Phosphatidylinositol 3-kinaProteinNitric oxidePI3KEndogenousNeuronalCarbonMammalianEnzymeAutophagyAMPKInhibitionCardiovascularDimethylMetabolicRenalProteinsTargetsArchaeaMoleculesMethionineCellularActivationPTENLungDecreaseEffectsImportantRoleResponseFormationAnalysisShownSystemsCancerMajorPotential
Phosphatidylinositol 3-kina3
- Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. (drugbank.com)
- We observed that H 2 S can improve left ventricular function and the deposition of myocardial collagen fibers, inhibit pyroptosis, down-regulate the expression of P-eif2α in myocardial tissue, and inhibit cell autophagy by activating the phosphatidylinositol 3-kinase (PI3K)/AKT1 signaling pathway (p (kjpp.net)
- Signals downstream of phosphatidylinositol 3-kinase (PI3K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. (sabbiotech.cn)
Protein13
- The underlying mechanisms of H 2 S in ameliorating neuronal apoptosis might be executed through inhibition of the activity of mammalian sterile 20-like kinase 1 (MST1) protein. (oncotarget.com)
- Additionally, we showed a so far unreported suppression of mitogen-activated protein kinase (MAPK) and protein phosphatase 1 pathways during torpor. (bvsalud.org)
- As the most common strategy to suppress metabolism, that is, cooling, does not reveal unequivocal beneficial effects and may even increase mortality, caloric restriction or modulation of energy-sensing pathways (i.e., sirtuins and AMP-activated protein kinase) may offer safe alternatives. (bvsalud.org)
- Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. (drugbank.com)
- Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. (drugbank.com)
- ROS may induce intracellular calcium increase and subsequent contraction of PASMCs via direct or indirect interactions with protein kinases, phospholipases, sarcoplasmic calcium channels, transient receptor potential channels, voltage-dependent potassium channels and L-type calcium channels, whose relevance may vary under different experimental conditions. (ersjournals.com)
- General protein kinase capable of phosphorylating several known proteins. (sabbiotech.cn)
- MNU 47 mg/kg, i.v.) and group IV (Tada- activate protein kinase G and map kinase pathway of lafil 4 mg/kg, p.o. (sagepub.com)
- Three arms exist in the ER stress response: the protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), activating transcription factor 6 (ATF6), and inositol-requiring enzyme 1 (IRE1) pathways, where each of the sensor proteins is a membrane protein ( Figure 1 ). (encyclopedia.pub)
- The mammalian ER stress response consists of three arms: the inositol-requiring enzyme 1 (IRE1), protein kinase R (PKR)-like ER kinase (PERK), and activating transcription factor 6 (ATF6) pathways. (encyclopedia.pub)
- Ghrelin protects the myocardium with hypoxia/reoxygenation treatment through upregulating the expression of growth hormone, growth hormone secretagogue receptor and insulin-like growth factor-1, and promoting the phosphorylation of protein kinase B. Int. J. Mol. (biossantibodies.com)
- Ghrelin protects the myocardium with hypoxia/reoxygenation treatment through upregulating the expression of growth hormone, growth hormone secretagogue receptor and insulin-like growth factor-1, and promoting the phosphorylation of protein kinase B. (2018) Int.J.Mol.Med. (biossantibodies.com)
- Phosphoinositide-3 kinase (PI3K) is a key signaling protein in cell metabolism, and serine/threonine kinase (Akt) is the primary target molecule downstream of PI3K. (springeropen.com)
Nitric oxide6
- Hydrogen sulfide (H 2 S) has been regarded as the third gaseous transmitter alongside nitric oxide (NO) and carbon monoxide (CO). In mammalian brain, H 2 S is produced redundantly by four enzymatic pathways, implying its abundance in the organ. (springer.com)
- Li L, Hsu A, Moore PK (2009) Actions and interactions of nitric oxide, carbon monoxide and hydrogen sulphide in the cardiovascular system and in inflammation-a tale of three gases! (springer.com)
- For instance, some studies have suggested that in addition to antioxidant enzymes, nitric oxide synthases (NOSs), and other traditional enzymes, novel molecular targets such as mitochondria-targeting hydrogen sulfide (H 2 S) donor AP39 and its auxiliary targets have recently been identified as critical participants in H 2 S synthesis for modulating the postischemic cardiomyocyte survival in a manner independent of classical cytosolic signaling mechanisms [ 7 , 8 ]. (hindawi.com)
- Hydrogen sulfide (H 2 S) is involved in many biological systems, and like nitric oxide and carbon monoxide, it is a signaling molecule in mammalian cells [ 12 ]. (biomedcentral.com)
