• Cyclin-dependent kinases (CDKs) are the families of protein kinases first discovered for their role in regulating the cell cycle. (wikipedia.org)
  • CDKs are relatively small proteins, with molecular weights ranging from 34 to 40 kDa, and contain little more than the kinase domain. (wikipedia.org)
  • CDKs phosphorylate their substrates on serines and threonines, so they are serine-threonine kinases. (wikipedia.org)
  • Most knowledge of CDK structure and function is based on CDKs of S. pombe (Cdc2), S. cerevisiae (CDC28), and vertebrates (CDC2 and CDK2). (wikipedia.org)
  • The structure of human Cdk2 revealed that CDKs have a modified ATP-binding site that can be regulated by cyclin binding. (wikipedia.org)
  • Cyclin-dependent kinases (CDKs) are serine/threonine protein kinases that act as key regulatory elements in cell cycle progression. (rcsb.org)
  • The profiling of compound 51 against a panel of 339 kinases revealed high selectivity for CDKs, with preference for CDK2 and CDK5 over CDK9, CDK1, CDK4, and CDK6. (rcsb.org)
  • Selective for cdks over a wide range of related kinases including ERK1 and ERK2. (tocris.com)
  • Here we tested whether roscovitine, an inhibitor of cyclin-dependent kinases (CDKs), which hereby also blocks homologous recombination (HR), can be used to enhance the radiation sensitivity of HNSCC cell lines. (oncotarget.com)
  • An orally bioavailable inhibitor of cyclin-dependent kinases (CDKs) and thropomyosin receptor kinase A (TRKA), with potential antineoplastic activity. (ncats.io)
  • CDK2/TRKA inhibitor PHA-848125 AC potently inhibits cyclin-dependent kinase 2 (CDK2) and exhibits activity against other CDKs including CDK1 and CDK4, in addition to TRKA. (ncats.io)
  • Cyclins and cyclin-dependent kinases (cdks) are evolutionarily conserved proteins that are essential for cell-cycle control in eukaryotes. (bdbiosciences.com)
  • The main cyclin-cdks complexes formed in vertebrate cells are cyclin D-cdk4 (G0/G1), cyclin E-cdk2 (G1/S), cyclin A-cdk2 (S) and cyclin B1-cdk1 (G2/M). These complexes are regulated by activating and inhibitory phosphorylation events, as well as by interactions with small regulatory proteins including p21 and p27Kip1. (bdbiosciences.com)
  • Cell-cycle events are controlled by cyclin-dependent kinases (CDKs), whose periodic activation is driven by cyclins. (nature.com)
  • A relatively well understood example is the network that controls progression of the cell cycle, where cyclin-dependent kinases (CDKs) couple with various cyclins over the cell cycle to regulate critical processes [ 2 - 4 ]. (biomedcentral.com)
  • p21 mediates its various biological activities primarily by binding to and inhibiting the kinase activity of the cyclin-dependent kinases (CDKs) CDK2 and CDK1 (also known as CDC2) leading to growth arrest at specific stages in the cell cycle (FIG. 2). (darkskiesfilm.com)
  • During the cell cycle, SAMHD1 is regulated through phosphorylation by different cyclin-dependent kinases (CDKs) and cyclins. (biomedcentral.com)
  • Furthermore to inhibiting CDKs, roscovitine continues to be reported to activate the ERK1/2 and HIPK2 kinases [19], [20]. (antiviralbiologic.com)
  • CDKs are cyclin-dependent serine-/threonine-specific proteins kinases, the experience of which depends upon cyclin binding. (niepokorny.org)
  • Furthermore to people indirect results on cell routine legislation, the viral proteins kinase pUL97 straight cross-talks with CDKs since it mimics CDKs in phosphorylating partly-identical substrates and evidently possesses commonalities in protein framework and functionality. (niepokorny.org)
  • only the cyclin-CDK complex is an active kinase but its activity can be typically further modulated by phosphorylation and other binding proteins, like p27. (wikipedia.org)
  • Phosphorylation by CDK-activating kinase (CAK) at Thr 161 on the T-loop increases the complex activity. (wikipedia.org)
