might start puberty but then it stops. (healthymale.org.au)
  • Testosterone treatment might be prescribed for boys with Klinefelter syndrome who have a very small penis. (healthymale.org.au)
  • Monitoring the growth and hormone function of boys with Klinefelter syndrome in the lead-up to puberty helps guide decisions about testosterone treatment, which may become necessary. (healthymale.org.au)
  • A form of primary testicular failure occurs in males with Klinefelter Syndrome, with elevated gonadotropin levels due to lack of feedback inhibition by the pituitary gland. (medscape.com)
  • A small percentage of males with Klinefelter syndrome are diagnosed before birth. (mayoclinic.org)
  • The number of males with Klinefelter syndrome is not known 2 . (healthymale.org.au)
  • Researchers believe that up to 65 percent of people with Klinefelter syndrome are never diagnosed. (medlineplus.gov)
  • Klinefelter syndrome can make it difficult for people with this condition to have biological children (a condition called infertility), but up to half of people with Klinefelter syndrome may be able to have children using assisted reproductive technologies. (medlineplus.gov)
  • People with Klinefelter syndrome tend to have better receptive language skills (the ability to understand speech) than expressive language skills (vocabulary and the production of speech) and may have difficulty communicating and expressing themselves. (medlineplus.gov)
  • People with Klinefelter syndrome very rarely have intellectual disabilities. (medlineplus.gov)
  • People with Klinefelter syndrome are more likely than those without Klinefelter syndrome to have autism spectrum disorder , which is a developmental disorder that affects communication and social interaction. (medlineplus.gov)
  • People with Klinefelter syndrome have an increased risk of developing metabolic syndrome, which is a group of conditions that include high blood glucose levels during prolonged periods without food (fasting), high blood pressure ( hypertension ), increased belly fat, and high levels of fats (lipids) such as cholesterol and triglycerides in the blood. (medlineplus.gov)
  • In 85% of cases, people with Klinefelter syndrome are born with one additional X chromosome. (ro.co)
  • That said, some experts suspect that many people with Klinefelter syndrome are never diagnosed-because their symptoms are very mild-so the true prevalence may be much higher (Kanakis, 2018). (ro.co)
  • Many people with Klinefelter syndrome are not diagnosed until after puberty because the symptoms usually do not appear before then. (ro.co)
  • Because of this, people with Klinefelter syndrome may be more likely to struggle in school and in the workplace. (ro.co)
  • Also called karyotype analysis, this test is used to confirm a diagnosis of Klinefelter syndrome. (mayoclinic.org)
  • A man who receives a positive diagnosis of Klinefelter syndrome will have to accept that it's very unlikely he'll ever biologically father a child. (wdxcyber.com)
  • The main effect of Klinefelter syndrome is abnormal growth and development of the testicles (testes). (ro.co)
  • If Klinefelter syndrome is not diagnosed prenatally, a patient with 47,XXY karyotype may demonstrate various subtle, age-related clinical signs that would prompt diagnostic testing. (medscape.com)
  • Klinefelter syndrome is diagnosed by examining someone's karyotype, which is done using a small sample of blood or other tissue. (healthymale.org.au)
  • Klinefelter syndrome is the most common sex chromosome disorder in males and the second most common condition caused by the presence of extra chromosomes. (clinicalpub.com)
  • The main difference between Turner Syndrome and Klinefelter Syndrome is that Turner Syndrome is the change in the genetic chromosomes in females while a Klinefelter Syndrome is a change in ancestral chromosomes in men. (difference.wiki)
  • However, some syndromes can affect these sex chromosomes, causing many issues for those involved, known as atypical sex chromosome patterns (Klinefelter and Turner syndrome). (hellovaia.com)
  • Klinefelter syndrome refers to a collection of characteristics in males that are caused by having two or more X chromosomes. (healthymale.org.au)
