Kinase kinase kinase x linked inhibitor of apoptosis protein. Medical search. Frequent questions

Inhibition of DNA-dependent protein kinase catalytic subunit by small molecule inhibitor NU7026 sensitizes human leukemic K562 cells to benzene metabolite-induced apoptosis. (cdc.gov)
Consistently, expression of active RAF suppressed apoptosis induced by hBAD and the inhibition of colony formation caused by hBAD could be prevented by RAF. (uni-wuerzburg.de)
Similar findings were made in bone marrow cells from gene-targeted mice lacking Bim and/or Puma infected with FLT3-ITD and treated with inhibitor, where loss of Puma only provided transient protection from apoptosis, but loss of Bim preserved clonal survival upon FLT3-ITD inhibition. (ashpublications.org)
ERK inhibition on PIP protein level in MDA MB 453 and HCC 1954 cell lines. (cdantigens.com)
study is, to the best of our knowledge, the first to confirm that ILL can inhibit the invasion and migration of A549 cancer cells, with the possible mechanisms potentially involving the inhibition of MMP-2 and -catenin protein expression resulting from the up regulation of NM23-H1 expression. (insulin-receptor.info)
Isolinderalactone (ILL) is certainly a kind of sesquiterpene substance obtained from the main tuber of (27) confirmed that ILL could induce apoptosis in the individual breast cancers MDA-MB-231 cell series, perhaps via the inhibition of microRNA hsa-miR-30c appearance and raising the appearance of suppressor of cytokine signaling 3 (SOCS3). (insulin-receptor.info)
Targeted inhibition of individual kinases of the MAPK signaling pathway using synthetic compounds represents a promising way to effective anti-cancer therapy. (mdpi.com)
Ibrutinib is a Bruton's tyrosine kinase (BTK) inhibitor that forms a covalent bond with a cysteine residue in the BTK active site, leading to inhibition of BTK enzymatic activity. (medscape.com)

IAPs limit activation of RIP kinases by TNF receptor 1 during development. (ozgene.com)
Loss of inhibitor of apoptosis proteins (IAPs), particularly cIAP1, can promote production of tumor necrosis factor (TNF) and sensitize cancer cell lines to TNF-induced necroptosis by promoting formation of a death-inducing signaling complex containing receptor-interacting serine/threonine-protein kinase (RIPK) 1 and 3. (ox.ac.uk)
c-IAP2 (inhibitor of apoptosis protein-2) belongs to IAPs family and besides exerting antiapoptotic effects through its interaction with multiple cytokines, it participates in inflammation, immunity and mitogenic kinase signal transduction, cell proliferation, invasion and metastasis also. (novusbio.com)
The IAPs are evolutionarily conserved proteins that serve to inhibit apoptosis by binding to and inhibiting activation of caspases (24-26). (immune-source.com)
2006] PMID:16356795 The inhibitors of apoptosis (IAPs) as cancer targets. (ac.be)
Inhibitors of apoptosis proteins (IAPs), mainly survivin and X-linked inhibitor of apoptosis (XIAP) prevent the processing of procaspase 3 to caspase 3, thereby inhibiting apoptosis. (oncologynurseadvisor.com)

The apoptosis was transduced by multiple signaling pathways mediated by FasL and TNFR2 and mainly activated the mitochondrial control of apoptosis via Bid and Bim, which was rescued by silencing Bid or/and Bim . (biomedcentral.com)
Our study suggests that our developed PIP5K1α inhibitor has a great potential on refining targeted therapeutics for treatment of triple-negative and ER+ BC with abnormal PI3K/AKT pathways. (lu.se)
For instance, CSC maintenance in glioblastoma, colon cancer, gastric cancer, and prostate cancer is regulated by CD133-mediated AKT, leucine-rich G-protein-coupled receptor 5 (LGR5)-mediated Wnt/β-catenin and speckle-type POZ protein (SPOP)-mediated Nanog pathways [ 4 - 8 ] . (oaepublish.com)
These events are influenced by and activate other molecular pathways, including phosphatidylinositol 3-kinase (PI3K), mammalian target of rapamycin (mTOR), and mitogen-activated protein kinase (MAPK),[2] and therapies are now available that target these pathocellular processes. (cancernetwork.com)
Akt pathways have effects on apoptosis, protein synthesis, metabolism and cell cycle. (springer.com)
AMPK pathways inhibit biosynthetic pathways with energy consumption, such as protein, fatty acid and glycogen synthesis. (springer.com)
More specifically, substrates with certain FYVE domains (named after the first four proteins in this motif, Fab1, YotB, Vac1p, and EEA1) bind PIP, and these pathways have been implicated in vesicular trafficking or receptor-mediated endocytosis ( 5 ). (asm.org)
What pathways are this gene/protein implicaed in? (cancerindex.org)
Therefore inhibits the phosphorylation of indication transducer and activator of transcription 3 (STAT3) and regulates the downstream digesting of STAT3 pathways, raising B-cell lymphoma-2 (Bcl-2) and Bcl-extra huge proteins appearance, and inhibiting X-linked inhibitor of apoptosis appearance. (insulin-receptor.info)
Cross-talk of the MAPK signaling pathway with other proteins and signaling pathways have a crucial impact on clinical outcomes of targeted therapies and plays important role during development of drug resistance in cancers. (mdpi.com)
We present in a synthetic fashion the main molecular and cellular pathways leading to drug-induced apoptosis in kidney and the mechanisms regulating it. (ac.be)
Another mechanism is up-regulation of pathways that inhibits cell apoptosis. (oncologynurseadvisor.com)

