Kinase ii. Medical search. Frequent questions

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase Hotspot SM platform. (guidetopharmacology.org)
Homeodomain-interacting protein kinases (HIPKs) belong to the CMGC kinase family and are closely related to dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs). (nature.com)
Homeodomain-interacting protein kinases (HIPKs) are an evolutionarily conserved kinase family comprising the members HIPK1, HIPK2, and HIPK3 in vertebrates, and, additionally, HIPK4 in mammals. (nature.com)
Proteins kinase CK2 (previously called casein kinase 2) is a pivotal and ubiquitously expressed member of the protein CX-6258 manufacture kinase CMGC subfamily which includes cyclin-dependent kinases (CDKs) mitogen-activated protein kinases (MAPKs) glycogen synthase kinases (GSKs) and CDK-like kinases (CLKs). (immune-source.com)
Protein Kinases Promising Targets for Anticancer Drug Researc. (intechopen.com)

In an effort to find new pharmacological modalities to overcome resistance to ATP-binding-site inhibitors of Bcr-Abl, we recently reported the discovery of GNF-2, a selective allosteric Bcr-Abl inhibitor. (rcsb.org)
Patient-reported Effects of Fedratinib, an Oral, Selective Inhibitor of Janus Kinase 2, on Myelofibrosis-related Symptoms and Health-related Quality of Life in the Randomized, Placebo-controlled, Phase III JAKARTA Trial. (iasp-pain.org)
Fedratinib, an oral, selective Janus-kinase 2 (JAK2) inhibitor, was investigated in the randomized, placebo-controlled, phase III JAKARTA study in adult patients with intermediate- or high-risk JAK-inhibitor-naïve MF. (iasp-pain.org)
Used as a CDK1 substrate (0.25 mM) and also a competitive inhibitor with IC 50 =50 µM for inhibition of apoptosis induced by perforin and fragmentin-2 in YAC-1 lymphoma cells (peptide A). (enzolifesciences.com)
Cycloheximide or Chk2 inhibitor pretreatment abrogated not only activation of Chk2 but also G 2 /M arrest and apoptosis mediated by DIM. (aspetjournals.org)
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfiler TM service. (guidetopharmacology.org)
1. Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. (2011) Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. (guidetopharmacology.org)
These images are a random sampling from a Bing search on the term "Janus Kinase Inhibitor. (fpnotebook.com)
Preoperatively, prepare patients with pheochromocytomas by treating them with an alpha-blocker or a tyrosine hydroxylase inhibitor, such as metyrosine, for 1-2 weeks, after which administration of a beta-blocker can be considered. (medscape.com)
During the late-breaking sessions at the annual EADV Congress, Kimball presented data from two trials - SUNSHINE and SUNRISE - that investigated the efficacy, safety and tolerability of the interleukin (IL) 17A inhibitor secukinumab ( Cosentyx ) vs placebo in the treatment of moderate to severe HS. (medscape.com)

Casein kinase-2 mediates cell survival through phosphorylation and degradation of inositol hexakisphosphate kinase-2. (nih.gov)
This positional scanning synthetic peptide combinatorial library (PS-SPCL) has been used in rapid identification of serine/threonine kinase phosphorylation motif. (anaspec.com)
In this study, we revealed that Homer3 was phosphorylated by calcium/calmodulin-dependent protein kinase II (CaMKII) in Purkinje cells, and the phosphorylation reduces the affinity for Homer target molecules, resulting in change of the solubility. (jneurosci.org)
Using radiolabeling, chemical crosslinking, chromatography and electron microscopy, we find that sodium ion concentration governs the oligomeric state of Histidine Kinase 2 and its phosphorylation by ATP. (biorxiv.org)
G 2 /M arrest was associated with DNA damage as indicated by phosphorylation of H 2 A.X at Ser139 and activation of checkpoint kinase 2 (Chk2) in all the three cell lines. (aspetjournals.org)
This antibody does not detect the non-phosphorylated α-subunit of rat CaM kinase II nor the ~60kDa β-subunit in either phosphorylation state. (enzolifesciences.com)
In summary, our work provides important insight into the substrates-TTBK2 kinase relationship and suggests that phosphorylation of substrates on multiple sites by TTBK2 is probably involved in the control of ciliogenesis in human cells. (muni.cz)
HIPKs belong to the CMGC group of serine/threonine kinases and are part of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. (nature.com)
c-Src tyrosine kinase plays an important role in signal transduction pathways, where its activity is regulated by phosphorylation of the two tyrosine residues. (intechopen.com)

