Kinase inhibitor with selectivity. Medical search. Frequent questions

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Anatomy14

Cell Line, Tumor Cell Line Cells, Cultured Tumor Cells, Cultured 3T3 Cells HeLa Cells Neurons Fibroblasts Cell Membrane Cell Nucleus CHO Cells Cytosol Oocytes HEK293 Cells

Organisms8

Rats, Sprague-Dawley Mice, Nude Cricetinae Mice, Inbred C57BL Mice, Knockout Cattle Rabbits Rats, Wistar

Diseases3

Leukemia, Myelogenous, Chronic, BCR-ABL Positive Lung Neoplasms Neoplasms

Chemicals and Drugs165

Protein Kinase Inhibitors Phosphatidylinositol 3-Kinases Protein-Serine-Threonine Kinases Protein Kinases src-Family Kinases Protein-Tyrosine Kinases Calcium-Calmodulin-Dependent Protein Kinases Enzyme Inhibitors Protein Kinase C Cyclin-Dependent Kinase Inhibitor p27 Cyclin-Dependent Kinases p38 Mitogen-Activated Protein Kinases Pyrimidines Cyclic AMP-Dependent Protein Kinases Mitogen-Activated Protein Kinase 1 Cyclin-Dependent Kinase Inhibitor p21 Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinase Kinases Piperazines JNK Mitogen-Activated Protein Kinases Benzamides Mitogen-Activated Protein Kinases p21-Activated Kinases Pyridines Receptor Protein-Tyrosine Kinases CDC2 Protein Kinase Antineoplastic Agents Indoles Quinazolines MAP Kinase Kinase Kinases rho-Associated Kinases Aurora Kinases Extracellular Signal-Regulated MAP Kinases Receptor, Epidermal Growth Factor Staurosporine Proto-Oncogene Proteins Chromones Genistein Creatine Kinase Casein Kinase II Morpholines MAP Kinase Kinase 1 Phosphotransferases (Alcohol Group Acceptor)Androstadienes Ribosomal Protein S6 Kinases Proto-Oncogene Proteins c-akt CDC2-CDC28 Kinases Casein Kinases eIF-2 Kinase Isoenzymes Pyruvate Kinase Flavonoids Cell Cycle Proteins Tyrosine MAP Kinase Kinase 4 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine Intracellular Signaling Peptides and Proteins Thymidine Kinase Cyclin-Dependent Kinase Inhibitor p57 Glycogen Synthase Kinase 3 1-Phosphatidylinositol 4-Kinase Recombinant Proteins Pyrroles I-kappa B Kinase Diacylglycerol Kinase Protein Kinase C-delta Cyclin-Dependent Kinase Inhibitor Proteins RNA, Messenger Cyclin-Dependent Kinase 2 Calcium Protein Kinase C-alpha Imidazoles Phosphoproteins Cyclins Thiazoles Isoquinolines Aurora Kinase A Tetradecanoylphorbol Acetate Nitriles Focal Adhesion Kinase 1 Myosin-Light-Chain Kinase Recombinant Fusion Proteins Tyrphostins AMP-Activated Protein Kinases Ribosomal Protein S6 Kinases, 90-kDa Janus Kinase 2 TOR Serine-Threonine Kinases Focal Adhesion Protein-Tyrosine Kinases Fusion Proteins, bcr-abl Cyclic AMP Serine Tumor Suppressor Proteins Carbazoles MAP Kinase Kinase 2 Aurora Kinase B MAP Kinase Kinase Kinase 1 Cyclic GMP-Dependent Protein Kinases Cyclin-Dependent Kinase Inhibitor p16 Carrier Proteins Adenosine Kinase Proto-Oncogene Proteins c-abl Butadienes Adenosine Triphosphate Protein Kinase C-epsilon DNA-Binding Proteins Cyclin-Dependent Kinase Inhibitor p18 RNA, Small Interfering Calcium-Calmodulin-Dependent Protein Kinase Type 2 Phenylurea Compounds Maleimides Pyrazoles Indole Alkaloids Phosphotyrosine Protein Kinase C beta Ligands Cyclin-Dependent Kinase 5 Cyclin-Dependent Kinase 4 Transcription Factors Phosphatidylinositol 3-Kinase Quinones Epidermal Growth Factor Membrane Proteins 3-Phosphoinositide-Dependent Protein Kinases Threonine Focal Adhesion Kinase 2 Phosphoprotein Phosphatases raf Kinases Proteins Mitogen-Activated Protein Kinase 8 Microtubule-Associated Proteins Casein Kinase I DNA Primers MAP Kinase Kinase 6 Phosphoglycerate Kinase Isoflavones Peptides MAP Kinase Kinase 3 Piperidines Purines Cyclin-Dependent Kinase Inhibitor p15 Ribosomal Protein S6 Kinases, 70-kDa Adaptor Proteins, Signal Transducing Nuclear Proteins Phosphorylase Kinase Arginine Kinase Choline Kinase Nucleoside-Phosphate Kinase NF-kappa B Benzenesulfonates DNA Lim Kinases Alkaloids Proto-Oncogene Proteins pp60(c-src)Niacinamide Type C Phospholipases Phosphatidylethanolamine Binding Protein Phosphoserine Diglycerides Proto-Oncogene Proteins c-kit Janus Kinase 1 Lactams, Macrocyclic Benzoquinones Naphthalenes Actins Proto-Oncogene Proteins c-pim-1

