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MAP Kinase Kinase KinasesMitogen-Activated Protein Kinase KinasesProtein KinasesMAP Kinase Kinase Kinase 1Protein-Serine-Threonine KinasesMAP Kinase Kinase Kinase 4MAP Kinase Signaling SystemProtein Kinase CCalcium-Calmodulin-Dependent Protein KinasesMAP Kinase Kinase Kinase 5Phosphatidylinositol 3-KinasesMAP Kinase Kinase Kinase 3Mitogen-Activated Protein KinasesMAP Kinase Kinase 1JNK Mitogen-Activated Protein KinasesMAP Kinase Kinase 4MAP Kinase Kinase Kinase 2p38 Mitogen-Activated Protein KinasesProtein Kinase InhibitorsPhosphorylationEnzyme ActivationMitogen-Activated Protein Kinase 1Cyclic AMP-Dependent Protein KinasesMAP Kinase Kinase 6MAP Kinase Kinase 3Signal TransductionMitogen-Activated Protein Kinase 3src-Family KinasesMAP Kinase Kinase 7Protein-Tyrosine KinasesMAP Kinase Kinase 2Calcium-Calmodulin-Dependent Protein Kinase KinaseMolecular Sequence Datap21-Activated KinasesExtracellular Signal-Regulated MAP KinasesProto-Oncogene ProteinsCDC2 Protein KinaseAmino Acid SequenceProtein Kinase C-alphaAMP-Activated Protein KinasesCell LineProtein Kinase C-deltaRibosomal Protein S6 KinasesIsoenzymesCells, CulturedTransfectionCyclin-Dependent KinasesCasein Kinase III-kappa B KinaseMutationEnzyme InhibitorseIF-2 KinaseCreatine KinaseProtein BindingCasein KinasesFlavonoidsBlotting, WesternIntracellular Signaling Peptides and ProteinsTetradecanoylphorbol AcetateApoptosisPyruvate KinaseProto-Oncogene Proteins c-rafSerineKineticsReceptor Protein-Tyrosine KinasesProto-Oncogene Proteins c-aktButadienesProtein Kinase C-epsilonBase SequenceRecombinant ProteinsProtein Kinase C betaPhosphotransferases (Alcohol Group Acceptor)Glycogen Synthase Kinase 3Thymidine KinaseCyclic GMP-Dependent Protein KinasesCalcium-Calmodulin-Dependent Protein Kinase Type 2rho-Associated Kinases3T3 CellsGene Expression Regulation, EnzymologicCell Line, Tumor1-Phosphatidylinositol 4-KinaseSequence Homology, Amino AcidProtein Structure, TertiaryPhosphoproteinsRecombinant Fusion ProteinsCDC2-CDC28 KinasesCyclic AMPSubstrate SpecificityBinding SitesPrecipitin TestsAurora KinasesNF-kappa BRNA, MessengerAdaptor Proteins, Signal TransducingTyrosineChromonesTumor Cells, CulturedCalciumAndrostadienesGene Expression Regulation
MAPKSerinePathwayInhibitorPeptidesGeneTyrosine kinasePlatelet-derived growthErk1ReceptorERKsPathwaysApoptosisELISA KitMapk1Phosphorylation of extracellularInhibitorsMAPKsAdenosineNuclearProliferationStress-activated proteinSpeciesAssayMiceSubunitRegulatesOxidative StressRegulationPhosphorylateCreative BioMartInterleukinOncogeneDownstreamEndothelialActivationGrowthSAPKMRNA and proteinCellActivityPathogenesisSurvivalMapk3Molecular
MAPK24
  • Mitogen-activated protein kinases (MAPK) p38 and c-Jun N-terminal kinases (JNKs) are activated during the cellular response to stress signals. (datadryad.org)
  • Their activity is regulated by the MAPK-phosphatase 1 (DUSP1), a key component of the anti-inflammatory response. (datadryad.org)
  • p38 MAP Kinase (MAPK), also called RK or CSBP (Cytokinin Specific Binding Protein), is the mammalian orthologue of the yeast Hog1p MAP kinase, which participates in a signaling cascade controlling cellular responses to cytokines and stress. (wikipedia.org)
  • Oxidative stress is the most powerfully specific stress activating p38 MAPK. (wikipedia.org)
  • Here we report a role for the phylogenetically ancient mitogen-activated protein kinase (MAPK) signalling pathway in mouse sex determination. (plos.org)
  • Moreover, we describe experiments showing the presence of activated MKK4, a direct target of MAP3K4, and activated p38 in the coelomic region of the XY gonad at 11.5 d post coitum, establishing a link between MAPK signalling in proliferating gonadal somatic cells and regulation of Sry expression. (plos.org)
  • This mutant, which we called boygirl ( byg ), was shown to contain an early stop codon that disrupts the autosomal gene encoding MAP3K4, a component of the mitogen-activated protein kinase (MAPK) signaling pathway. (plos.org)
