• High-throughput genotyping of KIR2DL2/L3, KIR3DL1/S1, and their HLA class I ligands using real-time PCR. (unityhealth.to)
  • These proteins are 50-58 kDa type I glycoproteins that belong to the Killer cell immunoglobulin-like receptor (KIR) family: (KIR2DL2/L3/S2). (bdbiosciences.com)
  • Lack of killer immunoglobulin-like receptor 2DS2 (KIR2DS2) and KIR2DL2 is associated with poor responses to therapy of recurrent hepatitis C virus in liver transplant recipients. (cdc.gov)
  • The activating receptor KIR2DS2 and the inhibitory receptor KIR2DL2 were more frequently found in AD patients than controls, and they were found at similar frequencies (62% of AD patients vs. 37.2% of controls, and 62.2% of AD patients vs. 36.4% of controls, respectively). (hhv-6foundation.org)
  • These two receptors are likely preferentially associated with each other, and when they are co-expressed, the inhibitory effects of KIR2DL2 override the activation of NK cells triggered by KIR2DS2. (hhv-6foundation.org)
  • The combination of KIR2DS2, KIR2DL2, and the KIR ligand HLA-C1 was observed significantly more often among AD patients, and the presence of HLA-C1 in the absence of KIR2DS2 and KIR2DL2 was markedly lower than in controls. (hhv-6foundation.org)
  • The group also evaluated HHV-6A infection in the presence of KIR2DL2 expressing cells to determine whether the KIR2DS2/KIR2DL2/C1 combination might increase a person's susceptibility to HHV-6 infections. (hhv-6foundation.org)
  • The diminished ability of KIR2DS2/KIR2DL2 expressing NK cells to clear HHV-6-infected cells with HLA-C1 present, paired with the increased frequency of this KIR/HLA combination among AD patients, suggests that underlying genetic factors may predispose to ineffective clearance of HHV-6(A). Consequently, HHV-6 infections may persist in the central nervous system and contribute to AD development and worsening. (hhv-6foundation.org)
  • Receptors, KIR2DL2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • This graph shows the total number of publications written about "Receptors, KIR2DL2" by people in this website by year, and whether "Receptors, KIR2DL2" was a major or minor topic of these publications. (umassmed.edu)
  • Below are the most recent publications written about "Receptors, KIR2DL2" by people in Profiles. (umassmed.edu)
  • Objective: To investigate the effect of blocking the inhibitory receptors KIR2DL1 and KIR2DL2/2DL3 with monoclonal antibody on cytotoxic activity of human NK cells. (zjujournals.com)
  • While wild-type NK cells were able to effectively kill HHV-6A-infected T cells expressing the HLA-C1 allele, NK cells with KIR2DL2 expression were not able to do so. (hhv-6foundation.org)
  • Furthermore, HHV-6A induced PKA activity and phosphorylation of Sp1 in the NK cells, which may increase expression of KIR2DL2 and thereby inhibit NK cell cytotoxicity. (hhv-6foundation.org)
  • Methods: Human peripheral blood NK cells were isolated by Rosettesep NK sorting kit.The cytotoxic activity of NK cells against human leukemia NB4,K-562,Raji cells and allogeneic mature or dendritic cells (DCs) was detected before or after KIR2DL1 and KIR2DL2/2DL3 were blocked.The effect of NK cells on T lymphocyte proliferation was detected by mixed lymphocyte reaction and TGF-β1 concentration in culture supernatant was measured. (zjujournals.com)
  • Cysteamine HCl Previously, we analyzed CMV reactivation in AML individuals following allogeneic HCT, observing the maturation of NKG2C+ NK cells that preferentially communicate KIR2DL2/3 and have enhanced capacity to produce IFN- in response to HLA class I-deficient target cells (16). (museopedrogocial.org)
  • Conjunctival scarring in trachoma is associated with the HLA-C ligand of KIR and is exacerbated by heterozygosity at KIR2DL2/KIR2DL3. (cdc.gov)
  • KIR3DL1 binds the Bw4 epitope of HLA-A or HLA-B. KIR2DL2 and KIR2DL3 each bind the C1 epitope, which takes place on many HLA-C and two HLA-B alleles (Moesta et al, 2008). (insulin-receptor.info)
  • It is similar in structure and function to the KIR2DL2 RECEPTORS and the KIR2DL3 RECEPTORS . (nih.gov)
  • KIR-ligand mismatch between recipient KIR and donor HLA[A2] showed a significant higher incidence when there was a mismatch in either KIR2DL2&HLA-Cw C1 or KIR2DL1/3&C2 group (12.7 vs. 25.6%, p=0.044). (atcmeetingabstracts.com)
  • 15. Decitabine Inhibits Gamma Delta T Cell Cytotoxicity by Promoting KIR2DL2/3 Expression. (nih.gov)