Janus kinase inhibitors in dermatology: Part II. (nih.gov)
A novel series of compounds based on the pyrrolo[2,1-f][1,2,4]triazine ring system have been identified as potent p38 alpha MAP kinase inhibitors. (rcsb.org)
GNF-5, an analogue of GNF-2 with improved pharmacokinetic properties, when used in combination with the ATP-competitive inhibitors imatinib or nilotinib, suppressed the emergence of resistance mutations in vitro, displayed additive inhibitory activity in biochemical and cellular assays against T315I mutant human Bcr-Abl and displayed in vivo efficacy against this recalcitrant mutant in a murine bone-marrow transplantation model. (rcsb.org)
We provide an overview on the current development of class II PI3 kinase inhibitors and outline the potential use for such inhibitors. (lu.se)
Nevertheless, recent advances in understanding the roles of class II PI3 kinases in different pathological contexts is leading to an increased interest in the development of specific inhibitors that can provide potential novel pharmacological tools. (lu.se)
A screen of 72 inhibitors against 456 human kinases. (guidetopharmacology.org)
2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. (guidetopharmacology.org)
inhibitors and potently obstructed the experience of both individual CK2?1 (hCK?1) and individual CK2?2 (hCK?2) (Suzuki et al. (immune-source.com)
inhibitors offer beneficial results on nephritis via Ck2?1 inhibition and undesireable effects on spermatogenesis via CK2?2 inhibition (Xu et al. (immune-source.com)
Which medications in the drug class Antineoplastic Agents, mTOR Kinase Inhibitors are used in the treatment of Non-Hodgkin Lymphoma (NHL)? (medscape.com)

This gene encodes a serine/threonine protein kinase that is involved in many different processes, including, cell signaling, microtubule organization and stability, and apoptosis. (antibodies-online.com)
Its lipid transfer activity is negatively regulated by casein kinase, a serine/threonine-protein kinase which phosphorylates STARD10 on a serine residue at position 284 (Olayioye et al. (reactome.org)
DYRKs are named after their characteristic dual-specificity, as they auto-phosphorylate a conserved tyrosine in their activation loop, but phosphorylate substrates on serine and threonine residues 2 . (nature.com)
C-terminally adjacent to the HID follows a proline, glutamate, serine, and threonine (PEST)-rich domain, mediating proteasomal degradation of these kinases. (nature.com)
DAPK1, located in human chromosomal locus 9q34.1, is a member of the DAPK family that belongs to the serine/threonine kinase (STK) superfamily. (frontiersin.org)
The full-length sequence of DAPK1 has 1,430 residues ( Farag and Roh, 2019 ), which consists of the catalytic domain (CD), the autoregulatory domain (ARD), eight ankyrin repeats, two P-loop motifs, the cytoskeletal binding domain, the death domain, and the serine-rich C-terminal tail. (frontiersin.org)

Serum creatine kinase levels (CK) can vary among healthy subjects, even when correcting for muscle mass. (medscape.com)

A series of novel 3,5-diamino-1,2,4-triazole benzyl ureas was identified as having potent anaplastic lymphoma kinase (ALK) inhibition exemplified by 15a, 20a, and 23a, which exhibited antiproliferative IC50 values of 70, 40, and 20 nM in Tel-ALK transformed Ba/F3 cells, respectively. (harvard.edu)
Therefore, Ca2+ /CaM binding suppression and the interaction of the kinase active site of CaMKK1 with the last two C-terminal helices of 14-3-3Î³ protein provide the structural basis for 14-3-3-mediated CaMKK1 inhibition. (bvsalud.org)