  • The aim of this study was to evaluate the role of mitogen-activated protein kinase (MAPK) family in serum-induced secretion of LIF and IL-6 by bone marrow stromal cells. (unboundmedicine.com)
  • FCS also induced activation of extracellular signal-regulated kinase (ERK), p38 MAPK and c-Jun NH(2)-terminal kinase (JNK). (unboundmedicine.com)
  • 3: Both PD98059 (MAPK/ERK kinase inhibitor) and SB203580 (p38 MAPK inhibitor) attenuated FCS-induced LIF protein production and gene expression. (unboundmedicine.com)
  • Erk3, also known as MAPK6 or p97 MAPK, is almost 50% identical to Erk1/2 at the kinase domain located in its amino-terminal region. (creativebiomart.net)
  • These data suggest that ANG II increases ACE and attenuates ACE2 expression in neurons via the ANG II type 1 receptor, p38 MAPK, and ERK1/2 signaling pathways. (nebraska.edu)
  • Redox Regulation of Cardiac ASK1 (Apoptosis Signal-Regulating Kinase 1) Controls p38-MAPK (Mitogen-Activated Protein Kinase) and Orchestrates Cardiac Remodeling to Hypertension. (ox.ac.uk)
  • Redox-sensitive ASK1 (apoptosis signal-regulating kinase 1) activates stress-regulated protein kinases (p38-MAPK [mitogen-activated protein kinases] and JNKs [c-Jun N-terminal kinases]) and promotes fibrosis in various tissues. (ox.ac.uk)
  • The mitogen-activated protein kinase (MAPK) signaling pathways are essential to the adaptation to the human host. (bath.ac.uk)
  • Our global phosphoproteome network analysis showed an enrichment for protein kinases, RNA recognition motif domains, and the MAPK signaling pathway. (bath.ac.uk)
  • We observed activation of mitogen-activated protein kinase (MAPK) in basal and suprabasal keratinocytes of human and transgenic mouse psoriatic lesions and healing mouse skin wounds, correlating in each case with suprabasal integrin expression. (jci.org)
  • Phenotypically normal human and transgenic mouse epidermis did not contain activated MAPK. (jci.org)
  • Transgene-positive keratinocytes produced more IL-1α than controls did, and keratinocyte MAPK could be activated by ligation of suprabasal integrins or treatment with IL-1α. (jci.org)
  • We propose that activation of MAPK by integrins, either directly or through increased IL-1α production, is responsible for epidermal hyperproliferation in psoriasis and wound healing, and that the sporadic phenotype of the transgenic mice may reflect the complex mechanisms by which IL-1 release and responsiveness are controlled in skin. (jci.org)
  • An activating hotspot mutation occurs at V600E and results in constitutive MAPK signalling and uncontrolled cellular growth. (hindawi.com)
  • The strawberries may be highly effective as a chemopreventive agent that acts by targeting the down-regulation of AP-1 and NF-kappaB activities, blocking MAPK signaling, and suppressing cancer cell proliferation and transformation. (cdc.gov)
  • The induction of ATF-3 expression was mediated by mitogen-activated protein kinase (MAPK) signaling pathways in GS-002-treated cells. (hindawi.com)
  • The IL-1Ra-producing bone marrow cells increase the number of IL-1Ra-producing microglia, reduce the availability of IL-1β, and modulate mitogen-activated protein kinase (MAPK) signaling in the ischemic cortex. (lu.se)
Serine2
  • A proline-directed serine/threonine protein kinase which mediates signal transduction from the cell surface to the nucleus. (uams.edu)
  • The BRAF (v-raf murine sarcoma viral oncogene homolog B) gene encodes a protein that belongs to the Raf family of serine/threonine protein kinases. (hindawi.com)
Pathway13
  • Similar to the SAPK/JNK pathway, p38 MAP kinase is activated by a variety of cellular stresses including osmotic shock, inflammatory cytokines, lipopolysaccharides (LPS), ultraviolet light, and growth factors. (wikipedia.org)
  • In the developing male (XY) gonad, sex-determining region of the Y (SRY) protein acts to up-regulate expression of the related gene, SOX9 , a transcriptional regulator that in turn initiates a downstream pathway of testis development, whilst also suppressing ovary development. (plos.org)