We investigated the role of phosphatidylinositol-4-phosphate 5-kinase alpha (PIP5Kα), a key upstream factor of PI3K/AKT, and the therapeutic effect of PIP5Kα inhibitor on subtypes of BC. (lu.se)
NVP-BEZ235 (a PI3K/mTOR inhibitor), TSSC3 and specific Chinese herbal remedies enhance chemosensitivity in Operating-system by raising apoptosis which would depend of autophagic cell loss of life. (rue2011.com)
For example, a major regulator of metabolism is phosphoinositol 3 kinase (PI3K). (hindawi.com)
Idelalisib is a phosphoinositide 3-kinase (PI3K) delta inhibitor. (medscape.com)

We present evidence that the cyclin-dependent kinase inhibitor p27 Kip1 , is phosphorylated at Thr 198 downstream of the Peutz-Jeghers syndrome protein-AMP-activated protein kinase (LKB1-AMPK) energy-sensing pathway, thereby increasing p27 stability and directly linking sensing of nutrient concentration and bioenergetics to cell-cycle progression. (elsevierpure.com)
This gene encodes the cyclin-dependent kinase inhibitor p21(WAF1/Cip1), a factor implicated in cell cycle, senescence, and cancer. (ed.ac.uk)

Additionally, FOXO1 trans-activate Bim protein, which a member of the Bcl-2 family that promotes apoptosis and plays a role in the intrinsic mitochondrial apoptotic pathway. (wikipedia.org)
However, BF + GCV only induced apoptosis via Fas/FasL signal pathway accompanied with increased P53 expression. (biomedcentral.com)
cIAPs are therefore required during development to limit activity of RIP kinases in the TNF receptor 1 signalling pathway. (ozgene.com)
Inactivation of the PI3-kinase pathway, but not of Ras-mitogen-activated protein (MAP) kinase signaling, was essential to elicit cytotoxic responses. (ashpublications.org)
The intersection between the differentially expressed genes (DEGs) and the HNK-targets was determined using a Venn diagram, and the results were analyzed using a protein-protein interaction network, hub gene selection, gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses, genetic alteration analysis, survival rate, and immune cell infiltration levels. (hindawi.com)
Under stress conditions that activate the LKB1-AMPK pathway with subsequent induction of autophagy, p27 knockdown results in apoptosis. (elsevierpure.com)
With its E3 ubiquitin-protein ligase activity via interaction with several proteins such as RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF1, BCL10 etc., c-IAP2 can regulate NFkB signaling - positive regulation of canonical and negative regulation of non-canonical pathway. (novusbio.com)
Involvement of C/EBPβ-related signaling pathway in methamphetamine-induced neuronal autophagy and apoptosis. (cancerindex.org)
Extracellular signal-regulated kinase (ERK) is a part of the mitogen-activated protein kinase (MAPK) signaling pathway which allows the transduction of various cellular signals to final effectors and regulation of elementary cellular processes. (mdpi.com)
75,76 Tumor necrosis factor (TNF)-α inhibits apoptosis by activating NF-κB and its downstream pathway, including IL6 and IL8, in androgen-independent prostate cancer cells, whereas it promotes apoptosis in androgen-dependent cancer cells. (oncologynurseadvisor.com)
Targeting this pathway with a small molecule inhibitor, LCRF-0004, resulted in decreased proliferation with a concomitant increase in apoptosis. (frontiersin.org)
In addition to its role in glucose metabolism, this pathway also regulates the redirection of free amino acids to protein synthesis via the mTOR-signaling pathway. (hindawi.com)
In the poster section, Joanna Shisler (University of Illinois at Urbana-Champaign [UIUC], Urbana) reported that the modified virus, Ankara, activates nuclear factor κB through the mitogen-activated protein kinase, extracellular signal-regulated kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway, possibly facilitating the host immune response. (cdc.gov)
In the poster section, Joanna Shisler (University of Illinois at Urbana-Champaign [UIUC], Urbana) reported that the modified virus, Ankara, activates nuclear factor κB through the mitogen-activated protein kinase, extracellular signal–regulated kinase (MEK)/extracellular signal–regulated kinase (ERK) pathway, possibly facilitating the host immune response. (cdc.gov)