Orthologous to human PIK3C2A (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha). (nih.gov)
Synthetic peptide corresponding to aa 281-294 (M 281 HRQET(PSO 3 )VDCLKKFN 294 ) of the α-subunit of mouse and rat CaM kinase II (Ca 2+ /Calmodulin-dependent Protein Kinase II) thiophosphorylated at (Thr 286 ). (enzolifesciences.com)
Recognizes the phosphorylated α-subunit of CaM kinase II. (enzolifesciences.com)
In mammals the CK2?2 subunit is certainly highly and solely expressed in the mind and testis helping the idea that CK2?2 provides specific features in these tissue (Guerra Siemer et al. (immune-source.com)
CK2?2-subunit knockout mice for instance create a condition much like globozoospermia in human beings (Xu et al. (immune-source.com)

In females (who have two X chromosomes), a mutation would have to occur in both copies of the gene to cause the disorder. (medlineplus.gov)
Flanagan JM, Rhodes M, Wilson M, Beutler E. The identification of a recurrent phosphoglycerate kinase mutation associated with chronic haemolytic anaemia and neurological dysfunction in a family from USA. (medlineplus.gov)

Janus kinase 2 (commonly called JAK2) is a non-receptor tyrosine kinase. (wikipedia.org)
It is a member of the Janus kinase family and has been implicated in signaling by members of the type II cytokine receptor family (e.g. interferon receptors), the GM-CSF receptor family (IL-3R, IL-5R and GM-CSF-R), the gp130 receptor family (e.g. (wikipedia.org)
Epo-R, Tpo-R, GH-R, PRL-R). The distinguishing feature between janus kinase 2 and other JAK kinases is the lack of Src homology binding domains (SH2/SH3) and the presence of up to seven JAK homology domains (JH1-JH7). (wikipedia.org)
The Janus kinase-signal transducer and activator of transcription (JAK-STAT) intracellular signaling pathway is implicated in the pathogenesis of a number of inflammatory dermatoses. (nih.gov)

Histidine kinase 2 (Hik2) is a sensor histidine kinase found in all known cyanobacteria and as chloroplast sensor kinase in eukaryotic algae and plants. (biorxiv.org)

To identify their cognate receptors, the grapevine family of LysM receptor kinases (LysM‐RKs) was annotated and their gene expression profiles were characterized. (uzh.ch)
Shiu, S. H. & Bleecker, A. B. Receptor-like kinases from Arabidopsis form a monophyletic gene family related to animal receptor kinases. (nature.com)

ABSTRACT Using data from the 2nd Gulf Registry of Acute Coronary Events (Gulf RACE-2) in 2008-09 we investigated the in-hospital complications and 1-year outcome of acute coronary syndrome (ACS) in patients with systemic hypertension from 6 Gulf countries. (who.int)

Find TAO Kinase 2 Proteins with a specific Grade. (antibodies-online.com)
Find TAO Kinase 2 Proteins for a variety of species such as anti-Human TAO Kinase 2, anti-Mouse TAO Kinase 2. (antibodies-online.com)
Find TAO Kinase 2 Proteins validated for a specific application such as ELISA, SDS, WB, Func. (antibodies-online.com)
Histidine kinase 2 is a sensor of sodium ion concentration and redox potential, regulating transcription of genes for light-harvesting and reaction center proteins of photosynthesis in cyanobacteria and chloroplasts of algae and plants. (biorxiv.org)
We describe extensive use of histidine kinase-based two-component systems and tyrosine kinase signaling, the presence of bacterial and plant type photoreceptors (phytochromes, cryptochrome, and phototropin) and of plant-type pentatricopeptide repeat proteins, as well as metabolic pathways, and a cell cycle control system typically found in more complex eukaryotes. (duke.edu)
and it has been within many diseases especially cancer rendering it an interesting focus on inside CX-6258 manufacture the druggable category of eukaryotic proteins kinases (Pagano et al. (immune-source.com)
The GST-removed hCK2?2 proteins which acquired a. (immune-source.com)
They are tetrameric proteins that contain two catalytic subunits and two type II-specific regulatory subunits. (uchicago.edu)

is a constitutively active protein kinase and is further fully activated by association with CK2? (immune-source.com)
CaM binding to the ARD triggers large conformational arrangements of DAPK1 through the disruption of the CD−ARD association, generating a constitutively active kinase. (frontiersin.org)