  • The Y-linked sex determining gene SRY regulates this process by initiating a pathway of gene and protein expression, including the expression of critical autosomal genes such as SOX9 . (plos.org)
  • Also, other proteins which involved in the same pathway with MAPK4 were listed below. (creativebiomart.net)
  • MK-8776 ERK1/2) pathway and phosphatidylinositide 3-kinases (PI3K) pathway [1C4]. (phytid.org)
  • We hypothesized that Mapk3/1 pathway regulates ovulation through transcriptional rules of ovulatory genes. (phytid.org)
  • B-Raf-dependent regulation of the MEK-1/mitogen-activated protein kinase pathway in PC12 cells and regulation by cyclic AMP. (wikidata.org)
  • Our phosphoproteomics allowed the identification of novel kinases and transcription factors (TFs) involved in osmotic stress and in the cell wall integrity (CWI) pathway. (bath.ac.uk)
  • This showed the involvement of the HOG pathway and identified novel protein kinases and transcription factors, which were confirmed by fungal genetics to be involved in promoting tolerance of cell wall damage. (bath.ac.uk)
  • The BRAF oncogene is an integral component of the MAP kinase pathway, and an activating V600E mutation occurs in 15% of sporadic colorectal cancer. (hindawi.com)
  • This pathway describes progression of a serrated precursor lesion, often followed by the onset of epigenetic instability involving promoter methylation and silencing of key tumour suppressor genes, and accounts for 15%-20% of sporadic colorectal cancer [ 1 , 2 ]. (hindawi.com)
  • This signal transduction pathway is initiated by epidermal growth factor ligands binding to and activating receptor tyrosine kinases (RTK) at the cell membrane. (hindawi.com)
  • Several studies suggest that melanoma may be resistant to treatment because of resistance to apoptosis and that this may be the result of activation of the extracellular signal regulated kinase (ERK1/2) pathway. (bmj.com)
Inhibitor6
  • There is also decreased mRNA and proteins great quantity from the transcription element, early development response 1 (Egr1) in inhibitor-treated granulosa cells. (phytid.org)
  • We here evaluated the effects of SP600125 (anthra[1,9- cd ]pyrazole-6 (2 H )-one), an inhibitor of c-Jun NH 2 -terminal kinase (JNK), on the activation of PSCs. (aspetjournals.org)
  • A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfiler TM service. (guidetopharmacology.org)
  • 1. Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. (2011) Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. (guidetopharmacology.org)
  • It lifts the mRNA levels of plasminogen activator (PA) and plasminogen activator inhibitor (PAI) to play a role of activation and regulation on PA and PAI-1, thus enhancing the activity of plasminogen activator and promoting the formation of new capillaries. (spandidos-publications.com)
  • Previous studies reported that ATF-3 was induced by treating cells with antitumorigenic compounds [ 14 - 18 ] and a phosphoinositide 3-kinase inhibitor [ 19 ]. (hindawi.com)
Peptides3
  • We evaluated the ability of different trypsin-revealed tethered ligand (TL) sequences of rat proteinase-activated receptor 2 (rPAR 2 ) and the corresponding soluble TL-derived agonist peptides to trigger agonist-biased signaling. (aspetjournals.org)
  • The peptides AAIGRL-NH 2 and LSIGRL-NH 2 triggered neither calcium nor MAP kinase signals. (aspetjournals.org)
  • Thus, PAR 2 can signal to multiple pathways that are differentially triggered by distinct proteinase-revealed TLs or by synthetic signal-selective activating peptides. (aspetjournals.org)
Gene9
  • The byg mutation is an A to T transversion causing a premature stop codon in the gene encoding MAP3K4 (also known as MEKK4), a mitogen-activated protein kinase kinase kinase. (plos.org)
  • 4: Expression of a dominant-negative mutant form of JNK1 that blocked FCS-induced JNK activity had no effect on protein production and gene expression of these cytokines. (unboundmedicine.com)