- The main focus of our research team has been the regulation and physiological functions of the nitric oxide/cGMP pathway and their contribution to disease initiation and progression. (org.gr)
- We have explored the therapeutic potential of modulators of the NO/cGMP pathway in cardiovascular and lung disease and have studied the pharmacology of nitric oxide donors, phosphodiesterase inhibitors, and soluble guanylyl cyclase activators and stimulators. (org.gr)
PI3K11
- In addition, angiotensin II (1 μM) H9c2 cardiomyocytes were injured in vitro experiments, and it was also observed that pyroptosis was inhibited after H 2 S (400 μmol/kg) intervention, the expression of P-eif2α in cardiomyocytes was significantly down-regulated, and the PI3K/AKT1 signaling pathway was activated at the same time. (kjpp.net)
- Therefore, increasing the expression of P-eif2α reverses the activation of the PI3K/AKT1 signaling pathway by H 2 S. In conclusion, these findings suggest that exogenous H 2 S can ameliorate MF in rats with AAC by inhibiting pyroptosis, and the mechanism may be associated with inhibiting the phosphorylation of eif2α and activating the PI3K/AKT1 signaling pathway to inhibit excessive cell autophagy. (kjpp.net)
- et al, Effect of Fushengong Decoction on PTEN/PI3K/AKT/NF-KB Pathway in Rats With Chronic Renal Failure via Dual-Dimension Network Pharmacology Strategy.In Front Pharmacol on 2022 Mar 15 by Hongyu Luo, Munan Wang,et al. (sabbiotech.cn)
- et al, CD155 Cooperates with PD-1/PD-L1 to Promote Proliferation of Esophageal Squamous Cancer Cells via PI3K/Akt and MAPK Signaling Pathways. (sabbiotech.cn)
- et al, Effect of Fushengong Decoction on PTEN/PI3K/AKT/NF-κB Pathway in Rats With Chronic Renal Failure via Dual-Dimension Network Pharmacology Strategy. (sabbiotech.cn)
- et al, The Flavagline Compound 1-(2-(dimethylamino)acetyl)-Rocaglaol Induces Apoptosis in K562 Cells by Regulating the PI3K/ Akt/mTOR, JAK2/STAT3, and MAPK Pathways. (sabbiotech.cn)
- Timosaponin A-III reverses multi-drug resistance in human chronic myelogenous leukemia K562/ADM cells via downregulation of MDR1 and MRP1 expression by inhibiting PI3K/Akt signaling pathway. (biossantibodies.com)
- Leucine attenuates muscle atrophy and autophagosome formation by activating PI3K/AKT/mTOR signaling pathway in rotator cuff tears. (biossantibodies.com)
- Resistin up-regulates LPL expression through the PPARγ-dependent PI3K/AKT signaling pathway impacting lipid accumulation in RAW264. (biossantibodies.com)
- Moreover, PI3K/Akt-mammalian target of rapamycin (mTOR) is one of the two detrimental signaling pathways that control autophagy. (springeropen.com)
- Khan MA, Jain VK, Rizwanullah M, Ahmad J, Jain K. PI3K/AKT/mTOR pathway inhibitors in triple-negative breast cancer: a review on drug discovery and future challenges. (eurekaselect.com)
Endogenous3
- Abe K, Kimura H (1996) The possible role of hydrogen sulfide as an endogenous neuromodulator. (springer.com)
- Elevated endogenous estrogens stimulate human uterine artery endothelial cell (hUAEC) hydrogen sulfide (H 2 S) production by selectively upregulating the expression of H 2 S synthesizing enzyme cystathionine β-synthase (CBS), but the underlying mechanisms are underdetermined. (bioscientifica.com)
- Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. (nih.gov)
Neuronal1
- Although these techniques tackle the coupling between neuronal activity and metabolism, they lack chemical specificity and fail in providing information on neuronal and glial metabolic pathways underlying those processes. (frontiersin.org)
Carbon3
- More recently, our group has expanded its work on gasotransmitters other than NO, such as carbon monoxide and hydrogen sulfide. (org.gr)
- Rate constants for the reaction of hydroxyl radicals with carbonyl sulfide, carbon disulfide and dimethyl thioether over the temperature range 299-430 K. (cdc.gov)
- We seek to understand some of the important abiotic chemical reaction pathways responsible for carbon turnover. (stanford.edu)
Mammalian1
- Nicholson RA, Roth SH, Zhang A, Zheng J, Brookes J, Skrajny B, Bennington R (1998) Inhibition of respiratory and bioenergetic mechanisms by hydrogen sulfide in mammalian brain. (springer.com)
Enzyme3
- While the expression of cystathionine β-synthase (CBS), an enzyme involved hydrogen sulfide (H 2 S) synthesis, was reduced in both aged males and females, decreased H 2 S generation was seen in only males. (uthscsa.edu)
- This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. (nih.gov)