Nonetheless the terminal JH domains retain a high level of homology to tyrosine kinase domains. (wikipedia.org)
c-Src tyrosine kinase consists of the N-terminal unique region, the Src homology 3 (SH3), SH2, linker, kinase domain, and the regulatory C-terminal tail. (intechopen.com)

The PI 3-kinase PI3KC2α regulates mouse platelet membrane structure and function independently of membrane lipid composition. (nih.gov)

Ca2+ /CaM-dependent protein kinase kinases 1 and 2 (CaMKK1 and CaMKK2) phosphorylate and enhance the catalytic activity of downstream kinases CaMKI, CaMKIV, and protein kinase B . Accordingly, CaMKK1 and CaMKK2 regulate key physiological and pathological processes , such as tumorigenesis , neuronal morphogenesis , synaptic plasticity , transcription factor activation, and cellular energy homeostasis , and promote cell survival . (bvsalud.org)

Glycogen synthase kinase-3 (GSK-3) a magic enzyme: it's role in diabetes mellitus and glucose homeostasis, interactions with fluroquionlones. (scielo.br)
This disease is mainly regulated by various enzymes and hormones among which Glycogen synthase kinase-3 (GSK-3) is a principle enzyme and insulin is the key hormone regulating it. (scielo.br)

Two-component signal transduction systems (TCSs) consist of sensor histidine kinases and response regulators. (biorxiv.org)

To further establish the involvement of Chk2 in DIM-mediated G 2 /M arrest, cells were transfected with dominant-negative Chk2 (DN-Chk2). (aspetjournals.org)
Blocking Chk2 activation by DN-Chk2 completely protected cells from DIM-mediated G 2 /M arrest. (aspetjournals.org)
These results clearly indicate the requirement of Chk2 activation to cause G 2 /M arrest by DIM in ovarian cancer cells. (aspetjournals.org)

Recombinant HIPKs and DYRK1A are auto-activated and phosphorylate the negative elongation factor SPT5, the transcription factor c-Myc, and the C-terminal domain of RNA polymerase II, suggesting a direct function in transcriptional regulation. (nature.com)

and (b) leucine-rich repeat kinase 2 (LRRK2) gene identified patient induced pluripotent stem cells (iPSCs), which were used to isolate EMVs and begin to characterize their cargoes. (nih.gov)

Homeodomain-interacting protein kinase-2 (HIPK2) is a positive regulator of p53 oncosuppressor function. (aacrjournals.org)
Within the HIPK family, HIPK1 and HIPK2 are the most closely related members, sharing about 93% sequence identity in their kinase domains, while HIPK3 is slightly less conserved with 87% identity. (nature.com)

The Arabidopsis mutant Atcerk1, impaired in chitin perception, was transformed with these three putative orthologous genes encoding VvLYK1‐1, ‐2, or ‐3 to determine if they would complement the loss of AtCERK1 function. (uzh.ch)

This complex inhibits mammalian target of rapamycin (mTOR) kinase, a key protein in cells that regulate the gene translation responsible for cell-cycle regulation. (medscape.com)
14-3-3 protein inhibits CaMKK1 by blocking the kinase active site with its last two C-terminal helices. (bvsalud.org)
Previous work shows that activating cAMP-dependent protein kinase (PKA) enhances airway epithelial wound repair while activating protein kinase C (PKC) inhibits wound repair. (cdc.gov)

The DYRK family has been characterized in organisms from yeast to humans and can be divided into five subfamilies, class I DYRKs, class II DYRKs, YAKs, HIPKs, and PRP4s 1 . (nature.com)
Although a congenital LN-2 deficiency in humans is associated with CNS white matter changes, LN-2-deficient ( dy/dy ) mice have shown abnormalities primarily within the peripheral nervous system. (rupress.org)

The phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases central to regulating a wide range of important intracellular processes. (lu.se)

Enables 1-phosphatidylinositol-3-kinase activity. (nih.gov)
Predicted to be part of phosphatidylinositol 3-kinase complex. (nih.gov)

