Kinase family translation initiation eukaryotic initiation factor 2. Medical search. Frequent questions

17 and 14 genes encode BR serine/threonine-protein kinase 2 (BRSK2) and eukaryotic translation-initiation factor 2-alpha kinase 3 (Eif2ak3), respectively. (onacademic.com)
Low concentrations of heme activate Heme-Regulated Inhibitor Kinase, which phosphorylates the Serine-51 of eIF-2{alpha}, and makes its interaction with eIF-2B nonproductive(eIF-2{alpha} sequesters eIF-2B). (en-academic.com)
This gene encodes one of the three members of the human AKT serine-threonine protein kinase family which are often referred to as protein kinase B alpha, beta, and gamma. (senescence.info)
These highly similar AKT proteins all have an N-terminal pleckstrin homology domain, a serine/threonine-specific kinase domain and a C-terminal regulatory domain. (senescence.info)

1. Baltzis, D. et al: The eIF2alpha kinases PERK and PKR activate glycogen synthase kinase 3 to promote the proteasomal degradation of p53. (signalchem.com)
It was shown that glutamine deprivation down-regulated the expression level of ATF6 (activating transcription factor 6), EIF2AK3/PERK (eukaryotic translation initiation factor 2 alpha kinase 3), GLO1 (glyoxalase I), BIRC5 (baculoviral IAP repeat-containing 5), and RAB5C (RAB5C, a member of RAS oncogene family) mRNAs in control glioma cells. (ukrbiochemjournal.org)
2012) Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK). (guidetopharmacology.org)
GSK2606414 is a novel, highly selective inhibitor of protein kinase R‑like endoplasmic reticulum kinase (PERK). (spandidos-publications.com)
This process activates protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), inositol-requiring kinase 1 and activating transcription factor (ATF) 6, and initiates unfolded protein response (UPR) signaling pathways ( 13 , 14 ). (spandidos-publications.com)
As one of three primary UPR effectors, PERK directly phosphorylates eukaryotic initiation factor 2α (eIF2α), which consequently inhibits initiation of general translation and reduces ER burden ( 15 ). (spandidos-publications.com)
ATF4 induces expression of the proapoptotic transcription factor CCAAT/enhancer-binding protein homologous protein (CHOP), which mediates PERK-induced apoptosis ( 16 ). (spandidos-publications.com)
Distinct cellular stresses cause the phosphorylation and activation the eIF2α kinases PERK, PKR, GCN2 and HRI. (biomedcentral.com)

Activated Benefit phosphorylates and inhibits eukaryotic initiation aspect 2 (eIF2) resulting in global translational attenuation. (cgp60474.com)
EIF2 - (Eukaryotic Initiation Factor 2) is an eukaryotic initiation factor. (en-academic.com)
Western blot analysis was used to measure eukaryotic initiation factor 2α (eIF2α) phosphorylation levels. (spandidos-publications.com)
However, eIF2α phosphorylation leads to selective translation of numerous mRNAs, including ATF4. (spandidos-publications.com)
Early accomplishments of the SNCGE in this area include discovering the novel regulatory mechanism that induces translation of GCN4 mRNA via small upstream ORFs (uORFs) in the mRNA leader by phosphorylation and inhibition of eIF2 by the kinase Gcn2, now understood to regulate expression of key transcription factors (Atf4 and Atf5) in mammals and implicated in learning and memory. (nih.gov)
We also made key contributions to identifying the eIF2α kinase Gcn2 and elucidating its regulation by amino acids, via allosteric control of kinase activity by uncharged tRNAs and Gcn2 regulatory domains, and by the TOR pathway through Gcn2-Ser577 phosphorylation. (nih.gov)
We identified the eIF2α phosphatases in yeast and made key contributions to elucidating the mechanism whereby phosphorylated eIF2 inhibits its GDP-GTP exchange factor, eIF2B, defining the catalytic and regulatory subcomplexes of eIF2B and their distinct roles in binding phosphorylated or nonphosphorylated eIF2. (nih.gov)
In starvation conditions, the reinitiating ribosomes bypass uORFs 2-4 and reinitiate at GCN4 instead, owing to lowered availability of the ternary complex (TC)-comprised of initiation factor 2 (eIF2), GTP, and initiator Met-tRNAi-which binds to the small (40S) ribosomal subunit to assemble a 43S preinitiation complex (PIC). (nih.gov)
TC abundance is reduced in starved cells by phosphorylation of eIF2α by Gcn2, converting eIF2 from substrate to inhibitor of its guanine nucleotide exchange factor (GEF) eIF2B. (nih.gov)
Phosphorylation of eIF2α on Ser51 inhibits 5' cap-dependent mRNA translation, resulting in the global suppression of protein synthesis to facilitate adaptation to a variety of stresses linked to protein synthesis, including proteotoxic stress, viral replication, heme depletion and amino acid withdrawal [ 2 ]. (biomedcentral.com)
Paradoxically, eIF2α phosphorylation also results in the increased translation of select mRNA bearing upstream open reading frames that favor 5' cap-independent translation [ 3 ]. (biomedcentral.com)
The eIF2α kinases phosphorylate Ser51 of eIF2α which leads to suppression of global protein synthesis but selective enhancement of translation of some mRNAs, such as that encoding ATF4. (biomedcentral.com)

