• The activating receptor KIR2DS2 and the inhibitory receptor KIR2DL2 were more frequently found in AD patients than controls, and they were found at similar frequencies (62% of AD patients vs. 37.2% of controls, and 62.2% of AD patients vs. 36.4% of controls, respectively). (hhv-6foundation.org)
  • These two receptors are likely preferentially associated with each other, and when they are co-expressed, the inhibitory effects of KIR2DL2 override the activation of NK cells triggered by KIR2DS2. (hhv-6foundation.org)
  • The combination of KIR2DS2, KIR2DL2, and the KIR ligand HLA-C1 was observed significantly more often among AD patients, and the presence of HLA-C1 in the absence of KIR2DS2 and KIR2DL2 was markedly lower than in controls. (hhv-6foundation.org)
  • The group also evaluated HHV-6A infection in the presence of KIR2DL2 expressing cells to determine whether the KIR2DS2/KIR2DL2/C1 combination might increase a person's susceptibility to HHV-6 infections. (hhv-6foundation.org)
  • The diminished ability of KIR2DS2/KIR2DL2 expressing NK cells to clear HHV-6-infected cells with HLA-C1 present, paired with the increased frequency of this KIR/HLA combination among AD patients, suggests that underlying genetic factors may predispose to ineffective clearance of HHV-6(A). Consequently, HHV-6 infections may persist in the central nervous system and contribute to AD development and worsening. (hhv-6foundation.org)
  • Lack of killer immunoglobulin-like receptor 2DS2 (KIR2DS2) and KIR2DL2 is associated with poor responses to therapy of recurrent hepatitis C virus in liver transplant recipients. (cdc.gov)
  • Activating receptor KIR2DS2 bound to HLA-C1 reveals the novel recognition features of activating receptor. (bvsalud.org)
  • 35. Activating receptor KIR2DS2 bound to HLA-C1 reveals the novel recognition features of activating receptor. (nih.gov)
  • A study has shown that this reduced gene coding for the activating receptor KIR2DS2 is usually associated with severe COVID-19 [31]. (scienza-under-18.org)
  • 106 disease terms (MeSH) has been reported with KIR2DS2 gene. (cdc.gov)