Phosphoglycerate kinase deficiency is a genetic disorder that affects the body's ability to break down the simple sugar glucose, which is the primary energy source for most cells. (medlineplus.gov)
The other form of phosphoglycerate kinase deficiency is often called the myopathic form. (medlineplus.gov)
Most people with phosphoglycerate kinase deficiency have either the hemolytic form or the myopathic form. (medlineplus.gov)
Phosphoglycerate kinase deficiency appears to be a rare disorder. (medlineplus.gov)
Phosphoglycerate kinase deficiency is caused by mutations in the PGK1 gene. (medlineplus.gov)
Females with one altered PGK1 gene, however, may have some features of phosphoglycerate kinase deficiency, such as anemia. (medlineplus.gov)
Aasly J, van Diggelen OP, Boer AM, Bronstad G. Phosphoglycerate kinase deficiency in two brothers with McArdle-like clinical symptoms. (medlineplus.gov)

Li, J. & Chory, J. A putative leucine-rich repeat receptor kinase involved in brassinosteroid signal transduction. (nature.com)

Blocking ROS generation by N -acetyl cysteine protects the cells from DIM-mediated G 2 /M arrest and apoptosis. (aspetjournals.org)
Only 0.5% of 2 ME-treated cells showed characteristics of apoptosis. (up.ac.za)
Conversely, increased morphological hallmarks of apoptosis were observed in SNO-treated cells after 21.5 h of 2 ME exposure. (up.ac.za)
The present preliminary study suggests that the accumulation observed in metaphase cells and the increase in Cdc2 kinase activity caused by 2 ME are consistent with morphological hallmarks of mitotic arrest and disrupted mitotic spindle formation, thus leading to induction of apoptosis in SNO cells. (up.ac.za)
Herpes simplex virus protein kinase US3 activates and functionally overlaps protein kinase A to block apoptosis. (uchicago.edu)

These buildings claim that the prolonged N-terminal portion fixes the activation portion and ?C helix the conformational plasticity which is certainly significant for on/off legislation of enzyme activity in CMGC kinases and thus allows CK2?1 to have constitutive activity. (immune-source.com)

A multifunctional calcium-calmodulin-dependent protein kinase subtype that occurs as an oligomeric protein comprised of twelve subunits. (curehunter.com)
A cyclic AMP-dependent protein kinase subtype primarily found in particulate subcellular fractions. (uchicago.edu)

Here we focus on the cellular functions of the three class II PI3K isoforms, PI3KC2α, PI3KC2β, and PI3KC2γ, in different cell systems and underline the emerging importance of these enzymes in different physiological and pathological contexts. (lu.se)

Ca 2+ /CaM binds to the death-associated protein kinase 1 (DAPK1) to regulate intracellular signaling pathways. (frontiersin.org)

Myosin II interacts with F-actin to generate contractile forces that result in axon retraction. (biologists.com)
The ARD interacts with the CD, residing the kinase in its autoinhibited state. (frontiersin.org)
But these effects are much stronger on CaMKK1 than on CaMKK2 because the CaMKK114-3-3Î³ complex has a more compact and rigid structure in which the active site of the kinase domain directly interacts with the last two C-terminal helices of the 14-3-3Î³ protein , thereby inhibiting CaMKK1. (bvsalud.org)

For the class II DYRK ortholog from D. melanogaster it was demonstrated that the critical tyrosine is cis -auto-phosphorylated by the nascent kinase in a transitory intermediate state during maturation at the ribosome 3 . (nature.com)

It differs from other enzyme subtypes in that it lacks a phosphorylatable activation domain that can respond to CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE KINASE. (curehunter.com)
We report on the mechanism of Hik2 activation and inactivation probed by chemical crosslinking and size exclusion chromatography together with direct visualisation of the kinase using negative-stain transmission electron microscopy of single particles. (biorxiv.org)
Our results provide evidence that VvLYK1‐1 and VvLYK1‐2, but not VvLYK1‐3, functionally complement the Atcerk1 mutant by restoring chitooligosaccharide‐induced MAPK activation and immune gene expression. (uzh.ch)
Collectively, these observations suggest that guidance cues cause axon retraction through the coordinated activation of myosin II and the formation of intra-axonal F-actin bundles for myosin-II-based force generation. (biologists.com)