Extracellular signal-regulated kinase (ERK) is a part of the mitogen-activated protein kinase (MAPK) signaling pathway which allows the transduction of various cellular signals to final effectors and regulation of elementary cellular processes. (mdpi.com)
For instance, it can be activated by oncogenic mutations of PTEN, VHL, the RAS/mitogen-activated protein kinase (MAPK) pathway and the phosphorylation of phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway. (spandidos-publications.com)

Complement C3a receptor 1 is the receptor for complement factor C3a, a component of the alternative complement cascade. (guidetomalariapharmacology.org)
However, the complement C5a receptor 2 may act as a decoy receptor for C5a, as it has no reported G protein signalling capacity. (guidetomalariapharmacology.org)
CB 2 receptor on eosinophils mainly mediates anti-inflammatory and immunomodulatory actions e.g. downregulation of pro-inflammatory mediator release. (guidetomalariapharmacology.org)
Image analysis of the matched maps identified 7 proteins that were either over- or down-expressed: activated protein kinase c receptor (LACK), alpha tubulin (×2), prostaglandin f2-alpha synthase, protein disulfide isomerase, vesicular transport protein and a hypothetical protein. (who.int)
complement C3d receptor 2 [Source:HGNC S. (gsea-msigdb.org)
colony stimulating factor 1 receptor [So. (gsea-msigdb.org)
AKT/PI3K forms a key component of many signalling pathways that involve the binding of membrane-bound ligands such as receptor tyrosine kinases, G-protein coupled receptors, and integrin-linked kinase. (senescence.info)
adiponectin receptor 2 [Source:HGNC Sy. (gsea-msigdb.org)

Recent evidence links synaptic plasticity and mRNA translation, via the eukaryotic elongation factor 2 kinase (eEF2K) and its only known substrate, eEF2. (nature.com)
A key element regulating the elongation phase is the eukaryotic elongation factor (eEF2) pathway [ 8 ]. (nature.com)
eukaryotic elongation factor 2 kinase [S. (gsea-msigdb.org)

Predicted to enable eukaryotic translation initiation factor 2alpha kinase activity. (zfin.org)

Even though EIF4EBP2 protein binds eIF4E and inhibits translation initiation, growth factors can release this inhibition by a phosphorylation-dependent disruption. (prospecbio.com)
3 In that clinical trial, some clinical responses associated with the reduction of eukaryotic translation initiation factor 4E (eIF4E) levels were seen. (haematologica.org)
AKT proteins also participate in the mammalian target of rapamycin (mTOR) signalling pathway which controls the assembly of the eukaryotic translation initiation factor 4F (eIF4E) complex and this pathway, in addition to responding to extracellular signals from growth factors and cytokines, is disregulated in many cancers. (senescence.info)
Markedly, we found that suppression of HIF-1α accumulation by celastrol correlated with strong dephosphorylation of mammalian target of rapamycin (mTOR) and its effectors, ribosomal protein S6 kinase (p70S6K) and eukaryotic initiation factor 4E (eIF4E) and extracellular signal-regulated kinase (ERK), pathways known to regulate HIF-1α expression at the translational level. (spandidos-publications.com)