BAD (Bcl-2 antagonist of cell death, Bcl-2 associated death promoter) is a pro-apoptotic member of the Bcl-2 protein family that is regulated by phosphorylation in response to survival factors. (uni-wuerzburg.de)
Although much attention has been devoted to the identification of phosphorylation sites in murine BAD (mBAD), little data are available with respect to phosphorylation of human BAD (hBAD) protein. (uni-wuerzburg.de)
RAF-induced phosphorylation of hBAD was not prevented by MEK inhibitors but could be reduced to control levels by use of the RAF inhibitor Sorafenib (BAY 43-9006). (uni-wuerzburg.de)
In addition, using surface plasmon resonance technique we analyzed the direct consequences of hBAD phosphorylation by RAF with respect to complex formation of BAD with 14-3-3 proteins and Bcl-XL. (uni-wuerzburg.de)
Phosphorylation of hBAD by active RAF promotes 14-3-3 protein association, whereby the phosphoserine 99 represents the major binding site. (uni-wuerzburg.de)
This pore-forming capacity is dependent on phosphorylation status and interaction with 14-3-3 proteins. (uni-wuerzburg.de)
To further analyze the regulation of hBAD function, we investigated the role of these newly identified phosphorylation sites on BAD-mediated apoptosis. (uni-wuerzburg.de)
Tumor necrosis factor receptor activation results in phosphorylation and inactivation of inhibitor kB by IKK, thus resulting in activation of NF-kB. (medscape.com)