  • Klinefelter syndrome is a genetic condition that affects males by causing them to be born with one or more extra X chromosomes. (ro.co)
  • But males born with Klinefelter syndrome have an extra copy of the X chromosome, or sometimes multiple extra X chromosomes. (ro.co)
  • Extant literature shows that Klinefelter syndrome (KS) is a chromosomal condition that affects the male physical, psychosocial and cognitive capacities due to the presence of one or more supernumerary X chromosomes among the affected individuals. (psychologywriting.com)
  • Unfortunately, the infertility aspect of Klinefelter's is rarely treatable, although some Klinefelter males have become Dads thanks to an assisted reproduction technique called ICSI . (sharedjourney.com)
  • PubMed was searched for 'Klinefelter,' 'Klinefelter's,' and 'XXY' in titles and abstracts. (mensfe.net)
  • Klinefelter Syndrome often referred to as XXY trisomy, XXY syndrome, and Klinefelter's Syndrome is a chromosomal disorder exclusively associated with males having one or more of the X chromosome than the normal 'XY' pattern. (hxbenefit.com)
  • The signs and symptoms of Klinefelter syndrome vary. (medlineplus.gov)
  • Treatments are available for some symptoms of Klinefelter syndrome - for example, testosterone therapy can help men who have some feminine features. (sharedjourney.com)
  • Symptoms of Klinefelter syndrome are smaller testes, less production of testosterone. (difference.wiki)
  • Symptoms of Klinefelter syndrome can be so mild in some individuals that they, their parents, and their doctors may not even realise they have the condition. (healthymale.org.au)
  • Terry Mullen, West Florida Electric Cooperative Association, Inc., is pictured after receiving the 2022 CCA H.E. Klinefelter Award at the 2022 CCA Institute in Santa Fe, N.M. Nominations for CCA's 2023 member awards are due April 14. (communicators.coop)
  • Individuals with Klinefelter syndrome typically have small testes that produce a reduced amount of testosterone (primary testicular insufficiency). (medlineplus.gov)
  • Klinefelter syndrome is characterized by hypogonadism (micro-orchidism [small testes], oligospermia/azoospermia), gynecomastia in late puberty, hyalinization and fibrosis of the seminiferous tubules, elevated urinary gonadotropin levels, and behavioral concerns. (medscape.com)
  • Adult Klinefelter men may have smaller-than-average testes . (sharedjourney.com)
  • It's not all about the testes: medical issues in Klinefelter patients. (medscape.com)
  • In Turner syndrome, uterus, vagina, and vulva are present, but they can not begin the period and do not produce child while in case of Klinefelter syndrome males have less developed and small testes, penis, vasa deferens so no functional sperm are produced. (difference.wiki)
  • If you or your son is diagnosed with Klinefelter syndrome, your health care team may include a doctor who specializes in diagnosing and treating disorders involving the body's glands and hormones (endocrinologist), a speech therapist, a pediatrician, a physical therapist, a genetic counselor, a reproductive medicine or infertility specialist, and a counselor or psychologist. (mayoclinic.org)
  • This chromosomal condition was first observed and documented by Harry Fitch Klinefelter Jr, an American endocrinologist, and rheumatologist in the 40s, and hence its name. (hxbenefit.com)
  • Until 1996, men with Klinefelter syndrome were considered infertile. (medscape.com)
  • This is because even for those with mild symptoms, most men with Klinefelter syndrome produce very few or no sperm and are infertile . (healthymale.org.au)
  • See our section on Klinefelter treatment, under Male Infertility: Drugs and Treatment, for more information. (sharedjourney.com)
  • We aimed to investigate change over time in incidence, prevalence and age at diagnosis among Turner syndrome (TS), Klinefelter syndrome (KS), Triple X syndrome (Triple X) and Double Y syndrome (Double Y). (biomedcentral.com)
  • Turner syndrome is the genetic abnormality of females while Klinefelter syndrome is a genetic abnormality of men. (difference.wiki)
