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Transcription FactorsMSX1 Transcription FactorTranscription, GeneticDNA-Binding ProteinsPromoter Regions, GeneticMolecular Sequence DataBase SequenceGene Expression RegulationSp1 Transcription FactorBinding SitesProtein BindingTranscriptional ActivationRNA, MessengerTrans-ActivatorsHomeodomain ProteinsSignal TransductionProtein-Serine-Threonine KinasesPhosphatidylinositol 3-KinasesCell LineNuclear ProteinsMAP Kinase Signaling SystemTranscription Factor AP-1Basic Helix-Loop-Helix Transcription FactorsAmino Acid SequenceProtein KinasesMutationGene Expression Regulation, DevelopmentalRepressor ProteinsTransfectionForkhead Transcription FactorsDNACell NucleusCell DifferentiationCells, CulturedBasic-Leucine Zipper Transcription FactorsPhosphorylationHeLa CellsCalcium-Calmodulin-Dependent Protein KinasesTranscription Factor AP-2Genes, ReporterProtein Kinase InhibitorsKruppel-Like Transcription FactorsTranscription Factors, TFIINF-kappa BRecombinant Fusion ProteinsChromatin ImmunoprecipitationSTAT3 Transcription FactorReverse Transcriptase Polymerase Chain ReactionProto-Oncogene ProteinsProtein Structure, TertiaryCloning, MolecularYY1 Transcription FactorCell Line, Tumorsrc-Family KinasesNFATC Transcription Factorsp38 Mitogen-Activated Protein KinasesGATA4 Transcription FactorTranscription Factor TFIIDGene ExpressionBlotting, WesternPaired Box Transcription FactorsActivating Transcription Factor 2Cyclic AMP-Dependent Protein KinasesElectrophoretic Mobility Shift AssayPlasmidsActivating Transcription Factor 3Protein Kinase CSequence Homology, Amino AcidZinc FingersSp3 Transcription FactorModels, BiologicalTranscription Initiation SiteGene Expression ProfilingEnhancer Elements, GeneticJNK Mitogen-Activated Protein KinasesTumor Cells, CulturedRegulatory Sequences, Nucleic AcidTranscription Factor TFIIBE2F1 Transcription FactorRNA Polymerase IIMitogen-Activated Protein Kinase 1Mice, KnockoutGene Expression Regulation, FungalSaccharomyces cerevisiaeDown-RegulationLuciferasesSaccharomyces cerevisiae ProteinsMEF2 Transcription FactorsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsRecombinant ProteinsMitogen-Activated Protein Kinase KinasesGATA3 Transcription FactorGATA1 Transcription FactorGATA2 Transcription FactorTCF Transcription FactorsSTAT1 Transcription FactorProtein-Tyrosine KinasesSequence AlignmentUp-RegulationMicrophthalmia-Associated Transcription Factor
GenesPhosphorylationReceptorsProteinsHomeodomain transcription factorsMAPKProteinSignalling pathwaySignal transductionRegulatesHomeoboxEnhancerGenetic FactorsDifferentiationRegulatoryMetabolismCellsNuclearRegulateInductionProliferationTumorEmbryoCellSuperfamilyTranscriptionalDevelopmentRoleMoleculesDiseaseHuman
Genes9
  • Serum response factor (SRF) plays a central role during myogenesis, being required for the expression of striated alpha-actin genes. (wikipedia.org)
  • We also show that Dlx and Smad proteins localize to promoters/enhancers of a number of common telencephalic genes in vivo and that Smad proteins co-activate transcription with Dlx family members, except with certain mutated human DLX proteins identified in autistic individuals. (biomedcentral.com)
  • SHH signaling regulates dorsoventral patterning of the neural tube by repressing genes that are associated with dorsal and lateral fates and by activating genes associated with ventral fates (reviewed by Briscoe and Ericson, 2001 ). (silverchair.com)
  • Although the etiology of dental agenesis The association between AXIN2 and CRC involves defects in the involved genetic and environmental factors, the genes more canonical WNT signaling pathway, which regulates and coordi- frequently associated with hypodontia in different populations are nates the AXIN complex for the degradation of β-catenin under 2,3 AXIN2, MSX1, PAX9, EDA, and WNT10. (sagepub.com)
  • Background: HOX genes encode a family of homeodomain-containing transcription factors involved in the determination of cell fate and identity during embryonic development. (123dok.net)
  • 25 The downstream target genes of MAPK signaling cascades comprise of the differentiation related transcription aspects Jun ATF2/AP1, C/EBPB and Egr one, which are known to get necessary for myeloid differentiation. (chk1inhibitor.com)
