• AKAP13 is a member of a group of four RhoGEF proteins known to be activated by G protein coupled receptors coupled to the G12 and G13 heterotrimeric G proteins. (wikipedia.org)
  • A common feature of all three GPCRs is that they can couple to the G12 family of heterotrimeric G proteins [ 13 ]. (biomedcentral.com)
  • Heterotrimeric G-proteins, consisting of Gα, Gβ and Gγ subunits are the major effector molecules of GPCR signaling. (biomedcentral.com)
  • In this active, GTP-bound conformation, Rho can bind to and activate specific effector proteins and enzymes to regulate cellular functions. (wikipedia.org)
  • GPCR-regulated AKAP13 (and these related GEF proteins) acts as an effector for G12 and G13 G proteins. (wikipedia.org)
  • Gα13 (GNA13) is the α subunit of a heterotrimeric G protein that mediates signaling through specific G protein-coupled receptors (GPCRs). (biomedcentral.com)
  • Efforts to understand the genes and signaling pathways that promote tumor invasion and metastasis have revealed that several G-protein coupled receptors (GPCRs) and their respective ligands function as metastatic drivers in breast as well other cancer types [ 2 - 6 ]. (biomedcentral.com)
  • When dissociated from the heterotrimeric complex these subunits interact with a variety of second messenger systems. (jefferson.edu)
  • Rho is a small GTPase protein that is inactive when bound to the guanine nucleotide GDP. (wikipedia.org)
  • The AKAP13 gene encodes a member of the AKAP family since the protein binds tightly to PKA, especially in the heart. (wikipedia.org)
  • Among these, the G12 family, consisting of Gα12 and Gα13, (the products of the GNA12 and GNA13 genes, respectively) is one of the most important in the context of cancer. (biomedcentral.com)
  • The AceA/ICL protein family shares the catalytic domain I, triosephosphate isomerase barrel (TIM-barrel). (bvsalud.org)
  • This graph shows the total number of publications written about "GTP-Binding Protein alpha Subunits" by people in this website by year, and whether "GTP-Binding Protein alpha Subunits" was a major or minor topic of these publications. (jefferson.edu)
  • Ectopic expression of miR-31 in MDA-MB-231 cells significantly reduced GNA13 mRNA and protein levels, as well as GNA13-3′-UTR-reporter activity. (biomedcentral.com)
  • Conversely, blocking miR-31 activity in MCF-10a cells induced GNA13 mRNA, protein and 3′-UTR reporter activity. (biomedcentral.com)
  • The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins that have the common function of binding to the regulatory subunit of protein kinase A (PKA), thus confining the holoenzyme to discrete locations within the cell. (wikipedia.org)
  • Therefore, these isoforms may function as scaffolding proteins to coordinate Rho signaling and protein kinase A signaling. (wikipedia.org)
  • Our findings show that the actions of thrombin on the proliferation of RA SFs, cell-cycle progression to the S phase, and IL-6 secretion were mainly mediated by the G13 and RhoGEF pathways. (biomedcentral.com)
  • This protein is also called AKAP-Lbc because it encodes the lymphocyte blast crisis (Lbc) oncogene, and ARHGEF13/RhoGEF13 because it contains a guanine nucleotide exchange factor (GEF) domain for the RhoA small GTP-binding protein. (wikipedia.org)
  • A-kinase anchor protein 13/Rho guanine nucleotide exchange factor 13 is guanine nucleotide exchange factor (GEF) for the RhoA small GTPase protein. (wikipedia.org)
  • In this active, GTP-bound conformation, Rho can bind to and activate specific effector proteins and enzymes to regulate cellular functions. (wikipedia.org)
  • The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins that have the common function of binding to the regulatory subunit of protein kinase A (PKA), thus confining the holoenzyme to discrete locations within the cell. (wikipedia.org)
  • We previously reported a receptor-binding domain (RBD)-sortase A-conjugated ferritin nanoparticle (scNP) vaccine that induced neutralizing antibodies against SARS-CoV-2 and pre-emergent sarbecoviruses and protected non-human primates (NHPs) from SARS-CoV-2 WA-1 infection. (bvsalud.org)
  • Rho is a major small GTP-binding protein that is involved in the regulation of various cell functions, including proliferation and cell migration, through activation of multiple signaling molecules in various types of cells. (biomedcentral.com)
  • Inhibition of apoptosis-regulated signaling kinase-1 and prevention of congestive heart failure by estrogen. (uchicago.edu)
  • This study demonstrates that varicella virus-vectored SIV vaccination with protein boosts induces a 37.5% efficacy rate against pathogenic SIV challenge by generating mucosal memory, virus specific neutralizing antibodies, binding antibodies, and polyfunctional T-cell responses. (bvsalud.org)