When FOXO1 is over expressed in human LNCaP prostate cancer cells, it causes apoptosis. (wikipedia.org)
In type 2 diabetes the beta cells of the pancreas, which normally produce insulin undergo apoptosis, which greatly reduces insulin production. (wikipedia.org)
Here, we have determined the growth-inhibitory and proapototic mechanisms of 2 small molecule inhibitors of FLT3, AG1295 or PKC412, in hematopoietic progenitor cells, human leukemic cell lines, and primary AML cells expressing FLT3-ITD. (ashpublications.org)
FLT3 (FMS-like tyrosine kinase 3) is a type III receptor tyrosine kinase (RTK) closely related to the platelet-derived growth factor (PDGF) receptor and c-Kit with important functions in the regulation of early hematopoietic cells. (ashpublications.org)
Several inhibitors have been described, such as AG1295, CEP701, PKC412, and SU-11 248, with cytotoxic effects to cell lines and primary AML cells in vitro expressing mutant FLT3. (ashpublications.org)
Testosterone levels315, an integrin-linked kinase (ILK) inhibitor, provides been proven to suppress the growth of breasts cancers, abdomen chronic and tumor lymphocytic leukemia cells. (exposed-skin-care.net)
This research displays that autophagic cell loss of life and apoptosis cooperatively contribute to the anticancer activity of Testosterone levels315 in AML cells. (exposed-skin-care.net)
We evaluated the influence of T315 on the manifestation of pThr173-ILK and total ILK, as well as proteins regulating cell proliferation and survival in AML cells (Physique 2). (exposed-skin-care.net)
T315 treatment did not switch the protein manifestation of pThr173-ILK and total ILK in either HL-60 or THP-1 cells (Physique 2A). (exposed-skin-care.net)
Cells (0.25 106 cells/mL) had been treated with T315 at the indicated focus or DMSO for 24 they would, and 20 g proteins … 2.3. (exposed-skin-care.net)
Testosterone levels315 Induces Apoptosis, Caspase Account activation and (PARP) Cleavage in AML Cell Lines In purchase to determine if PARP cleavage and caspase account activation take place in Testosterone levels315-mediated cytotoxicity, HL-60 and THP-1 cells had been incubated with Testosterone levels315 at 0, 1, 2 or 3 mol/M for 24 l. (exposed-skin-care.net)
Protein draw out of 20 g from … In order to further validate the caspase-3 activation induced by T315, Doramapimod HL-60 cells were incubated with T315 for 24 h with or without pretreatment of 50 mol/T Z-Val-Ala-Asp(OMe)-fluoromethyl ketone (Z-VAD(OMe)-FMK), a pan-caspase inhibitor (Physique 3D). (exposed-skin-care.net)
Treatment with Testosterone levels315 for 24 l activated dose-dependent boosts in microtubule-associated proteins 1A/1B light stores 3B (LC3C)-II reflection in HL-60 and THP-1 cells (Amount 4A). (exposed-skin-care.net)
In addition, it can stimulate apoptosis of cells containing damaged DNA. (medscape.com)
Microarray of mouse MPN revealed reduced expression of X-linked inhibitor of apoptosis (Xiap) and mitogen-activated protein kinase 8 (Mapk8) in JAK2 V617F relative to JAK2 WT cells, which were normalized by TNFR2 but not TNFR1 blockade. (elsevierpure.com)
XIAP and MAPK8 were also reduced in MF CD34 + cells compared to normal BM, and their ectopic expression induced apoptosis. (elsevierpure.com)
Unlike XIAP, expression of cellular IAP (cIAP) protein was increased in MF CD34 + cells. (elsevierpure.com)
Substantial data have provided convincing evidence establishing that human cancers emerge from cancer stem cells (CSCs), which display self-renewal and are resistant to anticancer drugs, radiation, and apoptosis, and express enhanced epithelial to mesenchymal progression. (oaepublish.com)
AVM induced the release of cleaved PARP and cleaved caspase‑3 caused apoptosis and inhibited the viability of these cells. (spandidos-publications.com)
2) We investigate induction of apoptosis in breast cancer cells by TRAIL receptor agonists. (cancer.gov)
Ongoing work is focused on understanding the biochemical and physiologic functions of the three mammalian Cbl proteins in epithelial cells and elucidating the differences in their specificity and/or function. (cancer.gov)
Cancer cells avoid apoptosis by a variety of genetic and epigenetic mechanisms. (cancer.gov)
In a second project we are investigating the induction of apoptosis by activation of death receptors for the ligand TRAIL in breast and ovarian cancer cells. (cancer.gov)
Our goal is to selectively trigger apoptosis in the cancer cells. (cancer.gov)
We have demonstrated that resistance to TRAIL-induced apoptosis can be overcome by co-incubation of the cells with chemotherapeutic agents, semi-synthetic retinoids (such as 4HPR), or molecularly targeted agents (such as anti-ErbB-2 antibodies). (cancer.gov)
Using an apoptosis-specific enzyme-linked immunosorbent assay, we showed that Acanthamoeba induces programmed cell death in brain microvascular endothelial cells. (asm.org)
These results were further confirmed using brain microvascular endothelial cells expressing dominant negative forms of phosphatidylinositol 3-kinase. (asm.org)
Acanthamoeba binding to HBMEC is mediated by a mannose-binding protein expressed on the surface of Acanthamoeba cells ( 2 ). (asm.org)
Cells had been harvested forty eight hours following the remedies and PIP protein degree was measured applying western blot evaluation. (cdantigens.com)
Cells that retain IKK activity may produce additional cytokines that trigger apoptosis in neighboring IKK-deficient cells, thus creating an amplification loop that eventually results in the death of all of the IKK-deficient cells. (medscape.com)
We've shown previously that garlic constituent diallyl trisulfide (DATS) inhibits growth of cultured and xenografted human prostate malignancy cells in association with apoptosis induction but the mechanism of cell death is not fully understood. (immune-source.com)
In contrast DATS-treated PC-3 and LNCaP cells exhibited noticeable induction of survivin and cIAP1 proteins. (immune-source.com)
In conclusion the present study indicates that this DATS-induced apoptosis in prostate malignancy cells is usually mediated in part by suppression of XIAP protein expression and that XIAP signifies a viable biomarker of DATS response for future medical investigations. (immune-source.com)
In cultured human being prostate malignancy cells DATS treatment offers Isochlorogenic acid B been shown to cause cell cycle arrest apoptosis induction and transcriptional repression of androgen receptor (13-19). (immune-source.com)
Prior function from our lab has established which the mitochondria-mediated apoptosis induction by DATS treatment is normally followed by induction of Bax and/or Bak in cultured and Isochlorogenic acid B xenografted individual prostate cancers cells (11 13 18 Nevertheless the function of IAP family members proteins in legislation of DATS-induced apoptosis is normally unclear. (immune-source.com)
Indeed apoptosis is inhibited in senescent cells. (globale-dermatologie.com)
extract could inhibit the development of Lewis GSK2126458 small molecule kinase inhibitor lung, A549 and SBC-3 cancers cells, and induce cancers cell apoptosis (23). (insulin-receptor.info)
Several years later, Kerr and co-workers 2 defined the morphological changes in cells undergoing this process, also known as apoptosis. (nature.com)
On the main one hands, autophagy assists tumor cells survive in the current presence of chemotherapy drugs through the elimination of its own broken organelles and protein (17). (rue2011.com)
Silencing of ATG14, also termed Beclin-1-linked autophagy-related essential regulator, elevated cisplatin-induced apoptosis in SaOS-2 cells (19). (rue2011.com)
Subsequently, the effect of an additional small molecular inhibitor, BMS-777607 (which targets MST1R (RON), MET, Tyro3, and Axl) also resulted in a decreased proliferative capacity of MPM cells. (frontiersin.org)
A successful therapy must therefore eliminate these cells known to be highly resistant to apoptosis. (hindawi.com)
In this paper, we describe the metabolic changes as well as the mechanisms of resistance to apoptosis occurring in cancer cells and cancer stem cells, underlying the connection between these two processes. (hindawi.com)
This agent binds CD20 on lymphocytes and induces apoptosis as well as initiating complement-mediated killing of bound cells. (medscape.com)
The function of the protein produced from the normal BCR gene is not completely understood, although it has been shown to help control signaling in cells. (medlineplus.gov)
The constantly active BCR-ABL1 protein signals cells to continue dividing abnormally and prevents them from self-destructing, which leads to overproduction of the abnormal cells and, eventually, a shortage of normal blood cells. (medlineplus.gov)

