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  • Inhibitor
  • Cyclin-dependent kinase 6 (CDK6) bound to the inhibitor ribociclib (detail view). (news-medical.net)
  • The Kinase Selectivity Profiling Systems provide a convenient 8-tube strip format that is optimized for fast and simple kinase inhibitor profiling. (promega.com)
  • Janus
  • The four JAK family members are: Janus kinase 1 (JAK1) Janus kinase 2 (JAK2) Janus kinase 3 (JAK3) Tyrosine kinase 2 (TYK2) Transgenic mice that do not express JAK1 have defective responses to some cytokines, such as interferon-gamma. (wikipedia.org)
  • phosphate
  • Phosphatidylinositol phosphate kinases (PIPK) are kinases that phosphorylate the phosphoinositides PtdInsP and PtdInsP2 that are derivatives of phosphatidylinositol (PtdIns). (wikipedia.org)
  • The activation loop of phosphatidylinositol phosphate kinases determines signaling specificity. (wikipedia.org)
  • Kinases should not be confused with phosphorylases, which catalyze the addition of inorganic phosphate groups to an acceptor, nor with phosphatases, which remove phosphate groups. (wikipedia.org)
  • Alternatively, some kinases utilize bound metal cofactors in their active sites to coordinate the phosphate groups. (wikipedia.org)
  • A kinase gets these phosphate groups from special molecules like ATP. (vanderbilt.edu)
  • A kinase transfers the phosphate group to certain amino acids. (vanderbilt.edu)
  • Aminoglycoside-3'-phosphotransferase (APH(3')), also known as aminoglycoside kinase, is an enzyme that primarily catalyzes the addition of phosphate from ATP to the 3'-hydroxyl group of a 4,6-disubstituted aminoglycoside, such as kanamycin. (wikipedia.org)
  • Mutations
  • Mutations in kinases that lead to a loss-of-function or gain-of-function can cause cancer and disease in humans, including certain types of leukemia and neuroblastomas, glioblastoma, spinocerebellar ataxia (type 14), forms of agammaglobulinaemia, and many others. (wikipedia.org)
  • Anitha M, Kaur G, Baquer NZ, Bamezai R. Dominant negative effect of novel mutations in pyruvate kinase-M2. (springer.com)
  • Missense mutations in pyruvate kinase M2 promote cancer metabolism, oxidative endurance, anchorage independence, and tumor growth in a dominant negative manner. (springer.com)
  • phosphatases
  • The Human Kinases & Phosphatases qBiomarker Copy Number PCR Array profiles the copy number of 23 genes encoding kinases or phosphatases reported to undergo frequent genomic alterations. (qiagen.com)
  • glycolysis
  • Chen J, Xie J, Jiang Z, Wang B, Wang Y, Hu X. Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2. (springer.com)
  • targets
  • However, in terms of signalling outputs and disease relevance, both kinases and pseudokinases are important signalling modulators in human cells, making kinases very important drug targets. (wikipedia.org)
  • metabolism
  • Reexpression of pyruvate kinase M2 in type 1 myofibers correlates with altered glucose metabolism in myotonic dystrophy. (springer.com)
  • Resveratrol inhibits cancer cell metabolism by down regulating pyruvate kinase M2 via inhibition of mammalian target of rapamycin. (springer.com)