- The first, ubiquitous, enzyme of the pathway, MtnA (methylthioribose-1-phosphate isomerase), belongs to a family of proteins related to eukaryotic intiation factor 2B alpha. (biomedcentral.com)
Autophagy2
- This study aimed to assess the effects of exogenous hydrogen sulfide (H 2 S) on abdominal aorta coarctation (AAC) induced myocardial fibrosis (MF) and autophagy in rats. (kjpp.net)
- Autophagy is a lysosomal breakdown pathway that is crucial for cell survival, homeostasis, and function. (springeropen.com)
AMPK1
- Hydrogen Sulfide and/or Ammonia Reduces Spermatozoa Motility through AMPK/AKT Related Pathways. (biossantibodies.com)
Inhibition3
- Warenycia MW, Smith KA, Blashko CS, Kombian SB, Reiffenstein RJ (1989) Monoamine oxidase inhibition as a sequel of hydrogen sulfide intoxication: increases in brain catecholamine and 5-hydroxytryptamine levels. (springer.com)
- Conclusion: The results confirm that Tadalafil treatment restored all the biological markers to the normal and its involvement in mitochondrial mediated death apoptosis pathway along with inhibition of inflammatory markers. (sagepub.com)
- Surgical incision induces learning impairment in mice partially through inhibition of the brain-derived neurotrophic factor signaling pathway in the hippocampus and amygdala. (biossantibodies.com)
Cardiovascular1
- Lead- (Pb-) induced hypertension has been shown in humans and experimental animals and cardiovascular effects of hydrogen sulfide (H 2 S) have been reported previously. (hindawi.com)
Dimethyl1
- Members of the marine Roseobacter clade can degrade dimethylsulfoniopropionate (DMSP) via competing pathways releasing either methanethiol (MeSH) or dimethyl sulfide (DMS). (beilstein-journals.org)
Metabolic2
- Many are highly dependent on the presence of oxygen, suggesting that the ecological niche may play an important role for the existence and/or metabolic steps of the pathway, even in phylogenetically related bacteria. (biomedcentral.com)
- Availability of a huge number of genome sequences (1004 ongoing or completed genome sequencing programmes are listed at http://wit.integratedgenomics.com/GOLD/ on February 17th, 2004) now allows scientists to explore new avenues in the deciphering of metabolic pathways. (biomedcentral.com)
Renal2
- Cao X, Bian J (2016) The role of hydrogen sulfide in renal system. (springer.com)
- some of the signaling pathways involved in renal senescence differ between male and female marmosets. (uthscsa.edu)
Proteins3
- Another line of research development centers on the establishment of novel chemical libraries aiming at mechanism-based or lead compound-based drug discovery for cancer/inflammation, particularly by targeting Bcl-2 family proteins and apoptosis pathways, transcription factors as well as epigenetic therapy with the aid of molecular docking and chemical synthesis. (utmb.edu)
- In addition to DNA repair proteins, bacteria and eukaryotes have damage response pathways whose function is to detect DNA damage and modulate cellular processes. (biomedcentral.com)
- In the PARK2-dependent pathway, PINK1 activates PARK2 to target many mitochondrial proteins, including NDP52, OPTN and p62, and it combines with LC3 to deliver damaged mitochondria to autophagosomes [ 15 ]. (ijbs.com)
Targets2
- The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
- In conclusion, we document gene regulation between hibernation phases, which may aid the identification of pathways and targets to prevent organ damage in transplantation or ischaemia-reperfusion. (bvsalud.org)
Archaea2
- Whilst archaea have eukaryal-type informational pathways such as DNA replication and transcription, archaeal DNA repair pathways are still poorly understood. (biomedcentral.com)
- Further work is needed to uncover the corresponding steps when dioxygen is scarce or absent (this is important to explore the presence of the pathway in Archaea). (biomedcentral.com)
Molecules1
- Converts two cysteine molecules to lanthionine and hydrogen sulfide. (nih.gov)
Methionine4
- Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. (nih.gov)
- This work uses genome in silico analysis to propose methionine salvage pathways for Klebsiella pneumoniae , Leptospira interrogans , Thermoanaerobacter tengcongensis and Xylella fastidiosa . (biomedcentral.com)
- A functional methionine salvage pathway was experimentally demonstrated, for the first time, in P. aeruginosa . (biomedcentral.com)
- Apparently, methionine salvage pathways are frequent in Bacteria (and in Eukarya), with recruitment of different polypeptides to perform the needed reactions (an ancestor of a translation initiation factor and RuBisCO, as an enolase, in some Firmicutes). (biomedcentral.com)