  • We conclude that Mapk3/1 regulates ovulation, at least partly, through Egr1 and its own focus on gene, in granulosa cells of ovulating follicles in mice. (phytid.org)
  • To check this hypothesis we used an pharmacologic approach to inhibition of Mapk3/1 activity devoid of disrupting the gene manifestation. (phytid.org)
  • The protein encoded by this gene is a member of the MAP kinase family. (antibodies-online.com)
  • Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. (antibodies-online.com)
  • The manifestations of neurofibromatosis type 1 (NF1) result from a mutation in or deletion of the NF1 gene. (medscape.com)
  • Using semi-quantitative reverse-transcription polymerase chain reaction (RT-PCR) and western blots experiments, we compared changes in ETS-1 and ETS-2 expression, their protein levels, and the regulation of some of their target gene expressions at different stages of the ocular tumoral progression in the transgenic mouse model, Tyrp-1-TAg, with those in normal eyes from control mice of the same age. (molvis.org)
  • GS-002 also induced endoplasmic reticular (ER) stress as evidenced by increases in ER stress-responsive proteins including glucose-regulated protein 78 (GRP78), growth arrest- and DNA damage-inducible gene 153 (GADD153), phosphorylated eukaryotic initiation factor 2 α (eIF2 α ), phosphorylated protein endoplasmic-reticular-resident kinase (PERK), and ATF-3. (hindawi.com)
Tyrosine kinase1
  • We have previously shown that excretory-secretory product-62 (ES-62), a homologue of phosphorylcholine-containing molecules that are secreted by human parasites and which is active in rodent models of filarial infection, is able to polyclonally activate certain protein tyrosine kinase and mitogen-activating protein kinase signal transduction elements in B lymphocytes. (eurekamag.com)
Platelet-derived growth1
  • SP600125 inhibited platelet-derived growth factor-induced proliferation, inducible monocyte chemoattractant protein-1 production, and serum-induced type I collagen production. (aspetjournals.org)
Erk13
  • Recognizes endogenous levels of total p44/p42 MAP kinase (Erk1,2) protein. (reageno.com)
  • To test this hypothesis by examining the expression of ERK1/2 and its activated form in histological sections of melanoma and its relation to known prognostic features of the disease. (bmj.com)
  • Expression of activated ERK1/2 in melanocytic lesions appears to be related to malignant potential so that activation of ERK1/2 may be important in melanoma progression. (bmj.com)
Receptor3
  • The mitogen-activated protein kinase homolog, WNK lysine deficient protein kinase 1 (WNK1), is activated downstream of epidermal growth factor receptor during decidualization. (bioone.org)
  • The lack of trypsin-triggered β-arrestin interactions correlated with impaired trypsin-activated TL-mutant receptor internalization. (aspetjournals.org)
  • Here, we asked if cell-based delivery of the interleukin-1 receptor antagonist (IL-1Ra), a known neuroprotectant in stroke, can promote neuroprotection, by modulating the detrimental inflammatory response in the tissue at risk. (lu.se)
ERKs2
  • Furthermore, strawberry extract also blocked TPA-induced phosphorylation of extracellular signal-regulated kinases (ERKs) and UVB-induced phosphorylation of ERKs and JNK kinase in JB6 P+ mouse epidermal cell culture. (cdc.gov)
  • MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. (antibodies-online.com)
Pathways2
  • Here, we show that bergenin, a phytochemical isolated from tender leaves of Shorea robusta , activates the MAP kinase and ERK pathways and induces TNF-α, NO and IL-12 production in infected macrophages. (frontiersin.org)
  • Together, the results of the current study suggest that the protective effect of vitexin reduces sevoflurane‑induced neuronal apoptosis through HIF‑1α‑, VEGF‑ and p38‑associated signaling pathways in newborn rats. (spandidos-publications.com)
Apoptosis4