Activation of NF-kB prevents apoptosis in response to the tumor necrosis factor family of cytokines. (medscape.com)

The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. (cancerindex.org)
It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). (cancerindex.org)
There was no switch in protein reflection of extracellular signalCregulated kinase 1 and 2 (ERK1/2) Doramapimod Doramapimod and phosphorylated ERK1/2 after Testosterone levels315 treatment. (exposed-skin-care.net)
Glycans, either alone or complexed with glycan-binding proteins, can deliver intracellular signals or control extracellular processes that promote initiation, execution and resolution of cell death programs. (nature.com)

T315 Induces Down-Regulation of Protein Kinase W (Akt) and Phosphorylated Akt in AML Cell Lines T315 has been reported as an ILK inhibitor [2]. (exposed-skin-care.net)
Docetaxel, in addition to stabilizing microtubules, also induces apoptosis by downregulating antiapoptotic proteins. (oncologynurseadvisor.com)

Inhibitor of apoptosis (IAP) proteins cIAP1, cIAP2, and XIAP (X-linked IAP) regulate apoptosis and cytokine receptor signalling, but their overlapping functions make it difficult to distinguish their individual roles. (ozgene.com)
Remarkably, hemizygosity for receptor-interacting protein kinase 1 (Ripk1) allowed Xiap(-/-)cIap1(-/-) double mutants to survive past birth, and prolonged cIap2(-/-)cIap1(-/-) embryonic survival. (ozgene.com)
X-linked Inhibitor of Apoptosis (XIAP) is implicated in the control of bacterial infections, and mutations in XIAP are causally linked to immunodeficiency in X-linked lymphoproliferative syndrome type-2 (XLP-2). (ox.ac.uk)
Dorsolateral prostates from DATS-treated TRAMP mice exhibited statistically significant down-regulation of XIAP and induction of survivin protein compared with those of control mice. (immune-source.com)
Ectopic expression of XIAP conferred partial but significant protection against DATS-induced apoptosis. (immune-source.com)
Elevated manifestation of IAP proteins including X-linked inhibitor of apoptosis (XIAP) and survivin has been reported in human being prostate cancers (27-29). (immune-source.com)

While in Lew Cantley's lab, Dr. Abbott began deciphering the signal transduction cascade initiated by bacterial activation of the Crohn's Disease susceptibility protein, NOD2. (case.edu)

The results suggested that BF-rTK + GCV induced tumor apoptosis without autophagy and necroptosis occurrence. (biomedcentral.com)
BF-rTK + GCV induced tumor apoptosis mediated by FasL and TNFR2 through the mitochondrial control of apoptosis via Bid and Bim without inducing necroptosis and autophagy. (biomedcentral.com)
Therefore, in addition to apoptosis, we researched if autophagy was included in Testosterone levels315-mediated cytotoxicity. (exposed-skin-care.net)
We discuss here the contribution of glycan-lectin interactions to the initiation, execution and resolution of apoptosis and their emerging roles in other cell death programs including autophagy. (nature.com)

The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. (cancerindex.org)
AXL, a tyrosine kinase receptor, is commonly overexpressed in several solid tumours and numerous hematopoietic malignancies including acute myeloid leukaemia, acute lymphocytic leukaemia, chronic myeloid leukaemia, chronic lymphocytic leukaemia and multiple myeloma. (cancerindex.org)
Receptor tyrosine kinase inhibitors targeting FLT3 have developed as attractive treatment options. (ashpublications.org)
Results DIM, but not I3C, increased adipocyte differentiation through upregulation of peroxisome proliferator‐activated receptor γ and CCAAT/enhancer‐binding protein α. (researchgate.net)
1) We study Cbl proteins, a family of ubiquitin ligases that negatively regulate signaling by receptor tyrosine kinases. (cancer.gov)
Taken with each other, these benefits support the interactions between FASN and HER proteins are restricted to HER2 and do not involve the HER1 receptor. (cdantigens.com)
MST1R (RON) is a trans-membrane receptor tyrosine kinase (RTK), which is part of the c-MET proto-oncogene family. (frontiersin.org)

Cbl proteins belong to the RING finger class of ubiquitin protein ligases (E3s) and function as E3s for activated tyrosine kinases. (cancer.gov)

NEMO/IKK -gamma is the regulatory subunit of the inhibitor kappa kinase (IKK) complex and is required for the activation of the transcription factor NF-kappaB (NF-kB). (medscape.com)

Next, we observed that Acanthamoeba specifically activates phosphatidylinositol 3-kinase. (asm.org)
Acanthamoeba -mediated brain endothelial cell death was abolished using LY294002, a phosphatidylinositol 3-kinase inhibitor. (asm.org)
This is the first demonstration that Acanthamoeba -mediated brain microvascular endothelial cell death is dependent on phosphatidylinositol 3-kinase. (asm.org)