Myosin II activity is required for axon retraction but not growth cone collapse. (biologists.com)
Formation of axonal F-actin bundles was independent of myosin II, but partially required RhoA-kinase activity. (biologists.com)
Conversely, RhoA-kinase activity was required to shut down F-actin polymerization underlying protrusive activity. (biologists.com)
I suggest that in the context of semaphorin 3A signaling, RhoA-kinase serves as a switch to change the function of the F-actin cytoskeleton from promoting protrusive activity to generating contractile forces. (biologists.com)
2013) A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery. (guidetopharmacology.org)
The effects of 1 × 10-6 M exogenous 2-methoxyestradiol (2 ME) were determined on cell morphology and cell division cycle (Cdc) 2 kinase activity in SNO oesophageal carcinoma cells. (up.ac.za)
Mutations in the PGK1 gene reduce the activity of phosphoglycerate kinase, which disrupts energy production and leads to cell damage or cell death. (medlineplus.gov)
Researchers speculate that different PGK1 gene mutations may have varying effects on the activity of phosphoglycerate kinase in different types of cells. (medlineplus.gov)

c-Src (cellular Src), encoded by Src gene, is a non-receptor tyrosine kinase first isolated as the normal cellular homolog to the potent avian sarcoma viral transforming oncogene v-Src [ 4 ]. (intechopen.com)

Thus we decided the first structure of hCK2?2 complexed with CC04820 in order to clarify the structural differences between hCK2?1 and hCK2?2. (immune-source.com)

This gene provides instructions for making an enzyme called phosphoglycerate kinase, which is involved in a critical energy-producing process in cells known as glycolysis. (medlineplus.gov)

We found that Homer3, the predominant isoform in Purkinje cells, is phosphorylated by calcium/calmodulin-dependent protein kinase II (CaMKII) both in vitro and in vivo . (jneurosci.org)

Two new phosphoglycerate kinase mutations associated with chronic haemolytic anaemia and neurological dysfunction in two patients from Spain. (medlineplus.gov)

CC04820 exhibited no selectivity with an IC50 of 17?nM for hCK2?1 and an IC50 of 11?nM for hCK2?2. (immune-source.com)

Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeutics. (nih.gov)

Specifically, the presence of tyrosine kinases in Acanthamoeba and Physarum as representatives of two distantly related subdivisions of Amoebozoa argues against the later emergence of tyrosine kinase signaling in the opisthokont lineage and also against the acquisition by horizontal gene transfer. (duke.edu)

2 and methods 2.1 Construction of the expression plasmid The coding region corresponding to amino-acid residues Met1-Gln334 of human CK2?2 was amplified by the polymerase chain reaction (PCR) and cloned into the vector pGEX-6P-1 (GE Healthcare) at the restriction sites BamHI-EcoRI providing the construct in a GST-fused form at the N-terminus. (immune-source.com)
To investigate the conformational change of c-Src tyrosine kinase, we applied network analysis to time series of correlation among residues. (intechopen.com)
With centrality measures such as betweenness centrality, degree centrality, and closeness centrality, we observed a few important residues that significantly contribute to the conformational change of c-Src tyrosine kinase for the different time steps. (intechopen.com)

I report that semaphorin 3A activates myosin II in growth cones and axons. (biologists.com)

Anatomy19

Organisms10

Chemicals and Drugs171

Analytical, Diagnostic and Therapeutic Techniques and Equipment13

Phenomena and Processes38

Disciplines and Occupations1

Information Science3

Protein kinases5

Inhibitor10

Phosphorylation9

Inhibitors10

Serine6

Creatine-Kinase1

Inhibition2

Subunit5

Mutation2

Janus4

Sensor kinase1

Receptor kinases2

Abstract1

Proteins8

Constitutively active2

Homology2

Regulates1

Catalytic activity1

Glycogen synthase2

Histidine1

Chk23

Recombinant1

LRRK21

HIPK22

Arabidopsis1

Inhibits3

Humans2

Phosphoinositide1

Phosphatidylinositol2

Deficiency7

Signal transduction1

Apoptosis5

CMGC1

Subtype2

PI3K1

Intracellular1

Interacts3

Ortholog1

Activation4

Activity8

Potent1

Structural1

Enzyme1

Isoform1

Mutations1

Selectivity1

Ovarian1

Lineage1

Residues3

Activates1