  • p38 mitogen-activated protein kinases are a class of mitogen-activated protein kinases (MAPKs) that are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock, and are involved in cell differentiation, apoptosis and autophagy. (wikipedia.org)
  • To investigate in vivo molecular mechanisms of silibinin efficacy, tumors and uninvolved skin from tumor-bearing mice were examined immunohistochemically for proliferation, p53, apoptosis, and activated caspase-3. (nih.gov)
  • The results demonstrated that Vitexin pretreatment significantly reduced neuronal apoptosis, and inhibited caspase‑3 activity, apoptosis regulator BAX protein expression and malondialdehyde levels in sevoflurane‑induced newborn rats. (spandidos-publications.com)
  • Activating transcription factor-(ATF-) 3, a stress-inducible transcription factor, is rapidly upregulated under various stress conditions and plays an important role in inducing cancer cell apoptosis. (hindawi.com)
ELISA Kit1
  • Description: A sandwich ELISA kit for detection of Mitogen Activated Protein Kinase Kinase 1 from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (ibiomagazine.org)
Mapk11
Phosphorylation of extracellular1
Inhibitors3
  • Stress kinases are well-described elements of the response to otic injury and the otoprotective potential of JNK inhibitors is being tested in clinical trials. (datadryad.org)
  • A series of N-benzylated isatin oximes were developed as inhibitors of the mitogen-activated kinase, JNK3. (rcsb.org)
  • A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase Hotspot SM platform. (guidetopharmacology.org)
MAPKs2
Adenosine1
Nuclear5
  • However, Erk3 is distinguished from other MAP kinases in that it lacks the conserved TXY motif in its activation loop, poss Encodes a nuclear and cytoplasmically localized MAP kinase involved in mediating responses to pathogens. (creativebiomart.net)
  • Inhibitory effect on activator protein-1, nuclear factor-kappaB, and cell transformation by extracts of strawberries (Fragaria x ananassa Duch. (cdc.gov)
  • antioxidant enzymes on tetradecanoylphorbol-13-acetate (TPA) or ultraviolet-B (UVB) induced activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) were studied. (cdc.gov)
  • SP600125 inhibited interleukin-1β-induced JNK activity and activator protein-1 activation, but it did not affect the activation of extracellular-regulated kinase, p38 mitogen-activated protein kinase, and nuclear factor-κB. (aspetjournals.org)
  • Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. (antibodies-online.com)
Proliferation1
  • BRAF is a protein kinase and part of the MAP kinase signalling cascade which involves transduction of a growth signal from the cell membrane to the nucleus via a chain of protein kinases and is responsible for cellular proliferation and survival. (hindawi.com)
Stress-activated protein1
  • Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1). (nih.gov)
Species4
Assay2
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Mitogen Activated Protein Kinase Kinase 1 (MAP2K1) in Tissue homogenates, cell lysates and other biological fluids. (ibiomagazine.org)
  • Their assay methods and plasma reference ranges (es- onset of fever and respiratory symptoms ( 1-3 ). (cdc.gov)
Mice8
  • Here, we assessed the protective effect of silibinin on UVB-induced skin carcinogenesis in SKH-1 hairless mice. (nih.gov)
  • These data show that transient inhibition of LH-stimulated MAPK3/1 activity abrogates ovulation in mice. (phytid.org)
  • A recently available research using granulosa-specific knockout (KO) mice [5] supplied proof for the need for Mapk3/1 signaling in LH signaling during ovulation. (phytid.org)
  • MEK), which abrogates Mapk3/1 activity without cytotoxicity when implemented as an individual dosage of 25g/g bodyweight in mice [10,11]. (phytid.org)
  • We have studied the transgenic mouse strain, Tyrp-1-TAg, to try to gain insight into possible molecular mechanisms common to pigmented ocular neoplasms occurring spontaneously in the eyes of these mice and human choroidal melanoma. (molvis.org)