EIF4EBP2 mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway. (prospecbio.com)
It was shown previously that inhibition of ERN1 (endoplasmic reticulum to nucleus signaling 1) pathway, a central mediator of the unfolded protein response, leads to suppression of tumor growth through down-regulation of key pro-proliferative and up-regulation of tumor suppressor factors and modifies the sensitivity of these genes to glucose and glutamine deprivation. (ukrbiochemjournal.org)
Targeted inhibition of individual kinases of the MAPK signaling pathway using synthetic compounds represents a promising way to effective anti-cancer therapy. (mdpi.com)
The mGluR5-ERK1/2 pathway is not constitutively overactive in the Fmr1 KO, however, suggesting that mRNA translation is hypersensitive to basal ERK1/2 activation in the absence of FMRP. (jneurosci.org)
We find that hypersensitivity to ERK1/2 pathway activation also contributes to audiogenic seizure susceptibility in the Fmr1 KO. (jneurosci.org)
These results suggest that the ERK1/2 pathway, and other neurotransmitter systems that stimulate protein synthesis via ERK1/2, represent additional therapeutic targets for FXS. (jneurosci.org)
These findings have helped to illuminate the molecular mechanism of TC recruitment and assembly of 43S PICS at an early stage of the initiation pathway. (nih.gov)
The integrated stress response (ISR) is an adaptive signaling pathway that contributes to the biology of a number of hematologic malignancies since they are inherently prone to numerous cellular stresses [ 2 ]. (biomedcentral.com)
The ISR (Fig. 1 ) is a complex signaling pathway that regulates cellular responses to stress stimuli and enables either adaptation or the instigation of cell death mechanisms [ 2 ]. (biomedcentral.com)

Plastid-specific ribosomal proteins (PSRPs) have been proposed to play roles in the light-dependent regulation of chloroplast translation. (cipsm.de)
Expression of the Escherichia coli tryptophanase operon depends on ribosome stalling during translation of the upstream TnaC leader peptide, a process for which interactions between the TnaC nascent chain and the ribosomal exit tunnel are critical. (cipsm.de)

Activation of EIF2AK2 leads to its autophosphorylation and then phosphorylation of its natural substrate, the alpha subunit of eukaryotic protein synthesis initiation factor-2. (signalchem.com)
In vitro kinase assays and immunoblotting using lysates from human MV4;11 leukemic cells showed inhibition of phosphorylation of known PIM downstream targets, such as BAD and eukaryotic translation initiation factor 4E-binding protein 1, by K00135. (ox.ac.uk)
eEF2 is itself regulated by inhibitory phosphorylation at Thr56 by an upstream kinase, eEF2 kinase (eEF2K), also known as calmodulin-dependent protein kinase III. (nature.com)
Phosphorylation of Eukaryotic Initiation Factor 2 by Heme-Regulated Inhibitor Kinase-Related Protein Kinases in Schizosaccharomyces pombe Is Important for Resistance to Environmental Stresses. (en-academic.com)
Phosphorylation of additional residues also occurs, for example, in response to insulin growth factor-1 and epidermal growth factor. (senescence.info)

In this study, 23 growth-related candidate genes containing 48 SNP markers were screened through bulked segregant analysis (BSA) among transgenic Yellow River carp family members showing significant separation of growth traits. (onacademic.com)
17 and 14 genes) were identified through combined genome-wide association study (GWAS) of candidate genes and validation of the full-sibling family approach. (onacademic.com)
The expression of a subset of genes encoding important tumor growth related factors in U87 glioma cells with ERN1 (endoplasmic reticulum to nucleus signaling 1) loss of function as well as upon glutamine deprivation was studied. (ukrbiochemjournal.org)
5 Moreover some of these genes contain polymorphisms which act as risk factors for the development of PD. (acnr.co.uk)
This compound markedly decreased the hypoxia-induced accumulation of HIF-1α protein dose-dependently, whereas it did not affect the expressions of HIF-1β and topoisomerase-I (topo‑I). Furthermore, celastrol prevented hypoxia-induced expression of HIF-1 target genes for vascular endothelial growth factor (VEGF) and erythropoietin (EPO). (spandidos-publications.com)
5′-GACGTG-3′) on the promoter region in various target genes ( 1 , 2 ). (spandidos-publications.com)
The family includes Boule (or Boll ), Dazl (or Dazla ) and DAZ genes. (ijbs.com)
Here we discuss DAZ family genes in a phylogenic perspective, focusing on the common and distinct features of these genes, and their pivotal roles during gametogenesis evolved during evolution. (ijbs.com)
DAZ (Deleted in Azoospermia) family genes are important fertility factors in many animals including humans. (ijbs.com)
DAZ family genes are highly conserved. (ijbs.com)