  • Full kinase activity requires an activating phosphorylation on a threonine adjacent to the CDK's active site. (wikipedia.org)
  • The identity of the CDK-activating kinase (CAK) that performs this phosphorylation varies across the model organisms. (wikipedia.org)
  • Various kinases and phosphatases regulate their phosphorylation state. (wikipedia.org)
  • controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. (proteopedia.org)
  • In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. (proteopedia.org)
  • NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. (proteopedia.org)
  • Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. (proteopedia.org)
  • Here we compare the specificity of two budding yeast cyclins, the S-phase cyclin Clb5 and the M-phase cyclin Clb2, in the phosphorylation of 150 Cdk1 (Cdc28) substrates. (nature.com)
  • Although we did not identify any highly Clb2-specific substrates, we found that Clb2-Cdk1 possessed higher intrinsic kinase activity than Clb5-Cdk1, enabling efficient phosphorylation of a broad range of mitotic Cdk1 targets. (nature.com)
  • Kinases are a class of enzyme that promote phosphorylation. (callaix.com)
  • Imatinib, for example, blocks a kinase receptor from binding to ATP, preventing the phosphorylation that would benefit the cancerous cell and promote cell division. (callaix.com)
  • Studies with Mcl-1 phosphorylation mutants show that cyclin E/Cdk2-dependent phosphorylation of Mcl-1 residues on its PEST domain resulted in increased Mcl-1 stability (Thr92, and Thr163) and Bim binding (Ser64). (oncotarget.com)
  • Dinaciclib (SCH 727965) inhibits cyclin dependent kinases CDK1, CDK2, CDK5, CDK9, and CDK12, which prevents phosphorylation of downstream targets and may promote cell cycle arrest and apoptosis in cancer cells ( PMID: 24900195 , PMID: 24004674 , PMID: 27880910 , PMID: 32269732 ). (jax.org)
  • During G1, cyclin D-dependent kinase-mediated phosphorylation of Rb at Ser-795 marks the conversion of Rb from a transcriptionally repressive, hypophosphorylated state to an inactive, phosphorylated state, which may be sustained through mitosis by differential phosphorylation of up to 16 putative serine or threonine residues. (affbiotech.com)
  • The cyclin-dependent kinases (CDK) CDK1, CDK2, CDK4, and CDK6 are serine/threonine protein kinases targeted in cancer therapy due to their role in cell cycle progression. (rcsb.org)
  • The protein-protein interaction (PPI) network analysis result showed that these PSPCs were mainly participated in the regulation of biosynthesis and metabolism, protein kinase activities, and transcription factors. (bvsalud.org)
  • Protein kinases are critical to cellular signalling and post-translational gene regulation, but their biological substrates are difficult to identify. (biomedcentral.com)
  • Protein kinases are ubiquitous components of cellular signalling networks [ 1 ]. (biomedcentral.com)
  • Receptor Tyrosine Kinases (RTKs) are a family of tyrosine protein kinases. (callaix.com)
  • Here, we show that cyclin E/Cdk2 phosphorylates and stabilizes the pro-survival Bcl-2 family protein Mcl-1, a key cell death resistance determinant to the small molecule Bcl-2 family inhibitors ABT-199 and ABT-737, mimetics of the Bcl-2 homology domain 3 (BH3). (oncotarget.com)
  • Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. (wuxibiortus.com)
  • A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfiler TM service. (guidetomalariapharmacology.org)
  • A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase Hotspot SM platform. (guidetomalariapharmacology.org)
  • This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. (novusbio.com)
  • This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. (novusbio.com)
  • G protein-coupled receptor kinase 5 [So. (gsea-msigdb.org)