  • This is the first study describing the production and distribution of ETS-1 and ETS-2 mRNAs and proteins using in situ hybridization and immunohistochemistry in murine ocular tissue sections of normal control eyes and tumoral eyes from mice of the same age. (molvis.org)
  • ETS-1 and ETS-2 mRNA and protein levels were much higher in the ocular tissues of Tyrp-1-TAg mice than in control ocular tissues from wild-type mice. (molvis.org)
  • We also demonstrated upregulation of ETS-1 and ETS-2 target expressions in Tyrp-1-TAg mice when comparing with the same target expressions in control mice. (molvis.org)
Subunit1
  • Furthermore, it was revealed that treatment with vitexin induced hypoxia inducible factor 1α subunit (HIF‑1α) and vascular endothelial growth factor (VEGF) protein expression, and suppressed phosphorylated‑p38 MAP kinase (p38) protein expression in sevoflurane‑induced newborn rat. (spandidos-publications.com)
Regulates3
  • Phosphorylation Regulates CAP1 (Cyclase-Associated Protein 1) Functions in the Motility and Invasion of Pancreatic Cancer Cells. (uams.edu)
  • Xiao, L, Haack, KKV & Zucker, IH 2013, ' Angiotensin II regulates ACE and ACE2 in neurons through p38 mitogen-activated protein kinase and extracellular signal-regulated kinase 1/2 signaling ', American Journal of Physiology - Cell Physiology , vol. 304, no. 11, pp. (nebraska.edu)
  • Hypoxia inducible factor-1 (HIF-1) is an oxygen-sensitive transcriptional regulator that regulates more than 70 downstream target genes, including vascular endothelial growth factor, erythropoietin, glucose transporter and so on ( 5 ). (spandidos-publications.com)
Oxidative Stress1
  • These results suggest that the ability of strawberries to block UVB- and TPA-induced AP-1 and NF-kappaB activation may be due to their antioxidant properties and their ability to reduce oxidative stress. (cdc.gov)
Regulation4
  • Western blot analysis of normal skin and tumor lysates showed that silibinin decreases the levels of cyclin-dependent kinase 2 and cyclin-dependent kinase 4 and associated cyclins A, E, and D1, together with an up-regulation of Cip1/p21, Kip1/p27, and p53. (nih.gov)
  • 2011) Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase. (guidetopharmacology.org)
  • Regulation of NF-kappaB RelA phosphorylation and transcriptional activity by p21(ras) and protein kinase Czeta in primary endothelial cells. (nih.gov)
  • The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response. (nih.gov)
Phosphorylate1
  • Activated p38 MAP kinase has been shown to phosphorylate and activate MAPKAP kinase 2 and to phosphorylate the transcription factors ATF2, Mac, MEF2, and p53. (wikipedia.org)
Creative BioMart1
Interleukin4
  • 1: In the haematopoietic microenvironment, bone marrow stromal cells play an important role in regulating haematopoiesis by expressing various cytokines, including leukaemia inhibitory factor (LIF) and interleukin-6 (IL-6). (unboundmedicine.com)
  • TY - JOUR T1 - Role of mitogen-activated protein kinase family in serum-induced leukaemia inhibitory factor and interleukin-6 secretion by bone marrow stromal cells. (unboundmedicine.com)
  • In contrast, IL (interleukin)-1β activated an alternative kinase, TAK1 (transforming growth factor-activated kinase 1). (ox.ac.uk)
  • Interleukin-1β activated both 46- and 54-kDa JNK, whereas platelet-derived growth factor-BB activated only 46-kDa JNK. (aspetjournals.org)
Oncogene2
  • The protein product of proto-oncogene RAS can increase activity of p38, and thereby cause excessively high activity of transcription factor NF-κB. (wikipedia.org)
  • The role of two members of the ETS (E26 avian leukemia oncogene) family of transcription factors, ETS-1 and ETS-2, has been investigated in many cancers but has not yet been studied in ocular tumors. (molvis.org)
Downstream1
  • The purpose of our research was to recognize novel transcription elements that play a significant part downstream of Mapk3/1 signaling along the way of ovulation. (phytid.org)
Endothelial2