EIF2AK2 plays a critical role in mRNA translation, cell proliferation and apoptosis. (signalchem.com)
In the brain, mRNA translation is a critical cellular mechanism, providing tailored responses to the different demands of general homeostasis and synaptic plasticity, and is regulated in both its initiation and elongation phases [ 6 ]. (nature.com)
Fragile X syndrome (FXS) is caused by loss of the FMR1 gene product FMRP (fragile X mental retardation protein), a repressor of mRNA translation. (jneurosci.org)
Our data suggest that elevated protein synthesis in the Fmr1 KO is due to saturation of mRNA translation downstream of the MAP kinase ERK1/2 which is basally activated by mGluR5. (jneurosci.org)
The localization of DAZ family proteins suggests that they can regulate mRNA translation occurring in the cytoplasm. (ijbs.com)

Orthologous to human EIF2AK3 (eukaryotic translation initiation factor 2 alpha kinase 3). (zfin.org)

We find that elevated basal protein synthesis in Fmr1 KO mice is selectively reduced to wild-type levels by acute inhibition of mGluR5 or ERK1/2, but not by inhibition of mTOR (mammalian target of rapamycin). (jneurosci.org)

diacylglycerol kinase delta [Source:HGNC. (gsea-msigdb.org)

These proteins are phosphorylated by phosphoinositide 3-kinase (PI3K). (senescence.info)

eukaryotic translational initiation aspect-2 kinase 3 (Benefit), inositol-requiring enzyme 1 (IRE1) and activating transcription aspect 6 (ATF6) thus activating these protein. (cgp60474.com)
Nevertheless, specific mRNAs gain a selective benefit for translation under these circumstances e.g. activating transcription aspect (ATF4). (cgp60474.com)
The present study investigated the effects of GSK2606414 on proliferation, apoptosis, and the expression of activating transcription factor 4 (ATF4), CCAAT/enhancer‑binding protein homologous protein (CHOP) and vascular endothelial growth factor (VEGF) in human retinal pigment epithelial (RPE) cells under endoplasmic reticulum (ER) stress. (spandidos-publications.com)
ETS transcription factor ELK3 [Source:HG. (gsea-msigdb.org)
Survival factors can suppress apoptosis in a transcription-independent manner by activating AKT1 which then phosphorylates and inactivates components of the apoptotic machinery. (senescence.info)
TCF-1 is an HMG family transcription factor which is known to be critical for T cell development. (gsea-msigdb.org)
E74 like ETS transcription factor 2 [S. (gsea-msigdb.org)
HMG-box transcription factor 1 [Source. (gsea-msigdb.org)
In hypoxia, several transcription factors are induced to respond to the decreased oxygen level. (spandidos-publications.com)
Among these transcription factors, hypoxia-inducible factor-1 (HIF-1) is one of the most important factors that play a critical role in controlling oxygen delivery and metabolic adaptation to hypoxic conditions. (spandidos-publications.com)

The helical domain of phosphoinositide 3-kinase. (eu.org)

cyclin dependent kinase inhibitor 2B [So. (gsea-msigdb.org)

Overview of all the structural information available in the PDB for UniProt: Q9P2K8 (eIF-2-alpha kinase GCN2) at the PDBe-KB. (wikipedia.org)

HEAT repeat domain, found in protein phosphatase 2a and initiation factor eIF4G. (eu.org)
MIF4G domain-like, found in eukaryotic initiation factor eIF4G, translation initiation factor eIF-2b epsilon and nuclear cap-binding protein CBP80. (eu.org)

bone morphogenetic protein 2 [Source:HGN. (gsea-msigdb.org)