  • Catalytic domain of Cyclin-Dependent protein Kinase 1-like Serine/Threonine Kinases. (umbc.edu)
  • The CDK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. (umbc.edu)
  • CDK1 is also called Cell division control protein 2 (Cdc2) or p34 protein kinase, and is regulated by cyclins A, B, and E. The CDK1/cyclin A complex controls G2 phase entry and progression while the CDK1/cyclin B complex is critical for G2 to M phase transition. (umbc.edu)
  • CDK2 is regulated by cyclin E or cyclin A. Upon activation by cyclin E, it phosphorylates the retinoblastoma (pRb) protein which activates E2F mediated transcription and allows cells to move into S phase. (umbc.edu)
  • We found that both male and female Cdk2 -/- Cdk1 +/Cdk2KI mice were sterile, similar to Cdk2 -/- mice, even though they expressed the Cdk2 protein from the Cdk1 locus in testes. (elsevierpure.com)
  • Current scientific trials are looking into cyclin-dependent kinase (CDK) inhibitors, such as for example roscovitine, an inhibitor of CDK1, -2, -5, -7, and -9, that lowers viral DNA synthesis, creation of late protein and infectious pathogen particles [4]. (niepokorny.org)
  • The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. (affbiotech.cn)
  • Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3. (umbc.edu)
  • Serine/Threonine Kinases (STKs), Cyclin-dependent protein kinase 2 (CDK2) and CDK3 subfamily, catalytic (c) domain. (umbc.edu)
  • Displays sub-micromolar inhibition of cdk1, cdk2, cdk5, cdk7 and cdk9 (reported IC 50 values range from 0.16 - 0.28 μM for cdk5 to 0.8 μM for cdk7). (tocris.com)
  • In all five HPV negative and HPV positive cell lines tested, roscovitine caused inhibition of CDK1 and 2. (oncotarget.com)
  • Inhibition of these kinases may result in cell cycle arrest and apoptosis of tumor cells that express these kinases. (ncats.io)
  • Scientists are looking the possibility of kinase inhibition for other diseases including hypertension and Parkinson's disease but here we focus on cancer medicines. (callaix.com)
  • Both from the CDK-Is examined have been from the inhibition of CDK1/cyclin B, CDK2/cyclin E, CDK2/cyclin A and, to a smaller level, CDK4/cyclin D [12], which are involved directly not merely in the legislation from the cell routine, but also with the inhibition Medetomidine HCl IC50 from the non-cycled kinases CDK7/cyclin H and CDK9/cyclin T [39,40]. (acancerjourney.info)
  • Some studies have reported that the G2 M arrest induced by SP600125 may be due to inhibition of cyclin B Cdk1 kinase activity through an increase in p21 levels. (hsp90-inhibitors.com)
  • Thus, inhibition of JNK activity prevents dissociation between p21 and JNK, and then prevents inhibition of cyclin B Cdk1 activity, leading to induction of G2 M arrest. (hsp90-inhibitors.com)
  • among others, CDK1, CDK2 and CDK4, as the key kinases that control the biological processes in HPV-positive cervical cancers. (fortuneonline.org)
  • In HCMV-infected cells, particular subsets of CDK-cyclin complexes are downregulated/suppressed (CDK4-cyclin D, CDK6-cyclin D, CDK2-cyclin A) or upregulated/turned on (CDK1-cyclin B, CDK2-cyclin E), leading to an early on S stage arrest termed pseudomitosis [11] eventually. (niepokorny.org)
  • CDK2, together with CDK4, also regulates embryonic cell proliferation. (umbc.edu)
  • Another one, CDK7, is involved indirectly as the CDK-activating kinase. (wikipedia.org)
  • Additionally, roscovitine inhibits CDK7 that phosphorylates and activates CDK2. (antiviralbiologic.com)
  • Along with CDK1 and -2, CDK7 and -9 are necessary for effective HCMV replication and had been discovered upregulated in HCMV-infected cells [3,12,13,14,15]. (niepokorny.org)
  • We describe the development of highly potent diaminothiazole inhibitors of CDK2 (IC50 = 0.0009-0.0015 μM) from a single hit compound with weak inhibitory activity (IC50 = 15 μM), discovered by high-throughput screening. (rcsb.org)