Cellular2
- Research may be complicated by the fact that the acute phase of HPV, which lasts seconds to minutes to match ventilation to perfusion on a breath-to-breath basis, in contrast to sustained HPV, which lasts minutes to hours, may result from different cellular pathways. (ersjournals.com)
- In addition to essential functions in cellular function, organelles serve important roles as sensors of stress and as hubs for signaling pathways. (encyclopedia.pub)
Activation3
- In both sexes, aging promoted kidney activation of transforming growth factor β-1 signaling pathway. (uthscsa.edu)
- dGLYAT was found to regulate Gadd45 -mediated JNK pathway activation and cell invasion. (sdbonline.org)
- Firstly, loss of dGLYAT suppressed scrib depletion- or Egr overexpression-induced JNK pathway activation and invasive cell migration. (sdbonline.org)
PTEN1
- MicroRNA-26b Modulates the NF-κB Pathway in Alveolar Macrophages by Regulating PTEN. (biossantibodies.com)
Lung1
- Wu CHK (2013) The role of hydrogen sulphide in lung diseases. (springer.com)
Decrease1
- Decrease in male mouse fertility by hydrogen sulfide and/or ammonia can Be inheritable. (biossantibodies.com)
Effects2
- Similar effects may be offered when mimicking hibernation by hydrogen sulfide (H2S). (bvsalud.org)
- Effects of HA-ADT on the apoptotic level and AKT/GSK-3 β / β -catenin pathway in human HCC cells. (bioz.com)
Important3
- [email protected] tion of the important signalling pathways [3]. (sagepub.com)
- This study demonstrated that the Receptor for Activated C-Kinase 1 (RACK1) is important in SC function. (sdbonline.org)
- We seem to understand important chemical pathways responsible for POP destruction in the environment, so we can design less persistent and problematic chemicals in the future. (stanford.edu)
Role3
- Background: Hydrogen sulfide (H 2 S) has shown a neuroprotective role in several cerebrovascular diseases. (oncotarget.com)
- Magierowski M, Jasnos K, Kwiecień S, Brzozowski T (2012) Role of hydrogen sulfide in the physiology of gastrointestinal tract and in the mechanism of gastroprotection. (springer.com)
- The role of DMSP degradation pathways for MeSH and DMS formation was further investigated by using the synthetic analogue DMTeP as a probe in feeding experiments with the wild-type strain and knockout mutants. (beilstein-journals.org)
Response4
- The pathophysiological nature of MIRI is the short-term disturbance of myocardial energy and metabolism caused by reflow after ischemia and hypoxia in the coronary artery and the dynamic changes in apoptosis and the prosurvival signaling pathways in response to related injury factors. (hindawi.com)
- Archaeal information processing pathways resemble those in eukaryotes, but archaeal damage response pathways remain poorly understood. (biomedcentral.com)
- We have identified a Golgi stress response pathway which is dysregulated in HD. (encyclopedia.pub)
- These data suggest that the observed naloxone-induced antinociceptive response is the consequence of the local expression of MORS196A-CSTA at specific PFTα solubility dmso sites of pain pathway. (mglursignaling.com)
Formation1
- The central theme of this methodology is the formation of alpha -aminoalkyl radicals from existing amino acid and alpha -amino alcohol derivatives by 1,5-hydrogen atom transfer and the subsequent trapping of these radicals with appropriate radicalphiles, thus generating quaternary centres with high efficiency and excellent stereocontrol. (exeter.ac.uk)
Analysis1
- Proteomics Analysis of Hepatocyte Proliferation Regulated by FGF, PDGF, Insulin, Oncostatin M and Interleukin 2 Signaling Pathways during Rat Liver Regeneration. (biossantibodies.com)
Shown1
- Hydrogen sulfide (H 2 S) has been shown to be a neuromodulator that is thought to have anti-apoptotic, anti-inflammatory, and anti-oxidative benefits. (biomedcentral.com)
Systems1
- Zhu X-Y, Gu H, Ni X (2011) Hydrogen sulfide in the endocrine and reproductive systems. (springer.com)
Cancer1
- YD277 Suppresses Triple-Negative Breast Cancer Partially Through Activating the Endoplasmic Reticulum Stress Pathway. (utmb.edu)
Major2
- Midbrain periaqueductal gray (PAG) and spinal cord dorsal horn are major action sites of opioid analgesics in the pain pathway. (mglursignaling.com)
- There are two major mitophagy pathways, namely, PARK2-dependent and PARK2-independent signaling [ 14 ]. (ijbs.com)
Potential1
- We explored signaling pathways as potential mechanistic events. (uthscsa.edu)