  • Individuals with Turner syndrome are monosomy 45X (2n-1) as one X chromosome is deleted while an individual with Klinefelter syndrome is trisomy 47X (2n+1) as one X chromosome is extra. (difference.wiki)
  • In Turner syndrome, females have undeveloped breast while in Klinefelter syndrome males have enlarged breast. (difference.wiki)
  • What are the symptoms of Turner syndrome and Klinefelter syndrome symptoms? (hellovaia.com)
  • Before diving into Klinefelter and Turner Syndrome in psychology, let's be sure we know what a sex chromosome is. (hellovaia.com)
  • Fig. 1 Blood testing for DNA is used to diagnose Klinefelter Syndrome and Turner Syndrome. (hellovaia.com)
  • Turner Syndrome and Klinefelter Syndrome symptoms present quite differently from one another. (hellovaia.com)
  • Klinefelter syndrome: expanding the phenotype and identifying new research directions. (uchicago.edu)
  • Boada R, Janusz J, Hutaff-Lee C, Tartaglia N. The cognitive phenotype in Klinefelter syndrome: a review of the literature including genetic and hormonal factors. (medscape.com)
  • Zitzmann M, Depenbusch M, Gromoll J, Nieschlag E. X-chromosome inactivation patterns and androgen receptor functionality influence phenotype and social characteristics as well as pharmacogenetics of testosterone therapy in Klinefelter patients. (medscape.com)
  • Klinefelter syndrome is the most common sex chromosome disorder and occurs in about 1 in every 500 live male births. (msdmanuals.com)
  • Klinefelter Syndrome is a genetic change that occurs when a boy is born with an extra copy of the X chromosome. (difference.wiki)
  • Klinefelter and Turner's syndromes are fascinating phenomena that researchers of various fields, including psychology, have sought to study. (hellovaia.com)
  • March 29, 2023 - The nationwide Cooperative Communicators Association (CCA) is accepting nominations for both the Michael Graznak and H.E. Klinefelter awards. (communicators.coop)
  • In 1942, Klinefelter et al published a report describing nine men with a constellation of features: testicular dysgenesis, microorchidism, eunuchoidism, gynecomastia, elevated urinary gonadotropins, and azoospermia. (medscape.com)
  • Visootsak J, Aylstock M, Graham JM Jr. Klinefelter syndrome and its variants: an update and review for the primary pediatrician. (medscape.com)
  • Individuals with Klinefelter syndrome may have have anxiety, depression , impaired social skills, or behavioral differences, such as emotional immaturity during childhood or difficulty with frustration. (medlineplus.gov)
  • Treatment, health education and social support can greatly benefit individuals with Klinefelter syndrome. (mayoclinic.org)
  • Individuals with Klinefelter Syndrome show reduced volume in several brain areas, including the amygdala, temporal and frontal regions, hippocampus, and insular cortex. (hellovaia.com)
  • By contrast, men with Klinefelter syndrome have a chromosome pattern that looks something like this: XXY. (wdxcyber.com)
  • Adolescent male with Klinefelter syndrome who has female-type distribution of pubic hair and testicular dysgenesis. (medscape.com)
  • Wikstrom AM, Dunkel L. Testicular function in Klinefelter syndrome. (medscape.com)
  • This story contains statements from a healthcare provider regarding a Klinefelter syndrome diagnosis that may upset some readers. (livingwithxxy.org)
  • Klinefelter syndrome is not a genetic or hereditary condition but transpires due to a randomized error in chromosomal patterning. (hxbenefit.com)
  • Blood or urine samples can reveal abnormal hormone levels that are a sign of Klinefelter syndrome. (mayoclinic.org)
  • In addition to its impact on development and fertility, Klinefelter syndrome is associated with many health problems, mainly due to reduced testosterone levels. (healthymale.org.au)
  • If you have Klinefelter syndrome and want to start a family, it might be possible for a fertility specialist to help you by using assisted reproductive technology (ART). (healthymale.org.au)
  • Klinefelter syndrome, also called 47,XXY, is a chromosomal condition that affects development in people who are assigned male at birth. (medlineplus.gov)
  • Klinefelter syndrome affects about 1 in 650 newborns who were assigned male at birth. (medlineplus.gov)
  • Klinefelter syndrome only affects the boys. (difference.wiki)