Analytical, Diagnostic and Therapeutic Techniques and Equipment18

Transfection Blotting, Western Models, Molecular Models, Biological Immunoblotting Inhibitory Concentration 50 Mutagenesis, Site-Directed Precipitin Tests Drug Design Cloning, Molecular Reverse Transcriptase Polymerase Chain Reaction Crystallography, X-Ray Immunohistochemistry Sequence Alignment Amino Acid Substitution Drug Screening Assays, Antitumor Xenograft Model Antitumor Assays Drug Evaluation, Preclinical

Phenomena and Processes45

MAP Kinase Signaling System Phosphorylation Signal Transduction Mutation Kinetics Enzyme Activation Protein Binding Apoptosis Dose-Response Relationship, Drug Substrate Specificity Amino Acid Sequence Transfection Binding Sites Cell Cycle Cell Proliferation Protein Structure, Tertiary Cell Division Base Sequence Structure-Activity Relationship Time Factors Drug Resistance, Neoplasm Cell Survival Sequence Homology, Amino Acid Gene Expression Regulation Inhibitory Concentration 50 Down-Regulation Molecular Structure Transcription, Genetic Gene Expression Regulation, Enzymologic Up-Regulation Drug Synergism Gene Expression G1 Phase Protein Conformation Cell Movement Cell Differentiation Protein Transport Catalytic Domain Promoter Regions, Genetic RNA Interference Mitosis Gene Expression Regulation, Neoplastic Amino Acid Substitution Protein Processing, Post-Translational Catalysis

Disciplines and Occupations2

Drug Design Immunohistochemistry

Information Science3

Molecular Sequence Data Amino Acid Sequence Base Sequence

Anatomy Organisms Diseases Chemicals and Drugs Analytical, Diagnostic and Therapeutic Techniques and Equipment Phenomena and Processes Disciplines and Occupations Information Science

Protein Kinase Inhibitors Phosphatidylinositol 3-Kinases Protein-Serine-Threonine Kinases MAP Kinase Signaling System Protein Kinases src-Family Kinases Protein-Tyrosine Kinases Calcium-Calmodulin-Dependent Protein Kinases Enzyme Inhibitors Protein Kinase C Phosphorylation Cyclin-Dependent Kinase Inhibitor p27 Cyclin-Dependent Kinases p38 Mitogen-Activated Protein Kinases Pyrimidines Cyclic AMP-Dependent Protein Kinases Mitogen-Activated Protein Kinase 1 Signal Transduction Cyclin-Dependent Kinase Inhibitor p21 Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinase Kinases Piperazines JNK Mitogen-Activated Protein Kinases Benzamides Mitogen-Activated Protein Kinases p21-Activated Kinases Cell Line, Tumor Pyridines Receptor Protein-Tyrosine Kinases CDC2 Protein Kinase Antineoplastic Agents Indoles Quinazolines Mutation MAP Kinase Kinase Kinases Molecular Sequence Data rho-Associated Kinases Kinetics Enzyme Activation Aurora Kinases Extracellular Signal-Regulated MAP Kinases Receptor, Epidermal Growth Factor Protein Binding Cell Line Staurosporine Proto-Oncogene Proteins Chromones Genistein Cells, Cultured Creatine Kinase Casein Kinase II Morpholines Apoptosis MAP Kinase Kinase 1 Phosphotransferases (Alcohol Group Acceptor)Dose-Response Relationship, Drug Androstadienes Ribosomal Protein S6 Kinases Substrate Specificity Proto-Oncogene Proteins c-akt CDC2-CDC28 Kinases Amino Acid Sequence Casein Kinases Transfection eIF-2 Kinase Blotting, Western Isoenzymes Pyruvate Kinase Flavonoids Binding Sites Tumor Cells, Cultured Cell Cycle Proteins Cell Cycle Tyrosine MAP Kinase Kinase 4 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine Intracellular Signaling Peptides and Proteins Thymidine Kinase Cyclin-Dependent Kinase Inhibitor p57 Cell Proliferation Glycogen Synthase Kinase 3 Protein Structure, Tertiary Cell Division 1-Phosphatidylinositol 4-Kinase Recombinant Proteins Pyrroles I-kappa B Kinase Diacylglycerol Kinase Models, Molecular Protein Kinase C-delta Cyclin-Dependent Kinase Inhibitor Proteins RNA, Messenger Cyclin-Dependent Kinase 2 Calcium Protein Kinase C-alpha Base Sequence Imidazoles Phosphoproteins Structure-Activity Relationship Time Factors

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