The motif is conserved in essential proteins throughout the eukaryotic domain of life and also in human viruses, suggesting that the motifs are required for basic cellular function. (eu.org)
Cell proteins were analysed with 2-dimensional electrophoresis and differentially expressed proteins were identified by matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry. (who.int)
Our preliminary study using 2D isolates were recovered from liq- new cases throughout the world cu- gel electrophoresis in drug sensitive/ uid nitrogen, and sub-cultured in taneous leishmaniasis (CL) remains resistant strains of L. tropica showed RPMI1640 medium (Gibco/BRL) a serious public health problem in that some proteins were differentially supplemented with 10% fetal bovine numerous countries [1,2]. (who.int)
AMP-activated protein kinase - 5 AMP activated protein kinase or AMPK consists of three proteins (subunits) that together make a functional enzyme, conserved from yeast to humans, that plays a role in cellular energy homeostasis. (en-academic.com)
DAZ family proteins are found almost exclusively in germ cells in distant animal species. (ijbs.com)
Basically, Daz family proteins function as adaptors for target mRNA transport and activators of their translation. (ijbs.com)
This family includes three members, Boule (or Boll ), Dazl (or Dazla ) and DAZ , encoding RNA binding proteins. (ijbs.com)
DAZ family proteins are located in the nucleus and/or in the cytoplasm of male and female germ cells at different developmental stages throughout the gametogenesis. (ijbs.com)
Combining with other proteins, DAZ family members play a crucial role in male and female gametogenesis conserved throughout the evolution. (ijbs.com)
Basically, DAZ family proteins have been proposed to function as adaptors for mRNA transport and activators of their translation. (ijbs.com)

2. Alirezaei, M. et al: Human immunodeficiency virus-1/surface glycoprotein 120 induces apoptosis through RNA-activated protein kinase signaling in neurons. (signalchem.com)
Long term and extreme ER tension induced -cell apoptosis is certainly connected with c-jun N-terminal kinase (JNK) activation [9], [15]. (cgp60474.com)

casein kinase 1 epsilon [Source:HGNC S. (gsea-msigdb.org)

EIF2AK2 acts as a critical mediator of gp120 neurotoxicity and is a substrate for a family of protein kinases that respond to various forms of environmental stress. (signalchem.com)
Under normoxic conditions, prolyl hydroxylases (PHDs) hydroxylate the cite-specific proline residues of HIF-1α in a reaction that uses O 2 as a substrate. (spandidos-publications.com)

This was followed by sustained MTOR (mechanistic target of rapamycin) activation, with enlarged cell size, glucose uptake and translation, which is detrimental to the quiescent HSCs. (ox.ac.uk)

kinase inhibitors for LRRK2 mutations. (acnr.co.uk)
Subsequently two other point mutations A30P (described in one German family) and E46K (one Basque family) were described. (acnr.co.uk)
2 However, resistance mechanisms and targeting strategies can be specific to certain subtypes and mutations. (haematologica.org)
These studies exploit a genetic selection for mutations that elevate initiation at near-cognate UUG start codons (Sui− phenotype) or suppress this aberrant initiation event (Ssu− phenotype) (Figure 1B). (nih.gov)

Eukaryotic translation initiation factor 2-alpha kinase 4 is an enzyme that in humans is encoded by the EIF2AK4 gene. (wikipedia.org)
There is a strong history of type 2 diabetes in carriers of the disease gene. (diabetesjournals.org)
It is likely that chromosome 10p12.1-p13 may harbor a maturity-onset diabetes of the young or type 2 diabetes gene. (diabetesjournals.org)

HCK proto-oncogene, Src family tyrosin. (gsea-msigdb.org)

family with sequence similarity 13 membe. (gsea-msigdb.org)
family with sequence similarity 8 memb. (gsea-msigdb.org)

The peptide transporter carbon starvation (CstA) family (transporter classification [TC] 2.A.114) belongs to the second largest superfamily of secondary transporters, the amino acid/polyamine/organocation (APC) superfamily. (cipsm.de)

Structural analysis identifies imidazo[1,2-b]pyridazines as PIM kinase inhibitors with in vitro antileukemic activity. (ox.ac.uk)
Thus, the identified inhibitors are ATP competitive but not ATP mimetic compounds, explaining their enhanced selectivity with respect to conventional type I kinase inhibitors. (ox.ac.uk)