  • Klinefelter syndrome is a common ancestral state that affects males. (difference.wiki)
  • Our mission is to deliver awareness of Klinefelter Syndrome and the education of those who could have it, the families in their lives as well as the medical community about the prevalence of it, the importance of early detection, available treatment options and other health issues. (blogspot.com)
  • Many men, however, find out that they have Klinefelter syndrome only after they try, and fail, to get their partners pregnant. (wdxcyber.com)
  • Klinefelter HF Jr, Reifenstein EC Jr, Albright F. Syndrome characterized by gynecomastia aspermatogenesis without a-Leydigism and increased excretion of follicle-stimulating hormone. (medscape.com)
  • Klinefelter syndrome is responsible for the less production of testosterone, the hormone which is essential for the primary characteristics of the males. (difference.wiki)
  • A longitudinal perspective of hormone replacement therapies (HRTs) on neuromotor capabilities in males with 47,XXY (Klinefelter syndrome). (bvsalud.org)
  • If you have a son with Klinefelter syndrome, you can help promote healthy mental, physical, emotional and social development. (mayoclinic.org)
  • Because men with Klinefelter syndrome tend to have low testosterone, they may have some physical characteristics that make them stand out from other men. (wdxcyber.com)
  • Klinefelter syndrome is diagnosed by means of a physical exam, blood tests and a chromosome analysis. (sharedjourney.com)
  • Klinefelter syndrome has physical, psychological, and behavioural symptoms. (hellovaia.com)
  • Infants and children with Klinefelter syndrome should be examined by their doctor at least every two years to monitor their physical development. (healthymale.org.au)
  • Klinefelter syndrome is a genetic disorder affecting 1 in every 500 to 1 in every 1000 men in the United States. (wdxcyber.com)
  • Klinefelter syndrome is the most common genetic disorder in men. (sharedjourney.com)
  • Klinefelter syndrome is the most common sex chromosome disorder. (msdmanuals.com)
  • Most men with Klinefelter syndrome are typically unable to father children because few or no sperm are produced in the testicles. (mayoclinic.org)
  • There are men with Klinefelter syndrome all over the world who have become fathers through adoption, or assisted reproduction procedures using sperm from an anonymous donor. (wdxcyber.com)
  • Since then, however, developments in microsurgical techniques and advances in artificial reproductive technologies (ART) have enabled over 50% of men with Klinefelter syndrome to sire their own children. (medscape.com)
  • Along with these developmental and reproductive symptoms, Klinefelter syndrome can lead to changes in how a person's brain forms and develops. (ro.co)
  • Clinical review: Klinefelter syndrome--a clinical update. (mensfe.net)
  • Bojesen A, Gravholt CH. Klinefelter syndrome in clinical practice. (medscape.com)
  • STUDENT INTERVIEW Stefan D. Schwarz: Life with Klinefelter Syndrome While doing research on Klinefelter syndrome, I came across a web site (Stefan's Klinefelter Syndrome website) authored by Stefan Schwarz in which he talked about living as an XXY male. (klinefeltersyndrome.org)
  • Survival of male patients with incontinentia pigmenti carrying a lethal mutation can be explained by somatic mosaicism or Klinefelter syndrome. (uchicago.edu)
  • From the male Republic until the book Klinefelter Syndrome of Homeric site in the later nanostructured, there refuses available name of helpAdChoicesPublishersLegalTermsPrivacyCopyrightSocial including. (jvigeant.com)
  • Affecting 1 out of every 500-1000 male neonates, Klinefelter syndrome is a somewhat widespread chromosomal aberration affecting humans. (hxbenefit.com)
  • Does the Klinefelter syndrome life expectancy differ from the average male? (hellovaia.com)
  • Moreover, there is a very, very small number of Klinefelter males who have managed to become biological fathers. (wdxcyber.com)
  • Although there's no way to repair the sex chromosome changes due to Klinefelter syndrome, treatments can help minimize its effects. (mayoclinic.org)
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