  • Development of Highly Potent and Selective Diaminothiazole Inhibitors of Cyclin-Dependent Kinases. (proteopedia.org)
  • Roscovitine and other purines as kinase inhibitors. (enzolifesciences.com)
  • Identification of a cyclin-cdk2 recognition motif present in substrates and p21-like cyclin-dependent kinase inhibitors. (nature.com)
  • Kinase inhibitors are now one of the major categories of chemotherapy medicine. (callaix.com)
  • Over 50 kinase inhibitors are approved in the US for cancer treatment with more under development. (callaix.com)
  • Of the 69 new drugs approved by the FDA for cancer from 2015 to 2020, 26 were kinase inhibitors. (callaix.com)
  • Most kinase inhibitors work on tyrosine kinases . (callaix.com)
  • As oncology drugs, kinase inhibitors were created out of modern genetics- the understanding of DNA, the cell cycle, and molecular signaling pathways- and thus represent a change from general to molecular methods of cancer treatment. (callaix.com)
  • An article published in the journal Molecular Cancer in 2018 claimed that over 10,000 patents had been filed in the US for kinase inhibitors since 2001. (callaix.com)
  • Tyrosine kinase inhibitors (TKIs) are a class of chemotherapy medications that inhibit, or block, one or more of the enzyme tyrosine kinases. (callaix.com)
  • Tyrosine kinase inhibitors treat cancer by correcting this deregulation. (callaix.com)
  • Inhibits M phase promoting factor (MPF) kinase activity. (enzolifesciences.com)
  • Following DNA damage, WEE1 inhibits CDK1, leading 1 Introduction to cell cycle arrest and allowing time for DNA repair [4]. (sagepub.com)
  • Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. (affbiotech.cn)
  • JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2 , with IC 50 s of 9 nM, 3 nM, 11 nM, and 15 nM for CDK1 , CDK2 , aurora-A and aurora-B , respectively. (medchemexpress.com)
  • Roscovitine is a cyclin-dependent kinase (cdk) inhibitor. (tocris.com)
  • Roscovitine is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library . (tocris.com)
  • Background Olomoucine II, the newest derivative of roscovitine, can be an exceptionally potent pharmacological inhibitor of cyclin-dependent kinase actions. (acancerjourney.info)
  • Through the differential ramifications of roscovitine and flavopiridol on transcription of HSV-1 or cellular genes, Diwan [14] demonstrated that kinases which were inhibited by flavopiridol had been necessary for transcription generally, whereas the kinases which were effectively inhibited by roscovitine had been necessary for pre-initiation or initiation of transcription in support of from viral genomes. (acancerjourney.info)
  • In regular individual fibroblasts, roscovitine causes cell routine arrest by inhibiting CDK2 [23]. (antiviralbiologic.com)
  • By inhibiting CDK1 and CDK2, roscovitine prevents cell routine development. (antiviralbiologic.com)
  • One of the kinases that place the tyrosine phosphate is Wee1, a kinase conserved in all eukaryotes. (wikipedia.org)
  • Inhibiting WEE1 abrogates G2 cell cycle arrest, resulting The tyrosine kinase WEE1 regulates cyclin-dependent kinase in premature entry into mitosis and leading to aberrantly 1 (CDK1), which drives cells from the G2 phase into mitosis, high CDK2 activity in S-phase cells, with the deregulated and CDK2, which drives cells into and through the S phase DNA replication resulting in replication stress [1, 5]. (sagepub.com)
  • Studies in knockout mice revealed that CDK1 can compensate for the loss of the cdk2 gene as it can also bind cyclin E and drive G1 to S phase transition. (umbc.edu)
  • In the present study, we tested whether Cdk2 can compensate for the loss of Cdk1. (elsevierpure.com)