The loss of RIPK1 or RIPK3, but not the RIPK3 substrate mixed lineage kinase domain-like protein, attenuated TNF secretion and thereby prevented apoptotic cell death and not necrosis. (ox.ac.uk)
The IAP family protein has emerged as crucial regulator of caspase-mediated apoptotic cell death by different stimuli (24-26). (immune-source.com)

We have shown that most breast and ovarian cancer cell lines are resistant to the induction of apoptosis by TRAIL, the ligand for the death receptors DR4 and DR5. (cancer.gov)

2007] PMID:17573556 Oncogenes as novel targets for cancer therapy (part I): growth factors and protein tyrosine kinases. (ac.be)

A colorectal cancer model was used to decipher the molecular mechanism of BF-rTK + GCV (bifidobacterial recombination thymidine kinase/ganciclovir) using a human apoptosis antibody array kit in a murine cancer model in vivo . (biomedcentral.com)
The molecular basis to understand the connection between phospholipids metabolism and cell cycle regulation through choline kinase is reported. (nih.gov)
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)
It is thus concluded that AVM inhibits the activity of BCR/ABL and their subsequent molecular signals, including AKT and MAPK, resulting in cytotoxicity via apoptosis. (spandidos-publications.com)
Other molecular processes, such as oxidative stress, apoptosis, or chromatin remodeling have been also proposed to play a causative role. (ed.ac.uk)
Modulation of the AR ERK feedback loop in molecular apocrine cell lines MDA MB 453 and HCC 1954 was carried out using AR inhibitor flutamide and MEK inhi bitor CI 1040 as we previously published. (cdantigens.com)
We also addressed the molecular inter actions of G28UCM, analysing FASN protein levels, apoptosis, and the phosphorylated forms of HER2, AKT and ERK1/2 proteins just after selleck chemical G28UCM combined with trastuzumab, erlotinib, gefitinib or lapatinib treatment method. (cdantigens.com)
Trastuzumab and HER tyrosine kinase inhibitors displayed molecular synergis tic interaction with G28UCM. (cdantigens.com)
Renal cell apoptosis induced by nephrotoxic drugs: cellular and molecular mechanisms and potential approaches to modulation. (ac.be)

Studies have exhibited that extract has antioxidant properties, and can inhibit tumor cell growth and induce apoptosis (23C26). (insulin-receptor.info)
It appears to induce apoptosis in malignant lymphocytes upon exposure. (medscape.com)

On the other hand DATS-induced apoptosis was only marginally affected by RNA interference of survivin or cIAP1. (immune-source.com)

Understanding the mechanisms that regulate signaling by these kinases should uncover new ways to inhibit cancer cell growth. (cancer.gov)
We are investigating the function of Cbl proteins, a family of proteins that regulate tyrosine kinase activity. (cancer.gov)
Different classes of RNA granules share some protein components and may use similar mechanisms to regulate mRNA translation/decay. (rupress.org)
These nutrient-driven post-translational modifications are highly altered in cancer and regulate protein functions in various cancer-associated processes. (biomedcentral.com)

71 Clusterin is a small heat shock glycoprotein overexpressed in most of the solid tumors, which promotes apoptosis by binding to various molecules such as BAX (BCL2-associated X protein) 72 and signal transducer and activator of transcription (STAT)−1. (oncologynurseadvisor.com)

Curcumin (CUM) and protease inhibitor cocktail (kitty. (insulin-receptor.info)

Induction of survivin protein expression resulting from DATS exposure was associated with an increase in its mRNA level. (immune-source.com)

Given the lack of effective treatments, we constructed a bifidobacterial recombinant thymidine kinase (BF-rTK) -ganciclovir (GCV) targeting system (BKV) to meet this requirement and to explore antitumor mechanisms. (biomedcentral.com)
Several mechanisms participate in the drug and apoptosis resistance phenotype in CSCs in various cancers. (oaepublish.com)
This article will review the CSCs drug and apoptosis resistance mechanisms and how to target CSCs. (oaepublish.com)
This new and unprecedented evidence for a link between SdhD dysfunction and p21(WAF1/Cip1) will open new avenues for the study of the mechanisms that cause tumors in Sdh mutants. (ed.ac.uk)
This approach has led to the discovery of novel inhibitors of the inflammatory disease kinase, RIPK2, and more recently to novel mechanisms to inhibit the pyroptotic pore protein, Gasdermin D. Both of these pharmaceutical intervention show efficacy in inflammatory diseases as diverse as Inflammatory Bowel Disease, Psoriasis, Sarcoidosis and Sepsis. (case.edu)
However, it GSK2126458 small molecule kinase inhibitor remains unclear whether ILL can inhibit lung malignancy cell metastasis and the associated mechanisms require further investigation. (insulin-receptor.info)

Body 3 Testosterone levels315-mediated cytotoxicity is certainly reliant on caspase account activation and apoptosis. (exposed-skin-care.net)
70,71 BCL2 inhibits mitochondrial release of cytochrome c and subsequently blocks the caspase cascade, thereby inhibiting apoptosis. (oncologynurseadvisor.com)