  • Alterations in normal flow induced by changes in outflow resistance or valve failure lead to endothelial disturbances that provoke localized inflammatory responses, which may intensify immune activation, leading to demyelination and disability in MS. Flow sensors that may be dysregulated include MKP-1, KLF2, and KLF4, which control adhesion molecule, eNOS, and blood-brain barrier function and iron deposition. (biomedcentral.com)
  • VEGF is purified from bovine pituitary follicular cells in 1959 and is a vascular endothelial cell-specific mitogen that promotes the growth of vascular endothelial cells. (spandidos-publications.com)
Activation3
  • Transient activation of AMP-activated protein kinase at G1/S phase transition is required for control of S phase in NIH3T3 cells. (nih.gov)
  • Upon trypsin activation, all constructs stimulated MAP kinase signaling, but only the wt-rPAR 2 and rPAR 2 -Ala 39-42 triggered calcium signaling. (aspetjournals.org)
  • The activation of this kinase requires its phosphorylation by upstream kinases. (antibodies-online.com)
Growth2
  • This abrogated expression of the decidual marker genes, insulin like growth factor binding protein 1 ( IGFBP1 ) and prolactin ( PRL ), and prevented adoption of decidual cell morphology. (bioone.org)
  • Neurofibromatosis type 1 (NF1) is a multisystem genetic disorder that is characterized by cutaneous findings, most notably café-au-lait spots and axillary freckling (see the images below), by skeletal dysplasias, and by the growth of both benign and malignant nervous system tumors, most notably benign neurofibromas. (medscape.com)
SAPK1
  • It does not crossreact with either JNK/ SAPK or p38 MAP kinase. (reageno.com)
MRNA and protein1
  • ANG II induced a significant dose-dependent increase in ACE and decrease in ACE2 mRNA and protein expression in CATH.a neurons. (nebraska.edu)
Cell5
  • Dysregulated NF-κB activity can activate genes that cause cancer cell survival, and can also activate genes that facilitate cancer cell metastasis to other tissues. (wikipedia.org)
  • A mouse catecholaminergic neuronal cell line (CATH.a) was treated with ANG II (30, 100, and 300 nM) for 24 h, and protein expression was determined by Western blot analysis. (nebraska.edu)
  • Here, an evaluation of the global A. fumigatus phosphoproteome under cell wall stress caused by the cell wall-damaging agent Congo red (CR) revealed 485 proteins potentially involved in the cell wall damage response. (bath.ac.uk)
  • In response to pancreatic injury and in cell culture, pancreatic stellate cells (PSCs) are transformed ("activated") into highly proliferative myofibroblast-like cells that express α-smooth muscle actin and produce extracellular matrix components. (aspetjournals.org)
  • In normal control adult mouse eyes, ETS-1 was mostly present in the nuclei of all neuroretinal layers whereas ETS-2 was mostly localized in the cytosol of the cell bodies of these layers with a smaller amount present in the nuclei. (molvis.org)
Activity4
  • and protein kinase activity. (nih.gov)
  • Alternatively, pharmacologic approach to inhibition of the proteins activity is normally economical, less frustrating and not at all hard compared to hereditary manipulation. (phytid.org)
  • Furthermore, using pharmacologic technique you can inhibit proteins activity activity transiently at an accurate physiological stage. (phytid.org)
  • As a result, PD0325901 treatment is a superb alterative solution to inhibit Mapk3/1 activity at specific time-points during follicular advancement. (phytid.org)
Pathogenesis1
  • Activated PSCs are implicated in the pathogenesis of pancreatic fibrosis and inflammation. (aspetjournals.org)
Survival1
  • There was a trend for overall survival to be related to p-ERK expression in patients with melanoma over 1 mm in thickness. (bmj.com)
Mapk31
  • This means that that the others 81% Mapk3/1-reliant genes are governed by transcription elements apart from Cebpa/b, that are yet to become discovered. (phytid.org)
Molecular1
  • The oxidative events that regulate AP-1 and NF-kappaB transactivation can be important molecular targets for cancer prevention. (cdc.gov)