  • 26 29 Yet, in spite of a lot of reviews for the function of important MAPK cascade kinases and their target genes in hematopoiesis,thirty it is not clear what reg ulates the MAPK cascades in VDD induced cell differentiation. (chk1inhibitor.com)
  • We established at mRNA level the expression of 84 genes partici pating inside the MAPK signaling network and cell cycle regulation employing Human MAP kinase RT2 Profile PCR Array. (chk1inhibitor.com)
  • To better understand the molecular changes associated with AD, genome-wide association studies (GWAS) have identified hundreds of candidate genes linked to the disease, like the receptor tyrosine kinase EphA1. (sdbonline.org)
Phosphorylation3
  • 2005 ). They act by stimulating specific membrane serine/threonine receptor complexes, the activin-like kinase receptors, resulting in the phosphorylation and activation of regulatory Smads (R-Smads). (biomedcentral.com)
  • In this study, we provide multiple lines of evidence showing that the post-translational phosphorylation of MSY3 by Akt kinase modulates the MSY3 repression of myogenin. (biomedcentral.com)
  • STAT transcription factors are recruited to the cytoplasmic region of CELL SURFACE RECEPTORS and are activated via PHOSPHORYLATION . (nih.gov)
Receptors2
  • Smads 1, 5 and 8 are mainly activated by BMP and GDF receptors, while Smads 2 and 3 are substrates for TGF-β, activin and Nodal receptors. (biomedcentral.com)
  • Cell surface cyclic AMP receptors are not included (CYCLIC AMP RECEPTORS), nor are the eukaryotic cytoplasmic cyclic AMP receptor proteins, which are the regulatory subunits of CYCLIC AMP-DEPENDENT PROTEIN KINASES. (bvsalud.org)
Proteins7
  • Furthermore, Smad proteins, transcriptional effectors of TGF-β signaling, are co-expressed and physically interact in the basal ganglia with Dlx homeodomain transcription factors, which are critical regulators of the differentiation, migration and survival of telencephalic GABAergic neurons. (biomedcentral.com)
  • In that regard, recent studies in non-neural cells have suggested the existence of functional interactions between Dlx proteins and Smad transcription factors, which are critical mediators of transforming growth factor-β (TGF-β) superfamily signaling pathways (Chiba et al. (biomedcentral.com)
  • MSY3 (MSY4, YB-2, CSDA, dbpA, ZONAB) is a member of the cold shock domain (CSD) family of proteins also known as Y-box proteins, which are evolutionarily conserved proteins that function as transcription factors and regulators of RNA metabolism and protein synthesis. (biomedcentral.com)
  • In cells receive the WNT signal, β-catenin is stabilized and joins the addition, AXIN2 has also been independently associated with DNA-bound T-cell factor family of transcription proteins for tooth agenesis and non-syndromic cleft lip palate (NSCLP). (sagepub.com)
  • This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. (cancer-genetics.org)
  • To check this hypothesis, we overexpressed inducible types of HES-1 and MSX-1 proteins in mouse ESCs and examined differentiation into Azlocillin sodium salt NC derivatives, including neural, soft muscle tissue, and chondrocyte-like cells, after activation of the transcription elements. (globaltechbiz.com)
  • Rel frequently combines with other related proteins (NF-KAPPA B, I-kappa B, relA) to form heterodimers that regulate transcription. (childrensmercy.org)
Homeodomain transcription factors1
  • Four members of the mouse Dlx protein family (Dlx1, 2, 5 and 6), part of the Antennapedia class of non-Hox homeodomain transcription factors, are expressed in the embryonic subpallium (Panganiban and Rubenstein 2002 ). (biomedcentral.com)
MAPK1
  • The 1,25D delicate HL60 cells had been compared with 1,25D resistant 40AF cells, and this recognized, for the first time, hematopoietic progenitor kinase one as the most upregulated MAPK gene within the one,25D resistant cells. (chk1inhibitor.com)
Protein2
  • Here we show that components of both bone morphogenetic protein/growth differentiation factor and TGF-β/activin/Nodal branches of TGF-β superfamily signaling are expressed in the developing subpallium. (biomedcentral.com)
  • The Y-box protein MSY3/Csda represses myogenin transcription in skeletal muscle by binding a highly conserved cis-acting DNA element located just upstream of the myogenin minimal promoter (myogHCE). (biomedcentral.com)