We will discuss three key proteins that function as tumor suppressors implicated in the development of pediatric (and some adult) cancers: pRB, p53, and PTEN. (medscape.com)
For instance, Li (23) identified that extract could Rabbit Polyclonal to ZADH1 inhibit the development of lung cancers A549 and SBC-3 cell lines, and induce cell apoptosis. (insulin-receptor.info)
Abnormal metabolism and the evasion of apoptosis are considered hallmarks of cancers. (hindawi.com)

Vashishth A, Shuaib M, Bansal T, Kumar S. Mycobacterium Tubercular Mediated Inflammation and Lung Carcinogenesis: Connecting Links. (lidsen.com)
In addition, chronic diagnostic test for follow-up of patients cy and for biochemical determination inflammation associated with the infec- with H. pylori gastritis and were able of tissue COX-2 activity using COX tion leads to damage in proteins, the to predict the risk of development of Activity Assay Kit (Cayman Chemical production of reactive oxygen species stomach cancer. (who.int)

Also, FOXO1 regulates TNF-related apoptosis-inducing ligand (TRAIL), which caused FOXO1-induced apoptosis in the human prostate cancer cell line LAPC4 when FOXO1 adenovirus-mediated overexpression was used. (wikipedia.org)
Since BCL2, a protein that indirectly inhibits cell apoptosis, is required for certain chemotherapies to work, the absence of BCL2 obscures their uses in prostate cancer. (oncologynurseadvisor.com)

The majority of inositol lipids reside in membranes and serve as substrates for kinases, phosphatases, and phospholipases. (asm.org)

Both compounds induced up-regulation of proapoptotic BH3-only proteins Bim and Puma, and subsequent cell death. (ashpublications.org)
Body 2 Testosterone levels315 induce dephosphorylation of proteins kinase T (Akt) without transformation of integrin-linked kinase (ILK) in AML cell lines. (exposed-skin-care.net)
Tumor suppressor genes encode proteins that normally provide negative control of cell proliferation. (medscape.com)
PTEN encodes a protein kinase of the same name and functions as a tumor suppressor through regulation of cell proliferation. (medscape.com)
Choline kinase alpha (ChoKalpha) is an enzyme involved in the metabolism of phospholipids recently found to play a relevant role in the regulation of cell proliferation, oncogenic transformation and human carcinogenesis. (nih.gov)
Growth factors such as fibroblast growth factor (FGF), vascular endothelial cell growth factor (VEGF), and angiopoietin-1 (Ang1) are upregulated to stimulate angiogenesis, while downregulation of endogenous protein inhibitors (thrombospondin 1 and interferon) disrupts the balance of physiologic angiogenesis. (cancernetwork.com)
The two SDHD-ESR cell lines also showed accumulation of this protein. (ed.ac.uk)
Bax and Bak caspases) or inhibitors of the cell death processes (e.g. (immune-source.com)
Herein, we review the role of glycans and glycan-binding proteins as essential components of the cell death machinery during physiologic and pathologic settings. (nature.com)
At that time, glycobiology, which is the study of carbohydrates and their recognition by motif-specific carbohydrate-binding proteins or lectins, lagged far behind the studies that defined the structural and cellular biology of cell death. (nature.com)
Glucosamine entering the cell is also converted to glucosamine-6-phosphate using GNK (GlcNAc kinase). (biomedcentral.com)
70 Mcl1 (myeloid cell leukemia differentiation protein 1) and other members of the BCL family, such as BCL-xl (B-cell lymphoma-extra-large), are also involved in resistance to Interleukin (IL)-6, stromal cell derived factor-1, and cytokine-induced apoptosis. (oncologynurseadvisor.com)
The protein produced from the normal ABL1 gene is involved in many cellular processes, including cell growth and division (proliferation), maturation (differentiation), movement (migration), and self-destruction (apoptosis). (medlineplus.gov)
Like the ABL1 protein, the abnormal protein produced from the fusion gene, called BCR-ABL1, can promote cell proliferation and block apoptosis. (medlineplus.gov)

Forkhead box protein O1 (FOXO1), also known as forkhead in rhabdomyosarcoma (FKHR), is a protein that in humans is encoded by the FOXO1 gene. (wikipedia.org)
The Herpes Simplex Virus thymidine kinase/ganciclovir (HSV-TK + GCV) system is currently one of the best-studied tumor suicide gene therapy systems [ 9 - 11 ]. (biomedcentral.com)
What does this gene/protein do? (cancerindex.org)
RB1 encodes the protein pRB and was the first tumor suppressor gene to be molecularly defined. (medscape.com)
Tumor-infiltrated macrophages were isolated from human GC tissues using magnetic beads, gene transcription was determined by real-time PCR, protein expression was monitored using western blots, metabolites were determined using HPLC, and transcriptional regulation was analyzed by the luciferase-based reporter gene system. (cancerindex.org)
Novel approaches using gene therapy, antisense strategies, recombinant proteins, or compounds obtained from both classical organic and combinatorial chemistry are examined. (ac.be)
is considered to be another relevant PDAC susceptibility gene [15], and it has been described that PALB2 protein binds to BRCA2 protein and contributes to its function [16]. (ipa2014.org)