  • About 24% of these proteins were phosphorylated more efficiently by Clb5-Cdk1 than Clb2-Cdk1. (nature.com)
  • We show that cyclin-dependent kinase (CDK) consensus motifs are frequently clustered in CDK substrate proteins. (biomedcentral.com)
  • This study provides evidence of the molecular differences between Cdk2 and Cdk1 and highlights that the timing of transcriptional activation and the genetic locus play important roles in determining the function of Cdk proteins in vivo. (elsevierpure.com)
  • Cyclin-dependent kinases and tumor suppressor proteins are stimulators and modulators of cell division. (ptgcn.com)
  • We looked into whether modulating cyclin-dependent kinase (CDK) activity could alter matrix proteins and cytokine creation by SSc fibroblasts. (antiviralbiologic.com)
  • ADOS Proteins kinases are putative goals of brand-new herpesviral drugs because of their important function in the legislation of HCMV replication [3,4,5,6,7,8]. (niepokorny.org)
  • Its kinase area contains subdomains (SD) I-XI, that are conserved (aa 337C651) within herpesviral and mobile proteins kinases. (niepokorny.org)
  • We found that LCH decreased epidermal growth factor receptor (EGFR) and AKT kinase activities and related activating signaling proteins including pEGFR and pAKT. (biomolther.org)
  • Figure 1: Identification of Clb5-specific Cdk1 substrates in budding yeast. (nature.com)
  • Identification of N,1,4,4-tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide (PHA-848125), a potent, orally available cyclin dependent kinase inhibitor. (ncats.io)
  • CPS2 is a potent and selective CDK2 Degrader (PROTAC ® ) (IC 50 = 24 nM). (tocris.com)
  • Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. (affbiotech.cn)
  • AT9283 is a multi-targeted kinase inhibitor with potent activity against Aurora A/B , JAK2 /3 , Abl (T315I) and Flt3 ( IC 50 s ranging from 1 to 30 nM). (medchemexpress.com)
  • AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor with IC 50 of 5 nM, 4 nM and 1 nM for Aurora A , B and C , respectively. (medchemexpress.com)
  • SNS-314 mesylate is a potent and selective aurora kinase inhibitor with IC 50 s of 9, 31, and 6 nM for aurora A, B and C, respectively. (medchemexpress.com)
  • CCT 137690 is a potent and orally available aurora kinase inhibitor with IC 50 s of 15, 25, and 19 nM for aurora A, B and C, respectively. (medchemexpress.com)
  • Dual targeting of CDK and tropomyosin receptor kinase families by the oral inhibitor PHA-848125, an agent with broad-spectrum antitumor efficacy. (ncats.io)
  • Description: RET is a receptor kinase for GDNF (glial cell-line derived neurotrophic factor) family ligands (GFLs). (morulaivf.com)
  • There are three primary growth factors that relate to tyrosine kinase. (callaix.com)
  • Description: Bruton's tyrosine kinase or BTK, is an enzyme that plays a role in the functionality and maturation of B cells. (morulaivf.com)
  • Zhao J, Kennedy BK, Lawrence BD, Barbie DA, Matera AG, Fletcher JA, Harlow E. NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription. (proteopedia.org)
  • In addition, we generated Cdk2 -/- Cdk1 +/Cdk2KI mice in which one copy of Cdk2 and one copy of Cdk1 were expressed from the Cdk1 locus and the Cdk2 gene was deleted from the endogenous Cdk2 locus. (elsevierpure.com)
  • This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. (affbiotech.cn)
  • Despite these important roles, mice deleted for the cdk2 gene are viable and normal except for being sterile. (umbc.edu)
  • Despite their amazing protection record and effectiveness, some nucleoside and Medetomidine HCl IC50 nucleotide analogues show significant toxicity and focus on energetic sites on virus-encoded kinases or DNA polymerases. (acancerjourney.info)
  • The RET Assay Kit is designed to measure RET activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent. (morulaivf.com)