Signalling pathway1
  • Subsequent studies further confirmed that Mage-D1 inhibits the NF-κB signalling pathway by combining with IκB kinase β (IKKβ) 22 , which is a vital regulator of odontoblast differentiation. (researchsquare.com)
Signal transduction1
Regulates1
  • DUSP6/MKP3 is a dual-specific phosphatase that regulates extracellular regulated kinase ERK1/2 and ERK5 activity, with an increasingly recognized role as tumor suppressor. (cancer-genetics.org)
Homeobox2
  • In vitro, Mage-D1 not only binds to p75 neurotrophin receptor (p75NTR) but also to distal-less homeobox 1(Dlx1) and msh homeobox 1 (Msx1). (researchsquare.com)
  • Further studies confirmed that p75NTR participates in the regulation of tooth development maybe by changing the activity of the key factor distal-less homeobox/msh homeobox (Dlx/Msx), and melanoma-associated antigen D1 (Mage-D1) seems to be play a role in the differentiation and mineralization of EMSCs 5 , 6 . (researchsquare.com)
Enhancer1
  • They include: Myocyte enhancer factors (MEFs), which promote myogenesis. (wikipedia.org)
Genetic Factors5
  • Each stage has various associated genetic factors lack of which will result in muscular defects. (wikipedia.org)
  • Associated Genetic Factors: PAX3 and c-Met Mutations in PAX3 can cause a failure in c-Met expression. (wikipedia.org)
  • Associated Genetic Factors: c-Met/HGF and LBX1 Mutations in these genetic factors causes a lack of migration. (wikipedia.org)
  • Associated Genetic Factors: PAX3, c-Met, Mox2, MSX1, Six, Myf5, and MyoD Mox2 (also referred to as MEOX-2) plays an important role in the induction of mesoderm and regional specification. (wikipedia.org)
  • Remarkably, at age 14 years, facial acne in girls was less influenced by genetic factors than in boys and was significantly influenced by common environmental factors [12]. (springer.com)
Differentiation3
  • When the growth factor runs out, the myoblasts cease division and undergo terminal differentiation into myotubes. (wikipedia.org)
  • This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. (cancer-genetics.org)
  • Manifestation of Hes1 and Msx1 in Wild-type Sera Cells in Pluripotent Circumstances and after NC Differentiation To investigate the part of and in the differentiation of mESCs into neural crest cells, we utilized the stromal cell-inducing activity of Pre-adipose 6 (PA6) cells for 5 times [17], accompanied by the addition of BMP4, which commits cells to differentiate into NC derivatives [6]. (globaltechbiz.com)
Regulatory3
  • Myogenic regulatory factors (MRFs): MyoD, Myf5, Myf6 and Myogenin. (wikipedia.org)
  • Myf5 is considered to be the earliest expressed regulatory factor gene in myogenesis. (wikipedia.org)
  • Basic helix-loop-helix (bHLH) myogenic regulatory factors coordinate the correct function and organization of many skeletal muscle functions. (biomedcentral.com)
Metabolism1
  • Through PPI network analysis and functional enrichment analysis, it had been found that the pharmacological mechanism of Xiaoyaosan mainly involved biological processes such as oxidative stress, kinase activity, and DNA metabolism. (bvsalud.org)
Cells5
  • If placed in cell culture, most myoblasts will proliferate if enough fibroblast growth factor (FGF) or another growth factor is present in the medium surrounding the cells. (wikipedia.org)
  • PAX3 mediates the transcription of c-Met and is responsible for the activation of MyoD expression-one of the functions of MyoD is to promote the regenerative ability of satellite cells (described below). (wikipedia.org)
  • The growth of individual tissue compartments is mainly related to the proliferation of the cells that comprise that compartment, whereas intercellular communication mediated by various morphogens and growth factors is responsible for coordination of growth between neighboring tissue compartments. (molcells.org)
  • Conclusions: Our results suggest that HOXD9 may be a novel marker of GCSCs and cell proliferation and/or survival factor in gliomas and glioma cancer stem-like cells, and a potential therapeutic target. (123dok.net)