Phosphatidylinositol 3-kinases (PI3Ks) are important signaling molecules that phosphorylate the 3′ OH position of the inositol ring of phosphoinositides (PIs), generating the second messengers PI(3)P, PI(3,4)P 2 , and PI(3,4,5)P 3 ( 4 , 17 ). (asm.org)

TP53 encodes the protein p53, which is known as the "guardian of the genome. (medscape.com)

A family of proteins that were originally identified in SACCHAROMYCES CEREVISIAE as being essential for maintaining the structure of minichromosomes00. (bvsalud.org)

Using bioinformatics analyses, we predicted HNK protein targets from several databases and retrieved the genes differentially expressed in mBCSCs from the GEO database. (hindawi.com)
In female incontinentia pigmenti patients, lyonization results in functional mosaicism of X-linked genes, which is manifested by the blaschkoid distribution of cutaneous lesions. (medscape.com)
During treatment with taxanes, BCL2 is phosphorylated, which prevents heterodimerization with other BCL family genes, thereby promoting apoptosis. (oncologynurseadvisor.com)
Aberrations of AR, erythroblast transformation-specific ( ETS ) genes, Tumor protein 53 (TP53), and Phosphatase and tensin homolog (PTEN) occurred in 40%-60% of 150 mCRPC cases in a recent study. (oncologynurseadvisor.com)
kDa glucose-regulated proteins), ATF6 (activating transcription aspect 6 isoform ), IRE1 (inositol-requiring enzyme 1 isoform ), and Benefit (proteins kinase RNA-like endoplasmic reticulum kinase) activate the transcription of many genes involved with both success and apoptosis. (ipa2014.org)

The only ligand recognized to bind MST1R (RON) is Macrophage Stimulating 1 (MST1), also known as Macrophage Stimulating Protein (MSP) or Hepatocyte Growth Factor-Like Protein (HGFL). (frontiersin.org)

Notably, in the presence of wild type hBAD, co-expression of survival kinases, such as RAF and PAK1, leads to a strongly increased proliferation, whereas substitution of serine 134 by alanine abolishes this process. (uni-wuerzburg.de)

Furthermore, HIF-1 actively limits the mitochondrial consumption of pyruvate at two levels: (i) through the enzyme PDK (PDH-kinase), which in turn inhibits PDH activity preventing the conversion of pyruvate into acetyl CoA, and thereby limiting mitochondrial metabolism of pyruvate [ 6 ] and (ii) through the direct activation of LDH [ 7 , 8 ]. (hindawi.com)

Recombinant MST1 treatment was unable to overcome the effect of LCRF-0004 in terms of either proliferation or apoptosis. (frontiersin.org)

However, only silencing of Bim, or its direct transcriptional activator FOXO3a, abrogated apoptosis efficiently. (ashpublications.org)

The effects of PIP5K1α and its inhibitor on growth and invasion of BC were confirmed by using in vitro assays including proliferation, migration, apoptosis and luciferase reporter assays and in vivo xenograft mouse models. (lu.se)

The tumor tissues were analyzed using apoptosis antibody arrays, real time PCR and western blot. (biomedcentral.com)
Incontinentia pigmenti is an X-linked dominant genodermatosis characterized by abnormalities of the tissues and organs derived from the ectoderm and neuroectoderm and represents a type of ectodermal dysplasia. (medscape.com)
Bowen, 2004} to detect apoptosis in fixed tissues, but no statistically significant results between SKs and normal skin samples were shown. (globale-dermatologie.com)

Anatomy18

Organisms6

Chemicals and Drugs174

Analytical, Diagnostic and Therapeutic Techniques and Equipment12

Phenomena and Processes41

Disciplines and Occupations1

Information Science3

Inhibition8

IAPs6

Pathways12

PI3K4

Cyclin-dependent kinase2

Pathway14

Phosphorylation8

Cells46

Tumor Necros1

Extracellular4

Induces2

Xiap6

Signal Transduction1

Autophagy4

Receptor7

Ubiquitin-Protein1

Subunit1

Phosphatidylinositol 3-kina3

Apoptotic2

Receptors1

Tyrosine kinases1

Molecular9

Induce apoptosis2

CIap11

Regulate4

Solid tumors1

Protease inhibitor1

Survivin1

Mechanisms6

Caspase2

Cancers3

Inflammation2

Prostate cancer2

Phosphatases1

Cell14

Gene7

Signaling molecules1

Encodes1

Family of proteins1

Genes5

Ligand1

Survival1

Mitochondrial1

Recombinant1

Transcriptional1

Migration1

Tissues3