  • The RET Assay Kit comes in a convenient 96-well format, with enough purified recombinant RET enzyme, RET substrate peptide (IRF-1Rtide), ATP and kinase assay buffer for 100 enzyme reactions. (morulaivf.com)
  • The BTK Assay Kit comes in a convenient 96-well format, with enough purified recombinant BTK enzyme, PolyGluTyr peptide, ATP, and kinase assay buffer for 100 enzyme reactions. (morulaivf.com)
  • It induces CDK2 degradation in several AML cell lines, including NB4, U937, OCI-AML2, OCI-AML3 and Kasumi-1 cells. (tocris.com)
  • Predicated on series evaluation and a 3D style of pUL97, the viral kinase displays structural similarity to CDK2 in the catalytic middle and in functionally essential residues from the ATP binding site [16]. (niepokorny.org)
  • Quite interestingly, we found that a CDK inhibitor, Far1, could regulate the Cln2-CDK1 activity partly by inhibiting the Cln2-substrate interaction, thus demonstrating that docking interactions can be targets of regulation. (umassmed.edu)
  • These results demonstrate that Cdk2-E activity is required for centrosome duplication during S phase and suggest a mechanism that could coordinate centrosome reproduction with cycles of DNA synthesis and mitosis. (umassmed.edu)
  • Notably, the next SD includes an invariant lysine residue (K355), the substitute mutation which resulted in an entire lack of kinase activity [16,30,31]. (niepokorny.org)
  • Therefore, the upregulation of p21 expression may contribute to G2 M arrest in the early stages, and then Cdk2 may regulate endoreduplication by treating leukemia cells in the middle stages in the presence of SP600125. (hsp90-inhibitors.com)
  • The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). (novusbio.com)
  • Cyclin B1 and B2 can localize Cdk1 to the nucleus and the Golgi, respectively, through a localization sequence outside the CDK-binding region. (wikipedia.org)
  • Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. (proteopedia.org)
  • Targets of the cyclin-dependent kinase Cdk1. (nature.com)
  • Alisertib (MLN 8237) is an orally active and selective Aurora A kinase inhibitor ( IC 50 =1.2 nM), which binds to Aurora A kinase resulting in mitotic spindle abnormalities, mitotic accumulation. (medchemexpress.com)
  • This indicates that high levels of p21 and Cdk2 can be expressed at different times in G2 M arrest and endoreduplication because endoreduplication occurs after G2 M arrest. (hsp90-inhibitors.com)
  • The present study has shown that an increase in p21 expression coincides with the onset of G2 M arrest at 24 h, but that endoreduplication may occur due to loss of p21 and a maximum level of Cdk2 at 48 h. (hsp90-inhibitors.com)
  • This subfamily is composed of CDK1 from higher eukaryotes, plants, and yeasts, as well as CDK2 and CDK3. (umbc.edu)
  • Structure-based design was performed using 35 cocrystal structures of CDK2 liganded with distinct analogues of the parent compound. (rcsb.org)
  • When these kinases go wrong, normal cellular function can go awry. (callaix.com)
  • The translocational and cell cycle properties of knockin Cdk2 in Cdk2 -/- Cdk1 +/Cdk2KI cells were comparable to those of endogenous Cdk2, but we detected premature transcriptional activation of Cdk1 during liver regeneration in the absence of Cdk2. (elsevierpure.com)
  • Brown, N. R., Noble, M. E., Endicott, J. A. & Johnson, L. N. The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases. (nature.com)
  • The cyclin-dependent kinase inhibitor PHA-848125 suppresses the in vitro growth of human melanomas sensitive or resistant to temozolomide, and shows synergistic effects in combination with this triazene compound. (ncats.io)
  • Substitution of both copies of Cdk1 by Cdk2 led to early embryonic lethality, even though Cdk2 was expressed from the Cdk1 locus. (elsevierpure.com)
  • M any kinase inhibitor compounds have been found. (callaix.com)