Kallikrein is a protease that cleaves high-molecular-weight-kininogen (HMWK) to generate cleaved HMWK and bradykinin, a potent vasodilator that increases vascular permeability resulting in swelling and pain associated with HAE. (medscape.com)
En la vía intrínseca, el factor XI es activado por el factor XIIa en presencia del cofactor HMWK (CININÓGENO DE ALTO PESO MOLECULAR). (bvsalud.org)
Molecular weight15
There are two main types of kininogen (KNG), high-molecular-weight-kininogen and low-molecular-weight-kininogen, with a third type - T-kininogen - only found in rats but not humans. (wikipedia.org)
High-molecular-weight-kininogen (HK) is a non-enzymatic cofactor involved in the kinin-kallikrein system, which plays a role in blood coagulation, blood pressure regulation, and inflammation. (wikipedia.org)
Low-molecular-weight-kininogen (LK) is mainly a precursor protein for kallidin. (wikipedia.org)
Bradykinin, the cleavage product of high molecular weightkininogen, is implicated by a class of drugs called angiotensin converting enzyme inhibitors (ACE inhibitors) that aim to increase bradykinin levels by impeding its degradation. (wikipedia.org)
Materials and Methods: Whole cells (105 cells/µl) or sonic extracts (1mg/ml) of the endodontic pathogens P. endodontalis, Enterococcus faecalis, and Fusobacterium nucleatum were incubated with low molecular weightkininogen (LMWK) (0.1mg/ml) and fibrinogen (0.1mg/ml) for 1 hour, 4 hours and 24 hours at 37C. (temple.edu)
Severe deficiency of contact activation factors (factor XII, prekallikrein, high-molecular-weight kininogen) does not cause increased bleeding risk during heparin therapy but does prolong the ACT and makes it impossible to use this test. (medscape.com)
Neutrophil adhesion on surfaces preadsorbed with high molecular weightkininogen under well-defined flow conditions. (nih.gov)
Severe high-molecular-weight kininogen deficiency: clinical characteristics, deficiency-causing KNG1 variants, and estimated prevalence. (uzh.ch)
Bradykinin, the primary mediator of swelling in HAE, is produced by cleavage of high-molecular weight (HMW) kininogen by plasma kallikrein. (ajmc.com)
As part of this function, human K1 exhibits unique dual-substrate specificity in hydrolyzing low molecular weightkininogen between both Arg-Ser and Met-Lys sequences. (rcsb.org)
Kininogens are precursor proteins for kinins, biologically active polypeptides involved in blood coagulation, vasodilation, smooth muscle contraction, inflammatory regulation, and the regulation of the cardiovascular and renal systems. (wikipedia.org)
The kininogens are multifunctional plasma proteins that participate in various phases of the inflammatory process. (temple.edu)
A related aim is to characterize the kininogenase activity of Porphyromonas endodontalis.Purpose: This study aims to determine the significant in vitro interaction between P. endodontalis, an endodontic pathogen, and the plasma proteins kininogen, a modulator of the inflammatory response, and fibrinogen, a major protein substrate of the coagulation cascade. (temple.edu)
Cell surface HABP1 binds a wide range of extracellular molecules, including hyaluronan, vitronectin, complement component C1q, HMW kininogen, and bacterial and viral proteins (2, 6 - 9). (rndsystems.com)
EMAILWIRE.COM, November 02, 2021 ) ROSTOCK and BERLIN, Germany -- ARAB NEWSWIRE -- A research paper on the frequently misdiagnosed disease Hereditary Angioedema (HAE) and the currently running clinical study Hereditary AngioedemaKininogen Assay (HAEKA) was recently published in the international. (emailwire.com)
Peroxidase1
Sheep anti human Kininogen, affinity purified, peroxidase conj. (sciencepro.com.br)
Gene2
HK and LK are created by the alternative splicing of the same kininogen (KNG) gene, which in humans, is located at chromosome 3q27. (wikipedia.org)
Kininogen gene (KNG) variation has a consistent effect on aldosterone response to antihypertensive drug therapy: the GERA study. (snpedia.com)
Plasma1
Increased levels of kininogen in the plasma and tissues are associated with injury, inflammation, myocardial infarction, and diabetes. (wikipedia.org)
Human1
Hier sind Kininogen (HMW) Antikörper für eine Vielzahl von Species wie anti-Human Kininogen (HMW), anti-Rat Kininogen (HMW), anti-Mouse Kininogen (HMW) zu finden. (antikoerper-online.de)
Levels1
Additionally, kininogen's role in the contact activation system means that increased levels of kininogen can also contribute to the development of hereditary angioedema, a disorder characterized by periodic episodes of swelling. (wikipedia.org)