  • We found that transcripts were increased in MGR cells, whereas coactivation of HGR+MGR caused a significant increase in (-found that some of the transcription factors associated with the development of the NC are coexpressed with pluripotency factors at the blastula and gastrula stages. (globaltechbiz.com)
Nuclear1
  • In embryos, chimeric variations of (mouse homologue of fused towards the ligand binding site of human being glucocorticoid receptor (GR) was utilized to activate HES-1 and MSX-1 by inducing their nuclear translocation after dexamethasone (Dex) addition. (globaltechbiz.com)
Regulate2
  • Signaling mechanisms mediated by the Transforming Growth Factor-β (TGF-β) superfamily regulate a variety of developmental processes. (biomedcentral.com)
  • It was subsequently shown to regulate several functions unrelated to catabolism, and to be both a negative and a positive regulator of transcription. (bvsalud.org)
Induction2
  • These coordinates are achieved through the induction of specific sets of transcription factors in response to a variety of extrinsic cues. (biomedcentral.com)
  • Nevertheless, many experimental techniques are designed inside a nonregulated style, precluding evaluation at different period factors during NC Rabbit Polyclonal to C-RAF induction. (globaltechbiz.com)
Proliferation1
  • c-Met is a tyrosine kinase receptor that is required for the survival and proliferation of migrating myoblasts. (wikipedia.org)
Tumor1
  • We will focus particularly on the roles of a tumor suppressor, neurofibromin 2 (NF2), whose expression is not only dependent on compartment-specific transcription factors, but is also subject to regulation by a Hippo-Yap feedback signaling circuit. (molcells.org)
Embryo1
  • In the embryo, zygotic transcription of Eph is confined to the nervous system. (sdbonline.org)
Cell2
  • In our previous studies, EMSCs were obtained from rat embryonic facial process tissue by fluorescence p75 neurotrophin receptor (p75NTR) activated cell sorting, providing a good stem cell model for studies of dental mineralization. (researchsquare.com)
  • Once activated they dimerize and translocate into the CELL NUCLEUS where they influence GENE expression. (nih.gov)
Superfamily1
  • Together, these results suggest that TGF-β superfamily signaling plays a role in telencephalic GABAergic neuron development through functional interactions with Dlx transcription factors. (biomedcentral.com)
Transcriptional1
  • A transcriptional regulator in prokaryotes which, when activated by binding cyclic AMP, acts at several promoters. (bvsalud.org)
Development1
  • These consequences further reveal the complexity of myogenesis and the importance of each genetic factor in proper muscle development. (wikipedia.org)
Role2
  • A role for a Drosophila Eph receptor tyrosine kinase (Eph) in the control of photoreceptor axon and cortical axon topography in the developing visual system is described. (sdbonline.org)
  • These observations reveal a conserved role for Eph kinases as determinants of topographic map formation in vertebrates and invertebrates (Dearborn, 2002). (sdbonline.org)
Molecules1
  • Secreted from neighboring tissues, signaling molecules of the Wnt, Fgf, and Bmp families cooperate to activate a distinct combination of transcription factors at the neural plate border. (biomedcentral.com)
Disease1
  • A large twin study demonstrated that 81 % of the variance of the disease was attributed to additive genetic effects, whereas the remaining 19 % was attributed to unique, unshared environmental factors [10]. (springer.com)
Human3
  • Real-world patient-reported outcomes and physician satisfaction with poly (ADP-ribose) polymerase inhibitors versus chemotherapy in patients with germline BRCA1/2-mutated human epidermal growth factor receptor 2-negative advanced breast cancer from the United States, Europe, and Israel. (jefferson.edu)
  • Real-World Study of Regional Differences in Patient Demographics, Clinical Characteristics, and BRCA1/2 Mutation Testing in Patients with Human Epidermal Growth Factor Receptor?2-Negative Advanced Breast Cancer in the United States, Europe, and Israel. (jefferson.edu)
  • Real-world study of patients with germline BRCA1/2-mutated human epidermal growth factor receptor 2?Negative advanced breast cancer: Patient demographics, treatment patterns, adverse events, and physician-reported satisfaction in the United States, Europe, and Israel. (jefferson.edu)