At the same time, the expression level of HSPB8 (heat shock 22kDa protein 8) and HSPA5/GRP78 (heat shock protein family A (Hsp70) member 5) mRNAs was resistant to glutamine withdrawal in these glioma cells. (ukrbiochemjournal.org)
DnaJ heat shock protein family (Hsp40). (gsea-msigdb.org)

According to the current model, scanning ribosomes translate the 5′-most uORF (uORF1) and, under non-starvation conditions, reinitiate translation at downstream uORFs 2, 3, or 4 and subsequently dissociate from the mRNA, keeping GCN4 translation repressed. (nih.gov)
A new study, recently published in eLife by Dr. John Gordan of UCSF, elaborates some of the downstream effects of protein kinase A (PKA) in certain cancers, including fibrolamellar. (fibrofoundation.org)

Obese and diabetic topics have raised plasma degrees of nonesterified essential fatty acids (NEFAs) and hyperglycemia, that are believed to trigger reduced insulin synthesis and impaired blood sugar responsiveness in pancreatic -cells, termed glucolipotoxicity [2] also, [3]. (cgp60474.com)

L'analyse d'image des cartes appariées a permis d'identifier sept protéines qui étaient soit surexprimées, soit sous-exprimées : le récepteur de la protéine kinase C activée, la tubuline alpha (×2), la prostaglandine F2-alpha synthase, la protéine disulfide isomérase, une protéine du transport vésiculaire et une protéine hypothétique. (who.int)
Heme-regulated inhibitor (HRI) kinase is a member of the eIF-2{alpha} kinase family. (en-academic.com)
Under normal cellular conditions, eIF-2{alpha} productively interacts with eIF-2B, giving rise to guanine-nucleotide exchange activity that is essential for protein translation. (en-academic.com)
choline kinase alpha [Source:HGNC Symbol. (gsea-msigdb.org)

The higher degree of plasticity of the motif and the transient interaction provides a regulatory mechanism that acts to secure a proper balance between phosphatase and kinase activity in a given signaling network. (eu.org)

We determined subnanometer-resolution cryo-electron microscopy structures of eukaryotic ribosome-Sec61 complexes. (cipsm.de)

Much attention has recently been focused on PIM kinases as potential targets for the treatment of hematopoietic malignancies and some solid cancers. (ox.ac.uk)

EIF4EBP2 belongs to the eukaryotic translation initiation factor 4E binding protein family. (prospecbio.com)

EIF2AK2 (also known as double-stranded RNA-activated protein kinase) is a protein kinase that has been shown to be involved in HIV/gp120-associated neurodegeneration (1). (signalchem.com)
Western blot analysis of EIF2AK2 in Caco-2 whole cell lysate with EIF2AK2 antibody at (A) 1 and (B) 2 ug/ml. (signalchem.com)

In collaboration with Jon Lorsch's group, we demonstrated that segments/residues in eIF1, eIF1A, tRNAi and 18S rRNA, which are implicated genetically in TC recruitment, also stimulate the rate of this reaction in a fully reconstituted yeast in vitro translation system. (nih.gov)

Anatomy21

Organisms12

Diseases1

Chemicals and Drugs137

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Phenomena and Processes68

Technology, Industry, Agriculture1

Information Science3

Serine4

PERK8

EIF212

Mitogen-activa2

Receptor8

Elongation factor3

2alpha kinase1

EIF4E4

Pathway9

Ribosomal2

Phosphorylation5

Genes10

MRNA translation5

EIF2AK31

Inhibition1

Diacylglycerol kinase1

PI3K1

Transcription10

Phosphoinositide1

Cyclin1

GCN21

EIF4G2

Source:HGN1

Proteins10

Apoptosis2

Epsilon1

Substrate2

Rapamycin1

Mutations4

Gene3

Proto-oncogene1

Sequence similarity2

Transporter1

Inhibitors2

Heat shock protein2

Downstream2

Pancreatic1

Alpha4

Phosphatase1

Ribosome1

Cancers1

Binding1

EIF2AK22

Vitro1