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  • cerebellar long-term depre
  • Here, we show that diacylglycerol kinase ζ (DGKζ) creates optimal conditions for the induction of cerebellar long-term depression (LTD). DGKζ works by regulating localization and activity of protein kinase Cα (PKCα), an important mediator of LTD, so that PKCα effectively responds to the stimulation that triggers LTD. (jneurosci.org)
  • Synaptic Plasticity
  • Considering that long-term synaptic plasticity is generally induced by short-lasting synaptic activity, regenerative mechanisms such as the positive feedback loop may be a common way to fill in the temporal gap between transient synaptic signaling and long-lasting kinase activities. (jneurosci.org)
  • Targets
  • They are bona fide Ras (a membrane-associated guanine nucleotide-binding protein) effectors and upstream activators of the ubiquitous ERK pathway , which has drawn the attention to these proteins as potential targets in cancer therapy . (axonmedchem.com)
  • Keap1
  • Under normal physiological conditions, nuclear Nrf2 contributes to vascular protection by inducing expression of the glutamate cysteine ligase modulatory subunit (GCLM) and the light chain component of system x c − (xCT) in human endothelial cells, while cytoplasmic Nrf2 is bound and inhibited by Kelch-like ECH-associated protein 1 (Keap1) [ 15 ]. (hindawi.com)
  • mechanism
  • Furthermore, these data highlight the need for precise titration of the MAP kinase signal to ensure the integrity of the spindle assembly process and provide a mechanism for generating genomic instability in tumors. (biomedcentral.com)
  • Downregulation of Raf-1 kinase inhibitory protein as a sorafenib resistance mechanism in hepatocellular carcinoma cell lines. (bioportfolio.com)
  • mammalian
  • The transcription factor BTB and CNC homology 1 (Bach1) is widely expressed in most mammalian tissues and functions primarily as a transcriptional suppressor by heterodimerizing with small Maf proteins and binding to Maf recognition elements in the promoters of targeted genes. (hindawi.com)
  • Cells were lysed in 200 μL mammalian protein extraction reagent (Pierce). (aacrjournals.org)
  • serum
  • Correlate a pattern of serum proteins present before treatment with sorafenib-related clinical benefits (e.g., response, time to progression, and/or survival) in these patients. (bioportfolio.com)
  • role
  • These results reveal a role for Raf Kinase Inhibitory Protein and the MAP kinase cascade in ensuring the fidelity of chromosome segregation prior to cell division. (biomedcentral.com)
  • Type I protein kinase A (PKAI) is overexpressed in the majority of human tumors and plays a relevant role in neoplastic transformation, conveying mitogenic signals of different growth factors and oncogenes. (aacrjournals.org)
  • Human UC11 astrocytoma cells were used to investigate the role of protein kinase C (PKC) and other kinases in neurokinin (NK)1 receptor desensitization. (wmin.ac.uk)
  • These results suggest that, although PKC does not mediate the process of rapid desensitization, it does have an inhibitory role at later times. (wmin.ac.uk)
  • interaction
  • CR1 contains a Ras-binding domain (RBD), which is necessary for the interaction with Ras and with membrane phospholipids required for membrane recruitment, and a cysteine-rich domain (CRD), which is a secondary Ras-binding site and also necessary for the interaction of CR1 with the kinase domain for Raf auto-inhibition. (axonmedchem.com)
  • activation
  • The activation of G protein-coupled receptors (GPCRs) 2 by pancreatic secretagogues, such as cholecystokinin (CCK) and acetylcholine, leads to the opening of second-messenger-gated Ca 2+ channels located on the endoplasmic reticulum (ER) and various apical acidic vesicles ( 9 - 14 ). (pubmedcentralcanada.ca)
  • known
  • Because Jerk/SCID mouse SIRP is certainly known to end up being able of communicating with individual Compact disc47 (21), these outcomes indicated that the defensive impact of individual Compact disc47 phrase is certainly most Esomeprazole Magnesium trihydrate supplier likely mediated through a SIRP-related system offering inhibitory indicators to receiver macrophages. (exposed-skin-care.net)
  • cell
  • Loss of any of these proteins is deleterious to the progression of the cell cycle and leads to catastrophic consequences if not corrected. (biomedcentral.com)
  • One of the mechanisms by which the cell ensures signaling fidelity involves modulators of signaling cascades such as scaffold proteins that potentiate or inhibit the output. (biomedcentral.com)
  • Depletion of these proteins would not compromise the cell acutely but could lead to slow accumulation of chromosomal abnormalities culminating in mutation and disease. (biomedcentral.com)