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  • phosphorylation
  • Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. (cancerindex.org)
  • In cardiomyocytes cultured on ECM, PE stimulated a rapid increase in tyrosine phosphorylation of focal adhesion proteins including FAK, paxillin and p130 Crk associated substrate (CAS) and subsequent formation of peripheral focal complexes. (businessdocbox.com)
  • Here, we show that in fibroblasts, insulin, epidermal growth factor (EGF) and serum activate ATF2 via a so far unknown two‐step mechanism involving two distinct Ras effector pathways: the Raf-MEK-ERK pathway induces phosphorylation of ATF2 Thr71, whereas subsequent ATF2 Thr69 phosphorylation requires the Ral-RalGDS-Src-p38 pathway. (embopress.org)
  • homology
  • has shown that, in tomato ( Lycopersicon esculentum ) fruit, the transcription of a gene, which showed high homology to a monomeric G-protein from pea, is rapidly but transiently up-regulated by ethylene. (plantphysiol.org)
  • and ( vii ) likely protein misclassifications exemplified by a predicted pleckstrin homology domain in a Candida albicans protein, previously described as an integrin. (pnas.org)
  • Such conserved motifs include the Src homology 3 (SH3) domain that binds to proline-rich amino acid sequences (Pro-X-X-Pro) ( 62 , 82 ) and the PDZ domain, a 80- to 90-amino acid modular protein interaction domain, named after the three proteins in which this domain was first identified (PSD-95/Discs large protein/ZO-1) ( 45 , 96 ). (physiology.org)
  • The other functional domain is the N-terminal CDC25-like domain, which possesses a structural homology to guanine nucleotide exchange proteins for Ras. (embl-heidelberg.de)
  • Cdc42
  • Overexpression of DOCK 180 induces activation of Rac, and DOCK 180 binds to Rac1, but not RhoA or Cdc42 ( 15 ). (jimmunol.org)
  • cytoskeleton
  • Through the recent application of molecular and proteomic approaches, we now know that the interactions between epithelial ion channels and actin can either be direct or indirect, the latter being mediated through scaffolding or actin-binding proteins that serve as links between the channels and the actin-based cytoskeleton. (physiology.org)
  • However, it was unclear from these studies whether the effects of actin on ion channel activity were related to actin directly binding to the channel or a channel-associated actin-binding protein or whether the observed effects were mediated through the activation or inactivation of cytoskeleton-associated second messengers. (physiology.org)
  • Na + /H + exchanger regulatory factors (NHERFs)] or actin-binding proteins (e.g., α-actinin, spectrin) that serve as a link between the channel and the actin-based cytoskeleton ( Table 1 ). (physiology.org)
  • Integrins are a family of heterodimeric transmembrane receptors (composed of α and β subunits) containing extracellular ligand binding domains that show binding specificity for extracellular matrix (ECM) components and a short cytoplasmic domain that serves to couple integrins with the actin cytoskeleton (3). (businessdocbox.com)
  • exocytosis
  • Exocytosis is a basic cell biological process mediated by transport, docking, and fusion of secretory vesicles carrying proteins and lipids to the plasma membrane. (upenn.edu)
  • Also through exocytosis, membrane proteins and lipids can be incorporated into specific domains of plasma membrane for cell surface expansion, cell growth, morphogenesis, and cell migration. (upenn.edu)
  • Ral-mediated exocytosis is also involved such biological processes as platelet activation, immune cell functions, neuronal plasticity, and regulation of insulin action. (wikipedia.org)
  • mitochondrial
  • Moreover, RalA specifically interacts with Exo84 and Sec5 to regulate transport of membrane proteins in polarized epithelial cells and GLUT4 to the plasma membrane, as well as mitochondrial fission for cell division. (wikipedia.org)
  • signal transduction
  • The network for 'regulation of ras protein signal transduction' in your query organism is displayed on the left, if relationships are supported by the integrated data. (princeton.edu)
  • Any process that modulates the frequency, rate or extent of Ras protein signal transduction. (princeton.edu)